World Journal of Mens Health最新文献

{"title":"Why Sex/Gender-Specific Medicine Matters in Men's Health Research: An Editorial Call to Action.","authors":"Hyun Jun Park","doi":"10.5534/wjmh.260142","DOIUrl":"https://doi.org/10.5534/wjmh.260142","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Driven Semen Analysis: Transforming Semen Analysis for Male Infertility Diagnostics.","authors":"Ashok Agarwal, Stanislava Mincheva, Ayad Palani, Quang Nguyen, Tan V Le, Walter D Cardona Maya, Rossella Cannarella, Mohammed Abdulgabbar Noman","doi":"10.5534/wjmh.250400","DOIUrl":"https://doi.org/10.5534/wjmh.250400","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Gender Perspective in Obesity and Gastric Cancer.","authors":"Nayoung Kim","doi":"10.5534/wjmh.260087","DOIUrl":"https://doi.org/10.5534/wjmh.260087","url":null,"abstract":"<p><p>There is sex difference of obesity and it might be related with sex hormones. For instance, estrogen regulates adipose tissue function and fat deposition by activation of the sympathetic nervous system, which leads to more adiposity in subcutaneous fat instead of visceral fat. There are strong evidences for the association between obesity and cancer, predominantly cancers of digestive organs including cardia gastric cancer (GC) and cancers of hormone sensitive organs in females. The main pathways linking obesity and cancer are hyperinsulinemia/insulin resistance and abnormalities of the insulin-like growth factor (IGF)-I system, sex hormone biosynthesis and pathway, and subclinical chronic low-grade inflammation and oxidative stress. There have been several reports regarding the effect of obesity on the development of cardia GC, especially in males. The body mass index (BMI) changes from underweight or normal to overweight (23.0-24.9 kg/m²) decrease the development of non-cardia GC in males but not in females. The prognosis of GC is the better as the BMI is higher, especially in males. Estrogen can explain for the sex difference of non-cardia cancer (mainly intestinal type) regarding obesity. The peripheral adipose tissue is responsible for the process of steroid aromatization to produce sex hormones including estrogen which can explain why the obese males have better survival or less development of non-cardia GC. In terms of cardia GC, the main cause is related with frequent gastroesophageal reflux in obese males. In addition, metabolic factors such as cholesterol, glucose and IGFs are related with GC similar to other obesity related cancers.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection of Biochemical Recurrence in Prostate Cancer Patients with PSA Levels ≤0.5 ng/mL; Comparison Study between [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 PET/CT.","authors":"Sangwoo Cho, Hyo Jung Seo, Sungun Bang, Sangwon Lee, Kang Su Cho, Seunghwan Lee, Mijin Yun","doi":"10.5534/wjmh.250330","DOIUrl":"https://doi.org/10.5534/wjmh.250330","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared the correct detection rates (CDR) of [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) in patients with prostate-specific antigen (PSA) ≤0.5 ng/mL after radical prostatectomy.</p><p><strong>Materials and methods: </strong>This retrospective study included 88 patients who underwent [¹⁸F]PSMA-1007 (n=41) or [⁶⁸Ga]Ga-PSMA-11 PET/CT (n=47) for PSA ≤0.5 ng/mL after radical prostatectomy. Patients were stratified into ultra-low biochemical recurrence (u-BCR, <0.2 ng/mL) and early BCR (e-BCR, 0.2-0.5 ng/mL) groups. CDRs, defined as the proportion of patients with true positive findings for each imaging modality, and positive predictive values (PPVs) were compared between radiotracers.</p><p><strong>Results: </strong>The overall CDR of [¹⁸F]PSMA-1007 was significantly higher than [⁶⁸Ga]Ga-PSMA-11 (70.7% <i>vs.</i> 23.4%, p<0.001) in both u-BCR (60.0% [9/15] <i>vs.</i> 19.0% [4/21], p=0.017) and e-BCR groups (76.9% [20/26] <i>vs.</i> 26.9% [7/26], p<0.001). Local recurrence was more frequently detected with [¹⁸F]PSMA-1007, particularly in the e-BCR group (46.2% <i>vs.