Eurointervention最新文献

{"title":"A randomised trial of carbon dioxide flushing to reduce vascular brain injury in patients undergoing TAVI.","authors":"Saud Ahmed Khawaja, Lydia Hanna, Abhinav Singh, Carla Lucarelli, Prerna Garg, Iqbal Malik, Nearchos Hadjiloizou, Neil Ruparelia, Adam Hartley, Ramzi Khamis, Matthew Shun Shin, Richard Gibbs, Ghada W Mikhail","doi":"10.4244/EIJ-D-26-00425","DOIUrl":"10.4244/EIJ-D-26-00425","url":null,"abstract":"<p><strong>Background: </strong>Stroke remains a significant concern in patients undergoing transcatheter aortic valve implantation (TAVI). Despite advances in TAVI technology and techniques, stroke rates have remained unchanged, with trials of cerebral embolic protection devices failing to reduce rates. The concept of air emboli has not been previously investigated in TAVI procedures. We hypothesised that gaseous emboli could play a significant role in TAVI and that carbon dioxide (CO₂) flushing of the TAVI valves could reduce the incidence of new neurological lesions post-TAVI.</p><p><strong>Aims: </strong>We aimed to demonstrate the neuroprotective benefits of CO₂ flushing in TAVI patients.</p><p><strong>Methods: </strong>INTERCEPTavi is a single-centre, blinded, randomised controlled pilot trial that studied the effects of flushing TAVI valves with CO₂ versus conventional saline on neurological outcomes post-TAVI, assessed using magnetic resonance imaging (MRI) and transcranial Doppler (TCD). Patients with aortic stenosis were randomised after obtaining vascular access. Periprocedural TCD assessed solid and gaseous emboli to the brain. Post-procedure, patients underwent brain MRI to detect lesions. Here, we report the primary outcome of feasibility, as well as the secondary MRI and mechanistic TCD outcomes.</p><p><strong>Results: </strong>A total of 60 patients were recruited and randomised 1:1 to CO₂ and saline flushing (TAVI-CO₂) versus saline flushing only (TAVI-S). CO₂ flushing significantly reduced the average number of lesions per patient (TAVI-CO₂: 4 lesions/patient vs TAVI-S: 8.5 lesions/patient; p=0.031). The total infarct area was numerically lower in the TAVI-CO₂ group (40.32 mm² vs 93.20 mm²), although this did not reach statistical significance (p=0.111). Similarly, TCD showed fewer microembolic signals in the TAVI-CO₂ arm, primarily due to a reduction in gaseous emboli, but this difference was not statistically significant (p=0.5).</p><p><strong>Conclusions: </strong>INTERCEPTavi is a pioneering, first-in-human randomised trial that demonstrated that CO₂ flushing of the TAVI valve reduces the number of cerebral lesions measured on MRI. CO₂ flushing is an accessible, cost-effective method that can be easily implemented in any catheter laboratory to provide neurological advantages.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"883-890"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary bioadaptors will replace drug-eluting stents: pros and cons.","authors":"David Erlinge, Giandomenico Mancini, Valeria Paradies","doi":"10.4244/EIJ-E-26-00014","DOIUrl":"https://doi.org/10.4244/EIJ-E-26-00014","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"837-839"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational wireless indices for the assessment of myocardial ischaemia.","authors":"Gianluca Campo, Simone Biscaglia, Andrea Erriquez, William F Fearon","doi":"10.4244/EIJ-D-25-01315","DOIUrl":"https://doi.org/10.4244/EIJ-D-25-01315","url":null,"abstract":"<p><p>The assessment of myocardial ischaemia is entering a new computational era. Beyond the traditional boundaries of anatomical imaging and invasive fractional flow reserve (FFR), emerging techniques based on coronary computed tomography (CT) angiography and invasive coronary artery angiography now allow the derivation of physiological information without pressure wires, hyperaemic agents, or additional procedures. These image-based indices, commonly referred to as FFR-CT and angiography-derived FFR, are reshaping both diagnostic and interventional cardiology. This review provides an updated synthesis of the latest evidence on their clinical integration. FFR-CT has demonstrated its ability to refine diagnostic pathways, reduce unnecessary invasive angiography, and safely guide management decisions within precision diagnostic strategies. In parallel, angiography-derived FFR has matured into a real-time wire-free