World Journal of Mens Health最新文献

{"title":"Impact of Varicocele on Pregnancy and Live Birth Outcomes in Men with Clinical Varicocele: Systematic Review of Controlled Studies.","authors":"Rossella Cannarella, Selahittin Çayan, Carlo Giulioni, Gokhan Çeker, Keerti Singh, Kareim Khalafalla, Amarnath Rambhatla, Raisa Galstyan, Shalaka Ramgir-Naidu, Logan Hubbard, Iman Shamohammadi, Kavindra Kumar Kesari, Faiza Rao, Archana Subarmaniuan, Vijay Kumar, Donny E Putra, Dharani Moorthv, Ayad Palani, Murat Dursun, Edoardo Pescatori, Ramadan Saleh, Taras Shatylko, Widi Atmoko, Armand Zini, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250023","DOIUrl":"https://doi.org/10.5534/wjmh.250023","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of varicocele on pregnancy and live birth outcomes in men with clinical varicocele in controlled studies.</p><p><strong>Materials and methods: </strong>A comprehensive literature search was conducted across the PubMed and Scopus databases using Boolean operators, covering all available records from each database's inception through June 30, 2024. The inclusion criteria focused on controlled studies that compared pregnancy-related outcomes-including pregnancy, miscarriage, and live birth rates-between men with clinical varicocele and those without. These studies included participants attempting conception either spontaneously or through assisted reproductive techniques.</p><p><strong>Results: </strong>Out of 3,532 articles screened, only two controlled studies met the inclusion criteria. The findings revealed no significant differences between men with and without varicocele in terms of time to achieve pregnancy (5.3 <i>vs.</i> 5.4 months, respectively; p=0.92) or the proportion of men who had previously conceived with their partner (58.9% vs. 63.4%, respectively; p=0.47). However, a significant difference was observed in live birth rates, with men with varicocele showing a lower rate than those without (71.2% <i>vs.</i> 76.4%; p=0.04).</p><p><strong>Conclusions: </strong>The relationship between varicocele and conception remains contentious, primarily due to the limited number of controlled studies available for analysis. Despite an extensive systematic search for controlled studies comparing pregnancy-related outcomes in men with and without clinical varicocele, only two studies met the inclusion criteria. These studies showed no significant differences in time to achieve pregnancy or previous conception rates between the two groups. However, men with varicocele exhibited a slightly lower, statistically significant, live birth rate compared to men without varicocele. This highlights the need for further research on this topic to provide evidence-based guidance on the impact of varicocele on fertility outcomes.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merit-based Academic Certification in Andrology: A Groundbreaking Initiative by the Global Andrology Forum.","authors":"Giovanni Colpi, Germar-Michael Pinggera, Aldo Calogero, Eric Chung, Rossella Cannarella, Taymour Mostafa, Ramadan Saleh, Ryan Smith, Ahmed El-Sakka, Selahittin Çayan, Omer Raheem, Haocheng Lin, Rajender Singh, Ates Kadioglu, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250038","DOIUrl":"https://doi.org/10.5534/wjmh.250038","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus.","authors":"Taha Hamoda, Rupin Shah, Taymour Mostafa, Germar-Michael Pinggera, Widi Atmoko, Amarnath Rambhatla, Manaf Al Hashimi, Selahittin Çayan, Giovanni Maria Colpi, Hiva Alipour, Edmund Ko, Armand Zini, Fotios Dimitriadis, Ayman Rashed, Hyun Jun Park, Ramadan Saleh, Tuncay Toprak, Aleksei Ryzhkov, Ateş Kadıoğlu, Hussein Kandil, Arif Kalkanli, Ahmed I El-Sakka, Gokhan Calik, Marco Falcone, Haitham Elbardisi, Mohamed Arafa, Christopher Chee Kong Ho, Marlon Pedrozo Martinez, Saleh Binsaleh, Ahmad Tarek Motawi, Nazim Gherabi, Akira Tsujimura, Hisanori Taniguchi, Raghavender Kosgi, Aldo E Calogero, Taras Shatylko, Dongsuk Kim, Charalampos Thomas, Nicholas N Tadros, Sotiris Andreadakis, Muhammad Ujudud Musa, Charalampos Konstantinidis, Mirko Preto, Tan V Le, Kareim Mohamed Khalafalla, Rossella