</i> 3.8%, p<0.001), while lymph node (LN) and distant metastases detection was comparable. In the u-BCR group, the recurrence sites identified by [¹⁸F]PSMA-1007 included local (n=3), LN (n=3), bone (n=2), and local plus LN (n=1), whereas [⁶⁸Ga]Ga-PSMA-11 identified local (n=1), LN (n=1), bone (n=1), and lung (n=1). In [¹⁸F]PSMA-1007, CDR was higher in high/very high-risk than in low/intermediate-risk patients in the u-BCR group (p=0.011). No such difference was observed with [⁶⁸Ga]Ga-PSMA-11. PPVs did not differ significantly between radiotracers (p=0.333).</p><p><strong>Conclusions: </strong>[¹⁸F]PSMA-1007 PET/CT showed higher CDR than [⁶⁸Ga]Ga-PSMA-11 PET/CT in patients at PSA ≤0.5 ng/mL after radical prostatectomy. Given the high detection performance, these findings support consideration of [¹⁸F]PSMA-1007 PET/CT for detection at PSA ≤0.5 ng/mL, particularly for prostate bed assessment in high/very high-risk patients.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Pharmacological Therapies for Erectile Dysfunction: What is New, What Works, What is Next.","authors":"Maged Ragab, Germar-Michael Pinggera, Aleksei Ryzhkov, Rupin Shah, Selahittin Çayan, Ashok Agarwal","doi":"10.5534/wjmh.250337","DOIUrl":"https://doi.org/10.5534/wjmh.250337","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Male Infertility Care: Emerging Technologies and Future Clinical Directions.","authors":"Taras Shatylko, Sezgin Gunes, Selahittin Çayan, Mohamed Arafa, Salıma Daoud, Germar-Michael Pinggera, Marjan Sabbaghian, Ateş Kadıoğlu, Ashok Agarwal","doi":"10.5534/wjmh.250412","DOIUrl":"https://doi.org/10.5534/wjmh.250412","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Live Birth Rates after Vasectomy: Data from the National Survey of Family Growth.","authors":"Tommy Jiang, Shufeng Li, Michael L Eisenberg","doi":"10.5534/wjmh.250378","DOIUrl":"https://doi.org/10.5534/wjmh.250378","url":null,"abstract":"<p><strong>Purpose: </strong>Vasectomy is considered the gold standard for permanent male contraception, with guideline-reported failure rates of 1:2,000. However, these estimates are based on cohorts that may not reflect the evolution of surgical techniques and changes to provider mix. Contemporary incidence of unintended pregnancies after vasectomy remain unclear.</p><p><strong>Materials and methods: </strong>We estimated vasectomy failure rates using data from the National Survey of Family Growth, a Centers for Disease Control and Prevention-sponsored survey measuring reproductive health in the United States population. We extracted data from four survey waves of families who underwent a household vasectomy. Pregnancy rates were analyzed using Kaplan-Meier curves and multivariable Cox proportional-hazards models to assess the impact of demographic factors on pregnancy rates post-vasectomy.</p><p><strong>Results: </strong>The 829 male and 1,172 female participants reported a household vasectomy. The pregnancy rate after vasectomy from all eligible male respondents was 1.92% at 1 year, 3.52% at 5 years, and 3.75% at 10 years. From female survey data, the 1-year pregnancy rate in married couples after vasectomy was 0.57% at 1 year, 1.82% at 5 years, and 2.41% at 10 years. Multivariate analysis of male respondents showed younger respondents (hazard ratio [HR]: 14.04, 95% confidence interval [CI]: 2.37-83.20, p<0.01) was associated with higher unintended pregnancy after vasectomy while higher education status was associated with lower rates of post-vasectomy pregnancy (HR: 0.19, 95% CI: 0.04-0.91, p=0.04).</p><p><strong>Conclusions: </strong>These data suggests that there may be nontrivial pregnancy rates after vasectomy with variation based on patient demographics. Further research is necessary to understand technical or patient related factors to lower unwanted pregnancies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intraoperative Doppler Ultrasound on Outcomes of Microsurgical Subinguinal Varicocelectomy: A Systematic Review and Meta-Analysis.","authors":"Aleksei Ryzhkov, Selahittin Çayan, Barış Altay, Hiva Alipour, Svetlana Sokolova, Ahmed Harraz, Germar-Michael Pinggera, Erman Ceyhan, Mohammed Abdulgabbar Noman, Cevahir Ozer, Jean de la Rosette, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250398","DOIUrl":"https://doi.org/10.5534/wjmh.250398","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of intraoperative Doppler ultrasound (IDU) during microsurgical subinguinal varicocelectomy (MSV) on surgical outcomes, complication rates, and reproductive parameters.