World Journal of Mens Health最新文献

{"title":"Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway.","authors":"Mancheng Xia, Yiming Yuan, Dong Fang, Xiaohui Tan, Fangzhou Zhao, Xinfei Li, Pengchao Gao, Zhuo Zhou, Tiegui Nan, Zhongcheng Xin, Xuesong Li, Ruili Guan","doi":"10.5534/wjmh.240065","DOIUrl":"10.5534/wjmh.240065","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the role and mechanism of thrombospondin-1 (TSP1) in the development of fibrosis in diabetes mellitus-induced erectile dysfunction (DMED).</p><p><strong>Materials and methods: </strong>DMED was induced by intraperitoneal streptozotocin injection. All rats were categorized into three groups: control group (n=8), DMED group (n=8) and DMED+Leu-Ser-Lys-Leu (LSKL) group (n=8). After eight weeks following the induction of diabetes mellitus, the DMED+LSKL group was subjected to intraperitoneal injections of LSKL twice weekly for four weeks. To measure intracavernous pressure (ICP), a 25-gauge needle connected to a PE tube containing heparin was inserted into the corpus cavernosum (CC). Additionally, a needle was inserted into the carotid artery to measure mean arterial pressure (MAP). Sirius red staining and Masson trichrome staining were utilized to assess CC fibrosis. Moreover, high glucose (HG)-induced CC smooth muscle cells (CCSMCs) and CC fibroblasts (CCFs) were treated with or without LSKL. Western blotting and immunofluorescence were utilized to assess the phosphorylation and expression of related proteins.</p><p><strong>Results: </strong>Compared with those in the control group, the ratio of the maximum ICP to the MAP markedly decreased in the DMED group, as did the ratio of smooth muscle to collagen and the ratio of collagen I to collagen III. These ratios were greater in the DMED+LSKL group than in the DMED group. TSP1 was highly expressed in the CC of DMED rats. <i>In vitro</i> experiments indicated that TSP1 expression significantly increased in the medium of CCSMCs and CCFs cultured in HG media and that the TGF-β pathway was activated in CCSMCs. Collagen IV was overexpressed in CCSMCs, indicating severe fibrosis was severe. Adding LSKL or knocking TSP1 down can prevent the activation of TGF-β signaling, as well as the overexpression of collagen IV in CCSMCs promoted by TSP1 secreted from CCSMCs itself or CCFs.</p><p><strong>Conclusions: </strong>TSP1 expression is increased in the CC of DMED rats. HG-induced TSP1 secretion via autocrine signaling from CCSMCs and/or paracrine signaling from CCFs to accelerate penile fibrosis. LSKL, an antagonist of TSP1, could improve erectile dysfunction by inhibiting the TGF-β/SMAD pathway.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"580-594"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer.","authors":"Zhizhou Li, Maoyu Wang, Shuxiong Zeng, Ziwei Wang, Yidie Ying, Qing Chen, Chen Zhang, Wei He, Chaoyang Sheng, Yi Wang, Zhensheng Zhang, Chuanliang Xu, Huiqing Wang","doi":"10.5534/wjmh.240062","DOIUrl":"10.5534/wjmh.240062","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence of an association between leukocyte telomere length (LTL) and prostate cancer (PCa) is accumulating; however, their shared genetic basis remains unclear.</p><p><strong>Materials and methods: </strong>Using summary statistics obtained from the genome-wide association study (GWAS), we quantified the global and local genetic correlations between two traits. Subsequently, we identified potential pleiotropic loci, common tissue-enriched regions, and risk gene loci while inferring assumed causal relationships.</p><p><strong>Results: </strong>Our study demonstrated a global genetic correlation between LTL and PCa (genetic correlation=0.066, p=0.017), which was further confirmed in local genomic regions. Cross-trait GWAS meta-analysis revealed 44 shared loci, including 10 novel pleiotropic single nucleotide polymorphisms appearing concurrently in significant local genetic correlation regions. Notably, two new loci (rs9419958; rs3730668) were additionally validated to co-localize. For the first time, we identified a significant shared genetic enrichment of both traits in the small intestine tissue at the terminal ileum, with functional genes in this region affecting both LTL and PCa. Concurrently, Mendelian randomization analysis indicated a positive causal relationship between LTL and PCa.