World Journal of Mens Health最新文献

{"title":"Genetic Testing for Monogenic Forms of Male Infertility Contributes to the Clinical Diagnosis of Men with Severe Idiopathic Male Infertility.","authors":"Rebeka Podgrajsek, Alenka Hodzic, Ales Maver, Martin Stimpfel, Aleksander Andjelic, Olivera Miljanovic, Momcilo Ristanovic, Ivana Novakovic, Dijana Plaseska-Karanfilska, Predrag Noveski, Sasa Ostojic, Antun Grskovic, Alena Buretic-Tomljanovic, Borut Peterlin","doi":"10.5534/wjmh.240149","DOIUrl":"10.5534/wjmh.240149","url":null,"abstract":"<p><strong>Purpose: </strong>In recent years, many genes have been associated with male infertility; however, testing of monogenic forms has not yet been clinically implemented in the diagnosis of severe forms of idiopathic male infertility, as the diagnostic utility has not been established yet. The aim of this study was therefore to answer if the implementation of genetic testing for monogenic forms of male infertility could contribute to the clinical diagnosis of men with severe forms of idiopathic male infertility.</p><p><strong>Materials and methods: </strong>Based on the ClinGene curation protocol, we defined a panel of genes with sufficient evidence for the involvement with severe male infertility. We tested the 21-gene panel in a representative multicentric cohort of men with significantly impaired spermatogenesis. We performed whole exome sequencing on 191 infertile men with severe forms of idiopathic male infertility; non-obstructive azoospermia, and severe oligozoospermia (<5 million spermatozoa/mL). The control group consisted of 216 men who fathered a child. DNA was prepared based on the Twist CORE exome protocol and sequenced on the Illumina NovaSeq 6000 platform. Variants were classified using the Association for Clinical Genomic Science (ACGS) Best Practice Guidelines for Variant Classification in Rare Disease 2020.</p><p><strong>Results: </strong>We identified potential monogenic disease-causing variants in four infertile men. Pathogenic/likely pathogenic variants in <i>STAG3</i> (c.2776C>T, p.Arg926^*; c.2817delG, p.Leu940fs), <i>MSH4</i> (c.1392delG, p.Ile465fs; c.2261C>T, p.Ser754Leu), <i>TEX15</i> (c.6848_6849delGA, p.Arg2283fs; c.6271dupA, p.Arg2091fs), and <i>TEX14</i> (c.1021C>T, p.Arg341^*) genes were found.</p><p><strong>Conclusions: </strong>In the present multicentric cohort study, a monogenic cause in 2.1% of infertile men was identified. These findings confirm the utility of monogenic testing and suggest the clinical use of monogenic testing for men with severe forms of idiopathic male infertility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"908-917"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analyses under the Microscope: Strengthening Systematic Review and Meta-Analyses in Andrology through Methodological Rigor.","authors":"Rossella Cannarella, Selahittin Cayan, Andrea Crafa, Ayad Palani, Tuncay Toprak, Widi Atmoko, Ramadan Saleh, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250142","DOIUrl":"10.5534/wjmh.250142","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"725-733"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Correlation Between Frailty and Lower Urinary Tract Symptoms in Elderly Male Using Korean-FRAIL Scale.","authors":"Zhao Luo, Chao Niu, ChenYu Yuan, Dong Yun Lee, Yu Seob Shin, Sung Chul Kam","doi":"10.5534/wjmh.240122","DOIUrl":"10.5534/wjmh.240122","url":null,"abstract":"<p><strong>Purpose: </strong>The K-FRAIL scale is a Korean version of the aging questionnaire that allows screening and diagnosis of easily observable aging in the elderly through a simple self-answer questionnaire. The objective of this study was to examine the relation between fraility and clinical symptoms of the lower urinary tract in elderly men using the K-FRAIL scale.</p><p><strong>Materials and methods: </strong>A prospective study was conducted on 100 patients who underwent urological examination at our hospital from January 2021 to December 2021. Among them, 62 patients who met the study criteria completed the following questionnaires and lower urinary tract symptoms (LUTS) parameters: K-FRAIL, International Prostate Symptom Score (IPSS), prostate specific antigen, transrectal ultrasonography, and uroflowmetry. In this cross-sectional study, we compared the K-FRAIL scale parameters with various clinical examination parameters in elderly men presenting with LUTS. We also assessed the time required to complete the scale.