{"title":"Insight into Fluorescence Imaging and Bioorthogonal Reactions in Biological Analysis","authors":"Yuexiang Ma, Qinhua Chen, Xiaoyan Pan, Jie Zhang","doi":"10.1007/s41061-020-00323-5","DOIUrl":"https://doi.org/10.1007/s41061-020-00323-5","url":null,"abstract":"<p>Fluorescence imaging is an important method in the field of biomedicine. Fluorescence imaging is nondestructive, has high efficiency and sensitivity, high resolution and allows real-time dynamic monitoring of living cells. However, it also has some disadvantages, such as high background signals and low selectivity. Bioorthogonal reactions, with the advantages of being both nondestructive and effective, are used to trace and analyze biological interactions in vivo. This review focuses on recent progress in understanding the mechanism of action of fluorescence probes.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"379 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00323-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4540915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qi Xue, Zixuan Zhang, Bryan K. Y. Ng, Pu Zhao, Benedict T. W. Lo
{"title":"Recent Advances in the Engineering of Single-Atom Catalysts Through Metal–Organic Frameworks","authors":"Qi Xue, Zixuan Zhang, Bryan K. Y. Ng, Pu Zhao, Benedict T. W. Lo","doi":"10.1007/s41061-021-00324-y","DOIUrl":"https://doi.org/10.1007/s41061-021-00324-y","url":null,"abstract":"<p>This mini-review highlights some recent progress in the engineering of single-atom catalysts (SACs) through metal–organic frameworks (MOFs) and derivatives. The inherent molecular and chemical specificities within the MOFs and derivatives can offer stabilisation of the SACs with high atomic isolation and dispersion. As MOFs are often considered an infinite array of self-assembled molecular catalysts, specifically designed structures can provide further functionalities to suit the needs of different catalytic applications. In brief, we can divide the preparation approaches into three main categories: (1) fabrication onto functional groups of the ligands, (2) fabrication onto Lewis acid sites of nodal centres, and (3) synthesis via a pyrolysis-mediated technique. Through these approaches, strong metal–support interactions can be established to aid the fine-tuning of the catalytic properties. We also discuss how recent progress in the development of state-of-the-art microscopic, spectroscopic, and crystallographic techniques has enabled scientists to elucidate the structure–activity relationship.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"379 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00324-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4540902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19","authors":"Dingzhong Li, Jianbing Hu, Dian Li, Weijun Yang, Shuang-Feng Yin, Renhua Qiu","doi":"10.1007/s41061-020-00318-2","DOIUrl":"https://doi.org/10.1007/s41061-020-00318-2","url":null,"abstract":"<p>COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, M<sup>pro</sup> inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"379 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00318-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4458976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges","authors":"Imtiaz Khan, Aliya Ibrar, Sumera Zaib","doi":"10.1007/s41061-020-00316-4","DOIUrl":"https://doi.org/10.1007/s41061-020-00316-4","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"379 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00316-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4211557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mireia Buaki-Sogó, Laura García-Carmona, Mayte Gil-Agustí, Leire Zubizarreta, Marta García-Pellicer, Alfredo Quijano-López
{"title":"Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices","authors":"Mireia Buaki-Sogó, Laura García-Carmona, Mayte Gil-Agustí, Leire Zubizarreta, Marta García-Pellicer, Alfredo Quijano-López","doi":"10.1007/s41061-020-00312-8","DOIUrl":"https://doi.org/10.1007/s41061-020-00312-8","url":null,"abstract":"<p>This article consists of a review of the main concepts and paradigms established in the field of biological fuel cells or biofuel cells. The aim is to provide an overview of the current panorama, basic concepts, and methodologies used in the field of enzymatic biofuel cells, as well as the applications of these bio-systems in flexible electronics and implantable or portable devices. Finally, the challenges needing to be addressed in the development of biofuel cells capable of supplying power to small size devices with applications in areas related to health and well-being or next-generation portable devices are analyzed. The aim of this study is to contribute to biofuel cell technology development; this is a multidisciplinary topic about which review articles related to different scientific areas, from Materials Science to technology applications, can be found. With this article, the authors intend to reach a wide readership in order to spread biofuel cell technology for different scientific profiles and boost new contributions and developments to overcome future challenges.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 6","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00312-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5167162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sina Matavos-Aramyan, Sadaf Soukhakian, Mohammad Hossein Jazebizadeh