solution within the catheterisation laboratory. Randomised studies confirm that physiology-guided revascularisation improves procedural efficiency and optimises outcomes compared with angiography alone. Beyond ischaemia detection, these technologies now extend to virtual stenting, procedural simulation, and the identification of vulnerable plaques through haemodynamic indices such as endothelial shear stress and perivascular inflammation mapping. Together, these developments mark a paradigm shift: from anatomy-based to physiology-driven and, ultimately, prediction-guided coronary intervention. By merging artificial intelligence, computational modelling, and advanced imaging, CT- and angiography-derived physiology offer the prospect of fully integrated real-time functional assessment. This convergence defines a new frontier in coronary medicine, where precision, automation, and clinical impact coalesce to transform everyday cardiovascular practice.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"847-863"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke prevention in TAVI: beyond solid emboli.","authors":"Alexandra J Lansky, Laya Ohadi","doi":"10.4244/EIJ-E-26-00013","DOIUrl":"https://doi.org/10.4244/EIJ-E-26-00013","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"842-843"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose catheter-directed thrombolysis in acute pulmonary embolism: progress with persistent uncertainty?","authors":"Felix Mahfoud, Felix Götzinger","doi":"10.4244/EIJ-D-26-00810","DOIUrl":"https://doi.org/10.4244/EIJ-D-26-00810","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"844-846"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous coronary artery dissection of the left anterior descending artery: a challenge in management.","authors":"Jacqueline Saw, Cathevine Yang","doi":"10.4244/EIJ-D-26-00799","DOIUrl":"https://doi.org/10.4244/EIJ-D-26-00799","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"840-841"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of patients with large anatomies undergoing transcatheter tricuspid valve replacement with the LuX-Valve Plus system.","authors":"Ole De Backer, Yinghao Lim, Ralph Stephan von Bardeleben, Arnaud Sudre, Augustin Coisne, Erwan Donal, Guillaume Leurent, Lionel Leroux, Mohammed Nejjari, Julien Dreyfus, Emmanuel Teiger, Thierry Folliguet, Thomas Cuisset, Pierre Deharo, Tobias Kister, Rodrigo Estévez-Loureiro, Eric Durand, Hélène Eltchaninoff, Yusuke Kobari, Jacob Eifer Møller, Tiffany Patterson, Guangyuan Song, Ignacio Cruz-Gonzalez, Omar Abdul-Jawad Altisent, Jean-François Obadia, Gilles Rioufol, Luis Nombela-Franco, Julien Ternacle, Didier Tchétché, Nicolas Dumonteil, Jörg Hausleiter, Juan F Granada, Thomas Modine","doi":"10.4244/EIJ-D-26-00062","DOIUrl":"https://doi.org/10.4244/EIJ-D-26-00062","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter tricuspid valve replacement (TTVR) is increasingly performed to treat patients with severe or greater symptomatic tricuspid regurgitation (TR) at high risk for surgery. However, patients with large tricuspid annuli are not eligible for most TTVR systems.</p><p><strong>Aims: </strong>This study aimed to report intraprocedural and 30-day clinical success rates for patients undergoing TTVR with the 55-70 mm LuX-Valve Plus system in the European TRINITY study cohort.</p><p><strong>Methods: </strong>The co-primary endpoints were intraprocedural and 30-day clinical success, as defined by the Tricuspid Valve Academic Research Consortium criteria. Clinical and echocardiographic outcomes were reported.</p><p><strong>Results: </strong>Enrolled patients (n=114) had a mean age of 77.8±5.8 years and a high Society of Thoracic Surgeons risk score of 9.9±6.0%. Intraprocedural success was 95.6%, with no cases of intraprocedural mortality or stroke. Two patients (1.8%) required cardiac surgery within the first 24 hours. At 30 days, 7 patients (6.1%) required a pacemaker implantation. Thirty-day clinical success was 91.2%, with residual severe TR being the primary reason for failure. In 93.7% of patients, residual TR was moderate or less. The mean Kansas City Cardiomyopathy Questionnaire score improved from 57.3±20.7 points to 71.0±23.5 points (p<0.001), and the proportion of patients with New York Heart Association Class III-IV symptoms reduced from 57.1% at baseline to 20.9% at 30 days (p<0.001).