World Journal of Mens Health最新文献

{"title":"Customizing Therapy in Men with Peyronie's Disease: Insights from Expert Case Discussions.","authors":"Germar-Michael Pinggera, Widi Atmoko, Selahittin Cayan, Eric Chung, Akira Tsujimura, Ahmed El-Sakka, Suks Minhas, Ates Kadioglu, Ashok Agarwal, Rupin Shah","doi":"10.5534/wjmh.250339","DOIUrl":"https://doi.org/10.5534/wjmh.250339","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Intake-Induced Aggravation of Chronic Prostatitis/Chronic Pelvic Pain Syndrome is Associated with Reduced Gut Microbiota-Driven Short-Chain Fatty Acid Propionate and Butyrate.","authors":"Chang Liu, Shaoyu Yue, Di Niu, Ligang Zhang, Jing Chen, Yang Chen, Yu Guan, Xiaoliang Hua, Xianguo Chen, Li Zhang, Hexi Du, Chaozhao Liang","doi":"10.5534/wjmh.240223","DOIUrl":"10.5534/wjmh.240223","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic prostatitis (CP) is a common urological disease and about 8.4% to 13.5% of men suffer from prostatitis symptoms in China. This study was conducted to evaluate the effect of alcohol usage on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and the role of the gut microbiome in this course.</p><p><strong>Materials and methods: </strong>A total of 151 individuals were recruited when they were diagnosed with CP/CPPS. Eventually, 38 patients were enrolled and grouped into three groups: the CP/CPPS group, alcohol group, and quitter group. 16S ribosomal ribonucleic acid sequencing was used to investigate the fecal samples, and a liquid chromatograph-mass spectrometer was used to analyze untargeted metabolomics. Next, targeted identification of short-chain fatty acids was carried out. T helper 17 (Th17) cells and cytokines were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively. Furthermore, the associations among intestinal microbiota, short-chain fatty acids, and clinical symptoms were evaluated through correlation analysis.</p><p><strong>Results: </strong>Alcohol consumption results in different microbial composition in patients with CP. Higher symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the alcohol group. Notably, correlation analysis revealed that several gut microbes were correlated with propionate and butyrate contents and patient's symptoms. Contrarily, lower symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the quitter group.</p><p><strong>Conclusions: </strong>This study preliminarily explores the potential association between alcohol and CP/CPPS, in which short-chain fatty acid-producing gut flora may play a key role. This study may enhance the understanding of the effect of alcohol on CP/CPPS and provide a preliminary foundation for formulating prevention strategies. The main limitation of this study is the small sample size, and further large-scale plus in-depth research ought to be carried out in the future.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"388-401"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vitamin B₆ in Testosterone Synthesis.","authors":"Saleem Ali Banihani","doi":"10.5534/wjmh.240250","DOIUrl":"10.5534/wjmh.240250","url":null,"abstract":"<p><p>Boosting testosterone production and maintaining its adequate concentrations in males is still a critical area of the ongoing research. Vitamin B₆ (VB6), also named pyridoxine, is an essential nutrient and biochemically an organic cofactor in various enzymatic reactions that activate several catabolic and anabolic processes, including energy production, neurotransmitter synthesis, immune system function. While various studies have revealed an indirect association between testosterone and VB6, a collective and comprehensive review of its role in testosterone synthesis has been lacking. Here, we review and summarize the involvement of VB6 in testosterone production and regulation. To achieve this, a thorough search of the PubMed and Scopus databases was conducted, identifying English-language articles published from August 1956 to the present using the keywords \"vitamin B₆\" and \"pyridoxine\" versus testosterone. Relevant studies contributing to a mechanistic understanding of this relationship were also included. In summary, VB6 is essential for testosterone production and regulation through various indirect