</p><p><strong>Conclusions: </strong>In conclusion, our study makes a significant contribution to the ongoing debate concerning the potential association between longer LTL and a higher risk of PCa. Additionally, we provide new evidence for the development of therapeutic targets for PCa and propose new directions for future risk prediction in this regard.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"616-632"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress Induces Changes in Molecular Markers Associated with Ferroptosis in Human Spermatozoa.","authors":"Pablo Contreras-Mellado, Anita Bravo, Fabiola Zambrano, Raúl Sánchez, Rodrigo Boguen, Jennie Risopatrón, Osvaldo Merino, Pamela Uribe","doi":"10.5534/wjmh.240085","DOIUrl":"10.5534/wjmh.240085","url":null,"abstract":"<p><strong>Purpose: </strong>Ferroptosis is a type of iron-dependent regulated cell death characterized by increased bioavailability of redox-active iron, loss of GPX4 antioxidant capacity, and oxidation of polyunsaturated fatty acid-containing phospholipids mediated by reactive oxygen species (ROS). The aim of this study was to evaluate the effect of oxidative stress induced by arachidonic acid (AA) on ferroptotic cell death in human spermatozoa.</p><p><strong>Materials and methods: </strong>Spermatozoa from normozoospermic donors were exposed to AA (5, 25, and 50 µM) for 1 hour at 37 ℃, including an untreated control. Oxidative stress was confirmed by evaluation of cytosolic and mitochondrial ROS production, viability, mitochondrial membrane potential (ΔΨm) and motility. Subsequently, molecular markers of ferroptosis including iron content, levels of GPX4, SLC7A11, ACSL4, IREB2 and lipid peroxidation were evaluated. The analyses were carried out using either flow cytometry, a microplate reader or confocal laser microscopy.</p><p><strong>Results: </strong>AA-induced oxidative stress showed increased cytosolic and mitochondrial ROS production accompanied by impaired ΔΨm, viability and motility in human spermatozoa. These results were associated with biochemical and molecular markers related to ferroptotic cell death including an increase in iron content in the form of ferrous (Fe²⁺) ions, SLC7A11, ACSL4, IREB2, a decrease in the level of GPX4, and an increase in the level of lipid peroxidation compared to the untreated control.</p><p><strong>Conclusions: </strong>This study revealed that AA-induced oxidative stress induces cell death with biochemical characteristics of ferroptosis in human spermatozoa, demonstrating another mechanism of alteration of sperm function induced by oxidative stress and could establish new therapeutic objectives to prevent the decrease in sperm quality mediated by oxidative stress.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"633-646"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone Replacement in Men with Sexual Dysfunction: An Abridged Version of the Cochrane Systematic Review.","authors":"Hunju Lee, Eu Chang Hwang, Cheol Kyu Oh, Solam Lee, Ho Song Yu, Jung Soo Lim, Hong Wook Kim, Thomas Walsh, Myung Ha Kim, Jae Hung Jung, Philipp Dahm","doi":"10.5534/wjmh.240146","DOIUrl":"10.5534/wjmh.240146","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effects of testosterone replacement therapy (TRT) compared to placebo or other medical treatments in men with sexual dysfunction.</p><p><strong>Materials and methods: </strong>We performed a comprehensive search with no restrictions on publication language or status up to 29 August 2023. We only included randomized controlled trials (RCTs).</p><p><strong>Results: </strong>We identified 43 studies with 11,419 randomized participants. We found that TRT likely results in little to no difference in erectile function assessed with the IIEF-EF (mean difference [MD]: 2.37, 95% confidence interval [CI]: 1.67 to 3.08; I²=0%; 6 RCTs, 2016 participants; moderate-certainty evidence) compared to placebo. TRT likely results in little to no change in sexual quality of life assessed with the Aging Males' Symptoms scale (MD: -2.31, 95% CI: -3.63 to -1.00; I²=0%; 5 RCTs, 1,030 participants; moderate-certainty evidence) compared to placebo. TRT also likely results in little to no difference in cardiovascular mortality (risk ratio: 0.83, 95% CI: 0.21 to 3.26; I²=0%; 10 RCTs, 3,525 participants; moderate-certainty evidence) compared to placebo. TRT also likely results in little to no difference in treatment withdrawal due to adverse events, prostate-related events, or lower urinary tract symptoms.