World Journal of Mens Health最新文献

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Adverse Effects of Nicotine on Human Sperm Nuclear Proteins. 尼古丁对人类精子核蛋白质的不利影响
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-07-11 DOI: 10.5534/wjmh.240072
Amir Masoud Firouzabadi, Ralf Henkel, Maryam Tofighi Niaki, Farzaneh Fesahat
{"title":"Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.","authors":"Amir Masoud Firouzabadi, Ralf Henkel, Maryam Tofighi Niaki, Farzaneh Fesahat","doi":"10.5534/wjmh.240072","DOIUrl":"10.5534/wjmh.240072","url":null,"abstract":"<p><p>The effects of smoking on human health have long been documented. However, only a few studies have highlighted the direct effects of nicotine on sperm function. Nicotine, as a chemical compound found in tobacco, has been shown to modulate different aspects of spermatogenesis and sperm functions. Nicotine can lead to a reduction in the number of sperm, their motility and functionality. It can change the molecular expressions involved in sperm function, including genes encoding sperm nuclear proteins. The most important nuclear proteins that play a critical role in sperm function are known as H2B histone family, member W, testis-specific (H2BFWT), transition protein 1 (TNP1), transition protein 2 (TNP2), protamine-1 (PRM1), and protamine-2 (PRM2). These proteins are involved in sperm chromatin condensation, which in turn affects fertilization and embryonic development. Any alteration in the expression of these genes due to nicotine exposure/usage may lead to adverse implications in couples' fertility and the health of future generations. Since research in this area is still relatively new, it underscores the importance of understanding the potential side effects of environmental factors such as nicotine on reproductive health.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"291-303"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Which Dermal Filler is Better for Penile Augmentation for Aesthetic Purposes? A Prospective, Single-Surgeon Study Based on Real-World Experience. 哪种皮肤填充剂更适合用于以美学为目的的阴茎增大术?基于真实世界经验的前瞻性、单一外科医生研究。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-07-31 DOI: 10.5534/wjmh.240105
Doo Won Kim, Hyun Cheol Jeong, Kyungtae Ko, Dae Yul Yang, Jong Keun Kim, Seong Ho Lee, Tae Hyo Kim, Won Ki Lee
{"title":"Which Dermal Filler is Better for Penile Augmentation for Aesthetic Purposes? A Prospective, Single-Surgeon Study Based on Real-World Experience.","authors":"Doo Won Kim, Hyun Cheol Jeong, Kyungtae Ko, Dae Yul Yang, Jong Keun Kim, Seong Ho Lee, Tae Hyo Kim, Won Ki Lee","doi":"10.5534/wjmh.240105","DOIUrl":"10.5534/wjmh.240105","url":null,"abstract":"<p><strong>Purpose: </strong>Several types of dermal fillers have been recently introduced and used for penile augmentation (PA). However, few studies have compared outcomes after the injection of different fillers. This study aimed to compare the clinical outcomes of hyaluronic acid (HLA), polylactic acid (PLA), and polymethyl methacrylate (PMA) filler injections, which are the most commonly used for aesthetic purposes.</p><p><strong>Materials and methods: </strong>This prospective study was conducted for 24 weeks after a filler injection by a surgeon between March 2017 and December 2021. Healthy adult men complaining of small penis were enrolled. Penile girth, satisfaction, and injection-associated adverse events (AEs) were assessed at baseline and 4, 12, and 24 weeks after injection.</p><p><strong>Results: </strong>Of the 301 men who received filler injections, 125, 134, and 42 received HLA, PLA, and PMA fillers, respectively. The augmentation effect was in the order of PMA, HLA, and PLA, respectively, at 24 weeks (PMA <i>vs.</i> HLA, p<0.001; HLA <i>vs.</i> PLA, p=0.006). Satisfaction levels increased significantly at 24 weeks in all groups (each with p<0.001). However, the increase in satisfaction levels was smaller in the PMA group (PMA <i>vs.