Cannarella, Kasonde Bowa, Balasingam Balagobi, Darren Jonathan Katz, Quang Nguyen, Raman Tanwar, Edson Borges Junior, Ashok Agarwal","doi":"10.5534/wjmh.250037","DOIUrl":"https://doi.org/10.5534/wjmh.250037","url":null,"abstract":"<p><strong>Purpose: </strong>Non-obstructive azoospermia (NOA), defined as the absence of sperm in the ejaculate due to testicular failure, is observed in 5% to 15% of infertile men and accounts for two-thirds of azoospermia cases. The management of NOA is marked by significant controversy and global variation in diagnostic and therapeutic approaches, highlighting the crucial need for well-designed and standardized clinical practice guidelines. We present comprehensive graded clinical practice recommendations and statements for diagnosing and treating NOA, aiming to establish standardized strategies that can globally help guide practitioners in their practice.</p><p><strong>Materials and methods: </strong>A comprehensive literature review was conducted to gather evidence on the epidemiological, diagnostic, and therapeutic aspects of NOA. The Global Andrology Forum (GAF) recommendations were developed through the collaboration of a global panel of experts using the Delphi method and surveys to achieve consensus. Statements were graded according to the Oxford Centre for Evidence-Based Medicine \"GRADE\" classification as either \"Strong\" or \"Weak.\" Statements receiving at least 80% expert consensus were graded as \"Strong,\" while others were categorized as \"Weak.\"</p><p><strong>Results: </strong>The GAF has formulated a total of 49 recommendations and statements on the diagnosis and treatment of NOA, including 21 for diagnosis and 28 for treatment. The recommendations and statements were evaluated and graded by a panel of 48 GAF experts from 25 countries worldwide. The majority of experts (60.5%) had more than 10 years of clinical experience in managing NOA.</p><p><strong>Conclusions: </strong>The GAF guidelines address discrepancies in NOA management across diverse clinical settings and provide comprehensive graded recommendations to guide clinicians in its diagnosis and treatment. Developed and graded by a large worldwide panel of experts, the current guidelines present simplified, high-standard strategies that can be seamlessly integrated into the daily global practice, offering practitioners a clear framework for managing NOA.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Quality and Readability of Information Related to Varicocele Obtained from ChatGPT 4.0 Remain Consistent Across Different Models of Inquiry?","authors":"Zhao Luo, Sung Chul Kam, Ji Yong Kim, Wenhao Hu, Chuan Lin, Hyun Jun Park, Yu Seob Shin","doi":"10.5534/wjmh.240331","DOIUrl":"https://doi.org/10.5534/wjmh.240331","url":null,"abstract":"<p><strong>Purpose: </strong>There is a growing tendency of individuals resorting to Chat-Generative Pretrained Transformer (ChatGPT) as a source of medical information on specific ailments. Varicocele is a prevalent condition affecting the male reproductive system. The quality, readability, and consistency of the information related to varicocele that individuals obtain through interactive access to ChatGPT remains uncertain.</p><p><strong>Materials and methods: </strong>This study employed Google Trends data to extract 25 trending questions since 2004. Two distinct inquiry methodologies were employed with ChatGPT 4.0: repetition mode (each question repeated three times) and cyclic mode (each question input once in three consecutive cycles). The generated texts were evaluated according to a number of criteria, including the Automated Readability Index (ARI), the Flesch Reading Ease Score (FRES), the Gunning Fog Index (GFI), the DISCERN score and the Ensuring Quality Information for Patients (EQIP). Kruskal-Wallis and Mann-Whitney U tests were employed to compare the text quality, readability, and consistency between the two modes.</p><p><strong>Results: </strong>The results demonstrated that the texts generated in repetition and cyclic modes exhibited no statistically significant differences in ARI (12.06±1.29 <i>vs.</i> 12.27±1.74), FRES (36.08±8.70 <i>vs.