</p><p><strong>Conclusions: </strong>TRT for men with sexual dysfunction showed no difference in erectile function, sexual quality of life, or cardiovascular mortality compared to placebo. Furthermore, it also appears to no difference in treatment withdrawals due to adverse events, prostate-related events, or lower urinary tract symptoms.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"539-551"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescen.","authors":"Fang Yang, Xiaoya Li, Meijing Wang, Xiucheng Lan, Jingyi Zhang, Junjun Li, Degui Chang, Xujun Yu","doi":"10.5534/wjmh.240254","DOIUrl":"10.5534/wjmh.240254","url":null,"abstract":"<p><p>Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the past half-century. Genetic defects alone cannot explain the rapid increase in incidence, and there is growing evidence that environmental factors or lifestyle changes are responsible for the high incidence in recent years. Testicular Leydig cells occupy an important role in the male reproductive system. In this study, we review the mechanisms by which environmental endocrine disruptors promote both death and senescence of testicular Leydig cells, refine the former into two programmed death modes, apoptosis, and autophagy, and further explore the interactions among them, thus summarizing the advances of the toxic effects of environmental endocrine disruptors on testicular Leydig cells, and expecting to provide a new therapeutic idea.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"477-491"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Society for Sexual Medicine (BSSM) Position Statement on Premature Ejaculation.","authors":"Geoff Ian Hackett, Mike Kirby, Patricia Schartau, Nick Ossei-Gerning, Janine David, Wai Gin Lee","doi":"10.5534/wjmh.240262","DOIUrl":"10.5534/wjmh.240262","url":null,"abstract":"<p><p>To provide an evidence based consensus on the diagnosis and management of premature ejaculation (PE). The British Society for Sexual Medicine (BSSM) takes issue with the advice to use off label treatments, such as daily selective serotonin reuptake inhibitors treatment, favoring on-demand dapoxetine. There is increasing evidence for the use of PDE5 inhibitors which are superior to a placebo for the treatment of PE. A recent meta-analysis of international PE guidelines supports the need for research to investigate the association of PE with erectile dysfunction (ED), prostatitis and thyroid disease, and supports the early use of PDE5 inhibitors either alone or in combination with dapoxetine or psychosexual interventions. Topical agents and non-pharmacological treatments also have a place, with new agents in the pipeline. The United Kingdom (UK) lacks formal guidance from the National Institute of Clinical Excellence (NICE) on any of the common male sexual dysfunctions, namely ED, PE, ejaculatory disorders, and male hypogonadism. As a result, general practitioners in the UK have relied on local guidance, and international guidelines which are heterogeneous, indicating diagnostic and therapeutic approaches that are often inconsistent. The aim of this position statement is to improve the management of PE in the UK.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"510-522"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians.","authors":"Sulagna Dutta, Kadir Bocu, Ashok Agarwal","doi":"10.5534/wjmh.240152","DOIUrl":"10.5534/wjmh.240152","url":null,"abstract":"<p><p>Leukocytospermia, defined as a leukocyte concentration in semen exceeding 1×10⁶ leukocytes/mL, significantly impacts male reproductive health by affecting sperm functionality and fertility outcomes. This condition arises from various etiological factors, including infections, autoimmune responses, lifestyle factors, and other physiological conditions. Adverse effects on sperm associated with leukocytospermia include acrosome damage and abnormalities in the sperm midpiece and tail. The review explores the complex interplay between leukocytospermia and oxidative stress, emphasizing the harmful effects on sperm DNA integrity and overall sperm quality. Due to the multifactorial nature of leukocytospermia, diagnosing this condition presents several challenges. Effective management strategies discussed include the use of antibiotics, anti-inflammatory agents, and assisted reproductive technologies. Diagnostic methods range from traditional peroxidase staining to more advanced techniques such as immunocytochemistry and flow cytometry, which offer higher sensitivity and