</i> HLA or PLA, p<0.05, for both penile appearance and sexual life). No serious or systemic AEs were recorded. Filler injection-associated local AEs in the HLA, PLA, and PMA groups occurred in 9 (7.2%), 16 (11.9%), and 6 (14.3%) men, respectively. There was no significant difference in AEs among the groups (p=0.299).</p><p><strong>Conclusions: </strong>The augmentative effect was greater in the PMA group than in the HLA and PLA groups, whereas the increase in satisfaction levels was smaller in the PMA group. Our study demonstrated the clinical course of different types of fillers and suggests that the filler type should be selected after detailed counseling considering individual characteristics and preferences.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"428-436"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urethral Sparing versus Trans-Vesical Robot-Assisted Simple Prostatectomy: A Comparative Analysis of Perioperative, Postoperative Outcomes, and Ejaculation Preservation. 尿道疏通术与经膀胱机器人辅助单纯前列腺切除术:围手术期、术后效果和射精保留的比较分析。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-05-30 DOI: 10.5534/wjmh.240023
Yu Seob Shin, Shang Weon Pak, Wonku Hwang, Seon Beom Jo, Jong Wook Kim, Mi Mi Oh, Hong Seok Park, Du Geon Moon, Sun Tae Ahn
{"title":"Urethral Sparing <i>versus</i> Trans-Vesical Robot-Assisted Simple Prostatectomy: A Comparative Analysis of Perioperative, Postoperative Outcomes, and Ejaculation Preservation.","authors":"Yu Seob Shin, Shang Weon Pak, Wonku Hwang, Seon Beom Jo, Jong Wook Kim, Mi Mi Oh, Hong Seok Park, Du Geon Moon, Sun Tae Ahn","doi":"10.5534/wjmh.240023","DOIUrl":"10.5534/wjmh.240023","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the perioperative and postoperative outcomes between traditional trans-vesical robot-assisted simple prostatectomy (TV-RASP) and the newly introduced urethral-sparing (US) RASP.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed 42 patients who underwent TV-RASP (n=22) or US-RASP (n=20) performed by two experienced surgeons at two tertiary centers. Perioperative outcomes including operation time, estimated blood loss, length of hospital stay, and catheterization time were assessed. Postoperative outcomes were evaluated using the International Prostate Symptom Score (IPSS), quality of life (QoL), uroflowmetry parameters, Male Sexual Health Questionnaire-Ejaculation Dysfunction-Short Form (MSHQ-EjD-SF) scores, and maintenance of anterograde ejaculation.</p><p><strong>Results: </strong>This study analyzed 22 and 20 patients who underwent TV-RASP and US-RASP, respectively. Except for the TV-RASP group being older (70.0 years) than the US-RASP group (64.5 years) (p=0.028), no differences among other baseline characteristics existed. Perioperative outcomes indicated that hospital stay and catheterization time were significantly shorter in the US-RASP group than in the TV-RASP group (p<0.001). At postoperative month 1, the median IPSS and QoL scores were significantly better in the US-RASP group than in the TV-RASP group (p=0.001 and p=0.002, respectively). However, at months 6 and 12, no significant differences were noted in IPSS, QoL, maximum flow rate, and postvoid residual urine between the two groups. Sexually active patients in the US-RASP group maintained postoperative MSHQ-EjD functional and bother scores, whereas the TV-RASP group experienced a decline. Notably, 75.0% of patients in the US-RASP group preserved antegrade ejaculation, compared to only 20.0% in the TV-RASP group (p<0.001).</p><p><strong>Conclusions: </strong>US-RASP is not inferior to TV-RASP in terms of functional outcomes. In addition, US-RASP yielded more rapid symptom improvements and preserved antegrade ejaculation than TV-RASP. However, larger prospective studies are required to confirm these findings and to further investigate the long-term efficacy and safety of US-RASP.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"387-395"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Effects of Mesenchymal Stem Cell Conditioned Medium in Rat Varicocele Model. 间充质干细胞调节介质对大鼠精索静脉曲张模型的治疗作用
