Topics in Current Chemistry最新文献

Unlocking the Potential: The Structural Wonders and Diverse Applications of Triazoles in Contemporary Science. 释放潜力：三氮唑在当代科学中的结构奇迹和多种应用。

IF 7.1 2区化学

Topics in Current Chemistry Pub Date : 2025-07-04 DOI: 10.1007/s41061-025-00510-2

Ayushi Bhatnagar, Rajendra Prasad Pakhariya, Gangotri Pemawat

{"title":"Unlocking the Potential: The Structural Wonders and Diverse Applications of Triazoles in Contemporary Science.","authors":"Ayushi Bhatnagar, Rajendra Prasad Pakhariya, Gangotri Pemawat","doi":"10.1007/s41061-025-00510-2","DOIUrl":"https://doi.org/10.1007/s41061-025-00510-2","url":null,"abstract":"<p><p>Triazoles, a captivating class of nitrogen-containing heterocyclic compounds, have emerged as pivotal players in contemporary chemistry, drawing significant attention for their exceptional versatility and wide-ranging applications. They have become essential building blocks in modern chemistry, exhibiting remarkable adaptability in a multiple areas of utility. Artificial intelligence (AI)-driven drug discovery in medicinal chemistry has sped up the process of finding bioactive triazole derivatives with improved therapeutic potential. Green chemistry techniques, such as metal-free protocols, ionic liquid-mediated synthesis, and click chemistry, have transformed their synthesis, which guarantees sustainability, effectiveness, and low environmental impact. Beyond the pharmaceutical industry, triazoles are essential to next-generation material science, helping to create anticorrosion coatings, biosensors, and high-performance solar cells. Their incorporation into organic electronics and nanotechnology has led to revolutionary breakthroughs in several industries by greatly enhancing energy storage systems, protective coatings, and sensor sensitivity. As studies continue, combining artificial intelligence and environmentally friendly synthesis techniques broadens the range of triazole applications, confirming their position as essential facilitators of scientific and technological advancement. These advancements not only streamline the creation of triazole derivatives but also expand the scope of their applications, propelling research and development across multiple domains.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"383 3","pages":"27"},"PeriodicalIF":7.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Synthetic Strategies and Biological Properties of Indazole Scaffolds: A Review. 吲哚唑支架的合成策略及生物学特性研究进展

IF 7.1 2区化学

Topics in Current Chemistry Pub Date : 2025-07-01 DOI: 10.1007/s41061-025-00509-9

S N Murthy Boddapati, Bhuvaneswari Chalapaka, Abraham Emmanuel Kola, Sreekantha Babu Jonnalagadda

{"title":"Recent Advances in Synthetic Strategies and Biological Properties of Indazole Scaffolds: A Review.","authors":"S N Murthy Boddapati, Bhuvaneswari Chalapaka, Abraham Emmanuel Kola, Sreekantha Babu Jonnalagadda","doi":"10.1007/s41061-025-00509-9","DOIUrl":"10.1007/s41061-025-00509-9","url":null,"abstract":"<p><p>Research on heterocyclic compounds is an area of continuous focus, capturing the interest of both synthetic and natural product chemists. Indazoles are one of the rare heterocycles that are available in nature. Indazole and its derivatives are one of the most important classes of heterocycles in pharmacological molecules. The structurally different indazole motifs, with impressive bioactivity, have drawn increasing attention from medicinal chemists in recent years for the continuous development of novel drug moieties. Thus, knowledge of the biological activities and synthetic pathways of indazole scaffolds is essential to enhancing further developments in the number of indazole-based lead molecules. The goal of the present review is to highlight information on the biological properties of some existing indazole-based drugs and activities of novel bioactive indazole compounds in clinical trails, with specific attention to the most recent advances in various synthetic strategies towards indazole and its derivatives over the past 7 years (2017-2024). Moreover, we discuss the substrate tolerance and mechanistic insights for most of the summarized synthetic protocols.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"383 3","pages":"26"},"PeriodicalIF":7.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Click-Triggered Bioorthogonal Bond-Cleavage Reactions. 点击触发的生物正交键裂解反应。

IF 7.1 2区化学

Topics in Current Chemistry Pub Date : 2025-06-14 DOI: 10.1007/s41061-025-00492-1

Patrick Keppel, Sebastian Hecko, Hannes Mikula

引用次数: 0

Dipyrroethanes/Dipyrroethenes: New Precursors for Porphyrinoids. 二吡咯烷/二吡咯烷：卟啉类化合物的新前体。

IF 7.1 2区化学

Topics in Current Chemistry Pub Date : 2025-06-02 DOI: 10.1007/s41061-025-00506-y

