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Tropical trees inherit low-frequency somatic mutations. 热带树木会遗传低频率的体细胞突变。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1016/j.tig.2024.05.003
Sou Tomimoto, Akiko Satake
{"title":"Tropical trees inherit low-frequency somatic mutations.","authors":"Sou Tomimoto, Akiko Satake","doi":"10.1016/j.tig.2024.05.003","DOIUrl":"10.1016/j.tig.2024.05.003","url":null,"abstract":"<p><p>A new study by Schmitt et al. revealed that somatic mutations in tropical trees are passed on to their offspring. Furthermore, the study noted that the majority of inherited mutations were present at low allelic frequencies within the tree.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"636-637"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive-strand RNA virus genome replication organelles: structure, assembly, control. 正链 RNA 病毒基因组复制细胞器：结构、组装和控制。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-08 DOI: 10.1016/j.tig.2024.04.003
Johan A den Boon, Masaki Nishikiori, Hong Zhan, Paul Ahlquist
{"title":"Positive-strand RNA virus genome replication organelles: structure, assembly, control.","authors":"Johan A den Boon, Masaki Nishikiori, Hong Zhan, Paul Ahlquist","doi":"10.1016/j.tig.2024.04.003","DOIUrl":"10.1016/j.tig.2024.04.003","url":null,"abstract":"<p><p>Positive-strand RNA [(+)RNA] viruses include pandemic SARS-CoV-2, tumor-inducing hepatitis C virus, debilitating chikungunya virus (CHIKV), lethal encephalitis viruses, and many other major pathogens. (+)RNA viruses replicate their RNA genomes in virus-induced replication organelles (ROs) that also evolve new viral species and variants by recombination and mutation and are crucial virus control targets. Recent cryo-electron microscopy (cryo-EM) reveals that viral RNA replication proteins form striking ringed 'crowns' at RO vesicle junctions with the cytosol. These crowns direct RO vesicle formation, viral (-)RNA and (+)RNA synthesis and capping, innate immune escape, and transfer of progeny (+)RNA genomes into translation and encapsidation. Ongoing studies are illuminating crown assembly, sequential functions, host factor interactions, etc., with significant implications for control and beneficial uses of viruses.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"681-693"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenome-metabolism nexus in the retina: implications for aging and disease. 视网膜的表观基因组-代谢关系：对衰老和疾病的影响。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-22 DOI: 10.1016/j.tig.2024.04.012
Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop
{"title":"Epigenome-metabolism nexus in the retina: implications for aging and disease.","authors":"Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop","doi":"10.1016/j.tig.2024.04.012","DOIUrl":"10.1016/j.tig.2024.04.012","url":null,"abstract":"<p><p>Intimate links between epigenome modifications and metabolites allude to a crucial role of cellular metabolism in transcriptional regulation. Retina, being a highly metabolic tissue, adapts by integrating inputs from genetic, epigenetic, and extracellular signals. Precise global epigenomic signatures guide development and homeostasis of the intricate retinal structure and function. Epigenomic and metabolic realignment are hallmarks of aging and highlight a link of the epigenome-metabolism nexus with aging-associated multifactorial traits affecting the retina, including age-related macular degeneration and glaucoma. Here, we focus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with emphasis on their contribution to human disease. In addition, we discuss potential mitigation strategies involving lifestyle changes that target the epigenome-metabolome relationship for maintaining retinal function.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"718-729"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A three-dimensional genomics view for speciation research. 用于物种研究的三维基因组学视图。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-15 DOI: 10.1016/j.tig.2024.05.009
Ashwini V Mohan, Paula Escuer, Camille Cornet, Kay Lucek
{"title":"A three-dimensional genomics view for speciation research.","authors":"Ashwini V Mohan, Paula Escuer, Camille Cornet, Kay Lucek","doi":"10.1016/j.tig.2024.05.009","DOIUrl":"10.1016/j.tig.2024.05.009","url":null,"abstract":"<p><p>Genomic information is folded in a three-dimensional (3D) structure, a rarely explored evolutionary driver of speciation. Technological advances now enable the study of 3D genome structures (3DGSs) across the Tree of Life. At the onset of 3D speciation genomics, we discuss the putative roles of 3DGSs in speciation.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"638-641"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of the dark: the emerging roles of lncRNAs in pain. 走出黑暗：lncRNA 在疼痛中的新作用。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1016/j.tig.2024.04.009
