World Journal of Mens Health最新文献

{"title":"Computed Tomography-Based Artificial Intelligence Analysis of Myosteatosis and Its Effect on Survival in Fournier Gangrene.","authors":"Byeong Jin Kang, Changmin Park, Hyun Jun Park","doi":"10.5534/wjmh.250350","DOIUrl":"https://doi.org/10.5534/wjmh.250350","url":null,"abstract":"<p><strong>Purpose: </strong>Fournier gangrene (FG) is a life-threatening necrotizing infection with a high mortality rate. Conventional prognostic indices, including the Fournier Gangrene Severity Index (FGSI), depended on static parameters and may not adequately capture baseline metabolic vulnerability. Myosteatosis, which is the pathological infiltration of fat within skeletal muscle, has been associated with poor outcomes in cancer and critical illness. This study evaluated the prognostic significance of myosteatosis in FG using artificial intelligence (AI)-based computed tomography (CT) analysis.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 40 male patients with FG, whose diagnosis was confirmed based on clinical, radiological, and surgical findings. Preoperative CT scans at the L3 level were assessed using AI-based software to quantify skeletal muscle quality. Quantitative parameters were automatically extracted to evaluate muscle quality. Patients were classified into myosteatosis or non-myosteatosis groups according to established cut-off values. Clinical characteristics, FGSI, septic shock, and in-hospital mortality were compared between groups. Predictors of in-hospital mortality were evaluated using multivariate logistic regression.</p><p><strong>Results: </strong>Of 40 patients, 22 (55.0%) had myosteatosis. These patients had higher rates of septic shock (45.5% <i>vs .</i> 11.1%, p<0.05) and in-hospital mortality (31.8% <i>vs .</i> 5.6%, p<0.05) than those without myosteatosis. Survivors demonstrated significantly higher normal attenuation muscle area (79.1±31.5 <i>vs.</i> 46.2±22.3, p<0.05) and lower myosteatosis percentage (37.9%±16.8% <i>vs.</i> 56.5%±15.2%, p<0.05). Multivariate analysis identified myosteatosis, FGSI >9, and cardiovascular disease as independent predictors of in-hospital mortality.</p><p><strong>Conclusions: </strong>AI-based CT analysis of myosteatosis is a reproducible method for assessing muscle quality in the FG. Myosteatosis was independently associated with septic shock and in-hospital mortality beyond body mass index and FGSI, suggesting its potential as a novel imaging biomarker for early risk stratification and individualized treatment planning.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Testosterone Decline and Metabolic Determinants in 27,687 Korean Men Aged ≥40 Years: A Nationwide Population-Based Study.","authors":"Tae Hyo Kim, Yu Seob Shin, Zhao Luo, Ji Kan Ryu, Jung Sik Huh, Hyeon Ju Kim, Kyung Hyun Moon, Hong Seok Shin, Hyun Jun Park, Min Chul Cho, Seung Hun Song, Won Ki Lee, Dong Sup Lee, Jun Ho Lee, Min Gu Park, Ho Seok Chung, See Min Choi, Sun Tae Ahn, Kang Sup Kim, Dong Yun Lee, Woong Jin Bae, Woo Suk Choi, Hwan Cheol Son, Sung Chul Kam","doi":"10.5534/wjmh.250369","DOIUrl":"https://doi.org/10.5534/wjmh.250369","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate age-related changes in serum testosterone levels and their associations with metabolic factors in a large, population-based cohort of Korean men. Although the age-related decline in testosterone has been established in Western populations, large-scale data in Asian men remain limited. Understanding regional differences is important for defining testosterone reference thresholds and associated health risks.</p><p><strong>Materials and methods: </strong>Data from 27,687 men aged ≥40 years who underwent routine health examinations at 20 hospitals across South Korea (2015-2024) were retrospectively analyzed. Clinical parameters included age, body mass index (BMI), fasting glucose, lipid profile, and prostate-specific antigen (PSA). Men receiving testosterone therapy or medications affecting androgen metabolism, or with a history of orchiectomy, chemotherapy, or testicular radiation, were excluded. Serum testosterone was measured from morning samples using chemiluminescent immunoassay, and biochemical hypogonadism was defined as total testosterone <2.5 ng/mL. Age-related trends were examined using ANOVA, and multivariable linear regression identified associations with metabolic variables.</p><p><strong>Results: </strong>The mean testosterone level was 4.8±1.8 ng/mL, showing a significant linear decline of approximately 0.021 ng/mL per year (p<0.001). The prevalence of biochemical hypogonadism increased from 5.5% (40-49 years) to 11.6% (≥70 years). In multivariable analysis, higher BMI, fasting glucose, and triglyceride levels were independently associated with lower testosterone, while PSA, high-density lipoprotein, and low-density lipoprotein were not significant.