Vratta Grover, Mangalampalli Ravikanth

{"title":"Dipyrroethanes/Dipyrroethenes: New Precursors for Porphyrinoids.","authors":"Vratta Grover, Mangalampalli Ravikanth","doi":"10.1007/s41061-025-00506-y","DOIUrl":"10.1007/s41061-025-00506-y","url":null,"abstract":"<p><p>Dipyrroethanes/dipyrroethenes (DPEs) containing two pyrroles connected by two meso sp<sup>3</sup>/sp<sup>2</sup> carbons are very useful precursors for the synthesis of very novel porphyrinoids. Dipyrromethanes/dipyrromethenes (DPMs) that consist of two pyrrole rings connected via one meso sp<sup>3</sup>/sp<sup>2</sup> carbon are the most popular precursors for the synthesis of several types of porphyrinoids. Dipyrromethanes/dipyrromethenes can be readily prepared by condensing aldehyde and pyrrole under acid-catalyzed conditions, whereas dipyrroethenes (DPEs) require a few skilled synthetic steps to be obtained in good quantities. Especially, dipyrroethenes exist in E/Z-isomeric mixtures but their separation is not required for the synthesis of porphyrinoids. In the last decade, DPEs have been used as key precursors to synthesize contracted porphyrins such as triphyrins(2.1.1), porphyrin isomers such as porphycene(2.0.2.0), and several expanded porphyrins. This review describes different methods available for the synthesis of 5,6-di(alkyl/aryl/heteroaryl) dipyrroethanes/dipyrroethenes and their use in the synthesis of different porphyrinoids ranging from contracted porphyrinoids to expanded porphyrinoids. The structure, reactivity, and physico-chemical properties of various porphyrinoids which were synthesized from DPEs are also discussed.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":"22"},"PeriodicalIF":7.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles 构建含氮杂环的分子内Povarov工具

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-30 DOI: 10.1007/s41061-023-00428-7

Carme Masdeu, Jesús M. de los Santos, Francisco Palacios, Concepción Alonso

{"title":"The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles","authors":"Carme Masdeu, Jesús M. de los Santos, Francisco Palacios, Concepción Alonso","doi":"10.1007/s41061-023-00428-7","DOIUrl":"10.1007/s41061-023-00428-7","url":null,"abstract":"<div><p>Nitrogen heterocycles are part of the structure of natural products and agents with important biological activity, such as antiviral, antibiotic, and antitumor drugs. For this reason, heterocyclic compounds are one of today’s most desirable synthetic targets and the Povarov reaction is a powerful synthetic tool for the construction of highly functionalized heterocyclic systems. This process involves an aromatic amine, a carbonyl compound, and an olefin or acetylene to give rise to the formation of a nitrogen-containing heterocycle. This review illustrates advances in the synthetic aspects of the intramolecular Povarov reaction for the construction of intricate nitrogen-containing polyheterocyclic compounds. This original review presents research done in this field, with references to important works by internationally relevant research groups on this current topic, covering the literature from 1992 to 2022. The intramolecular Povarov reactions are described here according to the key processes involved, using different combinations of aromatic or heteroaromatic amines, and aliphatic, aromatic, or heteroaromatic aldehydes. Some catalytic reactions promoted by transition metals are detailed, as well as the oxidative Povarov reaction and some asymmetric intramolecular Povarov processes.</p></div>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"381 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-023-00428-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5158265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Photothermal Catalytic CO2 Conversion: Beyond Catalysis and Photocatalysis 光热催化CO2转化:超越催化与光催化

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-30 DOI: 10.1007/s41061-023-00430-z

Fernando Fresno, Ana Iglesias-Juez, Juan M. Coronado

{"title":"Photothermal Catalytic CO2 Conversion: Beyond Catalysis and Photocatalysis","authors":"Fernando Fresno, Ana Iglesias-Juez, Juan M. Coronado","doi":"10.1007/s41061-023-00430-z","DOIUrl":"10.1007/s41061-023-00430-z","url":null,"abstract":"<div><p>In recent years, the combination of both thermal and photochemical contributions has provided interesting opportunities for solar upgrading of catalytic processes. Photothermal catalysis works at the interface between purely photochemical processes, which involve the direct conversion of photon energy into chemical energy, and classical thermal catalysis, in which the catalyst is activated by temperature. Thus, photothermal catalysis acts in two different ways on the energy path of the reaction. This combined catalysis, of which the fundamental principles will be reviewed here, is particularly promising for the activation of small reactive molecules at moderate temperatures compared to thermal catalysis and with higher reaction rates than those attained in photocatalysis, and it has gained a great deal of attention in the last years. Among the different applications of photothermal catalysis, CO<sub>2</sub> conversion is probably the most studied, although reaction mechanisms and photonic-thermal synergy pathways are still quite unclear and, from the reaction route point of view, it can be said that photothermal-catalytic CO<sub>2</sub> reduction processes are still in their infancy. This article intends to provide an overview of the principles underpinning photothermal catalysis and its application to the conversion of CO<sub>2</sub> into useful molecules, with application essentially as fuels but also as chemical building blocks. The most relevant specific cases published to date will be also reviewed from the viewpoint of selectivity towards the most frequent target products.</p></div>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"381 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-023-00430-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5166405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles 利用氨基吡唑的C, n -双亲核性质的多组分反应:吡唑融合杂环的构建