Abdella M Habib, James J Cox, Andrei L Okorokov
{"title":"Out of the dark: the emerging roles of lncRNAs in pain.","authors":"Abdella M Habib, James J Cox, Andrei L Okorokov","doi":"10.1016/j.tig.2024.04.009","DOIUrl":"10.1016/j.tig.2024.04.009","url":null,"abstract":"<p><p>The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene regulators that play essential roles in health and disease. In recent years, FAAH-OUT was identified as the first lncRNA associated with an inherited human pain insensitivity disorder. Several other lncRNAs have also been studied for their contribution to chronic pain and genome-wide association studies are frequently identifying single nucleotide polymorphisms that map to lncRNAs. For a long time overlooked, lncRNAs are coming out of the dark and into the light as major players in human pain pathways and as potential targets for new RNA-based analgesic medicines.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"694-705"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ribosome’s comeback: new role in body weight regulation 核糖体卷土重来：在体重调节中发挥新作用
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-31 DOI: 10.1016/j.tig.2024.07.006
{"title":"The ribosome’s comeback: new role in body weight regulation","authors":"","doi":"10.1016/j.tig.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.tig.2024.07.006","url":null,"abstract":"<p>The recent discovery of an association between ribosomal DNA (rDNA) copy number and body mass index (BMI) by <span><span>Law <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> sheds light on a possible role of 45S rDNA in body-weight regulation. This finding opens new avenues for further investigations into the effect of rDNA on various human phenotypes.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"11 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-08 DOI: 10.1016/s0168-9525(24)00140-9
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0168-9525(24)00140-9","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00140-9","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"11 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-08 DOI: 10.1016/s0168-9525(24)00137-9
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0168-9525(24)00137-9","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00137-9","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"61 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does TFIIH move nucleosomes? TFIIH 是否会移动核小体？
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-07-01 Epub Date: 2024-05-24 DOI: 10.1016/j.tig.2024.05.002
Mario Zurita
{"title":"Does TFIIH move nucleosomes?","authors":"Mario Zurita","doi":"10.1016/j.tig.2024.05.002","DOIUrl":"10.1016/j.tig.2024.05.002","url":null,"abstract":"<p><p>Transcription factor (TF) IIH is a factor involved in transcription, DNA repair, mitosis, and telomere stability. These functions stem from its helicase/ATPase and kinase activities. Recent reports on the structure and function of the transcription machinery, as well as chromosome compaction during mitosis, suggest that TFIIH also influences nucleosome movement, are explored here.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"560-563"},"PeriodicalIF":13.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The wild side of grape genomics. 葡萄基因组学的狂野一面
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tig.2024.04.014
Dario Cantu, Mélanie Massonnet, Noé Cochetel
{"title":"The wild side of grape genomics.","authors":"Dario Cantu, Mélanie Massonnet, Noé Cochetel","doi":"10.1016/j.tig.2024.04.014","DOIUrl":"10.1016/j.tig.2024.04.014","url":null,"abstract":"<p><p>With broad genetic diversity and as a source of key agronomic traits, wild grape species (Vitis spp.) are crucial to enhance viticulture's climatic resilience and sustainability. This review discusses how recent breakthroughs in the genome assembly and analysis of wild grape species have led to discoveries on grape evolution, from wild species' adaptation to environmental stress to grape domestication. We detail how diploid chromosome-scale genomes from wild Vitis spp. have enabled the identification of candidate disease-resistance and flower sex determination genes and the creation of the first Vitis graph-based pangenome. Finally, we explore how wild grape genomics can impact grape research and viticulture, including aspects such as data sharing, the development of functional genomics tools, and the acceleration of genetic improvement.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"601-612"},"PeriodicalIF":13.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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