World Journal of Mens Health最新文献

{"title":"Relationship between Prostate Cancer and Benign Hyperplasia: Role of Inflammation-Induced Oxidative Stress, Vitamin C, and Epigenetics.","authors":"Ewelina Zarakowska, Jolanta Guz, Daniel Gackowski, Ryszard Olinski","doi":"10.5534/wjmh.250116","DOIUrl":"10.5534/wjmh.250116","url":null,"abstract":"<p><p>Benign prostatic hyperplasia and prostate cancer (PC) frequently affect aging men, both involving irregular cell growth in the prostate. Inflammation is a major contributor to these conditions, whereas DNA methylation and hydroxymethylation are specifically involved in PC development. In this review, we address several potential factors influencing the progression of PC, including DNA epigenetic marks, ascorbate (vitamin C) concentration in the blood plasma, and its intracellular levels in leukocytes and prostate tissues. Moreover, a new aspect concerning the involvement of leukocytes (white blood cells) in PC formation will also be discussed, highlighting their potential utility for assessing early PC development through a minimally invasive approach.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"572-581"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authorship Accountability and Transparency: A Standardized Model from the Global Andrology Forum.","authors":"Aldo E Calogero, Rupin Shah, Rossella Cannarella, Tuncay Toprak, Amarnath Rambhatla, Ayad Palani, Asli Metin Mahmutoglu, Ramadan Saleh, Hiva Alipour, Ahmed El-Sakka, Marco Falcone, Christine Wyns, Eric Chung, Taha Hamoda, Germar-Michael Pinggera, Taymour Mostafa, Manaf Al Hashimi, Ashok Agarwal","doi":"10.5534/wjmh.250303","DOIUrl":"10.5534/wjmh.250303","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"484-490"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship between Dietary-Derived Antioxidants and Erectile Dysfunction: A Mendelian Randomization Study.","authors":"Liangyou Chen, Zhang Chen, Xu Zheng, Jie Wu, Zaisheng Zhu","doi":"10.5534/wjmh.250078","DOIUrl":"10.5534/wjmh.250078","url":null,"abstract":"<p><strong>Purpose: </strong>Current research suggests a correlation between erectile dysfunction (ED) and dietary-derived antioxidants. However, the causal relationship between these factors remains unclear. This study aims to investigate the causal relationship between dietary-derived antioxidants and ED using Mendelian randomization (MR) analysis, based on genetic prediction.</p><p><strong>Materials and methods: </strong>This study employed bidirectional two-sample MR analysis to investigate the causal relationship between dietary-derived antioxidants and ED. The primary results were based on inverse variance-weighted analysis with random effects. To assess the robustness and reliability of the findings, sensitivity analyses were conducted, including tests for heterogeneity, horizontal pleiotropy, and leave-one-out analysis. Additionally, multivariate MR analysis was performed to further validate the robustness of the results.</p><p><strong>Results: </strong>The inverse variance-weighted results revealed a significant causal relationship between plasma vitamin A levels and ED (odds ratio [OR]: 3.44; 95% confidence interval [95% CI]: 1.22-9.68; p=0.019), suggesting that elevated plasma vitamin A levels are a risk factor for ED. A reverse causal relationship was observed between ED and carotene levels (OR: 0.97, 95% CI: 0.95-1.00; p=0.04). After adjusting for smoking status, the causal association between vitamin A and ED remained significant. The heterogeneity test indicated variability in the relationship between carotene and ED, while the pleiotropy test revealed that the MR-PRESSO p-value for zinc and ED was less than 0.05.</p><p><strong>Conclusions: </strong>This study identifies specific causal relationships between dietary antioxidants and ED, providing a foundation for understanding the pathogenesis of ED, guiding the development of dietary intervention strategies, and informing clinical treatment approaches.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"646-654"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility.","authors":"Yiwei Gu, Hui Zhuo","doi":"10.5534/wjmh.250072","DOIUrl":"10.5534/wjmh.250072","url":null,"abstract":"<p><strong>Purpose: </strong>This study explores whether certain trace elements are genetically linked to male infertility by using large-scale genetic data and a method called Mendelian randomization (MR), which helps infer causal relationships.