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-09-10 DOI: 10.5534/wjmh.240059
Ege Can Serefoglu, Bircan Kolbasi, Muhammet Volkan Bulbul, Seda Karabulut, Cagri Cakici, Reyhan Zeynep Gundogdu Ozdemir, Ilknur Keskin
{"title":"Therapeutic Effects of Mesenchymal Stem Cell Conditioned Medium in Rat Varicocele Model.","authors":"Ege Can Serefoglu, Bircan Kolbasi, Muhammet Volkan Bulbul, Seda Karabulut, Cagri Cakici, Reyhan Zeynep Gundogdu Ozdemir, Ilknur Keskin","doi":"10.5534/wjmh.240059","DOIUrl":"10.5534/wjmh.240059","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the therapeutic effects of injection of conditioned medium of adipose-derived mesenchymal stem cells (ADMSC-CM) in a surgically created varicocele model in comparison with varicocelectomy.</p><p><strong>Materials and methods: </strong>Twenty-eight male Wistar Albino rats were randomly divided into four groups: sham group, varicocele group, varicocelectomy group, and ADMSC-CM injection group. Sperm parameters were analyzed in samples taken from the epididymis after treatment. Malondialdehyde and superoxide dismutase (SOD) levels in blood samples were examined by biochemical analysis. The testicular tissues were stained with hematoxylin-eosin for histological examination (Johnsen's Score). Additionally, Western Blot analyzes were performed to detect Claudin-11 levels, the functional protein of the blood-testis barrier, in testicular tissues.</p><p><strong>Results: </strong>Varicocelectomy and ADMSC-CM treatments significantly improved mean sperm parameters (concentration, progressive motility, motility, normal sperm morphology) (p≤0.05 for all). Both treatment groups had increased SOD levels along with a decrease in malondialdehyde levels (p≤0.05 for all). No significant difference was observed between the ADMSC-CM group and the varicocelectomy group in preserving normal testicular histology according to Johnsen's Score (p=0.114). Levels of Claudin-11 were significantly higher in the varicocelectomy and ADMSC-CM groups compared to the varicocele group (p≤0.05 for all).</p><p><strong>Conclusions: </strong>The therapeutic effects of ADMSC-CM in varicocele model may involve secretion of anti-inflammatory and regenerative factors from ADMSC. ADMSC-CM injection appears to be a promising new strategy in the treatment of varicocele.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"437-447"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight Loss as Therapeutic Option to Restore Fertility in Obese Men: A Meta-Analytic Study. 减肥作为恢复肥胖男性生育能力的治疗方案:一项元分析研究
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-08-21 DOI: 10.5534/wjmh.240091
Daniele Santi, Carla Greco, Arcangelo Barbonetti, Manuela Simoni, Mario Maggi, Giovanni Corona
{"title":"Weight Loss as Therapeutic Option to Restore Fertility in Obese Men: A Meta-Analytic Study.","authors":"Daniele Santi, Carla Greco, Arcangelo Barbonetti, Manuela Simoni, Mario Maggi, Giovanni Corona","doi":"10.5534/wjmh.240091","DOIUrl":"10.5534/wjmh.240091","url":null,"abstract":"<p><strong>Purpose: </strong>Weight loss has been shown to significantly elevate testosterone serum levels, though the impact on semen analysis parameters and fertility remains incompletely understood. The objective of this study was to examine the influence of body weight loss on semen parameters in obese men.</p><p><strong>Materials and methods: </strong>A meta-analysis was performed that included clinical trials in which a semen analysis before and after weight loss was evaluated. All strategies potentially available for weight loss were considered eligible. The primary outcome was the comparison of conventional semen analysis parameters before and after weight loss.</p><p><strong>Results: </strong>Twelve studies were considered including 345 subjects (mean age 37.6±7.9 years; mean baseline body mass index 45.4±6.0 kg/m²). Weight loss resulted in a significant increase of sperm concentration (effect size 0.495, standard error 0.251 [0.003, 0.986], p=0.049) and progressive motility (effect size 0.567, standard error 0.372 [0.370, 0.764], p<0.001). Moreover, a significant decrease of sperm DNA fragmentation index after weight loss (effect size -0.689, standard error 0.278 [-1.123, -0.255], p=0.002) was observed.