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Synthetic gametes and the non-identity problem: the babies of tomorrow. 合成配子和非同一性问题：未来的婴儿。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-10-01 Epub Date: 2025-09-11 DOI: 10.1016/j.tig.2025.08.004
Adrian Villalba, Joona Räsänen
{"title":"Synthetic gametes and the non-identity problem: the babies of tomorrow.","authors":"Adrian Villalba, Joona Räsänen","doi":"10.1016/j.tig.2025.08.004","DOIUrl":"10.1016/j.tig.2025.08.004","url":null,"abstract":"<p><p>Synthetic DNA technologies may eventually enable the creation of synthetic gametes, which would offer precise control over genetic inheritance. This possibility raises profound ethical questions about human identity, genetic selection, and evolutionary boundaries. While synthetic gametes sidestep person-affecting ethical concerns, they present challenges for balancing reproductive autonomy and minimizing heritable disease, prompting interdisciplinary reflection.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"845-848"},"PeriodicalIF":16.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tale of two sociogenomics: shall the twain ever meet? 两个社会基因组学的故事：两者会相遇吗？
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI: 10.1016/j.tig.2025.08.001
Gene E Robinson, Dalton Conley
{"title":"A tale of two sociogenomics: shall the twain ever meet?","authors":"Gene E Robinson, Dalton Conley","doi":"10.1016/j.tig.2025.08.001","DOIUrl":"10.1016/j.tig.2025.08.001","url":null,"abstract":"","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"831-844"},"PeriodicalIF":16.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathway-level convergence: an underexplored aspect of convergent evolution. 路径级收敛：收敛进化的一个未被充分探索的方面。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-10-01 Epub Date: 2025-07-29 DOI: 10.1016/j.tig.2025.06.009
Peter K Hoitinga, Siri Birkeland
{"title":"Pathway-level convergence: an underexplored aspect of convergent evolution.","authors":"Peter K Hoitinga, Siri Birkeland","doi":"10.1016/j.tig.2025.06.009","DOIUrl":"10.1016/j.tig.2025.06.009","url":null,"abstract":"<p><p>The extent to which evolution is repeatable at the genetic level remains a central question in biology. Convergent adaptations can arise through mutations in homologous genes, changes in different genes within the same pathways, or distinct molecular routes. Most research has focused on gene-level convergence, whereas relatively little is known about the prevalence of pathway-level convergence. Here, we synthesize theoretical perspectives on pathway-level convergence, focusing on how genetic complexity of a trait and divergence time between taxa shape the likelihood of convergence at the pathway versus gene level. We highlight methodological considerations and argue that integration with systems biology is critical for advancing the field. We aim to stimulate more hypothesis-driven research into the mechanisms and prevalence of pathway-level convergence.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"853-867"},"PeriodicalIF":16.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protist genomics: key to understanding eukaryotic evolution. 原生生物基因组学：理解真核生物进化的关键。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-10-01 Epub Date: 2025-06-13 DOI: 10.1016/j.tig.2025.05.004
Alexandra Schoenle, Ore Francis, John M Archibald, Fabien Burki, Jan de Vries, Kenneth Dumack, Laura Eme, Isabelle Florent, Elisabeth Hehenberger, Tarja T Hoffmeyer, Iker Irisarri, Enrique Lara, Michelle M Leger, Julius Lukeš, Ramon Massana, Varsha Mathur, Frank Nitsche, Jürgen F H Strassert, Alexandra Z Worden, Vyacheslav Yurchenko, Javier Del Campo, Ann-Marie Waldvogel
{"title":"Protist genomics: key to understanding eukaryotic evolution.","authors":"Alexandra Schoenle, Ore Francis, John M Archibald, Fabien Burki, Jan de Vries, Kenneth Dumack, Laura Eme, Isabelle Florent, Elisabeth Hehenberger, Tarja T Hoffmeyer, Iker Irisarri, Enrique Lara, Michelle M Leger, Julius Lukeš, Ramon Massana, Varsha Mathur, Frank Nitsche, Jürgen F H Strassert, Alexandra Z Worden, Vyacheslav Yurchenko, Javier Del Campo, Ann-Marie Waldvogel","doi":"10.1016/j.tig.2025.05.004","DOIUrl":"10.1016/j.tig.2025.05.004","url":null,"abstract":"<p><p>All eukaryotes other than animals, plants, and fungi are protists. Protists are highly diverse and found in nearly all environments, with key roles in planetary health and biogeochemical cycles. They represent the majority of eukaryotic diversity, making them essential for understanding eukaryotic evolution. However, these mainly unicellular, microscopic organisms are understudied and the generation of protist genomes lags far behind most multicellular lineages. Current genomic methods, which are primarily designed for animals and plants, are poorly suited for protists. Advancing protist genome research requires reevaluating plant- and animal-centric genomic standards. Future efforts must leverage emerging technologies and bioinformatics tools, ultimately enhancing our understanding of eukaryotic molecular and cell biology, ecology, and evolution.