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The wild side of grape genomics. 葡萄基因组学的狂野一面
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tig.2024.04.014
Dario Cantu, Mélanie Massonnet, Noé Cochetel
{"title":"The wild side of grape genomics.","authors":"Dario Cantu, Mélanie Massonnet, Noé Cochetel","doi":"10.1016/j.tig.2024.04.014","DOIUrl":"10.1016/j.tig.2024.04.014","url":null,"abstract":"<p><p>With broad genetic diversity and as a source of key agronomic traits, wild grape species (Vitis spp.) are crucial to enhance viticulture's climatic resilience and sustainability. This review discusses how recent breakthroughs in the genome assembly and analysis of wild grape species have led to discoveries on grape evolution, from wild species' adaptation to environmental stress to grape domestication. We detail how diploid chromosome-scale genomes from wild Vitis spp. have enabled the identification of candidate disease-resistance and flower sex determination genes and the creation of the first Vitis graph-based pangenome. Finally, we explore how wild grape genomics can impact grape research and viticulture, including aspects such as data sharing, the development of functional genomics tools, and the acceleration of genetic improvement.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"601-612"},"PeriodicalIF":13.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-06-03 DOI: 10.1016/s0168-9525(24)00116-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0168-9525(24)00116-1","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00116-1","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"66 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141255010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-06-03 DOI: 10.1016/s0168-9525(24)00113-6
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0168-9525(24)00113-6","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00113-6","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"25 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141255015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCNA cycling dynamics during DNA replication and repair in mammals. 哺乳动物 DNA 复制和修复过程中 PCNA 的循环动态。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.1016/j.tig.2024.02.006
Sukhyun Kang, Juyeong Yoo, Kyungjae Myung
{"title":"PCNA cycling dynamics during DNA replication and repair in mammals.","authors":"Sukhyun Kang, Juyeong Yoo, Kyungjae Myung","doi":"10.1016/j.tig.2024.02.006","DOIUrl":"10.1016/j.tig.2024.02.006","url":null,"abstract":"<p><p>Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp-loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C-like complex (RLC) is a PCNA-unloading clamp-loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"526-539"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell phylotranscriptomics of developmental and cell type evolution. 发育和细胞类型进化的单细胞系统转录组学
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-06-01 Epub Date: 2024-03-14 DOI: 10.1016/j.tig.2024.02.005
Fuqiang Ma, Chaogu Zheng
{"title":"Single-cell phylotranscriptomics of developmental and cell type evolution.","authors":"Fuqiang Ma, Chaogu Zheng","doi":"10.1016/j.tig.2024.02.005","DOIUrl":"10.1016/j.tig.2024.02.005","url":null,"abstract":"<p><p>Single-cell phylotranscriptomics is an emerging tool to reveal the molecular and cellular mechanisms of evolution. We summarize its utility in studying the hourglass pattern of ontogenetic evolution and for understanding the evolutionary history of cell types. The developmental hourglass model suggests that the mid-embryonic stage is the most conserved period of development across species, which is supported by morphological and molecular studies. Single-cell phylotranscriptomic analysis has revealed previously underappreciated heterogeneity in transcriptome ages among lineages and cell types throughout development, and has identified the lineages and tissues that drive the whole-organism hourglass pattern. Single-cell transcriptome age analyses also provide important insights into the origin of germ layers, the different selective forces on tissues during adaptation, and the evolutionary relationships between cell types.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"495-510"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FIRRM and FIGNL1: partners in the regulation of homologous recombination. FIRRM和FIGNL1：同源重组调控中的伙伴。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI: 10.1016/j.tig.2024.02.007
Stavroula Tsaridou, Marcel A T M van Vugt
{"title":"FIRRM and FIGNL1: partners in the regulation of homologous recombination.","authors":"Stavroula Tsaridou, Marcel A T M van Vugt","doi":"10.1016/j.tig.2024.02.007","DOIUrl":"10.1016/j.tig.2024.02.007","url":null,"abstract":"<p><p>DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"467-470"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic adaptations for the oceanic success of fish eggs. 鱼卵在海洋中成功的遗传适应。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI: 10.1016/j.tig.2024.01.004
Roderick Nigel Finn, Joan Cerdà
{"title":"Genetic adaptations for the oceanic success of fish eggs.","authors":"Roderick Nigel Finn, Joan Cerdà","doi":"10.1016/j.tig.2024.01.004","DOIUrl":"10.1016/j.tig.2024.01.004","url":null,"abstract":"<p><p>Genetic adaptations of organisms living in extreme environments are fundamental to our understanding of where life can evolve. Water is the single limiting parameter in this regard, yet when released in the oceans, the single-celled eggs of marine bony fishes (teleosts) have no means of acquiring it. They are strongly hyposmotic to seawater and lack osmoregulatory systems. Paradoxically, modern teleosts successfully release vast quantities of eggs in the extreme saline environment and recorded the most explosive radiation in vertebrate history. Here, we highlight key genetic adaptations that evolved to solve this paradox by filling the pre-ovulated eggs with water. The degree of water acquisition is uniquely prevalent to marine teleosts, permitting the survival and oceanic dispersal of their eggs.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"540-554"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare variants and handedness: spotlight on TUBB4B 罕见变体与手性：聚焦 TUBB4B
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-05-14 DOI: 10.1016/j.tig.2024.05.001
Sebastian Ocklenburg
{"title":"Rare variants and handedness: spotlight on TUBB4B","authors":"Sebastian Ocklenburg","doi":"10.1016/j.tig.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.tig.2024.05.001","url":null,"abstract":"<p>Twin studies suggest that additive genetic effects account for about a quarter of the variance in handedness. Recently, <span>Schijven <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> used exome-wide sequencing to provide evidence for a role of rare protein-coding variants in handedness. These included the gene encoding beta-tubulin, <em>TUBB4B</em>, suggesting that microtubules are relevant for handedness ontogenesis.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"8 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-05-06 DOI: 10.1016/s0168-9525(24)00086-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0168-9525(24)00086-6","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00086-6","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"23 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140887736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-05-06 DOI: 10.1016/s0168-9525(24)00083-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0168-9525(24)00083-0","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00083-0","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"40 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140887739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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