</i> 36.87±7.73), GFI (13.14±1.81 <i>vs.</i> 13.25±1.50), DISCERN scores (38.08±6.55 <i>vs.</i> 38.35±6.50) and EQIP (47.92±6.84 <i>vs.</i> 48.35±5.56) (p>0.05). These findings indicate that ChatGPT 4.0 consistently produces information of comparable complexity and quality across different inquiry modes.</p><p><strong>Conclusions: </strong>This study found that ChatGPT-generated medical information on \"varicocele\" demonstrates consistent quality and readability across different modes, highlighting its potential for stable healthcare information provision. However, the content's complexity poses challenges for general readers, and notable limitations in quality and reliability highlight the need for improved accuracy, credibility, and readability in AI-generated medical content.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Analysis Combined with Mendelian Randomization Identifies Genes Associated with Prostate Cancer Cells.","authors":"Weizhuo Wang, Kaiyu Lu, Xi Zhang, Kai Wei, Gang Cheng, Zheng Tang, Mingwei Zhan, Caibin Fan, Xu Fu","doi":"10.5534/wjmh.240298","DOIUrl":"https://doi.org/10.5534/wjmh.240298","url":null,"abstract":"<p><strong>Purpose: </strong>Prostate cancer is the second most common male cancer, with incidence increasing with age. When prostate cancer extends beyond the prostatic capsule, treatment options and prognosis change significantly. This study aims to investigate prognostic genes related to capsular invasion in prostate cancer by integrating single-cell data with Mendelian randomization (MR) analysis.</p><p><strong>Materials and methods: </strong>Single-cell sequencing data from six prostate cancer cases were obtained from the Gene Expression Omnibus (GEO) database. Cell clustering and annotation were performed using R, and high-dimensional weighted gene co-expression network analysis (hdWGCNA) identified differentially expressed genes in advanced-stage cancer. Single nucleotide polymorphism loci corresponding to these genes were retrieved from the UK Biobank (UKB), and MR exposure data were acquired from the ukb-b-13348 dataset. MR analysis assessed the impact of hdWGCNA-identified genes. Clinical and gene expression data from TCGA and GEO were analyzed using univariate Cox regression to evaluate gene effects on prognosis. Cellular functional experiments and immunohistochemistry assessed gene expression and function in prostate cancer.</p><p><strong>Results: </strong>We employed the Seurat package for quality control and integration of single-cell data from four patients. hdWGCNA identified three modules, from which 200 genes were selected. The combined analysis of eQTL and MR revealed that <i>TMEM59</i>, <i>JUNB</i>, <i>NECTIN2</i>, <i>OSBPL10</i>, <i>ATF3</i>, and <i>WLS</i> may have relevant associations with prostate cancer. Further investigation using TCGA and GEO data suggested that <i>TMEM59</i> might act as a protective factor in prostate cancer. Cellular experiments confirmed that <i>TMEM59</i> knockdown enhanced the proliferation and invasion capabilities of prostate cancer cells. Immunohistochemistry demonstrated a significant decrease in <i>TMEM59</i> expression in both normal and tumor tissues, particularly in the tumor group.</p><p><strong>Conclusions: </strong>These findings suggest that <i>TMEM59</i> may play a crucial role in the progression of prostate cancer and could serve as a prognostic predictor and therapeutic target for the disease.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Scientometric Landscape of Andrology: Trends, Gaps, and Future Directions in Male Reproductive Health: A Scoping Review.","authors":"Asli Metin Mahmutoglu, Ashok Agarwal, Hiva Alipour, Germar-Michael Pinggera, Kareim Khalafalla, Bahadir Sahin, Edoardo Pescatori, Fahimeh Piryaei, Manaf Al Hashimi, Rupin Shah","doi":"10.5534/wjmh.250006","DOIUrl":"https://doi.org/10.5534/wjmh.250006","url":null,"abstract":"<p><strong>Purpose: </strong>This scoping review examines the extent and focus of scientometric studies on male infertility and male sexual dysfunctions (MSDs) while assessing gaps in the current research. It highlights contributions from leading countries, institutions, and authors and identifies important emerging areas of research in male infertility and MSDs.