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA and MOOSE guidelines (PROSPERO: CRD420250656066). A comprehensive literature search was performed in PubMed and Scopus up to December 2024. Studies enrolling men with varicocele (Population) who underwent MSV with IDU (Intervention) were compared with those who underwent MSV without IDU (Comparison). Primary outcomes included fertility outcomes (pregnancy rates, sperm parameters), pain resolution, and postoperative complications (recurrence, hydrocele, testicular atrophy). Secondary outcomes included operative time, number of preserved arteries, ligated veins, and preserved lymphatic vessels. Statistical analyses used fixed- or random-effects models depending on heterogeneity.</p><p><strong>Results: </strong>Seven studies involving 1,044 patients were included. While no differences were found in sperm concentration or morphology, progressive sperm motility improved significantly with (mean difference [MD] 12.10%; 95% confidence interval [CI] 3.47 to 20.72; p=0.006). Pregnancy rates were similar between groups. Two studies assessed postoperative pain; both showed improvement, with one reporting higher complete pain resolution using Doppler, but heterogeneity prevented meta-analysis. No significant difference was observed in varicocele recurrence, hydrocele formation, or testicular atrophy. Intraoperative Doppler significantly reduced operative time in unilateral varicocelectomy (MD -5.90 minutes; 95% CI -9.78 to -2.02; p=0.003) but not in bilateral cases. IDU improved arterial preservation (MD 0.44 arteries per patient; 95% CI 0.32 to 0.57; p<0.0001) and led to more veins being ligated (MD 1.06 veins; 95% CI 0.80 to 1.33; p<0.0001).</p><p><strong>Conclusions: </strong>IDU enhances surgical precision by improving arterial identification and vein ligation, while reducing operative time in unilateral varicocelectomy. It significantly enhances sperm motility but shows no effect on pregnancy or complication rates.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superoxide Dismutase-Rich <i>Tetraselmis chuii</i> Supplementation Improves Semen Quality in Idiopathic Infertile Males: A Double-Blind Randomized Placebo-Controlled Trial.","authors":"Marina Leiva, Judit Castillo, Di Wang, Marta Guimerà, Raquel Ferreti, Alicia Diez, Laura Noguera, Lalia Mantecón, Dolors Manau, Rafael Oliva, Carlos Infante, Carlos Unamunzaga, Eva González, Juan Manuel Corral, Meritxell Jodar","doi":"10.5534/wjmh.250385","DOIUrl":"https://doi.org/10.5534/wjmh.250385","url":null,"abstract":"<p><strong>Purpose: </strong>Male infertility is a growing but poorly understood condition, largely evaluated through sperm parameters. Oxidative stress plays a crucial role in idiopathic cases, with 30%-80% of patients showing elevated reactive oxygen species levels in seminal plasma. Antioxidants are increasingly used in reproductive medicine, but their effectiveness may be limited by the lack of prior assessment in patients. This study aimed to evaluate the efficacy of a <i>Tetraselmis chuii</i>-derived ingredient, with a high superoxide dismutase (SOD) activity (TSOD), in improving sperm quality parameters, including sperm DNA fragmentation (SDF), and static oxidation-reduction potential (sORP).</p><p><strong>Materials and methods: </strong>In this randomized, double-blind, placebo-controlled clinical study, a total of 80 males with idiopathic infertility were recruited and randomly assigned to receive either TSOD (n=40) or placebo (n=40) at 250 mg/d for three months. Blood and semen samples were collected at baseline and post-treatment to assess hormonal profiles, semen parameters, SDF, and sORP. Additionally, socio-demographic data and reproductive outcomes were recorded.