Eurointervention最新文献

{"title":"Establishing the role of drug-coated balloons in bifurcation PCI: more difficult than it seems.","authors":"Tom Adriaenssens, Fernando Alfonso","doi":"10.4244/EIJ-E-26-00012","DOIUrl":"10.4244/EIJ-E-26-00012","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e802-e804"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated versus conventional balloons for side branch treatment in coronary bifurcation lesions: an optical coherence tomography substudy of the OCVC-BIF randomised trial.","authors":"Daisuke Nakamura, Takayuki Ishihara, Tomoharu Dohi, Daisuke Sakamoto, Shumpei Kosugi, Naotaka Okamoto, Atsushi Kikuchi, Tsutomu Kawai, Naoki Mori, Ryu Shutta, Minoru Ichikawa, Yasunori Ueda, Toshiaki Mano, Masami Nishino, Tetsuya Watanabe, Yoshiharu Higuchi, Eisuke Hida, Tomoharu Sato, Shungo Hikoso, Daisaku Nakatani, Yohei Sotomi, Yasushi Sakata, On Behalf Of The Ocvc-Bif Investigators","doi":"10.4244/EIJ-D-26-00428","DOIUrl":"10.4244/EIJ-D-26-00428","url":null,"abstract":"<p><strong>Background: </strong>Coronary bifurcation lesions remain prone to side branch (SB) ostial restenosis. Kissing balloon inflation (KBI) is the standard of care for provisional stenting, but it induces mechanical injury. Drug-coated balloons (DCBs) may pharmacologically inhibit neointimal hyperplasia to improve long-term patency.</p><p><strong>Aims: </strong>We sought to evaluate mechanistic vascular healing and luminal changes of the SB after adjunctive SB-DCB versus SB-conventional balloon treatment using high-resolution serial optical coherence tomography (OCT).</p><p><strong>Methods: </strong>The randomised OCVC-BIF trial compared adjunctive SB-DCB (n=149) with non-DCB treatment (n=150) following main vessel stenting and protocolled KBI. The present prespecified study was restricted to those patients who completed analysable follow-up OCT pullbacks (n=221). Endpoints included the SB volume change and the main vessel stent healing parameters.</p><p><strong>Results: </strong>There was no significant difference in the ostium, minimum SB area, or SB volume between the DCB and non-DCB groups following percutaneous coronary intervention (PCI). Serial OCT analysis showed that the DCB group exhibited a lumen volume gain at the SB of 0.14±5.64 mm3 from post-PCI to 9-month follow-up, whereas the non-DCB group showed a mean loss of 2.15±9.51 mm3. Although this difference reached statistical significance in the prespecified parametric analysis (p=0.042), in the sensitivity analysis using the Wilcoxon rank-sum test, the difference was attenuated (0.45 [interquartile range [IQR] -3.83, 4.00] in DCB vs -0.65 [IQR -5.00, 2.50] in non-DCB; p=0.093). While in the DCB group, the SB lumen volume change from immediately after PCI to follow-up was not statistically significant (p=0.81), the non-DCB group demonstrated a statistically significant reduction in SB lumen volume (p=0.03). At 9 months, the incidence of uncovered and malapposed struts was low and comparable between groups across all segments.</p><p><strong>Conclusions: </strong>Adjunctive SB-DCB treatment after KBI showed no adverse effect on main vessel stent healing and a possible signal towards preservation of the SB lumen. These findings may support the mechanistic feasibility of this strategy in selected bifurcation lesions. (Japan Registry of Clinical Trials: jRCTs052200077).