Click-Triggered Bioorthogonal Bond-Cleavage Reactions.

IF 7.1 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Topics in Current Chemistry Pub Date : 2025-06-14 DOI:10.1007/s41061-025-00492-1

Patrick Keppel, Sebastian Hecko, Hannes Mikula

引用次数: 0

Abstract

Bioorthogonal bond-cleavage reactions have evolved into powerful tools for chemical biology, representing a promising strategy for achieving controlled release of molecules under physiologically relevant conditions, even in living organisms. Since their discovery, significant efforts have been invested in the development and understanding of the underlying chemistries to enhance the click-to-release performance, biocompatibility, and stability of bioorthogonal tools. In this review, we aim to provide a concise overview of click-triggered bioorthogonal bond-cleavage reactions, with an emphasis on the mechanisms and characteristics of the most commonly applied click-to-release chemistries.

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点击触发的生物正交键裂解反应。

生物正交键裂解反应已经发展成为化学生物学的有力工具，代表了在生理相关条件下实现分子控制释放的有前途的策略，甚至在活的生物体中。自从他们的发现以来，人们已经投入了大量的努力来开发和理解潜在的化学物质，以提高生物正交工具的点击释放性能、生物相容性和稳定性。在这篇综述中，我们旨在简要概述点击触发的生物正交键裂解反应，重点介绍最常用的点击释放化学反应的机制和特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry Chemistry-General Chemistry

CiteScore

13.70

自引率

1.20%

发文量

期刊介绍： Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.