World Journal of Mens Health最新文献

{"title":"Induction of Spermatogenesis and Its Predictors in Men with Prepubertal-Onset Hypogonadotropic Hypogonadism Undergoing Gonadotropin Therapy.","authors":"Min Chul Cho, Hohyun Lee, Soo Woong Kim","doi":"10.5534/wjmh.250117","DOIUrl":"10.5534/wjmh.250117","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcomes of gonadotropin therapy (GT) using human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (rFSH) for inducing spermatogenesis in men with prepubertal-onset hypogonadotropic hypogonadism (HH), compare these outcomes between men with congenital and acquired etiologies, and identify factors associated with successful spermatogenesis.</p><p><strong>Materials and methods: </strong>This retrospective study included 65 men with prepubertal-onset HH who underwent GT to induce spermatogenesis. Baseline assessments included serum luteinizing hormone (LH), FSH, and testosterone levels, and testicular volume (TV) measurements. Treatment began with hCG injections administered thrice weekly for four weeks, followed by combined rFSH and hCG therapy. Serum testosterone levels were measured after hCG pretreatment. TV and semen analyses were evaluated every three months following the rFSH addition. Successful spermatogenesis was defined as the detection of at least one sperm in a semen sample.</p><p><strong>Results: </strong>Median baseline testosterone, LH, and FSH levels were 0.10 ng/mL, 0.05 IU/L, and 0.50 IU/L, respectively, with a median baseline TV of 4.0 mL. After hCG pretreatment, median serum testosterone level increased to 3.16 ng/mL. Treatment outcomes were analyzed in 50 patients who continued GT until spermatogenesis induction or for at least 12-months. Following therapy, median TV increased to 9.0 mL. Spermatogenesis was successfully induced in 41 patients (82.0%), with a median induction time of 7.5-months. In these patients, median sperm concentration, total motility, and morphology were 5.2×10⁶/mL, 35%, and 4%, respectively. Success of spermatogenesis induction did not differ between patients with congenital and acquired HH etiologies. Larger baseline TV was the only predictor of successful outcomes. Earlier spermatogenesis was correlated with larger baseline TV. Among six patients seeking conception, four achieved conception.</p><p><strong>Conclusions: </strong>GT can successfully induce spermatogenesis in 82% of patients with prepubertal-onset HH, regardless of etiology. Baseline TV was confirmed as a predictor of successful outcomes and earlier spermatogenesis induction.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"992-1001"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanisms of Testis Damage and Target Drug Development in the Ischemic-Reperfusion Injury of Acute Testicular Torsion: A Pediatric Urological Perspective.","authors":"Jae Min Chung, Hyun Jun Park, Sang Don Lee","doi":"10.5534/wjmh.250214","DOIUrl":"10.5534/wjmh.250214","url":null,"abstract":"<p><p>Acute testicular torsion (TT) in children is one of the most common urogenital emergencies, which potentially causes serious clinical outcome including testicular dysfunction, infertility, orchiectomy. Clinically, surgical correction must be performed within 6 hours to preserve the testis. Unfortunately, most children with acute TT came in after the golden time of 6 hours. As a result, testicular function significantly decreases due to ischemic or ischemic-reperfusion (I/R) injury to the testis, and in the worst case, orchiectomy may be required. Acute TT is well known to cause testicular damage through I/R injury mechanism. Ischemic injury can directly lead to tissue damage and organ dysfunction. Following testicular detorsion, testicular reperfusion causes also more severe damage than that induced by ischemia. The immediate restoration of blood flow is the primary therapeutic approach to treat TT. A number of previous experimental studies of TT in animals have been suggested a model of I/R injury in humans, and the use of different types medication and their role in decreasing cellular damage following reperfusion. However, there are currently no effective medications available for the clinical practice. Besides, according to the available evidence, the pharmacological mechanism of the currently known agents to avoid or reduce I/R injury, as well as their toxicity, side effects, safe doses and other issues, remain to be further elucidated in future preclinical and clinical trials. Based on recently published literatures, the authors would like to review the molecular mechanisms and target drug development of testis damage in the I/R injury of acute TT from a pediatric urological perspective.