</p><p><strong>Materials and methods: </strong>We obtained genetic data related to trace minerals and iron metabolism from three databases: the IEU Open GWAS, UK Biobank, and FinnGen Biobank. We used standard MR analysis tools to evaluate the relationship between genetic variants associated with trace elements and the risk of male infertility. The main analysis was performed using a statistical approach called the inverse variance-weighted method. Heterogeneity, horizontal pleiotropy, and potential outliers in the MR analysis results were evaluated.</p><p><strong>Results: </strong>The analysis suggested that higher genetically predicted iron levels may increase the risk of male infertility (odds ratio, 2.917; 95% confidence interval: 1.232-6.911; p=0.015). No similar associations were found for other elements such as copper, selenium, zinc, potassium, magnesium, calcium, ferritin, transferrin saturation, or total iron-binding capacity. The results were consistent across different analyses, with no signs of bias or genetic confounding.</p><p><strong>Conclusions: </strong>This study provides genetic support for a possible causal role of iron in male infertility. Further research, including clinical and experimental studies, is needed to confirm these findings.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"655-668"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer at the Microbial Crossroads: Illuminating a New Frontier in Precision Medicine.","authors":"Whi-An Kwon, Heeyeon Kim, Yong Sang Song","doi":"10.5534/wjmh.250045","DOIUrl":"10.5534/wjmh.250045","url":null,"abstract":"<p><p>The human body harbors a complex, dynamic community of trillions of microbes, collectively termed the microbiota, which profoundly affects homeostasis and disease processes, including cancer. Prostate cancer remains a major cause of morbidity and mortality among men worldwide; however, critical questions remain regarding its etiology, progression, and resistance to therapy. Multiple epidemiological studies have found associations between certain urinary and intestinal microorganisms and an increased prostate cancer risk, although the causal mechanisms remain incompletely understood. Recent studies suggest that dysregulated microbial communities, or dysbiosis, are hypothesized to drive chronic inflammation, induce genotoxic insults, and modulate steroid metabolism, thereby influencing tumor initiation and progression. Conflicting findings across different investigations often stem from heterogeneous sampling methods, population differences, and disparate bioinformat ics pipelines, underscoring the critical need for standardized protocols and reproducible data analytics. For example, diet induced alterations in the gut microbiota can shift systemic inflammatory and hormonal pathways in ways that predispose individuals to malignant transformation. Simultaneously, prostatic and urinary microbes are hypothesized to fuel local inflam mation and promote precursor lesions, although whether this microbial activity is causative or merely reflective of the exist ing tumor biology remains a key unresolved question. Microbiota-driven mechanisms also shape responses to radiotherapy, chemotherapy, and emerging immunotherapies, highlighting the potential of interventions such as probiotics, prebiotics, and fecal microbiota transplantation to enhance treatment efficacy and mitigate side effects. Innovative approaches, including ar tificial intelligence-assisted predictive modeling, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based microbial gene editing, and immunomodulatory strategies (<i>e.g.</i>, chimeric antigen receptor-T cells), offer new avenues for exploiting microbiota for therapeutic benefits. Nevertheless, unresolved questions regarding the long-term safety, ecological balance, and individual patient factors require caution. By integrating rigorous methodologies with these novel technologies, prostate cancer research may ultimately harness microbial insights to refine diagnostic tools, personalize therapies, and im prove patient outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"508-532"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel <i>Glycyrrhiza korshinskyi</i> Cultivar 'Wongam' Alleviates Benign Prostatic Hyperplasia <i>via</i> G1/S Checkpoint Arrest and Apoptosis: Insights from Network Pharmacology and Experimental Validation.","authors":"Hyo-Jung Kim, Bo-Ram Jin, Sa-Haeng Kang, Jong-Sik Jin, Dong-Gu Kim, Jeonghoon Lee, Wonnam Kim, Jong-Hyun Lee, Hyo-Jin An","doi":"10.5534/wjmh.250315","DOIUrl":"10.5534/wjmh.250315","url":null,"abstract":"<p><strong>Purpose: </strong>In traditional Chinese medicine, benign prostatic hyperplasia (BPH) is attributed to <i>qi</i> deficiency caused by blood stasis, and <i>Glycyrrhiza</i> species (licorice) have long been used to enhance <i>qi</i>, relieve congestion, and promote blood circulation. Wongam (WG), a newly developed licorice cultivar generated through hybridization and cultivated in the Republic of Korea, has not yet been evaluated for its anti-BPH properties. This study investigated the pharmacological potential of WG against BPH using an integrated approach combining network pharmacology with experimental validation.