specificity. Infections of the male genital tract, particularly male accessory gland infection and male genital tract infection, play a significant role in the etiology of leukocytospermia. These infections lead to an inflammatory response, resulting in leukocyte infiltration into the semen. Systemic conditions like diabetes mellitus and autoimmune disorders also contribute to leukocytospermia by provoking inflammatory responses that facilitate leukocyte presence in semen. This review underscores the importance of a comprehensive diagnostic approach that includes patient history, physical examination, and advanced laboratory tests. Treatment is tailored to the identified underlying cause, whether infectious or non-infectious. Lifestyle modifications, such as reducing stress, improving diet, and avoiding environmental toxins, are also recommended to enhance semen quality. For clinicians, this review provides a concise yet thorough overview of leukocytospermia, integrating the latest research findings and clinical insights to aid in the effective management of this condition, ultimately aiming to improve patient care in male reproductive health.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"465-476"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yes-Associated Protein Promotes Endothelial-Mesenchymal Transition to Mediate Diabetes Mellitus Erectile Dysfunction by Phosphorylating Smad3.","authors":"Ming Xiao, Xiaoli Tan, Huanqin Zeng, Biao Liu, Xiaopeng Tang, Yanghua Xu, Yinghao Yin, Jiarong Xu, Zhitao Han, Zitaiyu Li, Yuxin Tang, Liangyu Zhao","doi":"10.5534/wjmh.240126","DOIUrl":"10.5534/wjmh.240126","url":null,"abstract":"<p><strong>Purpose: </strong>The main objective of this study is to elucidate the role of endothelial-mesenchymal transition (EndMT) regulated by yes-associated protein (YAP) on diabetes mellitus erectile dysfunction (DMED).</p><p><strong>Materials and methods: </strong>High concentrations of glucose and palmitic acid (HGP) culturing simulated a diabetic condition <i>in vitro</i>. Cell proliferation, migration, tube formation, and marker gene changes of rat cavernous endothelial cells (RCECs) were measured after YAP overexpression or knockdown. Erectile function and histological outcomes were evaluated <i>in vivo</i>.</p><p><strong>Results: </strong>Nuclear YAP in RCECs was significantly increased after pretreatment with HGP. YAP overexpression enhanced the cell proliferation (0.236±0.004 <i>vs.</i> 0.148±0.008, p<0.001), migration (1.908±0.099 <i>vs.</i> 1.000±0.116, p<0.001), and tube formation (290.6±10.96 and 21,440.3±762.9 <i>vs.</i> 175.0±24.82 and 13,538.6±1,819.0, p<0.001) compared to the control group. Moreover, the ratios of intracavernous pressure (ICP) to mean arterial pressure (MAP) (0.642±0.051 <i>vs.</i> 0.850±0.070, p<0.05), and smooth muscle to collagen (0.155±0.010 <i>vs.</i> 0.274±0.023, p<0.01) were decreased in rats with YAP overexpression. The effects of HGP on CD31, eNOS, CD34, VE-cadherin, vimentin, α-SMA, and p-Smad3 expression were abrogated by inhibiting YAP in RCECs. YAP knockdown also restored the ICP/MAP (0.597±0.019 <i>vs.</i> 0.346±0.033, p<0.01), smooth muscle/collagen (0.13±0.010 <i>vs.</i> 0.08±0.026, p<0.05) and p-Smad3/Smad3 (1.61±0.291 <i>vs.</i> 3.26±0.332, p<0.01) ratios in type 2 diabetic rats.</p><p><strong>Conclusions: </strong>YAP promotes EndMT to impair erectile function in type 2 diabetic rats by phosphorylating Smad3, providing a new strategy for treating DMED.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"686-701"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Shorter Abstinence Periods on Semen Parameters: A Systematic Review and Meta-Analysis.","authors":"Marco Raditya, Alice Hari Soejono, Mario Alfonsus Siswanto, Widi Atmoko, Rupin Shah, Ashok Agarwal, Gerhard Reinaldi Situmorang, Ponco Birowo, Nur Rasyid","doi":"10.5534/wjmh.240035","DOIUrl":"10.5534/wjmh.240035","url":null,"abstract":"<p><strong>Purpose: </strong>The success of assisted reproductive technology (ART) relies heavily on semen parameters, and it is influenced by the length of the abstinence period. The World Health Organization (WHO) recommends a 2- to 7-day abstinence period. Even so, efficacy is still suboptimal. Thus, this study aims to determine whether shorter abstinence periods (<2 days) can improve semen parameters.