</p><p><strong>Conclusions: </strong>This meta-analytic analysis confirmed that body weight loss may improve qualitative and quantitative sperm characteristics providing evidence for suggesting weight loss to male partners with obesity and semen analysis alteration in couples attempting conception.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"333-343"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Varicocele Repair on Assisted Reproductive Technique Outcomes in Infertile Men: A Systematic Review and Meta-Analysis. 精索静脉曲张修复对不育男性辅助生殖技术结果的影响:系统回顾与元分析》。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-09-12 DOI: 10.5534/wjmh.240132
Ayad Palani, Rossella Cannarella, Ramadan Saleh, Gianmaria Salvio, Ahmed M Harraz, Andrea Crafa, Fahmi Bahar, Kadir Bocu, Naveen Kumar, Priyank Kothari, Germar-Michael Pinggera, Selahittin Cayan, Giovanni M Colpi, Widi Atmoko, Rupin Shah, Ashok Agarwal
{"title":"Impact of Varicocele Repair on Assisted Reproductive Technique Outcomes in Infertile Men: A Systematic Review and Meta-Analysis.","authors":"Ayad Palani, Rossella Cannarella, Ramadan Saleh, Gianmaria Salvio, Ahmed M Harraz, Andrea Crafa, Fahmi Bahar, Kadir Bocu, Naveen Kumar, Priyank Kothari, Germar-Michael Pinggera, Selahittin Cayan, Giovanni M Colpi, Widi Atmoko, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.240132","DOIUrl":"10.5534/wjmh.240132","url":null,"abstract":"<p><strong>Purpose: </strong>In this systematic review and meta-analysis, we investigated assisted reproductive technology (ART) success in infertile men with clinical varicocele and abnormal semen parameters who underwent varicocele repair (VR) before the ART procedure as compared to those who did not.</p><p><strong>Materials and methods: </strong>A comprehensive search of the Scopus, PubMed, Embase, and Cochrane Library databases was conducted using a specific query string to identify studies examining the impact of VR on ART outcomes, including fertilization rate, clinical pregnancy, pregnancy loss, and live-birth rate, until October 2023. Outcomes were analyzed based on the type of ART. Studies on VR in infertile men with non-obstructive azoospermia and those who underwent ART only due to female factor infertility were excluded from the study.</p><p><strong>Results: </strong>Out of 1,554 articles reviewed, only 9 met the inclusion criteria for the study. All the included articles were observational studies. The variability in study quality in the included literature resulted in a moderate overall risk of bias. Data analysis showed that for intrauterine insemination, there was no difference in the clinical pregnancy rate (odds ratio [OR] 1.01, 95% confidence interval [CI]: 0.42, 2.45; p=0.97). However, for intracytoplasmic sperm injection (ICSI), men with VR showed a significant improvement in fertilization rate (mean difference 10.9, 95% CI: 5.94, 15.89; p<0.01), clinical pregnancy rate (OR 1.38, 95% CI: 1.07, 1.78; p=0.01) and live-birth rate (OR 2.07, 95% CI: 1.45, 2.97; p<0.01), compared to men who did not undergo VR.</p><p><strong>Conclusions: </strong>The findings of this systematic review and meta-analysis suggest that VR has a positive impact on pregnancy and live birth rates after ICSI. However, biases like small sample sizes and heterogeneous populations highlight the need for larger, well-designed prospective studies to validate these findings.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"344-358"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tailoring Treatment: The Role of Sex/Gender-Specific Medicine. 定制治疗:性/性别特异性医学的作用。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-07-19 DOI: 10.5534/wjmh.240123
Nayoung Kim