mechanisms. These include its impact on hormonal signaling pathways like GnRH and prolactin, its role in activating enzymatic processes that affect testosterone synthesis, its modulation of androgen receptor sensitivity, and its protection against oxidative stress and homocysteine toxicity. Such critical role of VB6 in regulating testosterone levels in men is considered a strong incentive for researchers to conduct interventional studies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"227-236"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Endocrine Stratification of Non-Obstructive Azoospermia: Commentary on the Global Andrology Forum Guidelines.","authors":"Sandro La Vignera","doi":"10.5534/wjmh.250277","DOIUrl":"10.5534/wjmh.250277","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"471-472"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm DNA Fragmentation in Men with Varicocele: A Systematic Review and Meta-Analysis.","authors":"Ayad Palani, Selahittin Çayan, Rossella Cannarella, Ramadan Saleh, Baris Altay, Mustafa Kadihasanoglu, Ahmed Harraz, Fotios Dimitriadis, Erman Ceyhan, Andri Rezano, Ahmed Hussein Zwamel, Wael Ibrahim, Amina Benabbou, Ria Margiana, Essolakina Gnoneye, Md Mezbahul Moker Rabin, Jamiu Omirinde, Vahid Esmaeili, Armand Zini, Mohamed Arafa, Haitham Elbardisi, Tuncay Toprak, Murat Dursun, Kareim Khalafalla, Gianmaria Salvio, Eric Chung, Andrea Crafa, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250025","DOIUrl":"10.5534/wjmh.250025","url":null,"abstract":"<p><strong>Purpose: </strong>In this systematic review and meta-analysis, we investigated the relationship between varicocele and sperm DNA fragmentation (SDF) alongside conventional semen parameters.</p><p><strong>Materials and methods: </strong>A comprehensive systematic search was conducted to identify articles on SDF in men with varicocele published in the Scopus and PubMed databases. This included observational studies investigating levels of SDF as a primary outcome and conventional semen parameters as secondary outcomes in men with varicocele compared to men without varicocele.</p><p><strong>Results: </strong>Out of 476 retrieved articles, 40 met our inclusion criteria, with 35 included in our quantitative synthesis. Our analysis revealed that men with varicocele showed significantly higher SDF than men without varicocele (mean difference [MD] 15.34, 95% confidence interval [95% CI]: 9.74-20.9; p<0.001). The evaluation of SDF using different assays did not affect the results (p=0.7). Our results indicated a significant effect of varicocele on sperm concentration (MD -29 million/mL, 95% CI: -37, -21; p<0.001), total sperm count (MD -188 million/ejaculate, 95% CI: -325, -52; p=0.007), sperm vitality (MD -5.7%, 95% CI: -8.6, -2.8; p<0.001), total sperm motility (MD -17%, 95% CI: -29.0, -5.3; p=0.004), progressive sperm motility (MD -17%, 95% CI: -23,-11, p<0.001), normal sperm forms (MD -3.1%, 95% CI: -4.3, -1.8, p<0.001) and abnormal sperm forms (MD 2.25%, 95% CI: 0.77, 3.73; p=0.003). However, semen volume and the total motile sperm count were not significantly different between both groups (MD -113 million/ejaculate, 95% CI: -244.0, 18.1; p=0.09).</p><p><strong>Conclusions: </strong>Varicocele negatively impacts male fertility by increasing SDF. Our study supports using SDF analysis in patients with varicocele to aid clinicians in deciding on varicocele repair.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"268-289"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Scientometric Landscape of Andrology: Trends, Gaps, and Future Directions in Male Reproductive Health: A Scoping Review.","authors":"Asli Metin Mahmutoglu, Ashok Agarwal, Hiva Alipour, Germar-Michael Pinggera, Kareim Khalafalla, Bahadir Sahin, Edoardo Pescatori, Fahimeh Piryaei, Manaf Al Hashimi, Rupin Shah","doi":"10.5534/wjmh.250006","DOIUrl":"10.5534/wjmh.250006","url":null,"abstract":"<p><strong>Purpose: </strong>This scoping review examines the extent and focus of scientometric studies on male infertility and male sexual dysfunctions (MSDs) while assessing gaps in the current research. It highlights contributions from leading countries, institutions, and authors and identifies important emerging areas of research in male infertility and MSDs.