World Journal of Mens Health最新文献

{"title":"Inhibition of PREX1 Reverses Enzalutamide Resistance in Castration-Resistant Prostate Cancer.","authors":"Chung Un Lee, Seon-Yong Yeom, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Soo Jeon, Seong Il Seo","doi":"10.5534/wjmh.250135","DOIUrl":"10.5534/wjmh.250135","url":null,"abstract":"<p><strong>Purpose: </strong>Castration-resistant prostate cancer (CRPC) often progresses despite initial responses to enzalutamide owing to the development of resistance. Our study explored the mechanisms underlying resistance in enzalutamide-resistant prostate cancer cell lines, along with the role of phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 (PREX1) in CRPC resistance.</p><p><strong>Materials and methods: </strong>The sequencing of total RNA was performed to analyze the microarray gene expression profiles. In our colony formation assay, 1,000 cells per well were seeded into six-well plates to evaluate clonogenic survival. Phosphoprotein profiling was conducted to assess specific signaling pathways and estimate cell proliferation rates. Protein expression was analyzed by western blotting, and Rac GTPase activity was measured to evaluate the cellular responses to enzalutamide. Cell invasion was examined using Transwell migration assays. An <i>in vivo</i> model involving the subcutaneous implantation of tumor cells into mice was used to study tumorigenic potential under resistant conditions.</p><p><strong>Results: </strong>RNA sequencing revealed activation of the cancer migration pathway in enzalutamide-resistant prostate cancer cells with significant upregulation of PREX1. PREX1 knockdown reduced the proliferation and colony formation rates of resistant cell lines. Mechanistically, PREX1 suppression inhibited both epidermal growth factor receptor and its downstream signaling pathways, including signal transducers and activators of transcription 5, thereby reducing cell migration and epithelial-mesenchymal transition, independent of Rac activation. <i>In vivo</i>, tumors derived from PREX1-knockdown cells exhibited significantly lower weights than those derived from control cells.</p><p><strong>Conclusions: </strong>This study provides compelling evidence on the pivotal role of PREX1 in mediating enzalutamide resistance in CRPC. Our findings suggest that PREX1 is a promising therapeutic target that may modulate treatment efficacy and drug resistance in CRPC.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1046-1057"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Imagining Male Infertility Guidelines through the Global Andrology Forum.","authors":"Selahittin Çayan, Marlon Martinez, Aleksei Ryzhkov, Mert Basaranoglu, Germar-Michael Pinggera, Widi Atmoko, Tan V Le, Taras Shatylko, Edoardo Pescatori, Quang Nguyen, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.260024","DOIUrl":"10.5534/wjmh.260024","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"760-765"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminal Immature Germ Cells as a Predictor of Microdissection Testicular Sperm Extraction for Development of a Combined Predictive Model.","authors":"Nengqing Liu, Jie Chen, Xiaowu Fang, Zhanhui Ou, Shaoge Luo, Changming Cai, Xiaojun Wen, Jing Du, Jiaqi Wu, Wanna Ke, Shuyuan Liu, Xiufeng Lin","doi":"10.5534/wjmh.250156","DOIUrl":"10.5534/wjmh.250156","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between immature spermatogenic cells (IGC) in semen and sperm retrieval (SR) rate of microdissection testicular sperm extraction (m-TESE) in patients with non-obstructive azoospermia (NOA).</p><p><strong>Materials and methods: </strong>95 patients with NOA who underwent m-TESE between 2019 and 2024 were included. These patients underwent comprehensive clinical, laboratory, and histopathological evaluations. Multivariable logistic regression analysis was used to explore the association between several variables and m-TESE success rate in patients with NOA, and a predictive model was developed. Model validity and stability were assessed through five-fold cross-validation.</p><p><strong>Results: </strong>A positive SR was observed in 40.0% of patients undergoing m-TESE. Multivariate logistic regression analysis identified mean testicular volume (TV) (p=0.023, odds ratio [OR]=1.382, 95% confidence interval [CI]=1.046-1.826, area under the ROC curve [AUC]=0.681), IGC in semen (p<0.001, OR=13.757, 95% CI=3.663-51.671, AUC=0.785), and Johnsen score (p=0.005, OR=2.642, 95% CI=1.339-5.213, AUC=0.707) as significant predictors of positive SR, with IGC demonstrating the strongest predictive value. Four predictive models were constructed using the three factors: models A (Mean TV+Johnsen score, AUC=0.726±0.039), B (Mean TV+IGC, AUC=0.859±0.021), C (Johnsen score+IGC, AUC=0.864±0.029), and D (Mean TV, Johnsen score+IGC, AUC=0.874±0.028). Models showed significant improvements in predictive performance. The validity and stability of models B, C, and D containing IGC were better than those of model A without IGC (p<0.05).