</p><p><strong>Results: </strong>The age of the subjects was 66.8±5.96 years in the normal group and 71.6±9.83 years in the frail group (p=0.027). In terms of IPSS indicators, the total scores of the natural patient group and the frail patient group were 13.24±5.48 and 20.44±9.67 (p=0.001); in terms of patient serum testosterone indicators, the scores of the natural patient group and the frail patient group were 4.32±1.52 and 3.74±1.64, respectively (p=0.163). The results indicated that IPSS item 7 and serum testosterone were significant predictors (odds ratio [OR]=4.679, p=0.29; OR=0.391, p=0.043, respectively).</p><p><strong>Conclusions: </strong>The results of this study show that elderly men with fraility are more likely to develop nocturia and lower testosterone. When treating men with fraility, it will be helpful to know these characteristics and treat them.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"892-897"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prostate Cancer Treatment on Quality of Life of LGBTQ+ Patients: A Systematic Review.","authors":"Liliana Vartolomei, Patrik Petrov, Mihai Dorin Vartolomei, Shahrokh F Shariat","doi":"10.5534/wjmh.240203","DOIUrl":"10.5534/wjmh.240203","url":null,"abstract":"<p><p>The gay, bisexual, transgender, and queer + (LGBTQ+) community is underserved, and their needs are often misunderstood and/or overlooked. We aimed to analyze the current literature regarding prostate cancer's (PCa) impact on the quality of life (QoL) of LGBTQ+ patients with a focus on sexuality, identity, and psychosocial support. In June 2024, we searched the following databases, PubMed, Embase, and Clinicaltrials.gov, for relevant data regarding sexuality, identity, and psychosocial support of LGBTQ+ suffering from PCa using the keywords \"Prostate Cancer AND Gay or Prostate Cancer AND LGBTQ+.\" In sum, there were only a few records on the subject with very few clinical trials. Major concerns of inadequate care included the impact on sexual intercourse, sexual identity and role, mental health, and psychological support. Two U.S. trials reported on the deep health-related quality of LGBTQ+ community members in dealing with PCa. These revealed significant sufferings and disparities in care access, delivery, perception, and satisfaction in the LGBTQ+ patients affected by PCa. Current data suggest that LGBTQ+ patients with PCa are an under-researched population whose QoL concerns and needs are often overlooked. PCa has a significant impact on the sexual, emotional, and social well-being of the LGBTQ+ community; this impact seems different than the non-LGBTQ+ community, underlying the need for focused research and interventions.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"773-783"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The In-depth Comparative Analysis of Four Large Language AI Models for Risk Assessment and Information Retrieval from Multi-Modality Prostate Cancer Work-up Reports.","authors":"Lun-Hsiang Yuan, Shi-Wei Huang, Dean Chou, Chung-You Tsai","doi":"10.5534/wjmh.240173","DOIUrl":"10.5534/wjmh.240173","url":null,"abstract":"<p><strong>Purpose: </strong>Information retrieval (IR) and risk assessment (RA) from multi-modality imaging and pathology reports are critical to prostate cancer (PC) treatment. This study aims to evaluate the performance of four general-purpose large language model (LLMs) in IR and RA tasks.</p><p><strong>Materials and methods: </strong>We conducted a study using simulated text reports from computed tomography, magnetic resonance imaging, bone scans, and biopsy pathology on stage IV PC patients. We assessed four LLMs (ChatGPT-4-turbo, Claude-3-opus, Gemini-Pro-1.0, ChatGPT-3.5-turbo) on three RA tasks (LATITUDE, CHAARTED, TwNHI) and seven IR tasks. It included TNM staging, and the detection and quantification of bone and visceral metastases, providing a broad evaluation of their capabilities in handling diverse clinical data. We queried LLMs with multi-modality reports using zero-shot chain-of-thought prompting via application programming interface. With three adjudicators' consensus as the gold standard, these models' performances were assessed through repeated single-round queries and ensemble voting methods, using 6 outcome metrics.