</p><p><strong>Materials and methods: </strong>Network pharmacology was applied to identify potential molecular targets and pathways, and the predicted mechanisms were experimentally validated in BPH-1 cells and in rats with testosterone propionate (TP)-induced BPH.</p><p><strong>Results: </strong>WG alleviated prostate enlargement in rats with TP-induced BPH. Network pharmacology predicted that WG could modulate key regulators of cell cycle progression and apoptosis. Consistently, WG suppressed androgen receptor (AR) signaling in both BPH-1 cells and rats with TP-induced BPH. WG also inhibited G1/S checkpoint regulators and induced apoptosis by reducing B-cell lymphoma (Bcl)-2 and Bcl-xL/Bcl-2 associated X protein ratios, leading to the activation of caspase-9 and -3. Through these actions, WG prevented the activation of the AR signaling pathway, promoted cell cycle arrest, and triggered apoptosis, thereby mitigating BPH progression.</p><p><strong>Conclusions: </strong>These findings, supported by both network pharmacology predictions and experimental data, suggest that WG has promising therapeutic potential for the treatment of BPH.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"732-748"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravesical Cannabidiol for Inflammation and Pain in Interstitial Cystitis/Bladder Pain Syndrome <i>via</i> TLR4/NF-κB and TRPV1 Modulation.","authors":"Jun Jie Piao, Soomin Kim, Hwa Jong Lee, Guan Qun Zhu, Kyung-Hwa Jeon, Sang-Hyuck Park, Rui-Li Guan, Wen Jie Tian, Zhong Cheng Xin, Sae Woong Kim, Woong Jin Bae","doi":"10.5534/wjmh.250152","DOIUrl":"10.5534/wjmh.250152","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored the anti-inflammatory and analgesic mechanisms of intravesical cannabidiol (CBD) in cyclophosphamide (CYP)-induced interstitial cystitis/bladder pain syndrome (IC/BPS) rats.</p><p><strong>Materials and methods: </strong>Female Sprague-Dawley rats were divided into four groups of control, IC/BPS, IC/BPS+10 mg/kg CBD, and IC/BPS+100 mg/kg CBD (n=5/group). IC/BPS was induced by CYP injections, followed by intravesical CBD administration. Pain sensitivity and bladder function were assessed via Von Frey tests and cystometrograms. Histological, Western blot, and immunofluorescence analyses were performed on bladder tissues. SV-HUC1 cells were analyzed using western blot and scratch assays.</p><p><strong>Results: </strong>CBD improved bladder function, reducing instability, prolonging intercontractile intervals, and enhancing detrusor contraction pressure. The CBD 100 mg/kg group showed greater pain relief in Von Frey tests compared with other groups. Histology revealed reduced inflammation, mast cell infiltration, and fibrosis in bladder tissues. CBD decreased TNF-α, COX2, IL-6, and TRPV1 levels and inhibited the TLR4/MyD88/pNF-κB pathway. In SV-HUC1 cells, CBD suppressed epithelial injury and downregulated TRPV1, TLR4, MyD88, p-NF-κB, and Bax/Bcl-xL, demonstrating anti-inflammatory and anti-apoptotic effects.</p><p><strong>Conclusions: </strong>Intravesical CBD alleviates inflammation by inhibiting the TLR4/MyD88/pNF-κB pathway, reduces neuropathic pain via TRPV1 channels, and improves cell apoptosis and migration in CYP-induced IC/BPS model animals.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"678-690"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Causal Association between Erectile Dysfunction and Brain Cortical Structure: Insight from a Bidirectional Mendelian Randomization Study and Cross-Sectional Neuroimaging Study.","authors":"Wei Wang, Bowen Tang, Sushun Yuan, Hongchen Luan, Hengjun Xiao, Jiuxing Liang, Jun Chen","doi":"10.5534/wjmh.250060","DOIUrl":"10.5534/wjmh.250060","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the bidirectional causal relationship between erectile dysfunction (ED) and cerebral cortical structure.</p><p><strong>Materials and methods: </strong>This study employed bidirectional two-sample Mendelian randomization (MR) framework. Exposure and outcome data were derived from genome-wide association study (GWAS) datasets. The MR analysis incorporated inverse variance weighted regression as the primary method, supplemented by the weighted median method and MR-Egger regression, to evaluate causal relationships between ED and brain cortical structure metrics, including surface area (SA) and cortical thickness (TH). Cerebral cortical morphology in ED patients was assessed using 3D T1-weighted magnetic resonance imaging (MRI).