Q-rich activation domains: flexible 'rulers' for transcription start site selection?

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-12-07 DOI:10.1016/j.tig.2024.11.008

Andrea Bernardini, Roberto Mantovani

引用次数: 0

Abstract

Recent findings broadened the function of RNA polymerase II (Pol II) proximal promoter motifs from quantitative regulators of transcription to important determinants of transcription start site (TSS) position. These motifs are recognized by transcription factors (TFs) that we propose to term 'ruler' TFs (rTFs), such as NRF1, NF-Y, YY1, ZNF143, BANP, and members of the SP, ETS, and CRE families, sharing as a common feature a glutamine-rich (Q-rich) effector domain also enriched in valine, isoleucine, and threonine (QVIT-rich). We propose that rTFs guide TSS location by constraining the position of the pre-initiation complex (PIC) during its promoter recognition phase through a specialized, and still enigmatic, class of activation domains.

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富q激活域：转录起始位点选择的灵活“尺子”？

最近的研究结果拓宽了 RNA 聚合酶 II（Pol II）近端启动子基序的功能，使其从转录的定量调节因子变为转录起始位点（TSS）位置的重要决定因素。这些基调被转录因子（TFs）识别，我们建议将其称为 "统治者 "TFs（rTFs），如 NRF1、NF-Y、YY1、ZNF143、BANP 以及 SP、ETS 和 CRE 家族成员，它们的共同特征是具有富含谷氨酰胺（Q-rich）的效应结构域，同时富含缬氨酸、异亮氨酸和苏氨酸（QVIT-rich）。我们认为，在启动子识别阶段，rTFs 通过一类专门的、仍是谜一般的激活结构域来限制启动前复合体（PIC）的位置，从而引导 TSS 定位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.