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"868-882"},"PeriodicalIF":16.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of human accelerated regions on neuronal development: (Trends in Genetics, 41:6 p:459-461, 2025). 人类加速区对神经元发育的影响[j] .遗传学趋势，41:6 p:459-461, 2025。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-18 DOI: 10.1016/j.tig.2025.08.006
Jose Manuel Ruiz-Jiménez, Gabriel Santpere
{"title":"The impact of human accelerated regions on neuronal development: (Trends in Genetics, 41:6 p:459-461, 2025).","authors":"Jose Manuel Ruiz-Jiménez, Gabriel Santpere","doi":"10.1016/j.tig.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.tig.2025.08.006","url":null,"abstract":"","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":""},"PeriodicalIF":16.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Striking diversity of male-killing symbionts and their mechanisms. 杀死雄性共生体的惊人多样性及其机制。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-11 DOI: 10.1016/j.tig.2025.08.003
Hiroshi Arai, Toshiyuki Harumoto, Susumu Katsuma, Keisuke Nagamine, Daisuke Kageyama
{"title":"Striking diversity of male-killing symbionts and their mechanisms.","authors":"Hiroshi Arai, Toshiyuki Harumoto, Susumu Katsuma, Keisuke Nagamine, Daisuke Kageyama","doi":"10.1016/j.tig.2025.08.003","DOIUrl":"https://doi.org/10.1016/j.tig.2025.08.003","url":null,"abstract":"<p><p>Symbiosis is a fundamental characteristic of eukaryotic biology. Arthropods, including insects, often harbor maternally inherited endosymbiotic microbes, some of which have evolved the ability to selectively kill male hosts - a phenomenon known as 'male killing.' The evolutionary history and mechanisms of symbiont-induced male killing have remained poorly understood. However, recent studies have revealed a remarkable diversity of male-killing strategies and their associated causative genes in diverse bacteria and viruses that target different aspects of the host reproductive system. Some insects have evolved various suppressor genes to counteract male-killing actions. This review synthesizes the current knowledge on the evolution and mechanisms underlying microbe-induced male killing and explores their broader implications for the ecology and evolution of eukaryotic life forms.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":""},"PeriodicalIF":16.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasked: transposable elements as drivers and targets in cancer. 揭示：转座因子在癌症中的驱动和靶标。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-10 DOI: 10.1016/j.tig.2025.08.002
Mitchell F Grinwald, Wesley N Saintilnord, Ting Wang
{"title":"Unmasked: transposable elements as drivers and targets in cancer.","authors":"Mitchell F Grinwald, Wesley N Saintilnord, Ting Wang","doi":"10.1016/j.tig.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.tig.2025.08.002","url":null,"abstract":"<p><p>Transposable elements (TEs) - long considered 'junk DNA' - challenge the binary of threat and therapeutic opportunity in cancer. Their reactivation is not a singular event but a convergence of evolutionary legacy, regulatory disruption, and technological insight. This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state. Across regulatory control, viral mimicry, protein-coding potential, and antigen presentation, TEs blur the line between harm and utility. Each example reflects a broader theme: context defines consequence. By tracing historical shifts and technological advances, we argue for an integrated view: one where TEs are not just anomalies, but dynamic agents in the complexity of cancer.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":""},"PeriodicalIF":16.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes. 父亲环境暴露和经历对后代表型的表观遗传影响。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-01 Epub Date: 2025-06-03 DOI: 10.1016/j.tig.2025.04.015