</p><p><strong>Materials and methods: </strong>This study is a systematic review and meta-analysis. A literature search was performed across five databases: PubMed, Embase, ProQuest, Scopus, and Wiley Online Library using the PICO format. Retrieved articles were assessed according to eligibility criteria and the PRISMA flow diagram. Those eligible for quantitative analysis were assessed using forest plots. Risks of bias were tested using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>A total of 22 studies and 31,640 samples were included. Studies showed that short abstinence periods significantly reduced semen volume (mean difference [MD] -0.83, p<0.01), sperm concentration (MD -8.39, p<0.01), and DNA fragmentation (MD -3.82, p<0.01). No differences in sperm morphology were identified. Meanwhile, the overall effect for total (MD 2.30, p<0.05) and progressive motile sperm (MD 2.18, p<0.01) was significantly increased. Subgroup analysis on oligospermia patients revealed a significant increase in normal sperm morphology (MD 1.64, p<0.01) along with reduced DNA fragmentation (MD -3.30, p<0.05). However, no significant changes were seen among other sperm parameters.</p><p><strong>Conclusions: </strong>In conclusion, our findings suggest a shorter abstinence period could be beneficial due to its effect on sperm motility and DNA fragmentation. Additionally, oligospermia patients will benefit from improved sperm morphology. These findings can provide insight for future guidelines to promote a shorter abstinence period for improving ART outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"563-579"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Quotation Errors in Scientific Manuscripts: A Novel Approach from the Global Andrology Forum.","authors":"Asli Metin Mahmutoglu, Ashok Agarwal, Bahadir Sahin, Tomer-Avidor Reiss, Pallav Sengupta, Germar-Michael Pinggera, Hiva Alipour, Rossella Cannarella, Christine Wyns, Mohamed Arafa, Aldo E Calogero, Taymour Mostafa, Eric Chung, Ala'a Farkouh, Ahmad Motawi, Amarnath Rambhatla, Ayad Palani, Giovanni M Colpi, Murat Gül, Selahittin Çayan, Israel Maldonado Rosas, Taha Abo-Almagd Abdel-Meguid Hamoda, Rupin Shah","doi":"10.5534/wjmh.240255","DOIUrl":"10.5534/wjmh.240255","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated 1) the frequency of quotation errors in multi-authored medical manuscripts in andrology, 2) analyzed common types of quotation errors and the methods used to rectify them, and 3) evaluated their impact on manuscript accuracy, credibility, and research conclusions.</p><p><strong>Materials and methods: </strong>Twelve manuscripts written by the Global Andrology Forum (GAF) members between 2023 and 2024 were randomly selected for this study. The manuscripts and \"Quotation Verification Sheets\" were analyzed by senior GAF researchers to detect the number and types of quotation errors. The error rate was calculated by the total number of quotation errors and total number of all cited references in each manuscript. The impact on manuscript sections was assessed using a 0-4 grading scale. The Spearman correlation test was used to assess the correlation between scalar variables, and the Mann-Whitney U test was utilized to compare scalar variables between two groups.</p><p><strong>Results: </strong>The median value of quotation errors was 10.3%. Factual inaccuracy was the most common type of error, and was observed in all twelve manuscripts at various rates. The number of errors was significantly associated with the number of references (ρ=0.706; p=0.010) and in-text citations (ρ=0.636; p=0.026). Factual inaccuracy (ρ=0.588; p=0.044) and factual interpretation (ρ=0.861; p=0.013) were also correlated with the total number of quotation errors. However, no significant associations were found between quotation errors and author numbers or their qualifications. The quotation errors adversely impacted the manuscript discussion, followed by the overall message.</p><p><strong>Conclusions: </strong>Quotation errors are common in multi-authored medical manuscripts in andrology-related scientific articles. Journal editorial offices should incorporate quotation verification into the review process. Limiting references and in-text citations to only strictly necessary ones may help improve quotation accuracy. The quotation verification model proposed by GAF offers a practical and structured approach for detecting and correcting quotation errors.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"710-720"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}