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":"43 4","pages":"784-806"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Clinical Features and Survival Outcomes of Esophageal Cancer: A Comparative Study in the Korean Population.","authors":"Jin Hee Noh, Hyungchul Park, Do Hoon Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung","doi":"10.5534/wjmh.240192","DOIUrl":"10.5534/wjmh.240192","url":null,"abstract":"<p><strong>Purpose: </strong>Esophageal cancer is a predominantly male disease. However, the sex differences associated with esophageal cancer have not been thoroughly investigated. This study aimed to evaluate the differences between esophageal cancer in males and females in the Korean population.</p><p><strong>Materials and methods: </strong>We assessed patients diagnosed with esophageal cancer between 2005 and 2015 at a tertiary referral center. The clinical features of patients, histopathologic characteristics of tumors, and treatment and survival outcomes were compared between male and female patients.</p><p><strong>Results: </strong>We enrolled 2,068 patients, comprising 1,924 (93.0%) males and 144 (7.0%) females. The median age at diagnosis was younger for females than males (65 <i>vs.</i> 63 years, p=0.004). Squamous cell carcinoma was the predominant pathological type (99.0% in males and 93.1% in females); however, the proportion of adenocarcinoma cases was higher in females than males (0.8% <i>vs.</i> 5.6%, p<0.001). Multivariate analysis indicated favorable overall survival for female patients (hazard ratio [HR], 0.685; 95% confidence interval [CI], 0.548-0.857) and patients with high body mass index (≥25 kg/m², HR, 0.432; 95% CI, 0.355-0.526), and in early tumor stage (Stage 4, HR, 12.684; 95% CI, 7.451-21.591). The 5-year overall survival (44.8% <i>vs.</i> 53.5%, p=0.016) and recurrence-free survival rates (74.0% <i>vs.</i> 84.3%, p=0.036) were higher in females than in males.</p><p><strong>Conclusions: </strong>We found significant sex differences in esophageal cancer among the Korean population, with female patients demonstrating distinct clinical characteristics and more favorable survival outcomes compared to male patients. These findings underscore the importance of considering sex-specific factors in the management and prognosis of esophageal cancer.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"969-979"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Guidelines and Perspectives for Varicocele: A Clinical Consensus and Recommendations from the Korean Society for Sexual Medicine and Andrology.","authors":"Dae Keun Kim, Dong Soo Kim, Sung Chul Kam, Hyo Serk Lee, Won Ki Lee, Seung-Hun Song","doi":"10.5534/wjmh.240290","DOIUrl":"10.5534/wjmh.240290","url":null,"abstract":"<p><p>Varicocele is a common urological disease and varicocele has long been recognized as a condition that could affect male fertility. Although varicocele is the most common surgically correctable cause of male infertility, not all varicoceles require treatment. Because the appropriate diagnosis and management of varicoceles remain less clear in many patients, it is important to diagnose clinically significant varicoceles that can benefit from treatment. Even in the era of widespread assisted reproductive techniques, varicocele has substantial implications in infertility treatment. The Korean Society for Sexual Medicine and Andrology (KSSMA) has sought to develop guidelines for varicocele treatment tailored to clinical practices in Korea. This review summarizes the latest evidence for varicocele treatment, including clinical practice guidelines from various international professional societies, and represents the consensus opinion of experts within the KSSMA.