</p><p><strong>Conclusions: </strong>TTVR with the LuX-Valve Plus system to treat patients with severe or greater symptomatic TR and a large tricuspid annulus was associated with high intraprocedural and 30-day clinical success rates, significant TR reduction and functional improvement, and low permanent pacemaker implantation rates.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"891-902"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of spontaneous coronary artery dissection of the left anterior descending artery.","authors":"Alexander Marschall, Marcos García-Guimarães, Ricardo Sanz-Ruiz, Manel Sabaté, Maite Velazquez-Martín, Gabriela Veiga, Xacobe Flores-Rios, Helena Tizón-Marcos, Juan Manuel Nogales, Fernando Macaya, Soledad Ojeda, Santiago Camacho Freire, Gerard Roura, Pascual Bordes, Santiago Jimenez Valero, Xavier Carrillo-Suárez, Teresa Bastante, David Del Val, Rajiv Gulati, Fernando Alfonso","doi":"10.4244/EIJ-D-25-01394","DOIUrl":"10.4244/EIJ-D-25-01394","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous coronary artery dissection (SCAD) is an underrecognised cause of acute coronary syndrome (ACS). The left anterior descending artery (LAD) is most frequently affected, but the clinical and prognostic implications of SCAD in this location unclear.</p><p><strong>Aims: </strong>We sought to evaluate the clinical characteristics, angiographic features, management, and outcomes of patients with SCAD involving the LAD (LAD-SCAD) using data from a nationwide registry.</p><p><strong>Methods: </strong>The Spanish Registry on SCAD (SR-SCAD) is a prospective, multicentre registry enrolling consecutive patients with angiographically confirmed SCAD from 34 hospitals across Spain. Coronary angiograms were reviewed by a central core laboratory, and all clinical events were independently adjudicated. Primary endpoints were in-hospital major adverse events and long-term major adverse cardiovascular and cerebrovascular events (MACCE). Outcomes were compared between patients with and without LAD involvement.</p><p><strong>Results: </strong>Among 388 patients (mean age 54±11.5 years), 190 (49%) had LAD involvement, after excluding 8 patients with concomitant left main extension. Compared with other vessels, LAD dissections were longer (35 mm [interquartile range [IQR] 22-50] vs 30 mm [IQR 20-40]; p=0.01), more often multivessel (16% vs 3%; p<0.001) and multisegment (30% vs 19%; p=0.024), with higher creatine kinase-myocardial band (170 U/L [IQR 112-190] vs 24 U/L [IQR 4-78]; p=0.032), lower left ventricular ejection fraction (55±5.4% vs 58±6.6%; p=0.034), and more frequently treated with percutaneous coronary intervention (27% vs 17%; p=0.027). Notably, LAD involvement independently predicted higher long-term MACCE (adjusted hazard ratio 2.00, 95% confidence interval: 1.10-3.97; p=0.046), compared with SCAD in other locations.</p><p><strong>Conclusions: </strong>LAD-SCAD identifies patients with more complex angiographic features and higher long-term risk compared with non-LAD-SCAD. Despite frequent percutaneous coronary intervention, outcomes were not improved in this high-risk LAD population, emphasising the prognostic relevance of dissection location and supporting individualised treatment.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"874-882"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose, short-duration catheter-directed thrombolysis for acute intermediate-high-risk pulmonary embolism: the BETULA trial.","authors":"Jacob Schultz, Gro Egholm, Mikael Kjær Poulsen, Bo Løfgren, Morten Würtz, Hanne Maare Søndergaard, Mads Jønsson Andersen, Jacob Valentin Hansen, Gratien Andersen, Shifan Thangavel, Søren Mellemkjær, Anushree Burade, Mannudeep Kalra, Jens Erik Nielsen-Kudsk, Asger Andersen","doi":"10.4244/EIJ-D-26-00292","DOIUrl":"10.4244/EIJ-D-26-00292","url":null,"abstract":"<p><strong>Background: </strong>Catheter-directed thrombolysis (CDT) reduces the right-to-left ventricular ratio (RV/LV ratio) in patients with intermediate-risk pulmonary embolism (PE). Prior randomised studies comparing CDT to anticoagulation used ultrasound-assisted devices and high doses of thrombolytics with extended infusion durations, which may increase healthcare costs and complications, thereby limiting its clinical applicability.