</p><p><strong>Materials and methods: </strong>A literature search was performed using Web of Science Core Collection (WoSCC), Scopus, and PubMed following the methodological framework of a scoping review. Bibliometric/scientometric studies on male infertility and sexual dysfunctions were included in this review.</p><p><strong>Results: </strong>A total of 2,525 articles were assessed for eligibility, with 36 studies included in this review. Through a detailed analysis of the articles, this study identifies significant contributions from countries such as the USA, China, and Italy, with leading institutions and authors playing a crucial role in advancing research on oxidative stress (OS), sperm DNA fragmentation (SDF), varicocele, and assisted reproductive technologies. Notably, OS and SDF have emerged as critical areas influencing both infertility diagnosis and treatment outcomes, while varicocele research remains centered on surgical interventions and their reproductive implications. In the domain of MSDs, erectile dysfunction (ED), especially diabetes-related ED, has seen a surge in research attention, with innovative treatments showing promise for future clinical applications. Despite progress in these areas, the review identifies significant gaps in research on premature ejaculation, Peyronie's disease, and other MSDs.</p><p><strong>Conclusions: </strong>This review underscores the value of scientometric analysis in andrology, providing a comprehensive overview of current research trends, key contributors, and emerging areas in male infertility and sexual dysfunctions. While significant advancements have been made in several key areas of male infertility and ED, notable gaps remain in underexplored MSDs conditions. By identifying these gaps and regional contributions, this analysis serves as a foundation for guiding future research efforts. Utilizing scientometric insights can foster innovation, improve treatment strategies, and propel advancements in male reproductive and sexual health research.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"370-387"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal Shock Wave Therapy through the Integrin-β1/NRF2 Axis.","authors":"Dongxu Lin, Kang Li, Wenbo Kuang, Zhong Chen, Mengyang Zhang","doi":"10.5534/wjmh.250222","DOIUrl":"10.5534/wjmh.250222","url":null,"abstract":"<p><strong>Purpose: </strong>Although low-intensity extracorporeal shock wave therapy (Li-ESWT) is used clinically for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), its mechanisms remain inadequately understood. This study aimed to explore Li-ESWT-mediated mechanotransduction signaling and its association with ferroptosis in CP/CPPS models.</p><p><strong>Materials and methods: </strong>Experimental autoimmune prostatitis (EAP) was induced by intradermal prostate antigen immunization. Rats received Li-ESWT, with additional groups treated with the ferroptosis inducer RAS-selective lethal 3 (RSL3) or iron chelator deferoxamine (DFO). The rats were analyzed histologically and biochemically to assess immune responses, fibrosis, oxidative stress, ferroptosis markers, and related signaling. <i>In vitro</i>, Li-ESWT was applied to lipopolysaccharide (LPS)-stimulated RWPE-1 cells. The Integrin-β1-NRF2-xCT/GPX4 axis was modulated <i>via</i> siRNA or overexpression plasmid, with Ferrostatin-1 used as a reference control. The changes in NRF2-xCT/GPX4 expression, ferrous iron, and lipid peroxidation were evaluated to clarify the mechanisms by which Li-ESWT regulates ferroptosis.</p><p><strong>Results: </strong>EAP rats recapitulated key pathological features of CP/CPPS, which were alleviated by Li-ESWT. Specifically, Li-ESWT reduced the inflammatory response by inhibiting CD3⁺ T cells and CD68⁺ macrophages infiltration, suppressed fibrosis by preventing epithelial-mesenchymal transition and smooth muscle hyperplasia, and attenuated hyperalgesia by inhibiting mast cell degranulation. RSL3 exacerbated these pathological changes, whereas DFO attenuated them. Li-ESWT also suppressed oxidative stress and ferroptosis, as indicated by reduced reactive oxygen species and ferrous iron accumulation, lipid peroxidation, and ferroptosis-driving factors (ACSL4, LPCAT3, ALOX15, COX-2) levels. Li-ESWT also upregulated the Integrin-β1 and NRF2-xCT/GPX4 expression. <i>In vitro</i>, Integrin-β1 knockdown reduced NRF2, xCT, and GPX4 expression, abolishing the protective effects of Li-ESWT against LPS-induced ferroptosis, as evidenced by increased lipid peroxidation and ferrous iron accumulation. Similarly, NRF2 knockdown negated the anti-ferroptotic effect of Li-ESWT, whereas ectopic overexpression of xCT/GPX4 restored ferroptosis suppression.