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-26 DOI: 10.1007/s41061-023-00427-8

Tasneem Parvin

{"title":"Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles","authors":"Tasneem Parvin","doi":"10.1007/s41061-023-00427-8","DOIUrl":"10.1007/s41061-023-00427-8","url":null,"abstract":"<div><p>Synthesis of pyrazole-fused heterocycles has gained considerable attention in recent years due to their wide applications in medicinal chemistry. Aminopyrazoles are versatile building blocks for the synthesis of pyrazole-fused heterocycles by multicomponent reactions. Due to the presence of multiple reaction sites, they have fascinating chemical reactivity. Thus, they have been extensively used in multicomponent reactions for the construction of pyrazole-fused heterocycles. Although few review articles on the preparation and applications of aminopyrazoles are known in the literature, to date there is no dedicated review article on the construction of pyrazole-fused heterocycles exploring the reactivity of amino pyrazoles as <i>C</i>,<i>N</i>-binucleophiles in multicomponent reactions. Considering this, herein the multicomponent reactions for the construction of pyrazole-fused heterocycles exploring <i>C</i>,<i>N</i>-binucleophilic nature of amino pyrazoles have been reported.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"381 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5016569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser-Induced Transfer of Functional Materials 功能材料的激光诱导转移

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-22 DOI: 10.1007/s41061-023-00429-6

Connie Kong Wai Lee, Yexin Pan, Rongliang Yang, Minseong Kim, Mitch Guijun Li

{"title":"Laser-Induced Transfer of Functional Materials","authors":"Connie Kong Wai Lee, Yexin Pan, Rongliang Yang, Minseong Kim, Mitch Guijun Li","doi":"10.1007/s41061-023-00429-6","DOIUrl":"10.1007/s41061-023-00429-6","url":null,"abstract":"<div><p>Patterning is crucial for the large-scale application of functional materials. Laser-induced transfer is an emerging patterning method for additively depositing functional materials to the target acceptor. With the rapid development of laser technologies, this laser printing method emerges as a versatile method to deposit functional materials in either liquid or solid format. The emerging applications such as solar interfacial evaporation, solar cells, light-emitting diodes, sensors, high-output synthesis, and other fields are rising fields benefiting from laser-induced transfer. Following a brief introduction to the principles of laser-induced transfer, this review will comprehensively deliberate this novel additive manufacturing method, including preparing the donor layer and the applications, advantages, and limitations of this technique. Finally, perspectives for handling current and future functional materials using laser-induced transfer will also be discussed. Non-experts in laser technologies can also gain insights into this prevailing laser-induced transfer process, which may inspire their future research.</p></div>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"381 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-023-00429-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4872213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oxime Esters: Flexible Building Blocks for Heterocycle Formation 肟酯:杂环形成的柔性构建块

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-18 DOI: 10.1007/s41061-023-00431-y

Faeze Yousefnejad, Fatemeh Gholami, Bagher Larijani, Mohammad Mahdavi

引用次数: 0

Spectroscopic Determination of Acetylcholine (ACh): A Representative Review 光谱法测定乙酰胆碱(ACh)的研究进展

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2023-05-11 DOI: 10.1007/s41061-023-00426-9

Paweł Świt, Aleksandra Pollap, Joanna Orzeł

{"title":"Spectroscopic Determination of Acetylcholine (ACh): A Representative Review","authors":"Paweł Świt, Aleksandra Pollap, Joanna Orzeł","doi":"10.1007/s41061-023-00426-9","DOIUrl":"10.1007/s41061-023-00426-9","url":null,"abstract":"<div><p>Acetylcholine (ACh) is one of the most crucial neurotransmitters of the cholinergic system found in vertebrates and invertebrates and is responsible for many processes in living organisms. Disturbances in ACh transmission are closely related to dementia in Alzheimer’s and Parkinson’s disease. ACh in biological samples is most often determined using chromatographic techniques, radioenzymatic assays, enzyme-linked immunosorbent assay (ELISA), or potentiometric methods. An alternative way to detect and determine acetylcholine is applying spectroscopic techniques, due to low limits of detection and quantification, which is not possible with the methods mentioned above. In this review article, we described a detailed overview of different spectroscopic methods used to determine ACh with a collection of validation parameters as a perspective tool for routine analysis, especially in basic research on animal models on central nervous system. In addition, there is a discussion of examples of other biological materials from clinical and preclinical studies to give the whole spectrum of spectroscopic methods application. Descriptions of the developed chemical sensors, as well as the use of flow technology, were also presented. It is worth emphasizing the inclusion in the article of multi-component analysis referring to other neurotransmitters, as well as the description of the tested biological samples and extraction procedures. The motivation to use spectroscopic techniques to conduct this type of analysis and future perspectives in this field are briefly discussed.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":"381 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-023-00426-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4474000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1