Topics in Current Chemistry最新文献_第8页

Magnetic Nanoparticles as MRI Contrast Agents 磁性纳米颗粒作为MRI造影剂

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-05-07 DOI: 10.1007/s41061-020-00302-w

Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín

{"title":"Magnetic Nanoparticles as MRI Contrast Agents","authors":"Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín","doi":"10.1007/s41061-020-00302-w","DOIUrl":"https://doi.org/10.1007/s41061-020-00302-w","url":null,"abstract":"Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular?MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00302-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4315882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 88

DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions dna支架的近距离组装和多酶反应的限制

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-04-04 DOI: 10.1007/s41061-020-0299-3

Jinglin Fu, Zhicheng Wang, Xiao Hua Liang, Sung Won Oh, Ezry St. Iago-McRae, Ting Zhang

{"title":"DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions","authors":"Jinglin Fu, Zhicheng Wang, Xiao Hua Liang, Sung Won Oh, Ezry St. Iago-McRae, Ting Zhang","doi":"10.1007/s41061-020-0299-3","DOIUrl":"https://doi.org/10.1007/s41061-020-0299-3","url":null,"abstract":"Cellular functions rely on a series of organized and regulated multienzyme cascade reactions. The catalytic efficiencies of these cascades depend on the precise spatial organization of the constituent enzymes, which is optimized to facilitate substrate transport and regulate activities. Mimicry of this organization in a non-living, artificial system would be very useful in a broad range of applications—with impacts on both the scientific community and society at large. Self-assembled DNA nanostructures are promising applications to organize biomolecular components into prescribed, multidimensional patterns. In this review, we focus on recent progress in the field of DNA-scaffolded assembly and confinement of multienzyme reactions. DNA self-assembly is exploited to build spatially organized multienzyme cascades with control over their relative distance, substrate diffusion paths, compartmentalization and activity actuation. The combination of addressable DNA assembly and multienzyme cascades can deliver breakthroughs toward the engineering of novel synthetic and biomimetic reactors.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-0299-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4146676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Towards Active Self-Assembly Through DNA Nanotechnology 利用DNA纳米技术实现主动自组装

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-03-12 DOI: 10.1007/s41061-020-0297-5

Jinyi Dong, Chao Zhou, Qiangbin Wang

{"title":"Towards Active Self-Assembly Through DNA Nanotechnology","authors":"Jinyi Dong, Chao Zhou, Qiangbin Wang","doi":"10.1007/s41061-020-0297-5","DOIUrl":"https://doi.org/10.1007/s41061-020-0297-5","url":null,"abstract":"Self-assembly, which is ubiquitous in living systems, also stimulates countless synthetic molecular self-assembling systems. Most synthetic self-assemblies are realized by passive processes, going from high-energy states to thermodynamic equilibrium. Conversely, living systems work out of equilibrium, meaning they are energy-consuming, dissipative and active. In recently years, chemists have made extensive efforts to design artificial active self-assembly systems, which will be pivotal to emulating and understanding life. Among various strategies, emerging approaches based on DNA nanotechnology have attracted a lot of attention. Structural- as well as dynamic-DNA-nanotechnology offer diverse tools with which to design building blocks and to shape their assembly behaviors. To achieve active self-assembly, a synergy of diverse DNA techniques is essential, including structural design, controllable assembly–disassembly, autonomous assembly, molecular circuits, biochemical oscillators, and so on. In this review, we introduce progress towards, or related to, active assembly via DNA nanotechnology. Dynamic DNA assembly systems ranging from passive assembly–disassembly systems, to autonomous assembly systems to sophisticated artificial metabolism and time-clocking oscillation systems will be discussed. We catalogue these systems from the perspective of free energy change with the reaction process. We end the review with a brief outlook and discussion.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-0297-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4499872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Improvements in Catalyst Synthesis and Photocatalytic Oxidation Processing Based on the Use of Ultrasound 基于超声的催化剂合成和光催化氧化工艺的改进