</p><p><strong>Aims: </strong>We sought to evaluate the efficacy and safety of low-dose, short-duration CDT compared with unfractionated heparin (UFH) in patients with acute intermediate-high-risk PE.</p><p><strong>Methods: </strong>In this open-label, randomised controlled trial, patients with acute intermediate-high-risk PE were randomised 1:1 to receive CDT (4 mg recombinant tissue plasminogen activator [r-tPA] per catheter over 2 hours) plus UFH or UFH alone. The primary endpoint was the change in RV/LV ratio at 24 hours. Secondary endpoints included thrombus burden reduction, changes in vital signs and echocardiographic measures of RV function, length of hospital stay, 30-day mortality, and 90-day recurrent PE. Safety endpoints included major and minor bleeding.</p><p><strong>Results: </strong>Between August 2020 and October 2024, 60 patients were randomised, with 58 completing follow-up (CDT: n=29; UFH: n=29). CDT plus UFH improved the RV/LV ratio at 24 hours compared with UFH alone (-0.17 vs +0.02; p=0.01). Secondary endpoints did not differ between groups. One death occurred in the UFH group. One patient experienced haemodynamic deterioration during CDT, successfully managed with additional r-tPA. No major bleeding occurred. Minor bleeding occurred in three patients (10%) in the CDT group and one (3%) in the UFH group (p=0.29).</p><p><strong>Conclusions: </strong>Low-dose, short-duration CDT plus UFH improved the RV/LV ratio without increasing major bleeding compared with UFH alone in intermediate-high-risk PE.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 16","pages":"903-912"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term clinical outcomes of high-risk plaques with negative fractional flow reserve: the PECTUS-obs study.","authors":"Rick H J A Volleberg, Jan-Quinten Mol, Geert A A Versteeg, Joske L van der Zande, Anouar Belkacemi, Renicus S Hermanides, Martijn Meuwissen, Alexey V Protopopov, Peep Laanmets, Oleg V Krestyaninov, Casper F Laclé, Rohit M Oemrawsingh, Jan-Peter van Kuijk, Karin Arkenbout, Dirk J van der Heijden, Saman Rasoul, Erik Lipšic, Laura Rodwell, Cyril Camaro, Peter Damman, Tomasz Roleder, Elvin Kedhi, Maarten A H van Leeuwen, Robert-Jan M van Geuns, Niels van Royen","doi":"10.4244/EIJ-D-26-00416","DOIUrl":"10.4244/EIJ-D-26-00416","url":null,"abstract":"<p><strong>Background: </strong>High-risk plaques (HRP) in non-flow-limiting, deferred non-culprit lesions have been associated with adverse short-term cardiovascular outcomes after myocardial infarction (MI). However, the long-term prognostic implications remain largely unknown.</p><p><strong>Aims: </strong>This study sought to evaluate the long-term association between HRP and clinical outcome after MI Methods: In the prospective, observational PECTUS-obs study, 438 patients with recent MI underwent optical coherence tomography (OCT) of all fractional flow reserve-negative non-culprit lesions. Patients were grouped according to the presence or absence of at least one OCT-identified HRP. The current study evaluates the final long-term outcome. The primary patient-level endpoint was defined as major adverse cardiovascular events (MACE), a composite of cardiac death, non-fatal MI, or unplanned revascularisation, excluding all periprocedural, indeterminate, and stent failure-related events.</p><p><strong>Results: </strong>After a median follow-up of 1,828 days (interquartile range [IQR] 1,821-1,842), the presence of at least one HRP was associated with MACE (hazard ratio [HR] 1.87, 95% confidence interval [CI]: 1.11-3.14; p=0.017). Among the individual endpoint components, non-fatal MI (HR 4.07, 95% CI: 1.23-13.52; p=0.013) and unplanned revascularisation (HR 1.97, 95% CI: 1.07-3.64; p=0.027) occurred more frequently in patients with at least one HRP. In an exploratory landmark analysis, the risk associated with presence of HRP was observed only during the first 2 years of follow-up. The lesion-level incidence of target lesion failure did not differ significantly between groups (HR 1.65, 95% CI: 0.91-2.96; p=0.097).</p><p><strong>Conclusions: </strong>Non-flow-limiting, high-risk non-culprit plaques are associated with adverse patient-level clinical outcomes during long-term follow-up after MI, potentially with a more pronounced short-term risk.</p><p><strong>Clinicaltrials: </strong>gov: NCT03857971.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"864-873"},"PeriodicalIF":9.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}