</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e820-e831"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: From feasibility to optimisation in PINNACLE-I.","authors":"Stefan Verheye","doi":"10.4244/EIJ-D-26-00314","DOIUrl":"10.4244/EIJ-D-26-00314","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e836"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: From feasibility to optimisation in PINNACLE-I.","authors":"Andrea Denegri, Michal Pruc, Lukasz Szarpak","doi":"10.4244/EIJ-D-26-00290","DOIUrl":"10.4244/EIJ-D-26-00290","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e834-e835"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemorrhagic acute myocardial infarction.","authors":"Ankur Kalra, Rohan Dharmakumar","doi":"10.4244/EIJ-D-26-00478","DOIUrl":"10.4244/EIJ-D-26-00478","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e805-e807"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular lithotripsy in comparison to rotational atherectomy for calcified lesions: the ICARE OFDI randomised trial.","authors":"Benjamin Honton, Pascal Motreff, Jean-Sébastien Mallet, Thomas Hovasse, Matthieu Godin, Guilhem Malclès, Jerome Brunet, Nicolas Meneveau, Pierre Deharo, Benoit Lattuca, Erwan Bressollette, Michael Angioi, Hakim Benamer, Edouard Gerbaud, Bruno Pereira, Vincenzo Cesario, Antoine Poinas, Clémence Laperche, Antoine Sauguet, Géraud Souteyrand, Nicolas Amabile, Nicolas Combaret","doi":"10.4244/EIJ-D-26-00426","DOIUrl":"10.4244/EIJ-D-26-00426","url":null,"abstract":"<p><strong>Background: </strong>The management of calcified coronary lesions remains challenging. Although several devices for advanced plaque modification are available, their relative efficacy is debated.</p><p><strong>Aims: </strong>We aimed to compare intravascular lithotripsy (IVL)- and rotational atherectomy (RA)-based strategies for calcified plaque preparation during percutaneous coronary interventions (PCI).</p><p><strong>Methods: </strong>This multicentre, prospective, randomised non-inferiority trial compared IVL with RA for plaque preparation in moderate-to-severe stable calcified coronary lesions. All interventions were guided by optical frequency domain imaging. A non-inferiority margin of 0.75 mm² was prospectively defined based on prior intracoronary imaging studies, and the sample size calculation was based on a standard deviation of 1.9 mm², a one-sided alpha risk of 5%, and a power of 80%, under the assumption of no true difference between groups. The primary endpoint was the minimal stent area (MSA) following stent implantation. The target lesion failure (TLF) rate was analysed after 12 months.</p><p><strong>Results: </strong>A total of 169 patients (RA: n=86, IVL: n=83; 81.1% male; mean age 71.8±8.2 years) were included in the final analysis. The baseline characteristics of each group were balanced. Calcified nodules were identified in 48% of the patients. IVL was not inferior to RA for the primary endpoint (6.0±2.3 mm² vs 5.9±2.2 mm², respectively; p for non-inferiority<0.05). Adequate geometrical stent expansion was similar in both groups (RA: 65.1%, IVL: 65.1%; p=0.994), whereas major strut malapposition was more frequently observed in the RA group (RA: 80.2% vs IVL: 57.8%; p=0.002). There was no difference between groups in terms of periprocedural complications. The TLF rates between groups after 12 months were equivalent (RA: 1.2%, IVL: 2.4%; p=0.61).</p><p><strong>Conclusions: </strong>In this trial, the IVL strategy was non-inferior to the RA strategy regarding MSA for PCI in moderate-to-severe calcified coronary lesions, with a comparable safety profile and equivalent clinical outcomes.