{"title":"Tailoring Treatment: The Role of Sex/Gender-Specific Medicine.","authors":"Nayoung Kim","doi":"10.5534/wjmh.240123","DOIUrl":"10.5534/wjmh.240123","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"259-264"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radial Type Low-Intensity Extracorporeal Shockwave Therapy Enhances Penile Microvascular Perfusion in an Aging Rat Model: A Novel Interventional Strategy to Treat Erectile Dysfunction. 桡动脉型低强度体外冲击波疗法可增强老化大鼠模型的阴茎微血管灌注:治疗勃起功能障碍的新型介入策略。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-05-30 DOI: 10.5534/wjmh.240032
Saager Tilak Chawla, Jad Shahan, Nolan Soutipan, Samuel Ryan Sorkhi, Yong Sun Choi, Woong Jin Bae, Sae Woong Kim, Tung-Chin Hsieh, Mahadevan Raj Rajasekaran
{"title":"Radial Type Low-Intensity Extracorporeal Shockwave Therapy Enhances Penile Microvascular Perfusion in an Aging Rat Model: A Novel Interventional Strategy to Treat Erectile Dysfunction.","authors":"Saager Tilak Chawla, Jad Shahan, Nolan Soutipan, Samuel Ryan Sorkhi, Yong Sun Choi, Woong Jin Bae, Sae Woong Kim, Tung-Chin Hsieh, Mahadevan Raj Rajasekaran","doi":"10.5534/wjmh.240032","DOIUrl":"10.5534/wjmh.240032","url":null,"abstract":"<p><strong>Purpose: </strong>Physiological aging is associated with microvascular dysfunction, including in the penis, and this may contribute to age-related erectile dysfunction (ED). Low-intensity extracorporeal shockwave therapy (Li-ESWT) is a non-invasive intervention for ED, but its effect on penile microvascular function, remains unclear. Our objectives are to (i) evaluate the effect of Li-ESWT (specifically radial type ESWT [rESWT]) on penile microvascular perfusion (PMP) in aging rats, (ii) elucidate a possible mechanism, and (iii) evaluate its impact on angiogenic and smooth muscle biomarkers in cavernosal tissue.</p><p><strong>Materials and methods: </strong>Male rats (n=9; 15-18 months) were anesthetized and subjected to rESWT while monitoring PMP. The nitric oxide (NO) pathway involvement was assessed by measuring the effect of rESWT on PMP following an intracavernosal injection of N(G)-nitroarginine methyl ester (L-NAME) (NO synthase inhibitor). To elucidate the cellular mechanism, another group of rats received repeated rESWT (n=4) or no treatment (n=4) three times/week for two weeks. Rats were euthanized at the end of the study and penile tissues were analyzed for angiogenic markers (vascular endothelial growth factor-A [VEGF-A], endothelial nitric oxide synthase [eNOS]) and smooth muscle content (α-actin) using immunostaining, Western blot, and quantitative polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>rESWT resulted in more than a 2-fold increase in PMP (from 68.5 arbitrary units; 163.7 AU). L-NAME injection produced a <40%-50% decrease (185.3 to 101.0 AU) in rESWT-induced PMP response. Immunostaining revealed increased α-actin, eNOS, and VEGF-A in the cavernosum and these findings were confirmed by qPCR and Western blot results.</p><p><strong>Conclusions: </strong>rESWT improved PMP, which may be mediated <i>via</i> increased VEGF expression, which stimulates the NO/cyclic guanosine monophosphate pathway, resulting in sustained PMP. rESWT devices could offer a safe, non-invasive treatment for age-related ED.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"396-406"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Diabetes and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis of Observational Studies. 糖尿病与前列腺癌风险之间的关系:观察性研究的系统回顾和元分析》。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-06-24 DOI: 10.5534/wjmh.240022
Ana Paula Pagano, Bruna Ramos da Silva, Flávio Teixeira Vieira, Luiz Fernando Meira Filho, Sarah A Purcell, John D Lewis, Michelle L Mackenzie, Paula J Robson, Jennifer E Vena, Flávia Moraes Silva, Carla M Prado