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-03-03 DOI: 10.1007/s41061-020-0293-9

Parag R. Gogate

{"title":"Improvements in Catalyst Synthesis and Photocatalytic Oxidation Processing Based on the Use of Ultrasound","authors":"Parag R. Gogate","doi":"10.1007/s41061-020-0293-9","DOIUrl":"https://doi.org/10.1007/s41061-020-0293-9","url":null,"abstract":"The efficacy of photocatalysis strongly depends on the activity of the catalysts and the operational factors, especially factors associated with mass transfer and the possibility of catalyst deactivation. The use of ultrasound has great potential to enhance catalyst activity, during both the synthesis and actual oxidation processes due to the cavitational effects of turbulence and liquid streaming. This article presents an overview of the application aspects of ultrasound, both in the synthesis of the photocatalyst and applications for wastewater treatment. A review of the literature revealed that the use of ultrasound in the synthesis processes can result in a catalyst with a lower mean size and higher surface area as well as uniform size distribution. The application of ultrasound in the actual photocatalytic oxidation facilitates enhancement of the oxidation capacity, leading to higher degradation rates, sometimes synergistic results and definitely?lower treatment times. This article also presents guidelines for the selection of the best operating conditions for the use of ultrasound in photocatalytic systems and includes a discussion on the possible reactor configurations suitable for large-scale operations. Overall, a combination of ultrasound with photocatalytic oxidation or the optimized application of ultrasound in catalyst synthesis can yield significant benefits.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-0293-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4131068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Conductive Metal–Organic Frameworks: Mechanisms, Design Strategies and Recent Advances 导电金属有机框架:机制、设计策略和最新进展

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-02-24 DOI: 10.1007/s41061-020-0289-5

Xiangling Deng, Jie-Ying Hu, Jiye Luo, Wei-Ming Liao, Jun He

引用次数: 44

Aptamer-Functionalized DNA Nanostructures for Biological Applications 核酸适体功能化DNA纳米结构的生物学应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-02-07 DOI: 10.1007/s41061-020-0283-y

Xiaoyi Fu, Fangqi Peng, Jungyeon Lee, Qi Yang, Fei Zhang, Mengyi Xiong, Gezhi Kong, Hong-min Meng, Guoliang Ke, Xiao-Bing Zhang

{"title":"Aptamer-Functionalized DNA Nanostructures for Biological Applications","authors":"Xiaoyi Fu, Fangqi Peng, Jungyeon Lee, Qi Yang, Fei Zhang, Mengyi Xiong, Gezhi Kong, Hong-min Meng, Guoliang Ke, Xiao-Bing Zhang","doi":"10.1007/s41061-020-0283-y","DOIUrl":"https://doi.org/10.1007/s41061-020-0283-y","url":null,"abstract":"DNA nanostructures hold great promise for various applications due to their remarkable properties, including programmable assembly, nanometric positional precision, and dynamic structural control. The past few decades have seen the development of various kinds of DNA nanostructures that can be employed as useful tools in fields such as chemistry, materials, biology, and medicine. Aptamers are short single-stranded nucleic acids that bind to specific targets with excellent selectivity and high affinity and play critical roles in molecular recognition. Recently, many attempts have been made to integrate aptamers with DNA nanostructures for a range of biological applications. This review starts with an introduction to the features of aptamer-functionalized DNA nanostructures. The discussion then focuses on recent progress (particularly during the last five?years) in the applications of these nanostructures in areas such as biosensing, bioimaging, cancer therapy, and biophysics. Finally, challenges involved in the practical application of aptamer-functionalized DNA nanostructures are discussed, and perspectives on future directions for research into and applications of aptamer-functionalized DNA nanostructures are provided.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-0283-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4293678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

High-performance biosensing based on autonomous enzyme-free DNA circuits 基于自主无酶DNA电路的高性能生物传感

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-02-03 DOI: 10.1007/s41061-020-0284-x

Hong Wang, Huimin Wang, Itamar Willner, Fuan Wang

引用次数: 23

DNA-Driven Nanoparticle Assemblies for Biosensing and Bioimaging 用于生物传感和生物成像的dna驱动纳米粒子组件