</p><p><strong>Conclusions: </strong>Li-ESWT ameliorates inflammation, fibrosis, hyperalgesia in the CP/CPPS model, likely through ferroptosis mitigation <i>via</i> activating the Integrin-β1/NRF2 pathway.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"451-468"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of N6-Methyladenosine Modification Profiling in Diabetic Erectile Dysfunction.","authors":"Penghui Yuan, Wenjia Deng, Honggang Cao, Yipiao Liu, Lingang Cui, Teng Li, Qingjun Meng, Taotao Sun","doi":"10.5534/wjmh.240328","DOIUrl":"10.5534/wjmh.240328","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic erectile dysfunction (DMED) is a prevalent condition with limited treatment options. The role of RNA N6-methyladenosine (m⁶A) modification in the pathogenesis of DMED remains elusive. This study aimed to investigate the underlying m⁶A modification patterns and identify potential therapeutic targets for DMED.</p><p><strong>Materials and methods: </strong>A rat model of DMED was established using streptozotocin injection and confirmed by apomorphine-induced penile erection. Erectile function was assessed <i>via</i> cavernous nerve electrostimulation. Fibrosis in the corpus cavernosum was evaluated using Masson's trichrome staining. RNA m⁶A modification levels and the expression of associated methyltransferases were examined by dot blot and quantitative real-time PCR. MeRIP-seq and RNA-seq were employed to identify differentially methylated and expressed genes. Conjoint analysis was performed to explore associated biological processes and identify key genes, which were subsequently validated.</p><p><strong>Results: </strong>Elevated levels of RNA m⁶A modification were observed in DMED, accompanied by altered expression of METTL14 and METTL3. A total of 2,789 genes associated with 3574 m⁶A peaks were identified (p<0.05). Differentially methylated m⁶A genes were implicated in muscle cell differentiation, cell junction organization, and Wnt signaling pathways. Combined analysis of MeRIP-seq and RNA-seq identified and validated POSTN and LOX as key genes. These genes were associated with fibrosis, cell-matrix adhesion, and regulated Notch signaling pathway, and were predominantly enriched in corpus cavernosum fibroblasts of DMED.</p><p><strong>Conclusions: </strong>This exploratory study provides the first exploration of RNA m⁶A modification in DMED, and offers novel insights into the pathogenesis of DMED and potential therapeutic targets.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"413-426"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Varicocele on Pregnancy and Live Birth Outcomes in Men with Clinical Varicocele: Systematic Review of Controlled Studies.","authors":"Rossella Cannarella, Selahittin Çayan, Carlo Giulioni, Gokhan Çeker, Keerti Singh, Kareim Khalafalla, Amarnath Rambhatla, Raisa Galstyan, Shalaka Ramgir-Naidu, Logan Hubbard, Iman Shamohammadi, Kavindra Kumar Kesari, Faiza Rao, Archana Subarmaniuan, Vijay Kumar, Donny E Putra, Dharani Moorthv, Ayad Palani, Murat Dursun, Edoardo Pescatori, Ramadan Saleh, Taras Shatylko, Widi Atmoko, Armand Zini, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250023","DOIUrl":"10.5534/wjmh.250023","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of varicocele on pregnancy and live birth outcomes in men with clinical varicocele in controlled studies.</p><p><strong>Materials and methods: </strong>A comprehensive literature search was conducted across the PubMed and Scopus databases using Boolean operators, covering all available records from each database's inception through June 30, 2024. The inclusion criteria focused on controlled studies that compared pregnancy-related outcomes-including pregnancy, miscarriage, and live birth rates-between men with clinical varicocele and those without. These studies included participants attempting conception either spontaneously or through assisted reproductive techniques.