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"748-757"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Conceptual Model Linking Benign Prostatic Hyperplasia Circadian Disruption, Testosterone Deficiency, and Frailty in Older Adults.","authors":"Yu-Hsiang Lin, Yi-Kai Chang, Yu-Ting Chen","doi":"10.5534/wjmh.250128","DOIUrl":"10.5534/wjmh.250128","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1002-1003"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Varicocele Repair on Testicular Endocrine Function: A Systematic Review and Meta-Analysis.","authors":"Rossella Cannarella, Rupin Shah, Edmund Ko, Parviz Kavoussi, Amarnath Rambhatla, Taha Abo-Almagd Abdel-Meguid Hamoda, Ramadan Saleh, Ahmed M Harraz, Aldo E Calogero, Damayanthi Durairajanayagam, Tuncay Toprak, Gokhan Calik, Andrea Crafa, Sezgin Gunes, Nazim Gherabi, Shinnosuke Kuroda, Hussein Kandil, Murat Gül, Florence Boitrelle, Ramy Abou Ghayda, Raghavender Kosgi, Vilvapathy Senguttuvan Karthikeyan, Giorgio I Russo, Selahittin Cayan, Rajender Singh, Eric Chung, Carlo Giulioni, Gian Maria Busetto, Ashok Agarwal","doi":"10.5534/wjmh.240109","DOIUrl":"10.5534/wjmh.240109","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The objective of this manuscript is to assess the effect of varicocele repair (VR) in patients with clinical varicoceles on serum total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and inhibin B serum levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The study was performed in compliance with the Meta-Analysis and Systematic Reviews of Observational Studies (MOOSE) guidelines and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). All eligible studies were selected following the PICOS (Population, Intervention, Comparison/Comparator, Outcomes, Study design) model. The values of each outcome measured after VR were compared to the before parameters and, when available, to the values on patients with unrepaired varicocele, and to those of healthy controls with no varicocele. For total testosterone, the values were sub-analyzed based on the mean total testosterone levels before VR (&lt;300 ng/dL or &gt;300 ng/dL), the fertility status, the time of follow-up and the technique used for VR.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From a total of 460 abstracts retrieved, 48 articles were included in our meta-analysis. Serum total testosterone levels were significantly higher after VR compared to both pre-treatment levels (mean difference [MD] 82.45 ng/dL, 95% confidence interval [CI]: 64.14-100.76; p&lt;0.00001) and to the levels of patients with unrepaired varicocele (MD 91.64 ng/dL, 95% CI: 62.30-120.99; p&lt;0.00001). They did not differ from the levels of healthy controls with no varicocele (MD -22.01 ng/dL, 95% CI: -68.59-24.58; p=0.35). The increase resulted to be independent from the mean total testosterone levels before VR, fertility status, time of follow-up and type of VR. After VR, a trend toward lower serum LH levels was found compared to before values (MD -0.37 IU/L, 95% CI: -0.74-0.01; p=0.06). When compared to the levels of patients with unrepaired VR, LH levels after VR were significantly lower (MD -0.96 IU/L, 95% CI: -1.56 to -0.35; p=0.002). LH levels were not significantly higher than healthy men without varicocele (MD 0.84 IU/L, 95% CI: -0.68-2.36; p=0.28). Patients with VR had significantly lower FSH levels compared to their pre-treatment values (MD -1.43 IU/L, 95% CI: -1.82 to -1.04; p&lt;0.00001), and also to those of patients with non-repaired varicocele (MD -2.35 IU/L, 95% CI: -4.06 to -0.65; p=0.007). When compared to healthy controls with no varicocele, FSH levels were significantly higher (MD 2.71 IU/L, 95% CI: 1.12-4.31; p=0.0009). Lastly, after VR no significant change in inhibin B serum levels was seen compared to pre-treatment levels (MD 11.76 pg/mL, 95% CI: -3.83-27.35; p=0.14).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The present meta-analysis is the largest to date to assess the impact of VR on Leydig cell and Sertoli cell function using a before-after analysis for uncontrolled studies, and using data from patients with unrepaired varicoceles or","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"818-843"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Progress of Deep Grid Incision and Sealing with Collagen Fleece for Treatment of Peyronie's Disease: Prospective Observational Study for 3 Years.","authors":"Du Geon Moon, Sun Beom Cho, Won Ku Hwang, Hyo Jong Kim, Sun Tae Ahn","doi":"10.5534/wjmh.240201","DOIUrl":"10.5534/wjmh.240201","url":null,"abstract":"<p><strong>Purpose: </strong>Despite recent popularity, partial plaque excision and sealing with TachoSil has concern about tunica regeneration from graft and lack of long-term results. Previously, we introduced multiple deep grid incisions of Peyronie's plaque to minimize tunical defect with consequent veno-occlusal erectile dysfunction. To assess the efficacy of modified grid incision of plaque and sealing with collagen fleece in postoperative progress of 34 patients for 3 years.