</p><p><strong>Results: </strong>Among 350 stage IV PC patients with simulated reports, 115 (32.9%), 128 (36.6%), and 94 (26.9%) belonged to LATITUDE, CHAARTED, and TwNHI high-risk, respectively. Ensemble voting, based on three repeated single-round queries, consistently enhances accuracy with a higher likelihood of achieving non-inferior results compared to a single query. Four models showed minimal differences in IR tasks with high accuracy (87.4%-94.2%) and consistency (ICC>0.8) in TNM staging. However, there were significant differences in RA performance, with the ranking as follows: ChatGPT-4-turbo, Claude-3-opus, Gemini-Pro-1.0, and ChatGPT-3.5-turbo, respectively. ChatGPT-4-turbo achieved the highest accuracy (90.1%, 90.7%,91.6%), and consistency (ICC 0.86, 0.93, 0.76) across 3 RA tasks.</p><p><strong>Conclusions: </strong>ChatGPT-4-turbo demonstrated satisfactory accuracy and outcomes in RA and IR for stage IV PC, suggesting its potential for clinical decision support. However, the risks of misinterpretation impacting decision-making cannot be overlooked. Further research is necessary to validate these findings in other cancers.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"918-933"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Different Modalities of Regenerative Therapies in the Treatment of Erectile Dysfunction: A Global Survey and Global Andrology Forum Expert Recommendations.","authors":"Manaf Al Hashimi, Germar-M Pinggera, Taymour Mostafa, Rupin Shah, Bahadir Sahin, Eric Chung, Amarnath Rambhatla, Selahittin Cayan, Hiva Alipour, Maged Ragab, Omer Raheem, Mohamed Arafa, Hussain Alnajjar, Ateş Kadioglu, Abheesh Varma Hegde, Ahmed Harraz, Ashok Agarwal","doi":"10.5534/wjmh.240214","DOIUrl":"10.5534/wjmh.240214","url":null,"abstract":"<p><strong>Purpose: </strong>There is increased interest in regenerative therapies (RTs) to treat erectile dysfunction (ED). However, the need for society's guidelines has led to varied practices. This study aims to investigate current global practices, address the heterogeneity in treatment protocols and evaluations, and establish expert recommendations in clinical practice.</p><p><strong>Materials and methods: </strong>Senior experts from the Global Andrology Forum (GAF) created a 32-question survey to evaluate the clinical aspects of various RT modalities and compare them with each other and with phosphodiesterase type 5 inhibitors (PDE5is). The survey was distributed worldwide to ED specialists through online Google Forms, the GAF website, international professional societies, and direct emails. The responses were analyzed and are presented as percentage frequencies. Additionally, an expert consensus on recommendations for RT use was reached at via a modified Delphi method.</p><p><strong>Results: </strong>Out of 163 respondents from 39 countries, the majority (80.1%) were using low-intensity shockwave therapy (LISWT), followed by platelet-rich plasma (PRP) 61.3% and stem cell therapy (SCT) 17.8%. Efficacy comparisons revealed no perceived significant differences among RT modalities (p=0.124). Compared to PDE5is, the efficacy of LISWT and PRP was considered lower by the respondents, while SCT was rated better by almost half of those who used SCT. The duration of improvement varied (p=0.279), with most improvements lasting 1 to 6 months. The treatment protocols used for LISWT were mainly consistent but varied widely for PRP and SCT. Adverse effects were minimal, particularly for LISWT (p<0.001). The costs varied significantly (p<0.001), with SCT being the most expensive. The evidence for efficacy was rated as primarily moderate to strong for LISWT but poor for PRP and SCT (p=0.027).</p><p><strong>Conclusions: </strong>Most respondents utilized LISWT, followed by PRP, with SCT being the least commonly utilized. The high break heterogeneity in treatment protocols and evaluation of RT underscores the need for further studies and guidelines to establish best practices.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"875-891"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Bariatric Surgery on Male Infertility: An Updated Meta-Analysis and Literature Review.","authors":"Dragos Puia, Marius Ivanuta, Catalin Pricop","doi":"10.5534/wjmh.240147","DOIUrl":"10.5534/wjmh.240147","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to perform a meta-analysis to assess the evolution of sperm parameters and some sex hormones in obese males with idiopathic infertility who underwent bariatric surgery.