</p><p><strong>Materials and methods: </strong>A literature search was performed using Web of Science Core Collection (WoSCC), Scopus, and PubMed following the methodological framework of a scoping review. Bibliometric/scientometric studies on male infertility and sexual dysfunctions were included in this review.</p><p><strong>Results: </strong>A total of 2,525 articles were assessed for eligibility, with 36 studies included in this review. Through a detailed analysis of the articles, this study identifies significant contributions from countries such as the USA, China, and Italy, with leading institutions and authors playing a crucial role in advancing research on oxidative stress (OS), sperm DNA fragmentation (SDF), varicocele, and assisted reproductive technologies. Notably, OS and SDF have emerged as critical areas influencing both infertility diagnosis and treatment outcomes, while varicocele research remains centered on surgical interventions and their reproductive implications. In the domain of MSDs, erectile dysfunction (ED), especially diabetes-related ED, has seen a surge in research attention, with innovative treatments showing promise for future clinical applications. Despite progress in these areas, the review identifies significant gaps in research on premature ejaculation, Peyronie's disease, and other MSDs.</p><p><strong>Conclusions: </strong>This review underscores the value of scientometric analysis in andrology, providing a comprehensive overview of current research trends, key contributors, and emerging areas in male infertility and sexual dysfunctions. While significant advancements have been made in several key areas of male infertility and ED, notable gaps remain in underexplored MSDs conditions. By identifying these gaps and regional contributions, this analysis serves as a foundation for guiding future research efforts. Utilizing scientometric insights can foster innovation, improve treatment strategies, and propel advancements in male reproductive and sexual health research.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum (GAF) Clinical Guidelines on the Management of Infertile Men with Varicocele.","authors":"Selahittin Çayan, Germar-M Pinggera, Widi Atmoko, Taha Hamoda, Rupin Shah, Armand Zini, Eric Chung, Giovanni Maria Colpi, Amarnath Rambhatla, Hiva Alipour, Edmund Y Ko, Nicholas Tadros, Parviz Kavoussi, Manaf Al Hashimi, Taymour Mostafa, Hyun Jun Park, Mikkel Fode, Christopher Chee Kong Ho, Edoardo Pescatori, Ahmed El-Sakka, Mohamed Arafa, Ayman Rashed, Marco Falcone, Gokhan Calik, Aleksei Igorevich Ryzhkov, Tan V Le, Giorgio Ivan Russo, Tuncay Toprak, Fotios Dimitriadis, Shingai Bertrand Angelo Mutambirwa, Muhammad Ujudud Musa, Iman Shamohammadi, Hussein Kandil, Murat Gül, Haitham Elbardisi, Ahmad Tarek Motawi, Sava Micic, Murat Dursun, Taras Shatylko, Coskun Kaya, Ryan Patrick Smith, Nasser Mogharabian, Kareim Khalafalla, Mustafa Kadihasanoglu, Raghavender Kosgi, Osvaldo Rajmil, Yassir Jassim Mohammed, Ashok Agarwal","doi":"10.5534/wjmh.250004","DOIUrl":"https://doi.org/10.5534/wjmh.250004","url":null,"abstract":"<p><strong>Purpose: </strong>Varicocele is among the most common reversible causes of male infertility. Although varicocele is prevalent and there is a growing body of literature on the subject, there are still numerous debates surrounding the matter. This study presents Global Andrology Forum (GAF) clinical guidelines on the management of infertile men with varicocele.</p><p><strong>Materials and methods: </strong>A team of clinicians and reproductive experts reviewed contemporary evidence on all aspects of varicocele, including systematic reviews, meta-analyses, and the results of the GAF global survey of practices. They then formulated expert statements and recommendations, subject to a modified Delphi process until a consensus was reached. The final statements and recommendations were rated using the GRADE system.