</p><p><strong>Results: </strong>After three months of supplementation, the TSOD group exhibited a significant increase in serum levels of luteinizing and follicle-stimulating hormone, resulting in improved sperm concentration and progressive motility. A significant reduction in both total and double-strand SDF was also observed exclusively in the TSOD group, particularly among males with initially pathological sORP values. Following a 3-month wash-out period, seminal parameters tended to return toward baseline values, while serum hormonal levels and SDF remained relatively stable. Notably, the improvements in semen quality were translated into superior reproductive outcomes, as the TSOD group achieved significantly higher live birth rates compared to the control group.</p><p><strong>Conclusions: </strong>TSOD supplementation demonstrates clinical efficacy in improving sperm quality parameters and reproductive outcomes in males with oxidative stress-related idiopathic infertility. However, its use should be preceded by redox status assessment to identify patients most likely to benefit.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Factor Erythroid 2-Related Factor 2 Negatively Regulates Docetaxel-Induced Ferroptosis in Castration-Resistant Prostate Cancer Cells.","authors":"Chunjin Ke, Jiahua Gan, Zilong Guo, Kai Cui, Jihua Tian, Zhenghao Liu, Ping Lei, Zhiquan Hu, Chunguang Yang","doi":"10.5534/wjmh.250299","DOIUrl":"https://doi.org/10.5534/wjmh.250299","url":null,"abstract":"<p><strong>Purpose: </strong>We explored whether docetaxel (DTX) induced ferroptosis in castration-resistant prostate cancer (CRPC) cells and further investigated its mechanism of action and its regulation of the tumor immune microenvironment.</p><p><strong>Materials and methods: </strong>First, DTX-induced characteristic changes in the morphology, metabolism and protein expression of CRPC cells as well as electron microscopy ultrastructure were used to verify the occurrence of ferroptosis. Then, through transcriptome sequencing and gene set enrichment analysis, the nuclear factor erythroid 2-related factor 2 (<i>NRF2</i>) gene was screened out according to the differentially expressed genes and their key signaling pathways. Silencing NRF2 (si-NRF2) to explore its regulatory mechanism on DTX-induced ferroptosis in CRPC cells. Finally, TFRC-CAR-T cells combined with DTX were constructed to explore their antitumour ability and immune regulation.</p><p><strong>Results: </strong>The cell viability of CRPC cells decreased with increasing DTX concentration, and this downwards trend could be partially rescued by ferroptosis inhibitor (ferrostatin-1). Intracellular lipid reactive oxygen species and malondialdehyde levels were significantly increased in DTX-induced CRPC cells, while the levels of glutathione and glutathione peroxidase activity were significantly decreased. Transmission electron microscopy reveals marked mitochondrial shrinkage, spheroidal remodeling, and membrane densification. Transcriptome sequencing and gene set enrichment analysis revealed that the <i>NRF2</i> gene in the antioxidant stress pathway is primarily involved in regulating ferroptosis. Immunohistochemistry and cytological Western Blot showed DTX chemotherapy activates NRF2 while also up-regulating transferrin receptor (TFRC) in CRPC cells. si-<i>NRF2</i> gene enhance the sensitivity of DTX-induced ferroptosis in CRPC cells. The killing effect of TFRC-CAR-T cells alone on CRPC cells was weak, while DTX combined with TFRC-CAR-T cells demonstrated stronger killing ability and enhanced cytokine secretion compared to DTX alone.</p><p><strong>Conclusions: </strong>DTX induces ferroptosis in CRPC cells, a process negatively regulated by NRF2. DTX combined with TFRC-CAR-T cells had a stronger lethal effect to CRPC cells and increase cytokine secretion.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}