</p><p><strong>Materials and methods: </strong>From Aug 2018, 34 patients with stable Peyronie's disease (PD) underwent surgery involving three major steps: 1) dissection of the neurovascular bundle or urethra according to plaque location, 2) multiple deep grid incisions of plaque for complete curvature correction, and 3) sealing with collagen fleece without suture. We assessed the stretched penile length, totally straightness, penile sonography, erectile function preoperatively and 3, 6, 12 months and annually postoperatively. This study was approved by the Institutional Review Board.</p><p><strong>Results: </strong>Mean age was 59.4 years (29-72 years). Mean curvature was 53.5 degree (35-100 degree), with hinge and hourglass deformity in 12 and 8 patients, respectively. Five patients required inflatable penile prosthesis (IPP) insertion, with one more at 30 months. The mean follow-up was 42.3 months. Penile rehabilitation, including daily massage, reduced subcutaneous thickening by 12 months postoperatively. All patients initially achieved complete straightness, with two experiencing recurrent curvature. Four patients had subcutaneous hematomas, subsiding in two. Minor skin issues occurred in three IPP patients. Postoperative erectile function was satisfactory in 85.0% of patients. Most regained preoperative length by 1.6 years. Global Assessment Questionniare satisfaction increased from 69.0% at 1 year to 90.0% until 3 years.</p><p><strong>Conclusions: </strong>The modified grid incision with collagen fleece sealing effectively treats PD without causing tunica albuginea defects. Long-term follow-up is essential for monitoring erectile function and penile length recovery, ensuring successful clinical outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"898-907"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pentosan Polysulfate Sodium and Maculopathy in Patients with Interstitial Cystitis: A Systematic Review and Meta-Analysis.","authors":"Jongsoo Lee, Yun Jin Kim, Konghee Lee, Young Kook Kim, Taeho Greg Rhee, Sung Ryul Shim, Jae Heon Kim","doi":"10.5534/wjmh.240295","DOIUrl":"10.5534/wjmh.240295","url":null,"abstract":"<p><strong>Purpose: </strong>Pentosan polysulfate sodium (PPS) is the only pharmacological intervention approved by the US Food and Drug Administration for treating interstitial cystitis (IC) to date. However, PPS may induce an adverse event, maculopathy, which can be a significant challenge. To determine the risk of PPS-induced maculopathy in patients with IC.</p><p><strong>Materials and methods: </strong>PubMed and Embase were systematically searched through July 2024. Two authors also independently and manually searched all relevant studies. We included national level cohort studies using healthcare claim big data or real-world data with the following criteria: (1) patients diagnosed with IC; (2) interventions included PPS as an active treatment; (3) comparisons were specified as non-PPS interventions; and (4) the primary outcome of interest was the risk of maculopathy. The pairwise meta-analysis was performed to compare the PPS treatment group with control used in IC. The primary outcome measure was the hazard ratio (HR), odds ratio (OR), and proportional report ratio (PRR) of maculopathy after receiving the PPS treatment, as compared to non-PPS interventions.</p><p><strong>Results: </strong>A comprehensive literature search was conducted, and identified 6 studies with 411,098 patients. The pooled risk for maculopathy due to PPS in patients with IC was significant (HR, 1.678; 95% confidence interval [95% CI], 1.066-2.642]). The heterogeneity test produced a Higgins' <i>I</i>-squared statistic, which was 83.6%. In the subgroup analysis of follow-up period of less than 5 years (HR, 1.285; 95% CI, 1.139-1.449) and more (HR, 1.341; 95% CI, 1.307-1.375) were statistically significant, indicating that the patients with IC who had a long-term PPS treatment were more likely to have maculopathy than the control groups.</p><p><strong>Conclusions: </strong>This is the first study to investigate the relationship between PPS and its association with the risk of maculopathy in patients with IC through a systematic review and meta-analysis.