</p><p><strong>Results: </strong>Out of 3,532 articles screened, only two controlled studies met the inclusion criteria. The findings revealed no significant differences between men with and without varicocele in terms of time to achieve pregnancy (5.3 <i>vs.</i> 5.4 months, respectively; p=0.92) or the proportion of men who had previously conceived with their partner (58.9% vs. 63.4%, respectively; p=0.47). However, a significant difference was observed in live birth rates, with men with varicocele showing a lower rate than those without (71.2% <i>vs.</i> 76.4%; p=0.04).</p><p><strong>Conclusions: </strong>The relationship between varicocele and conception remains contentious, primarily due to the limited number of controlled studies available for analysis. Despite an extensive systematic search for controlled studies comparing pregnancy-related outcomes in men with and without clinical varicocele, only two studies met the inclusion criteria. These studies showed no significant differences in time to achieve pregnancy or previous conception rates between the two groups. However, men with varicocele exhibited a slightly lower, statistically significant, live birth rate compared to men without varicocele. This highlights the need for further research on this topic to provide evidence-based guidance on the impact of varicocele on fertility outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"290-300"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Factors Associated with Premature Ejaculation in Japan: First Nationwide Cross-Sectional Survey by the Japanese Society for Sexual Medicine.","authors":"Masato Shirai, Akira Tsujimura, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Yoshikazu Sato, Atsushi Nagai, Koichi Nagao, Haruaki Sasaki","doi":"10.5534/wjmh.250094","DOIUrl":"10.5534/wjmh.250094","url":null,"abstract":"<p><strong>Purpose: </strong>Premature ejaculation (PE) is a most common sexual complaint among men worldwide, but its prevalence and associated factors in Japan remain underexplored. This study aimed to determine the prevalence of self-reported PE, lifelong PE (LPE), and acquired PE (APE) among Japanese men, as well as to identify associated factors, distress levels, and healthcare-seeking behaviors through a nationwide cross-sectional survey.</p><p><strong>Materials and methods: </strong>This internet-based nationwide cross-sectional survey was conducted among Japanese men from 20 to 79 years old by the Clinical Research Promotion Committee of the Japanese Society for Sexual Medicine (JSSM). Data were collected using validated questionnaires, including the International Society for Sexual Medicine (ISSM) criteria for LPE and APE.</p><p><strong>Results: </strong>Of 37,485 invited participants, 6,228 provided valid responses (response rate: 16.61%), with 5,331 sexually active men included in the analysis. The prevalence of self-reported PE distress was 23.39%. ISSM-defined LPE and APE were observed in 0.54% and 3.47% of respondents, respectively. Univariate analysis identified erectile dysfunction (ED), psychotropic drug use, neurological diseases, trauma, aortic aneurysm surgery, and partnership dissatisfaction as significant associated factors for both LPE and APE. Multivariate analysis confirmed ED as the common associated factor. Despite 51.00% of respondents expressing a desire for treatment, only 4.81% had sought medical help.</p><p><strong>Conclusions: </strong>This study provides the first epidemiological insights into PE in Japan, revealing a notable prevalence and identifying ED as a key associated factor. Despite significant distress, most affected individuals do not seek medical help, highlighting the necessity for greater public awareness and better access to treatment options. Future research should focus on longitudinal assessments to explore causal relationships and evaluate potential interventions.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"334-346"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}