</p><p><strong>Materials and methods: </strong>We systematically searched MEDLINE and Embase databases for studies that documented sperm parameters and sex hormones before and after surgery.</p><p><strong>Results: </strong>Twelve studies have been included with a total of 285 patients. The heterogeneity was deemed moderate, with an I² value of 28%. The random effects model analysis indicated a statistically significant negative association between weight loss surgery and sperm concentration. The standardized mean difference (SMD) was -5.44, with a 95% confidence interval (CI) ranging from -7.65 to -3.22. The p-value was <0.0001. Twelve articles recorded the sperm volume before and after undergoing bariatric surgery. The analysis revealed no statistically significant alteration in sperm volume following surgery (SMD=-0.16, 95% CI -0.53-0.22; p=0.42). We assessed the total sperm count available in seven studies. The analysis did not prove any significant difference between groups (SMD=12.29, 95% CI -15.01-39.58; p=0.38). Evaluated in five studies, semen pH did not evolve significantly (SMD=-0.02, 95% CI -0.12-0.09; p=0.76). Also, total motility did not improve significantly (SMD=0.61, CI -2.86-4.09; p=0.73), and the included studies had a low heterogeneity (I²=29%). Following bariatric surgery, there was a significant increase in levels of both total testosterone and sex hormone-binding globulin (SHBG) (SMD=-6.40, 95% CI -9.12 to -3.67, p<0.00001 for total testosterone and -22.22, 95% CI -26.11 to -18.33, p<0.00001 for SHBG).</p><p><strong>Conclusions: </strong>Our data suggests that bariatric surgery does not provide any benefits in terms of sperm parameters. Obesity likely affects fertility through processes that are not well understood.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"807-817"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer and Suicide Risk: A Systematic Review and Meta-Analysis.","authors":"Yun Jin Kim, Eun Ji Lee, Sung Ryul Shim, Jae Heon Kim","doi":"10.5534/wjmh.240168","DOIUrl":"10.5534/wjmh.240168","url":null,"abstract":"<p><strong>Purpose: </strong>Suicide is a substantial public health concern, and there are a variety of contributing factors. Prostate cancer is known to be a disease at high risk of suicide regardless of country and age. Nonetheless, comprehensive information about associated risk levels and underlying determinants remains limited. To systematically evaluate the suicide risk in prostate cancer patients compared to control by systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>PubMed, Embase, and the Cochrane Library were searched from the earliest available indexing date through May 2024. The criteria for selecting the subjects were as follows: (1) studies including patients who had prostate cancer, (2) intervention was not specified, (3) comparison was made with people without prostate cancer selected as the control group, and (4) outcomes were measured as standardized mortality ratio (SMR) or relative risk (RR), or hazard ratio (HR) of suicide in prostate cancer. Random-effects model were used to estimate pooled effect sizes. Meta-regression analyses were conducted to identify the potential moderator effects between prostate cancer and the risk of suicide.</p><p><strong>Results: </strong>A systematic review and meta-analysis of these 25 studies that included a total of 4,987,941 participants were performed. The pooled SMR for overall suicide risk in prostate cancer compared with control groups was 1.251 (95% confidence interval [95% CI]: 1.120-1.383). The pooled RR or HR was 1.712 (95% CI: 1.306-2.243). The suicide risk of prostate cancer patients showed statistically significant in all cases of SMR and RR or HR. The suicide risk was also significantly higher in most subgroup analyses according to age and research follow-up period.</p><p><strong>Conclusions: </strong>The findings of this systematic review and meta-analysis support the association between prostate cancer and increased risk of suicidal tendencies. Follow-up for prostate cancer patients should be highly integrated with psychiatric and psychological care to improve the psychosocial function of patients.