</p><p><strong>Results: </strong>A total of 31 statements and recommendations on the evaluation and management of varicocele were introduced and scored by 24 experts. All experts agreed with the final statements. Varicocele is a significant contributor to male infertility. Its diagnosis is based mainly on physical examination, although imaging can be used in certain cases. Clinical varicocele associated with abnormal sperm parameters is the primary unanimous indication of varicocele repair. However, other indications can still be considered, and recommendations for a tailored approach to controversial situations have been presented. There is inadequate evidence on the use of medical therapy for varicocele.</p><p><strong>Conclusions: </strong>These clinical guidelines on the management of infertile men with varicocele, based on the GAF surveys, systematic reviews, and meta-analyses, point out the pivotal importance of varicocele in modern Andrology. Continued research is crucial to improving diagnostic accuracy and treatment outcomes, ultimately enhancing reproductive health for men with varicocele. Therefore, the current guidelines allow clinicians to develop effective management strategies for a common issue and address practical questions where evidence is lacking.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Reproductive Medicine.","authors":"Selahittin Çayan, Ala'a Farkouh, Ashok Agarwal, Widi Atmoko, Christine Wyns, Mohamed Arafa, Armand Zini, Rupin Shah, Hiva Alipour, Eric Chung, Ramadan Saleh, Germar-Michael Pinggera, Charalampos Konstantinidis, Manaf Al Hashimi, Edoardo Pescatori, Amarnath Rambhatla, Tuncay Toprak, Aldo E Calogero, Murat Gül, Hyun Jun Park, Baris Altay, Marco Falcone, Ayman Rashed, Tan V Le, Fahmi Bahar, Taras Shatylko, Sadık Görür, Ahmed I El-Sakka, Barış Saylam, Selcuk Sarikaya, Ryan Patrick Smith, Luca Boeri, Ozan Efesoy, Erman Ceyhan, Giorgio Ivan Russo, Cevahir Ozer, Christopher Chee Kong Ho, Nur Dokuzeylul Gungor, Deniz Noyan Özlü, Juan Manuel Corral Molina, Muhammad Ujudud Musa, Akira Tsujimura, Fatih Gokalp, Mohamed Saeed Mohamed, Keisuke Okada, Kareim Khalafalla, Shinnosuke Kuroda, Saleh Binsaleh, Ahmad Tarek Motawi, Iman Shamohammadi, Nasser Mogharabian, Manh Truong Manh, Emad Abdelraheem Taha, Konstantinos Makarounis, Siu King Mak, Shedeed Ashour Shedeed, Charalampos Thomas, Taymour Mostafa","doi":"10.5534/wjmh.250005","DOIUrl":"https://doi.org/10.5534/wjmh.250005","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the evidence on sperm DNA fragmentation (SDF) and its clinical applications in reproductive medicine, highlighting benefits, limitations, and guidelines for its use to assist clinicians in objective decision-making.</p><p><strong>Materials and methods: </strong>A multidisciplinary team of clinicians and reproductive experts from the Global Andrology Forum (GAF) reviewed the latest evidence on SDF, covering indications, testing methods, recurrent pregnancy loss, varicocele and its repair, assisted reproductive technologies (ART), treatment of associated conditions, antioxidant therapy, and sperm selection for ART. Expert statements and recommendations were developed and graded with the GRADE system using a modified Delphi process.</p><p><strong>Results: </strong>Based on the GAF surveys, systematic reviews, and meta-analyses related to SDF, 52 experts introduced and scored 24 statements and recommendations using the GRADE system. Of these, 87.5% (21/24) achieved strong ratings, reflecting broad consensus, while 12.5% (3/24) were rated weak. The guidelines provide evidence-based recommendations for clinical scenarios, including the role of SDF in infertility, recurrent pregnancy loss, and ART outcomes.</p><p><strong>Conclusions: </strong>While there is growing interest and evidence regarding the clinical benefit of SDF testing and its utility in managing male infertility, significant gaps in the literature limit its routine use in clinical practice. The guidelines offer a structured framework for integrating SDF testing into male infertility management, emphasizing a tailored approach based on individual clinical scenarios. Clinicians must balance the benefits and limitations of SDF testing and antioxidant treatment to optimize care in reproductive medicine. These guidelines are critical for advancing evidence-based practices in male infertility management.