</p><p><strong>Results: </strong>Whole-brain analysis demonstrated no significant association between ED and global SA or TH. Regional analyses revealed that ED was associated with reduced SA of the caudal anterior cingulate gyrus, increased SA of the insula, operculum, pars triangularis, and supramarginal gyrus, as well as increased TH of the insula and decreased TH of the transverse temporal gyrus. Regarding the effects of cerebral cortical characteristics on incidence of ED, TH in the inferior parietal gyrus, medial orbitofrontal gyrus, posterior cingulate gyrus, precentral gyrus and SA of cuneus exhibited significant effects on elevated risk of ED. Furthermore, the structure of insula, pars opercularis and precentral gyrus was further confirmed by MRI as associated with ED symptoms.</p><p><strong>Conclusions: </strong>ED has been identified to be associated with structural alterations in multiple brain regions, suggesting potential associations with impairments in cognitive function, regulation of language processing, and sensory integration. Moreover, alterations in cortical structures of specific brain regions may serve as a predictor of ED incidence, offering novel insights for future prevention and therapeutic interventions. Overall, our results indicate the existence of a potential bidirectional interaction between genital sensory pathways and central neurological processes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"691-701"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Activation Patterns during Sexual Arousal: A Comparative Time-Course Functional Magnetic Resonance Imaging Study in Postoperative Female-to-Male Transgender Individuals, Cisgender Men, and Premenopausal Women.","authors":"Gwang-Won Kim, Ho Seok Chung, Mina Lee, Hyun-Suk Lee, Kwangsung Park, Gwang-Woo Jeong","doi":"10.5534/wjmh.250205","DOIUrl":"10.5534/wjmh.250205","url":null,"abstract":"<p><strong>Purpose: </strong>This study used functional magnetic resonance imaging with time-course analysis to compare the temporal dynamics of brain activation patterns associated with visual sexual arousal among postoperative female-to-male (FtM) transgender individuals, men, and women.</p><p><strong>Materials and methods: </strong>A total of 57 volunteers participated in this study, including 17 FtM transgender individuals undergoing cross-sex hormone therapy, 20 cisgender men, and 20 premenopausal cisgender women.</p><p><strong>Results: </strong>The levels of free testosterone (free-T) and estradiol in FtM transgender individuals were more similar to those in cisgender men than in premenopausal women. The time-course analysis of brain activity while viewing a 9-minute erotic video revealed distinct patterns of blood-oxygenation-level-dependent (BOLD) signal changes across the three groups: FtM transgender individuals showed the greatest BOLD signal changes between 4 and 5 minutes; men's group between 2 and 3 minutes; and women's groups between 5 minutes 30 seconds and 6 minutes 30 seconds. The between-group analysis showed differential brain activity in the insula and caudate nucleus among the three groups. Compared to women, men showed significantly higher activities in both regions, whereas FtM transgender individuals exhibited significantly higher activity only in the insula, but not in the caudate nucleus (p<0.05). Free-T levels were positively correlated with BOLD signal changes in the insula and caudate nucleus.</p><p><strong>Conclusions: </strong>These findings suggest that both the brain activation patterns during visual sexual arousal and the hormone levels in FtM transgender individuals more closely resemble those of cisgender men than cisgender women. Our findings would be helpful for further understanding of the interrelationship between gender identity and biological sex in FtM transgender individuals by examining time-resolved brain activation patterns in connection with sex hormone levels.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"721-731"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merit-based Academic Certification in Andrology: A Groundbreaking Initiative by the Global Andrology Forum.","authors":"Giovanni Colpi, Germar-Michael Pinggera, Aldo Calogero, Eric Chung, Rossella Cannarella, Taymour Mostafa, Ramadan Saleh, Ryan Smith, Ahmed El-Sakka, Selahittin Çayan, Omer Raheem, Haocheng Lin, Rajender Singh, Ates Kadioglu, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250038","DOIUrl":"10.5534/wjmh.250038","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"473-479"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}