</p><p><strong>Conclusion: </strong>The presence of IGC in the semen of patients with NOA may serve as a predictive factor for successful SR using m-TESE. Models incorporating IGC significantly enhanced stability and validity, highlighting their potential clinical utility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"982-993"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Testosterone Deficiency Thresholds: A Call to Integrate Organ-Specific Needs and Circadian Influences.","authors":"Yu-Hsiang Lin","doi":"10.5534/wjmh.250307","DOIUrl":"10.5534/wjmh.250307","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1117-1119"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Live Birth Rates after Vasectomy: Data from the National Survey of Family Growth.","authors":"Tommy Jiang, Shufeng Li, Michael L Eisenberg","doi":"10.5534/wjmh.250378","DOIUrl":"10.5534/wjmh.250378","url":null,"abstract":"<p><strong>Purpose: </strong>Vasectomy is considered the gold standard for permanent male contraception, with guideline-reported failure rates of 1:2,000. However, these estimates are based on cohorts that may not reflect the evolution of surgical techniques and changes to provider mix. Contemporary incidence of unintended pregnancies after vasectomy remain unclear.</p><p><strong>Materials and methods: </strong>We estimated vasectomy failure rates using data from the National Survey of Family Growth, a Centers for Disease Control and Prevention-sponsored survey measuring reproductive health in the United States population. We extracted data from four survey waves of families who underwent a household vasectomy. Pregnancy rates were analyzed using Kaplan-Meier curves and multivariable Cox proportional-hazards models to assess the impact of demographic factors on pregnancy rates post-vasectomy.</p><p><strong>Results: </strong>The 829 male and 1,172 female participants reported a household vasectomy. The pregnancy rate after vasectomy from all eligible male respondents was 1.92% at 1 year, 3.52% at 5 years, and 3.75% at 10 years. From female survey data, the 1-year pregnancy rate in married couples after vasectomy was 0.57% at 1 year, 1.82% at 5 years, and 2.41% at 10 years. Multivariate analysis of male respondents showed younger respondents (hazard ratio [HR]: 14.04, 95% confidence interval [CI]: 2.37-83.20, p<0.01) was associated with higher unintended pregnancy after vasectomy while higher education status was associated with lower rates of post-vasectomy pregnancy (HR: 0.19, 95% CI: 0.04-0.91, p=0.04).</p><p><strong>Conclusions: </strong>These data suggests that there may be nontrivial pregnancy rates after vasectomy with variation based on patient demographics. Further research is necessary to understand technical or patient related factors to lower unwanted pregnancies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1076-1085"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Daily Phosphodiesterase 5 Inhibitors in the Management of Diabetic Neuropathy-The Importance of a Multidisciplinary Approach.","authors":"Geoff Ian Hackett","doi":"10.5534/wjmh.250253","DOIUrl":"10.5534/wjmh.250253","url":null,"abstract":"<p><p>This paper explores the common pathological links between diabetic neuropathy (DN), affecting over 50% of men with type 2 diabetes mellitus and erectile dysfunction (ED) affecting approximately 75%. Current guidelines for DN only consider drugs to modify neurological pain pathways without influencing the underlying pathologies. By blocking pain pathways, most of these drugs can adversely affect ED and sexual function but these issues are rarely discussed in clinics where the relief of pain is considered as paramount. Because of the close overlap of vascular and neurological processes involved in DN and ED, and their high prevalence, this paper investigates the evidence for chronic dosing with phosphodiesterase 5 inhibitors. These drugs have established benefits for endothelial dysfunction, glucose metabolism and nerve regeneration, thus treating the underlying processes rather than simply blocking pain fibres. Because of the high prevalence of DN and ED, perhaps the time has come for early prevention rather than waiting for the development of intractable symptoms that are often poorly responsive to conventional treatments.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"807-811"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Evaluation of Semen Analysis Could Reveal New Infertility-Related Markers: A Pilot Study.","authors":"Daniele Santi, Carlotta Pozza, Giorgia Spaggiari, Daniele Gianfrilli, Emilia Sbardella, Donatella Paoli, Laura Roli, Maria Cristina De Santis, Marco Bonomi, Tommaso Trenti, Andrea M Isidori, Manuela Simoni","doi":"10.5534/wjmh.250096","DOIUrl":"10.5534/wjmh.250096","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a pilot study aiming at evaluating whether machine learning could be a useful model to evaluate semen analysis, improving the diagnostic work-up of male partner of infertile couples.