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.","authors":"Amir Masoud Firouzabadi, Ralf Henkel, Maryam Tofighi Niaki, Farzaneh Fesahat","doi":"10.5534/wjmh.240072","DOIUrl":"10.5534/wjmh.240072","url":null,"abstract":"<p><p>The effects of smoking on human health have long been documented. However, only a few studies have highlighted the direct effects of nicotine on sperm function. Nicotine, as a chemical compound found in tobacco, has been shown to modulate different aspects of spermatogenesis and sperm functions. Nicotine can lead to a reduction in the number of sperm, their motility and functionality. It can change the molecular expressions involved in sperm function, including genes encoding sperm nuclear proteins. The most important nuclear proteins that play a critical role in sperm function are known as H2B histone family, member W, testis-specific (H2BFWT), transition protein 1 (TNP1), transition protein 2 (TNP2), protamine-1 (PRM1), and protamine-2 (PRM2). These proteins are involved in sperm chromatin condensation, which in turn affects fertilization and embryonic development. Any alteration in the expression of these genes due to nicotine exposure/usage may lead to adverse implications in couples' fertility and the health of future generations. Since research in this area is still relatively new, it underscores the importance of understanding the potential side effects of environmental factors such as nicotine on reproductive health.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"291-303"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Dermal Filler is Better for Penile Augmentation for Aesthetic Purposes? A Prospective, Single-Surgeon Study Based on Real-World Experience.","authors":"Doo Won Kim, Hyun Cheol Jeong, Kyungtae Ko, Dae Yul Yang, Jong Keun Kim, Seong Ho Lee, Tae Hyo Kim, Won Ki Lee","doi":"10.5534/wjmh.240105","DOIUrl":"10.5534/wjmh.240105","url":null,"abstract":"<p><strong>Purpose: </strong>Several types of dermal fillers have been recently introduced and used for penile augmentation (PA). However, few studies have compared outcomes after the injection of different fillers. This study aimed to compare the clinical outcomes of hyaluronic acid (HLA), polylactic acid (PLA), and polymethyl methacrylate (PMA) filler injections, which are the most commonly used for aesthetic purposes.</p><p><strong>Materials and methods: </strong>This prospective study was conducted for 24 weeks after a filler injection by a surgeon between March 2017 and December 2021. Healthy adult men complaining of small penis were enrolled. Penile girth, satisfaction, and injection-associated adverse events (AEs) were assessed at baseline and 4, 12, and 24 weeks after injection.</p><p><strong>Results: </strong>Of the 301 men who received filler injections, 125, 134, and 42 received HLA, PLA, and PMA fillers, respectively. The augmentation effect was in the order of PMA, HLA, and PLA, respectively, at 24 weeks (PMA <i>vs.</i> HLA, p<0.001; HLA <i>vs.</i> PLA, p=0.006). Satisfaction levels increased significantly at 24 weeks in all groups (each with p<0.001). However, the increase in satisfaction levels was smaller in the PMA group (PMA <i>vs.</i> HLA or PLA, p<0.05, for both penile appearance and sexual life). No serious or systemic AEs were recorded. Filler injection-associated local AEs in the HLA, PLA, and PMA groups occurred in 9 (7.2%), 16 (11.9%), and 6 (14.3%) men, respectively. There was no significant difference in AEs among the groups (p=0.299).</p><p><strong>Conclusions: </strong>The augmentative effect was greater in the PMA group than in the HLA and PLA groups, whereas the increase in satisfaction levels was smaller in the PMA group. Our study demonstrated the clinical course of different types of fillers and suggests that the filler type should be selected after detailed counseling considering individual characteristics and preferences.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"428-436"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}