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"853-865"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Incontinence after Radical Prostatectomy According to Procedural Types: Retrospective Cohort Study Using National Health Insurance Data.","authors":"Ki Min Kim, Jeong Woo Lee, Gi Hwan Bae, Min Gi Chun, Serin Lee, Eun Ji Lee, Jaehun Jung, Jae Heon Kim","doi":"10.5534/wjmh.240013","DOIUrl":"10.5534/wjmh.240013","url":null,"abstract":"<p><strong>Purpose: </strong>Although surgical procedures including robotic surgery in radical prostatectomy have evolved, urinary incontinence after surgery are still not resolved. This study was to evaluate the risk of clinically significant incontinence after radical prostatectomy according to various procedural types.</p><p><strong>Materials and methods: </strong>The retrospective cohort study included prostate cancer (n=14,484) in South Korea between 2002 and 2017 as shown in the National Health Insurance Data. Clinically significant incontinence was defined as postprostatectomy incontinence (PPI) requiring anti-incontinence surgery or received specific medication within months after surgery. The prevalence and relative risks of PPI were evaluated according to different procedural types after propensity score matching (PSM). The risks of PPI were compared among those difference procedural types including robotic-assisted radical prostatectomy (RALP), open radical prostatectomy (ORP) and laparoscopic radical prostatectomy (LRP) using the hazard ratio (HR).</p><p><strong>Results: </strong>Among 25,903 cohort participants including RALP (n=18,937), ORP (n=4,979), and LRP (n=1,987), overall prevalence of PPI was 2.06% (n=536). According to procedural types, prevalence of PPI in LRP, RARP, and ORP were 3.67%, 1.81%, and 2.43%, respectively. Risk of PPI after PSM and after adjustment of age, Charlson comorbidity index, and hospital volume was 0.456 (95% confidence interval [95% CI] 0.30-0.69) between LRP and RARP, 0.67 (95% CI 0.46-0.98) between LRP and ORP, and 1.404 (1.06-1.86) between RARP and ORP. Adjusted HR after PSM was 0.495 (95% CI 0.33-0.74) between LRP and RARP, 0.674 (95% CI 0.46-0.98) between LRP and ORP, 1.242 (95% CI 0.94-1.64) between RARP and ORP.</p><p><strong>Conclusions: </strong>The prevalence of PPI which needed anti-incontinence surgery was not low among who received radical prostatectomy. Those patients who underwent LRP had higher risk for PPI than those who underwent ORP. However, further research is required to fully determine whether RARP can help to prevent PPI.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"844-852"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Rates of Sex Hormone Receptors with Their Clinical Correlates in Gastric Cancer Patients and Normal Controls.","authors":"Yonghoon Choi, Nayoung Kim, Ji Hyun Park, Chin-Hee Song, Hyeon Jeong Oh","doi":"10.5534/wjmh.240272","DOIUrl":"10.5534/wjmh.240272","url":null,"abstract":"<p><strong>Purpose: </strong>Sex hormones affect development and prognosis of gastric cancer (GC). This study aimed to compare the sex hormone receptor expression between control and GC, and to evaluate its correlation with patient characteristics.</p><p><strong>Materials and methods: </strong>110 patients (74 with GC, 36 controls) underwent immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) for estrogen receptors (ERs) α and β and androgen receptor (AR). The effect of ERs and AR on the clinicopathological and tumor characteristics were analyzed.</p><p><strong>Results: </strong>The positive rate of ERα, ERβ, and AR in GC tissue was 64.9%, 78.4%, and 60.8% by IHC and 41.4%, 27.6%, and 48.3% in RT-PCR respectively. In control, the positive rate of those was 16.7%, 80.6%, and 38.9% by IHC and 22.2%, 58.3%, and 19.4% in RT-PCR respectively. The IHC and RT-PCR results showed concordance with each other, and ERα and AR expressions were positively correlated with cancer, while ERβ showed the opposite pattern. ERα expression was correlated with <i>Helicobacter pylori</i> negativity (p<0.001), diffuse or mixed-type histology (p=0.014), and undifferentiated histology (p<0.001), and AR expression was related to <i>H. pylori</i> negativity (p<0.001), cardiac cancer (p=0.040), and undifferentiated histology (p<0.001). The higher expression rate of ERα in males and that of AR in females seemed to be related with cancer, showing sex differences.</p><p><strong>Conclusions: </strong>The expression rates of ERα, ERβ, and AR were different depending on sex, histologic type and <i>H. pylori</i> infection status, which may explain sex-based differences in GC.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"980-991"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}