</p><p><strong>Materials and methods: </strong>A retrospective observational study was conducted using real-world data on male evaluated in routine andrological clinical practice at two Italian tertiary centers. The study utilized two distinct datasets: the first (UNIROMA) encompassed three distinct variables, including semen analysis, sex hormones, and testicular ultrasound parameters. The second dataset (UNIMORE) was constructed incorporating semen analysis, sex hormones, biochemical examinations, and parameters related to environmental pollution. The XGBoost analysis, as part of machine learning techniques, was applied separately to each dataset, as the two datasets did not share a significant overlap in terms of variables.</p><p><strong>Results: </strong>The UNIROMA dataset comprised 2,334 male subjects. The XGBoost analysis exhibited the highest accuracy (area under the curve [AUC], 0.987) in predicting patients with azoospermia compared to other categories. Remarkably, our analysis revealed that among the most influential predictive variables, follicle-stimulating hormone serum levels (F-score=492.0), inhibin B serum levels (F-score=261), and bitesticular volume (F-score=253.0) stood out. The UNIMORE dataset consisted of 11,981 records. The XGBoost analysis demonstrated a good predictive accuracy (AUC, 0.668), especially for identifying the azoospermia group. Notably, the most crucial predictive variables were environmental pollution parameters (PM10, F-score=361; NO₂, F-score=299) and biochemical data (white blood cells, F-score=326; red blood cells, F-score=299).</p><p><strong>Conclusions: </strong>This pilot study applies machine learning to two extensive datasets, suggesting that changes in semen analysis may be linked to other variables, such as testicular ultrasound characteristics, red blood cell count, and environmental pollution.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"965-981"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of HIV and Other Sexually Transmitted Infections in Older Men: A Trend Analysis Study.","authors":"Yongtao Hu, Ruijie Hu, Qiao Qi, Shuchen Liu, Kun Tang, Kaixuan Zhang, Changsheng Zhan, Chaozhao Liang","doi":"10.5534/wjmh.250106","DOIUrl":"10.5534/wjmh.250106","url":null,"abstract":"<p><strong>Purpose: </strong>Literature on the trends in the disease burden of HIV and other sexually transmitted infections (STIs) in older men remains sparse. We aim to investigate the burden and trends of these diseases at the global, regional, and national levels.</p><p><strong>Materials and methods: </strong>Data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were used to analyze the age-standardized incidence rate (ASIR) and the age-standardized disability-adjusted life-years rate (ASDR) due to HIV and other STIs in older men. We calculated the average annual percentage change (AAPC) to analyze the 1990-2021 temporal trends.</p><p><strong>Results: </strong>Globally, the ASIR of HIV in older men showed a downward trend (AAPC, -1.99; 95% confidence interval [CI], -2.11 to -1.86). The ASDR of HIV increased from 1990 to 2004, and then gradually declined after reaching a peak in 2004. The increase in the ASIR of other STIs between 1990 and 2021 was slight (AAPC, 0.07; 95% CI, 0.05 to 0.09) but the ASDR of other STIs decreased substantially (AAPC, -1.42; 95% CI, -1.48 to -1.36). Regionally, Sub-Saharan Africa and Caribbean had the highest ASIR and ASDR of HIV and other STIs. The largest regional-level increase in the ASIR of HIV between 1990 and 2021 was observed in Oceania (AAPC, 10.6; 95% CI, 9.43 to 11.79). Nationally, the trends in the burden of these diseases in older men varied significantly across 204 countries and territories.</p><p><strong>Conclusions: </strong>Significant advancement has been achieved in alleviating the global burden caused by HIV and other STIs over the past three decades. With population growth and aging, HIV and other STIs in older men remain health challenges worldwide. Our findings are useful for policymakers to understand the epidemiology of these diseases and establish efficient strategies for prevention.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"952-964"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Varicocele on Reproductive Hormones in Men: A Systematic Review and Meta-Analysis.","authors":"Imad Ziouziou, Ayad Palani, Ahmad Tarek Motawi, Nazim Gherabi, Parisa Dolati, Ramadan Saleh, Huda Mossa Omran, Divyanu Jain, Dimas Tri Prasetyo, Zahra Zandieh, Neelam Kumari Shah, Vidhu Dhawan, Ahmed M Harraz, Rossella Cannarella, Mohamed Arafa, Aldo E Calogero, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250207","DOIUrl":"10.5534/wjmh.250207","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of varicocele on testicular function remains debated. This systematic review and meta-analysis evaluated its effects on reproductive hormones, testicular volume, and semen parameters.