</p><p><strong>Conclusions: </strong>This large nationwide study demonstrates a negative association between serum testosterone levels and age among Korean men. Obesity, hyperglycemia, and hypertriglyceridemia were additional contributors to reduced testosterone levels. Regular hormonal assessment and metabolic risk management are recommended for early detection and prevention of testosterone deficiency. Longitudinal studies are needed to clarify causal pathways and long-term outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Gap in Erectile Dysfunction Evaluation: Practical Insights for the Frontline Urologist.","authors":"Widi Atmoko, Edoardo Pescatori, Germar-Michael Pinggera, Eric Chung, Akira Tsujimura, Tuncay Toprak, Mohamed Arafa, Taras Shatylko, Marco Falcone, Manaf Al Hashimi, Baris Altay, Ahmed El-Sakka, Omer Raheem, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250340","DOIUrl":"https://doi.org/10.5534/wjmh.250340","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Sex/Gender-Specific Medicine Matters in Men's Health Research: An Editorial Call to Action.","authors":"Hyun Jun Park","doi":"10.5534/wjmh.260142","DOIUrl":"https://doi.org/10.5534/wjmh.260142","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Driven Semen Analysis: Transforming Semen Analysis for Male Infertility Diagnostics.","authors":"Ashok Agarwal, Stanislava Mincheva, Ayad Palani, Quang Nguyen, Tan V Le, Walter D Cardona Maya, Rossella Cannarella, Mohammed Abdulgabbar Noman","doi":"10.5534/wjmh.250400","DOIUrl":"https://doi.org/10.5534/wjmh.250400","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection of Biochemical Recurrence in Prostate Cancer Patients with PSA Levels ≤0.5 ng/mL; Comparison Study between [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 PET/CT.","authors":"Sangwoo Cho, Hyo Jung Seo, Sungun Bang, Sangwon Lee, Kang Su Cho, Seunghwan Lee, Mijin Yun","doi":"10.5534/wjmh.250330","DOIUrl":"https://doi.org/10.5534/wjmh.250330","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared the correct detection rates (CDR) of [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) in patients with prostate-specific antigen (PSA) ≤0.5 ng/mL after radical prostatectomy.</p><p><strong>Materials and methods: </strong>This retrospective study included 88 patients who underwent [¹⁸F]PSMA-1007 (n=41) or [⁶⁸Ga]Ga-PSMA-11 PET/CT (n=47) for PSA ≤0.5 ng/mL after radical prostatectomy. Patients were stratified into ultra-low biochemical recurrence (u-BCR, <0.2 ng/mL) and early BCR (e-BCR, 0.2-0.5 ng/mL) groups. CDRs, defined as the proportion of patients with true positive findings for each imaging modality, and positive predictive values (PPVs) were compared between radiotracers.</p><p><strong>Results: </strong>The overall CDR of [¹⁸F]PSMA-1007 was significantly higher than [⁶⁸Ga]Ga-PSMA-11 (70.7% <i>vs.</i> 23.4%, p<0.001) in both u-BCR (60.0% [9/15] <i>vs.</i> 19.0% [4/21], p=0.017) and e-BCR groups (76.9% [20/26] <i>vs.</i> 26.9% [7/26], p<0.001). Local recurrence was more frequently detected with [¹⁸F]PSMA-1007, particularly in the e-BCR group (46.2% <i>vs.</i> 3.8%, p<0.001), while lymph node (LN) and distant metastases detection was comparable. In the u-BCR group, the recurrence sites identified by [¹⁸F]PSMA-1007 included local (n=3), LN (n=3), bone (n=2), and local plus LN (n=1), whereas [⁶⁸Ga]Ga-PSMA-11 identified local (n=1), LN (n=1), bone (n=1), and lung (n=1). In [¹⁸F]PSMA-1007, CDR was higher in high/very high-risk than in low/intermediate-risk patients in the u-BCR group (p=0.011). No such difference was observed with [⁶⁸Ga]Ga-PSMA-11. PPVs did not differ significantly between radiotracers (p=0.333).</p><p><strong>Conclusions: </strong>[¹⁸F]PSMA-1007 PET/CT showed higher CDR than [⁶⁸Ga]Ga-PSMA-11 PET/CT in patients at PSA ≤0.5 ng/mL after radical prostatectomy. Given the high detection performance, these findings support consideration of [¹⁸F]PSMA-1007 PET/CT for detection at PSA ≤0.5 ng/mL, particularly for prostate bed assessment in high/very high-risk patients.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Pharmacological Therapies for Erectile Dysfunction: What is New, What Works, What is Next.","authors":"Maged Ragab, Germar-Michael Pinggera, Aleksei Ryzhkov, Rupin Shah, Selahittin Çayan, Ashok Agarwal","doi":"10.5534/wjmh.250337","DOIUrl":"https://doi.org/10.5534/wjmh.250337","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Male Infertility Care: Emerging Technologies and Future Clinical Directions.","authors":"Taras Shatylko, Sezgin Gunes, Selahittin Çayan, Mohamed Arafa, Salıma Daoud, Germar-Michael Pinggera, Marjan Sabbaghian, Ateş Kadıoğlu, Ashok Agarwal","doi":"10.5534/wjmh.250412","DOIUrl":"https://doi.org/10.5534/wjmh.250412","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intraoperative Doppler Ultrasound on Outcomes of Microsurgical Subinguinal Varicocelectomy: A Systematic Review and Meta-Analysis.","authors":"Aleksei Ryzhkov, Selahittin Çayan, Barış Altay, Hiva Alipour, Svetlana Sokolova, Ahmed Harraz, Germar-Michael Pinggera, Erman Ceyhan, Mohammed Abdulgabbar Noman, Cevahir Ozer, Jean de la Rosette, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250398","DOIUrl":"https://doi.org/10.5534/wjmh.250398","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of intraoperative Doppler ultrasound (IDU) during microsurgical subinguinal varicocelectomy (MSV) on surgical outcomes, complication rates, and reproductive parameters.