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"866-874"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum Clinical Practice Guidelines on the Management of Premature Ejaculation.","authors":"Taymour Mostafa, Germar-Michael Pinggera, Manaf Al Hashimi, Bahadır Sahin, Selahittin Çayan, Rupin Shah, Eric Chung, Amarnath Rambhatla, Mohamed Arafa, Widi Atmoko, Omer Raheem, Ayman Rashed, Tan V Le, Nicholas Tadros, Hiva Alipour, Edmund Ko, Baris Altay, Shedeed Ashour, Mohamad Moussa, Ricky Adriansjah, Giorgio Ivan Russo, Gian Maria Busetto, Iman Shamohammadi, Ioannis Sokolakis, Muhammad Ujudud Musa, Fahmi Bahar, Gökhan Çeker, Tuncay Toprak, Massimiliano Timpano, Nguyen Quang, Manh Nguyen Truong, Sang Thanh Le, Rossella Cannarella, Ahmad Motawi, Kadir Bocu, Luca Boeri, Giovanni M Colpi, Gianmaria Salvio, Kareim Mohamed Khalafalla, Marco Falcone, Nazim Gherabi, Sunil Jindal, Taha Hamoda, Kasonde Bowa, Teng Aik Ong, Sedigheh Bahmyari, Ahmed El-Sakka, Amr El Meliegy, Emad Taha, Christopher Chee Kong Ho, Gokhan Calik, Aldo E Calogero, Niwanda Yogiswara, Walter D Cardona Maya, Hussain Al Najjar, Maged Ragab, Ashok Agarwal","doi":"10.5534/wjmh.240260","DOIUrl":"10.5534/wjmh.240260","url":null,"abstract":"<p><strong>Purpose: </strong>Premature ejaculation (PE) is a commonly encountered male sexual dysfunction (MSD) with various definitions, diagnostic criteria, and treatment options, leading to significant heterogeneity and controversy in its management. This study aimed to explore the global practice patterns of the diagnosis and management of PE.</p><p><strong>Materials and methods: </strong>A cross-sectional, global, online survey on PE was conducted using a questionnaire developed by an international cohort of experts. Results were analyzed using R version 4.1.2. Additionally, expert recommendations were formulated using a modified Delphi method.</p><p><strong>Results: </strong>The survey was completed by 264 participants from 41 countries. The majority of respondents were below the age of 45 years and were urologists focusing on andrology and sexual health. PE diagnosis was primarily based (by 61.5%) on an intravaginal ejaculatory latency time of less than one minute. Lifelong PE was the most common category reported (47.7%), and most respondents (84.2%) observed ante-portas PE in less than 25% of cases. Distinguishing PE from erectile dysfunction was challenging for many respondents (60.7%). Diabetes mellitus was the most common comorbidity (17.1%). Pharmacological therapy was the most common treatment method (34.3%), with dapoxetine being the most preferred medication (37.9%). Surgical methods were infrequently used. Emerging treatments like hyaluronic acid gel glans augmentation were favored by only 11.7%. Patient satisfaction was the primary criterion for successful PE treatment (55.9%), and cost was a significant concern for many (35.5%).</p><p><strong>Conclusions: </strong>This global survey highlights significant diversity in the diagnostic and treatment strategies for PE. Standard diagnostic criteria are generally accepted, off-label medication is widely used in therapy, and the role of surgery is still controversial. A multi-modal therapy approach, tailored to the patient's specific needs, is favored. Further research into the neurobiology of PE and the development of effective and safe options is crucial for improving the management of PE.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"944-968"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and Socioeconomic Affecting Factors for Prostate Cancer Screening Behavior.","authors":"Ki Min Kim, Jae Heon Kim","doi":"10.5534/wjmh.240110","DOIUrl":"10.5534/wjmh.240110","url":null,"abstract":"<p><p>There has been much controversy about the effectiveness of prostate cancer (PC) screening in the treatment of PC. Recently, with the increase in advanced and metastatic PCs, prostate-specific antigen (PSA) screening is again emphasized. However, no systematic study has examined the factors influencing PSA screening behavior. This study highlights the importance of socioeconomic factors, such as income, education, marital status, insurance status, and medical accessibility, in PC screening behavior. We conducted a search for articles related to PSA screening through Cochrane, Embase, and PubMed, and we chose 40 articles. And we divided factors associated with PSA screening into two groups, such as individual characteristic factors and socioeconomic factor. In addition to identifying individual factors that could affect both medical providers and patients, this review will also highlight the importance of socioeconomic factors including income, education, marital status, insurance status, and medical accessibility affecting PC screening behavior. Future guidelines should integrate these socioeconomic factors, particularly for patients with unfavorable socioeconomic status.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"734-747"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}