{"title":"Association Between Diabetes and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis of Observational Studies.","authors":"Ana Paula Pagano, Bruna Ramos da Silva, Flávio Teixeira Vieira, Luiz Fernando Meira Filho, Sarah A Purcell, John D Lewis, Michelle L Mackenzie, Paula J Robson, Jennifer E Vena, Flávia Moraes Silva, Carla M Prado","doi":"10.5534/wjmh.240022","DOIUrl":"10.5534/wjmh.240022","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic diseases such as diabetes mellitus may play a role in the development and progression of prostate cancer (PC); however, this association remains to be explored in the context of specific PC stages. The objective of this study was to systematically review the evidence for an association between diabetes and overall, early, or advanced PC risk.</p><p><strong>Materials and methods: </strong>A systematic review with meta-analysis was performed (MEDLINE, EMBASE, and CINAHL) from inception until September 2023. Cohort and case-control studies that assessed PC risk in adult males (≥18 years) associated with type 2 diabetes mellitus or diabetes (if there was no distinction between diabetes type) were included. The Newcastle-Ottawa Scale (NOS) was used to assess study bias; those with NOS<7 were excluded. Evidence certainty was assessed with the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method.</p><p><strong>Results: </strong>Thirty-four studies (n=26 cohorts and n=8 case-controls) were included. Of these, 32 assessed diabetes and all PC stages combined, 12 included early PC stages, and 15 included advanced PC stages. Our meta-analysis showed diabetes had a protective effect against early PC development (n=11, risk ratio [RR]=0.71; 95% confidence interval [CI]=0.61-0.83, I²=84%) but no association was found for combined (n=21, RR=0.95; 95% CI=0.79-1.13, I²=99%) or advanced PC stages (n=15, RR=0.96; 95% CI=0.77-1.18, I²=98%) at diagnosis. According to GRADE, the evidence certainty was very low.</p><p><strong>Conclusions: </strong>Diabetes may be protective against early PC stages, yet evidence linking diabetes to risk across all stages, and advanced PC specifically, is less conclusive. High heterogeneity may partially explain discrepancy in findings and was mostly associated with study design, method used for PC diagnosis, and risk measures. Our results may aid risk stratification of males with diabetes and inform new approaches for PC screening in this group, especially considering the reduced sensitivity of prostate-specific antigen values for those with diabetes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"304-320"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long Term Cardiovascular Safety of Testosterone Therapy: A Review of the TRAVERSE Study. 睾酮疗法的长期心血管安全性:TRAVERSE 研究回顾。
IF 4 3区 医学
World Journal of Mens Health Pub Date : 2025-04-01 Epub Date: 2024-08-02 DOI: 10.5534/wjmh.240081
Geoffrey Ian Hackett
{"title":"Long Term Cardiovascular Safety of Testosterone Therapy: A Review of the TRAVERSE Study.","authors":"Geoffrey Ian Hackett","doi":"10.5534/wjmh.240081","DOIUrl":"10.5534/wjmh.240081","url":null,"abstract":"<p><p>TRAVERSE (TheRapy for Assessment of long-term Vascular events and Efficacy ResponSE in hypogonadal men) is multicentre randomized, double-blind, placebo-controlled, noninferiority trial of testosterone therapy, enrolling 5,246 men 45 to 80 years of age who had pre-existing or a high risk of cardiovascular disease and who reported symptoms of hypogonadism. Subjects required two fasting testosterone levels of less than 10.4 nmol/L. Patients were randomly assigned to receive daily transdermal 1.62% testosterone gel (dose adjusted to maintain testosterone levels between 12 nmol/L and 26 nmol/L) or placebo gel for a mean 27.1 months. The primary cardiovascular safety end point was the first occurrence of any component of a composite of death from cardiovascular causes, non-fatal myocardial infarction, or non-fatal stroke, assessed in a time-to-event analysis. TRAVERSE found no increase in major adverse cardiac events or prostate related events, including prostate cancer, effectively addressing the concerns raised by the United States Food and Drug Administration.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"282-290"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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