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA and MOOSE guidelines (PROSPERO: CRD420250656066). A comprehensive literature search was performed in PubMed and Scopus up to December 2024. Studies enrolling men with varicocele (Population) who underwent MSV with IDU (Intervention) were compared with those who underwent MSV without IDU (Comparison). Primary outcomes included fertility outcomes (pregnancy rates, sperm parameters), pain resolution, and postoperative complications (recurrence, hydrocele, testicular atrophy). Secondary outcomes included operative time, number of preserved arteries, ligated veins, and preserved lymphatic vessels. Statistical analyses used fixed- or random-effects models depending on heterogeneity.</p><p><strong>Results: </strong>Seven studies involving 1,044 patients were included. While no differences were found in sperm concentration or morphology, progressive sperm motility improved significantly with (mean difference [MD] 12.10%; 95% confidence interval [CI] 3.47 to 20.72; p=0.006). Pregnancy rates were similar between groups. Two studies assessed postoperative pain; both showed improvement, with one reporting higher complete pain resolution using Doppler, but heterogeneity prevented meta-analysis. No significant difference was observed in varicocele recurrence, hydrocele formation, or testicular atrophy. Intraoperative Doppler significantly reduced operative time in unilateral varicocelectomy (MD -5.90 minutes; 95% CI -9.78 to -2.02; p=0.003) but not in bilateral cases. IDU improved arterial preservation (MD 0.44 arteries per patient; 95% CI 0.32 to 0.57; p<0.0001) and led to more veins being ligated (MD 1.06 veins; 95% CI 0.80 to 1.33; p<0.0001).</p><p><strong>Conclusions: </strong>IDU enhances surgical precision by improving arterial identification and vein ligation, while reducing operative time in unilateral varicocelectomy. It significantly enhances sperm motility but shows no effect on pregnancy or complication rates.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superoxide Dismutase-Rich <i>Tetraselmis chuii</i> Supplementation Improves Semen Quality in Idiopathic Infertile Males: A Double-Blind Randomized Placebo-Controlled Trial.","authors":"Marina Leiva, Judit Castillo, Di Wang, Marta Guimerà, Raquel Ferreti, Alicia Diez, Laura Noguera, Lalia Mantecón, Dolors Manau, Rafael Oliva, Carlos Infante, Carlos Unamunzaga, Eva González, Juan Manuel Corral, Meritxell Jodar","doi":"10.5534/wjmh.250385","DOIUrl":"https://doi.org/10.5534/wjmh.250385","url":null,"abstract":"<p><strong>Purpose: </strong>Male infertility is a growing but poorly understood condition, largely evaluated through sperm parameters. Oxidative stress plays a crucial role in idiopathic cases, with 30%-80% of patients showing elevated reactive oxygen species levels in seminal plasma. Antioxidants are increasingly used in reproductive medicine, but their effectiveness may be limited by the lack of prior assessment in patients. This study aimed to evaluate the efficacy of a <i>Tetraselmis chuii</i>-derived ingredient, with a high superoxide dismutase (SOD) activity (TSOD), in improving sperm quality parameters, including sperm DNA fragmentation (SDF), and static oxidation-reduction potential (sORP).</p><p><strong>Materials and methods: </strong>In this randomized, double-blind, placebo-controlled clinical study, a total of 80 males with idiopathic infertility were recruited and randomly assigned to receive either TSOD (n=40) or placebo (n=40) at 250 mg/d for three months. Blood and semen samples were collected at baseline and post-treatment to assess hormonal profiles, semen parameters, SDF, and sORP. Additionally, socio-demographic data and reproductive outcomes were recorded.</p><p><strong>Results: </strong>After three months of supplementation, the TSOD group exhibited a significant increase in serum levels of luteinizing and follicle-stimulating hormone, resulting in improved sperm concentration and progressive motility. A significant reduction in both total and double-strand SDF was also observed exclusively in the TSOD group, particularly among males with initially pathological sORP values. Following a 3-month wash-out period, seminal parameters tended to return toward baseline values, while serum hormonal levels and SDF remained relatively stable. Notably, the improvements in semen quality were translated into superior reproductive outcomes, as the TSOD group achieved significantly higher live birth rates compared to the control group.</p><p><strong>Conclusions: </strong>TSOD supplementation demonstrates clinical efficacy in improving sperm quality parameters and reproductive outcomes in males with oxidative stress-related idiopathic infertility. However, its use should be preceded by redox status assessment to identify patients most likely to benefit.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}