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-02-03 DOI: 10.1007/s41061-020-0282-z

Yuan Zhao, Lixia Shi, Hua Kuang, Chuanlai Xu

{"title":"DNA-Driven Nanoparticle Assemblies for Biosensing and Bioimaging","authors":"Yuan Zhao, Lixia Shi, Hua Kuang, Chuanlai Xu","doi":"10.1007/s41061-020-0282-z","DOIUrl":"https://doi.org/10.1007/s41061-020-0282-z","url":null,"abstract":"DNA molecules with superior flexibility, affinity and programmability have garnered considerable attention for the controllable assembly of nanoparticles (NPs). By controlling the density, length and sequences of DNA on NPs, the configuration of NP assemblies can be rationally designed. The specific recognition of DNA enables changes to be made to the spatial structures of NP assemblies, resulting in differences in tailorable optical signals. Comprehensive information on the fabrication of DNA-driven NP assemblies would be beneficial for their application in biosensing and bioimaging. This review analyzes the progress of DNA-driven NP assemblies, and discusses the tunable configurations determined by the structural parameters of DNA skeletons. The collective optical properties, such as chirality, fluorescence and surface enhanced Raman resonance (SERS), etc., of DNA-driven NP assemblies are explored, and engineered tailorable optical properties of these spatial structures are achieved. We discuss the development of DNA-directed NP assemblies for the quantification of DNA, toxins, and heavy metal ions, and demonstrate their potential application in the biosensing and bioimaging of tumor markers, RNA, living metal ions and phototherapeutics. We hihghlight possible challenges in the development of DNA-driven NP assemblies, and further direct potential prospects in the practical applications of macroscopical materials and photonic devices.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-0282-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4117275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Metal–Organic Frameworks Towards Desulfurization of Fuels 金属-有机框架在燃料脱硫中的应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-01-29 DOI: 10.1007/s41061-020-0280-1

Leiduan Hao, Matthew J. Hurlock, Guodong Ding, Qiang Zhang

引用次数: 26

Carbon Nanotubes in Biomedicine 碳纳米管在生物医学中的应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2020-01-14 DOI: 10.1007/s41061-019-0278-8

Viviana Negri, Jesús Pacheco-Torres, Daniel Calle, Pilar López-Larrubia

{"title":"Carbon Nanotubes in Biomedicine","authors":"Viviana Negri, Jesús Pacheco-Torres, Daniel Calle, Pilar López-Larrubia","doi":"10.1007/s41061-019-0278-8","DOIUrl":"https://doi.org/10.1007/s41061-019-0278-8","url":null,"abstract":"Nowadays, biomaterials have become a crucial element in numerous biomedical, preclinical, and clinical applications. The use of nanoparticles entails a great potential in these fields mainly because of the high ratio of surface atoms that modify the physicochemical properties and increases the chemical reactivity. Among them, carbon nanotubes (CNTs) have emerged as a powerful tool to improve biomedical approaches in the management of numerous diseases. CNTs have an excellent ability to penetrate cell membranes, and the sp2 hybridization of all carbons enables their functionalization with almost every biomolecule or compound, allowing them to target cells and deliver drugs under the appropriate environmental stimuli. Besides, in the new promising field of artificial biomaterial generation, nanotubes are studied as the load in nanocomposite materials, improving their mechanical and electrical properties, or even for direct use as scaffolds in body tissue manufacturing. Nevertheless, despite their beneficial contributions, some major concerns need to be solved to boost the clinical development of CNTs, including poor solubility in water, low biodegradability and dispersivity, and toxicity problems associated with CNTs’ interaction with biomolecules in tissues and organs, including the possible effects in the proteome and genome. This review performs a wide literature analysis to present the main and latest advances in the optimal design and characterization of carbon nanotubes with biomedical applications, and their capacities in different areas of preclinical research.","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"378 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2020-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-019-0278-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4571581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 84