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e808-e819"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To crack or to ablate? The contemporary calcium dilemma.","authors":"Emanuele Barbato, Emanuele Gallinoro","doi":"10.4244/EIJ-D-26-00622","DOIUrl":"10.4244/EIJ-D-26-00622","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e800-e801"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wall shear stress in eruptive versus non-eruptive calcified nodules.","authors":"Diego Gallo, Atomu Tajima, Maurizio Lodi Rizzini, Umberto Morbiducci, Carlos Collet","doi":"10.4244/EIJ-D-26-00088","DOIUrl":"10.4244/EIJ-D-26-00088","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e832-e833"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotype-guided management of ANOCA: are we ready?","authors":"Rocco A Montone","doi":"10.4244/EIJ-D-26-00715","DOIUrl":"10.4244/EIJ-D-26-00715","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e762-e764"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P2Y12 inhibitor monotherapy versus dual antiplatelet therapy after complex percutaneous coronary intervention in patients with acute coronary syndromes: a NEO-MINDSET trial substudy.","authors":"Guy F A Prado, Pedro Beraldo de Andrade, Stefano Garzon Dias Lemos, Marcelo Franken, Patricia Oliveira Guimaraes, Caio de Assis Moura Tavares, Fabio Grunspun Pitta, Felipe Mateus Teixeira Bezerra, Willterson Carlos Bandeira, Maria Sanali, Silvia Regina Lamas Assis, Frederico Monfardini, Lailah Cristina de Carvalho Abrão, Rosana Coura Rocha, Fernanda Mangione, Vitor Arantes Pazolini, Adriadne Justi Bertolin, Murillo Antunes, Fabio Serra Silveira, Bruno Ramos Nascimento, Louis N Ohe, Esmeralci Ferreira, Fernanda B A Sampaio, Rogerio Sarmento-Leite, Marco V Wainstein, Cristiano Guedes Bezerra, Jose Airton Arruda, Breno Oliveira Almeida, Valeria Paradies, Jose Mariani Junior, Pedro Alves Lemos Neto","doi":"10.4244/EIJ-D-26-00409","DOIUrl":"10.4244/EIJ-D-26-00409","url":null,"abstract":"<p><strong>Background: </strong>Whether the anatomical complexity of percutaneous coronary intervention (PCI) in patients with acute coronary syndromes (ACS) influences the effects of antiplatelet therapy remains unknown.</p><p><strong>Aims: </strong>We aimed to evaluate the impact of coronary anatomical complexity on clinical outcomes in patients receiving potent P2Y₁₂ inhibitor monotherapy or dual antiplatelet therapy (DAPT).</p><p><strong>Methods: </strong>In the NEO-MINDSET trial, patients with ACS were randomised after successful PCI to 12-month ticagrelor- or prasugrel-based monotherapy or DAPT, initiated within the first 4 days of hospitalisation. The co-primary endpoints were (i) a composite of death, myocardial infarction, urgent target vessel revascularisation, or stroke; and (ii) Bleeding Academic Research Consortium (BARC) Type 2, 3, or 5 bleeding. Complex PCI was defined by one or more of the following criteria: three-vessel PCI, ≥3 treated lesions, ≥3 stents implanted, total stent length >60 mm, two-stent bifurcation, or stenting in the left main coronary artery, in a bypass graft, or in a chronic total occlusion lesion.</p><p><strong>Results: </strong>Of the 3,408 randomised patients with available procedural data, 791 (23.2%) underwent complex PCI. Compared with the non-complex PCI group, patients in the complex PCI group were older (mean age 60.63±10.52 years vs 59.33±10.83 years; p=0.005) and had a higher prevalence of hypertension (67.9% vs 62.9%; p=0.010). Among patients undergoing complex PCI, 1, 2, or ≥3 complexity criteria were present in 45.5% (n=360), 22.5% (n=178), and 32.0% (n=253), respectively. PCI complexity did not significantly modify the treatment effects of monotherapy versus DAPT on the ischaemic co-primary endpoint (p-interaction=0.68). Likewise, PCI complexity did not have an effect on the comparative risk of BARC Type 2, 3, or 5 bleeding between monotherapy versus DAPT.</p><p><strong>Conclusions: </strong>In this post hoc analysis of the NEO-MINDSET trial, PCI complexity did not significantly modify the treatment effects of potent P2Y₁₂ inhibitor monotherapy versus DAPT on the co-primary ischaemic or bleeding outcomes.</p><p><strong>Clinicaltrials: </strong>gov: NCT04360720.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e765-e772"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}