Huan Liao, Da Lu, Sonali N Reisinger, Mehrshad Rashidi Mehrabadi, Carolina Gubert, Anthony J Hannan
{"title":"Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes.","authors":"Huan Liao, Da Lu, Sonali N Reisinger, Mehrshad Rashidi Mehrabadi, Carolina Gubert, Anthony J Hannan","doi":"10.1016/j.tig.2025.04.015","DOIUrl":"10.1016/j.tig.2025.04.015","url":null,"abstract":"<p><p>Recent decades have revealed increasing evidence for epigenetic inheritance through paternal environmental exposures and experiences, affecting offspring health outcomes across diverse species. Key epigenetic mediators in sperm may include DNA methylation, chromatin modifications, as well as small and long non-coding (nc)RNAs. Identified environmental influences extend beyond lifestyle factors (e.g., exercise, diet, alcohol, and nicotine use) to include stress, infections, pollutants, and other toxins. Evidence from humans, rodents, and other species suggests that various paternal exposures before conception substantially shape the phenotypes in offspring, via developmental modulation, including changes to brain and behavior, metabolism, endocrinology, and physiology. These findings raise concerns regarding human epigenetic inheritance, because the relevant environmental exposures have changed significantly in recent decades, potentially increasing the risk of future generations for various disorders ('transgenerational epigenopathy'). Here, we integrate evidence for paternal environmental exposures affecting offspring phenotypes, and associated epigenetic mechanisms, critically discussing potential implications for medicine and other scientific fields.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"735-761"},"PeriodicalIF":16.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generative AI: a partner for genetic counseling? 生成人工智能：基因咨询的合作伙伴？
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-01 Epub Date: 2025-07-31 DOI: 10.1016/j.tig.2025.07.002
Kenny Wong, Vivian Pan, Colleen Caleshu
{"title":"Generative AI: a partner for genetic counseling?","authors":"Kenny Wong, Vivian Pan, Colleen Caleshu","doi":"10.1016/j.tig.2025.07.002","DOIUrl":"10.1016/j.tig.2025.07.002","url":null,"abstract":"<p><p>Generative artificial intelligence (AI)'s arrival in genetic counseling presents both opportunities and challenges. While offering the potential to ease burdens (e.g., by automating routine screening and summarizing patient histories) and expand access (e.g., through AI-driven preliminary education and interactive counseling), its integration demands careful evaluation, ethical design focusing on equity and privacy, and robust collaboration to ensure increased access and improved patient outcomes.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"725-729"},"PeriodicalIF":16.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial omics enters the microscopic realm: opportunities and challenges. 空间组学进入微观领域：机遇与挑战。
IF 16.3 2区 生物学
Trends in Genetics Pub Date : 2025-09-01 Epub Date: 2025-06-02 DOI: 10.1016/j.tig.2025.05.002
Yichen Si, Joo Sang Lee, Goo Jun, Hyun Min Kang, Jun Hee Lee
{"title":"Spatial omics enters the microscopic realm: opportunities and challenges.","authors":"Yichen Si, Joo Sang Lee, Goo Jun, Hyun Min Kang, Jun Hee Lee","doi":"10.1016/j.tig.2025.05.002","DOIUrl":"10.1016/j.tig.2025.05.002","url":null,"abstract":"<p><p>Spatial transcriptomics (ST) enables systematic profiling of whole-transcriptome gene expression in tissues while preserving spatial context. Recent advances in sequencing- and imaging-based ST technologies have ushered in the era of microscopic-resolution ST (μST), allowing transcriptome mapping at cellular and even subcellular scales with unprecedented precision. Despite these advances, μST faces substantial challenges, including sparse transcript discovery per submicron (or micron)-sized spatial units and data fragmentation across platforms, hindering integration and analysis. There is also a growing demand for scalable, segmentation-free, and universally applicable analysis methods, as well as strategies for 3D mapping, multi-omics integration, and artificial intelligence (AI)-driven spatial analysis. In this review, we highlight recent breakthroughs, outline key challenges, and discuss emerging experimental and computational solutions shaping the future of μST.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"774-787"},"PeriodicalIF":16.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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