{"title":"Retraction Note to: Mononuclear Cu Complexes Based on Nitrogen Heterocyclic Carbene: A Comprehensive Review","authors":"Sina Matavos-Aramyan, Sadaf Soukhakian, Mohammad Hossein Jazebizadeh","doi":"10.1007/s41061-020-00308-4","DOIUrl":"https://doi.org/10.1007/s41061-020-00308-4","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 4-5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00308-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4104310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in the Synthesis of Perimidines and their Applications","authors":"Nusrat Sahiba, Shikha Agarwal","doi":"10.1007/s41061-020-00307-5","DOIUrl":"https://doi.org/10.1007/s41061-020-00307-5","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 4-5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00307-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4410078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daily Rodriguez-Padron, Md Ariful Ahsan, Mohamed Fathi Sanad, Rafael Luque, Alain R. Puente Santiago
{"title":"Proteins-Based Nanocatalysts for Energy Conversion Reactions","authors":"Daily Rodriguez-Padron, Md Ariful Ahsan, Mohamed Fathi Sanad, Rafael Luque, Alain R. Puente Santiago","doi":"10.1007/s41061-020-00306-6","DOIUrl":"https://doi.org/10.1007/s41061-020-00306-6","url":null,"abstract":"<p>In recent years, the incorporation of molecular enzymes into nanostructured frameworks to create efficient energy conversion biomaterials has gained increasing interest as a promising strategy owing to both the dynamic behavior of proteins for their electrocatalytic function and the unique properties of the synergistic interactions between proteins and nanosized materials. Herein, we review the impact of proteins on energy conversion fields and the contribution of proteins to the improved activity of the resulting nanocomposites. We address different strategies to fabricate protein-based nanocatalysts as well as current knowledge on the structure–function relationships of enzymes during the catalytic processes. Additionally, a comprehensive review of state-of-the-art bioelectrocatalytic materials for water-splitting reactions such as hydrogen evolution reaction (HER) and oxygen evolution reactions (OER) is afforded. Finally, we briefly envision opportunities to develop a new generation of electrocatalysts towards the electrochemical reduction of N<sub>2</sub> to NH<sub>3</sub> using theoretical tools to built nature-inspired nitrogen reduction reaction catalysts.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 4-5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00306-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4753737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remote C–H Functionalization of 8-Aminoquinoline Ring","authors":"Zhihui Xu, Xiaogang Yang, Shuang-Feng Yin, Renhua Qiu","doi":"10.1007/s41061-020-00303-9","DOIUrl":"https://doi.org/10.1007/s41061-020-00303-9","url":null,"abstract":"<p>8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C–H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2–C7 on the 8-aminoquinoline ring, which involves the formation of C–C and C–Z (Z?=?heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 4-5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00303-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4426659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering Functional DNA–Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications","authors":"Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing","doi":"10.1007/s41061-020-00305-7","DOIUrl":"https://doi.org/10.1007/s41061-020-00305-7","url":null,"abstract":"<p>DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson–Crick hybridization properties. The DNA–protein conjugate with combined properties enables a broad range of applications, such as sensitive and selective bioassays, therapeutic agents, and building blocks for programmable nanoassemblies. In this review, we survey the conjugates from the aspects of conjugation chemistries as well as applications in biomedical and nanotechnology fields. We highlight the functions of both biological moieties of a conjugate for target binding and signal transduction in bioassays. We also review the use of DNA–protein conjugates for the construction of a variety of functional and dynamic nanostructures, from isolated hybrid cages to three-dimensional (3D) protein crystalline lattices. Moreover, these conjugates have been used as carriers to deliver enzymes or functional nucleic acids for disease treatments and gene editing.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00305-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4944034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}