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted in PubMed and Scopus for studies published up to January 2025, following the PECO model: Population-adult men; Exposure-varicocele; Comparator-men without varicocele; Outcomes-reproductive hormone levels, testicular volume, and semen quality.</p><p><strong>Results: </strong>Of 1,622 records, 32 studies met the inclusion criteria. Men with varicocele had significantly higher follicle-stimulating hormone (FSH) (mean difference [MD] 2.18 IU/L, 95% confidence interval [CI] 1.37-2.99, p<0.001) and luteinizing hormone (LH) levels (MD 0.63 IU/L, 95% CI 0.08-1.17, p=0.02), and significantly lower total testosterone (MD -0.71 ng/mL, 95% CI -1.20 to -0.23, p=0.004). No significant differences were observed in free testosterone, prolactin, or estradiol levels between men with and without varicocele. However, testicular volume was significantly reduced in the varicocele group-both on the right (MD -1.40 mL, 95% CI -2.69 to -0.12, p=0.03) and left side (MD -2.97 mL, 95% CI -4.03 to -1.91, p<0.001). Men with varicocele also had significantly lower sperm concentration (MD -34.72 ×10⁶/mL, 95% CI -48.41 to -21.03, p<0.001), motility (MD -20.62%, 95% CI -29.69 to -11.55, p<0.001), vitality (MD -14.75%, 95% CI -24.60 to -4.90, p=0.003), and normal morphology (MD -10.15%, 95% CI -16.53 to -3.78, p=0.002).</p><p><strong>Conclusions: </strong>Varicocele is associated with elevated FSH and LH levels, alongside reductions in total testosterone, testicular volume, and semen quality. These findings indicate a detrimental effect on both spermatogenesis and Leydig cell function. Clinicians should consider these hormonal and functional impairments when evaluating and managing infertile men with varicocele.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"864-882"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Associations of <i>Helicobacter pylori</i> Seropositivity and Intestinal Metaplasia with Colorectal Adenoma: A Korean Multicenter Cross-Sectional Study.","authors":"Hee Jin Kim, Nayoung Kim, Sung Eun Kim, Ju Yup Lee, Kwangwoo Nam, Hyun Joo Song, Wan Sik Lee, Seon Hee Lim, Hyun Jin Kim, Gwang Ho Baik, Min Woo Lee, Suck Chei Choi","doi":"10.5534/wjmh.260174","DOIUrl":"10.5534/wjmh.260174","url":null,"abstract":"<p><strong>Purpose: </strong>Male sex is a recognized risk factor for colorectal adenoma, yet whether the associations of <i>Helicobacter pylori</i>, atrophic gastritis (AG), and intestinal metaplasia (IM) with colorectal adenoma differ by sex remains unclear. This study evaluated the sex-stratified and combined associations of anti-<i>H. pylori</i> IgG seropositivity, AG, and IM with conventional colorectal adenoma.</p><p><strong>Materials and methods: </strong>This multicenter cross-sectional study included 806 participants from a Korean health-screening cohort who underwent gastroscopy with <i>H. pylori</i> testing and colonoscopy within 3 years. Anti-<i>H. pylori</i> IgG seropositivity was determined by enzyme-linked immunosorbent assay, AG and IM were assessed endoscopically. Multivariable logistic regression models were adjusted for age, sex, body mass index, smoking, and alcohol consumption.</p><p><strong>Results: </strong>Colorectal adenoma was identified in 209 participants (25.6%). Anti-<i>H. pylori</i> IgG seropositivity was independently associated with colorectal adenoma (adjusted odds ratio [aOR], 1.848; 95% confidence interval [CI], 1.323 to 2.581; p<0.001). AG was not significant after adjustment. IM was independently associated in a separate model (aOR, 1.648; 95% CI, 1.125 to 2.415; p=0.010), but showed only borderline significance in the combined model when including <i>H. pylori</i> seropositivity (aOR, 1.440; 95% CI, 0.973 to 2.131; p=0.068), whereas anti-<i>H. pylori</i> IgG seropositivity remained significant. Participants with both <i>H. pylori</i> seropositivity and IM showed the highest odds of colorectal adenoma. In sex-stratified analyses, anti-<i>H. pylori</i> IgG seropositivity was independently associated in males (aOR, 1.811; 95% CI, 1.147 to 2.860; p=0.011) but not in females, whereas IM was independently associated in females (aOR, 2.086; 95% CI, 1.129 to 3.856; p=0.019) but not in males. Formal interaction tests were not statistically significant.</p><p><strong>Conclusions: </strong>Anti-<i>H. pylori</i> IgG seropositivity and IM were associated with conventional colorectal adenoma, whereas AG was not significant after adjustment. Sex-stratified analyses suggested potential sex-related patterns, with <i>H. pylori</i> seropositivity appearing more prominent in males and IM appearing more prominent in females.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1097-1107"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}