World Journal of Mens Health最新文献

{"title":"Development of a Training Program for Meta-Analytical Research: A Novel Approach to Minimizing Errors in Medical Systematic Reviews and Meta-Analyses.","authors":"Ayad Palani, Hiva Alipour, Ashok Agarwal, Andrea Crafa, Ramadan Saleh, Bahadır Şahin, Wael Zohdy, Damayanthi Durairajanayagam, Fotios Dimitriadis, Erman Ceyhan, Rossella Cannarella, Tuncay Toprak, Widi Atmoko, Marco Falcone, Naveen Kumar, Giorgio Ivan Russo, Trang Nguyen, Gokhan Calik, Deniz Kulaksiz, Konstantinos Makarounis, Kadir Böcü, Fikri Rizaldi, Ricky Adriansjah, Hakan Keskin, Vineet Malhotra, Nguyen Phuoc, Sezgin Gunes, Carlo Giulioni, Ahmad Motawi, Germar-M Pinggera, Imad Ziouziou, Gökhan Çeker, Christopher Ho, Fereshteh Dardmeh, Fahmi Bahar, Nazim Gherabi, Parisa Dolati, Priyank Kothari, Aram Adamyan, Rupin Shah","doi":"10.5534/wjmh.250008","DOIUrl":"https://doi.org/10.5534/wjmh.250008","url":null,"abstract":"<p><strong>Purpose: </strong>The Global Andrology Forum (GAF) has developed an innovative training method to equip novice researchers with the fundamental skills to conduct high-quality systematic reviews and meta-analyses (SRMAs) under the supervision of senior experts. This article aims to describe and evaluate the effectiveness of the GAF training program in enhancing these skills.</p><p><strong>Materials and methods: </strong>A six-module training program was designed to cover the key steps in SRMA studies, enabling GAF members to conduct high-quality SRMAs. Initially launched as a synchronous (remote) training program, it was later transitioned into an asynchronous format and implemented on the Moodle platform. Trainees participating in the synchronous training program were asked to evaluate the course using a specially designed questionnaire. Participants' assessments of the asynchronous course were collected at various stages. Data from both training models were statistically analyzed.</p><p><strong>Results: </strong>Among the trainees who participated in the questionnaire on the original synchronous course (n=101), the majority rated the material and assessments as clear, helpful, and effective in enhancing their knowledge. Additionally, the trainees indicated that the features offered in the training made them feel comfortable and engaged. Of the 29 participants enrolled in the asynchronous program, 22 took part in the assessment. Among them, 12 (54.5%) completed all course requirements, achieving an average score of 83.7%, qualifying them for conducting SRMAs.</p><p><strong>Conclusions: </strong>The GAF SRMA online training program has proven to be an effective and well-received initiative for equipping researchers with essential skills to conduct high-quality SRMAs. By addressing the diverse needs of trainees through its innovative and flexible design, the program has demonstrated its capacity to enhance knowledge and engagement. The successful implementation of this training program highlights its potential to significantly improve the quality of SRMAs in medical research, thereby contributing to the advancement of evidence-based medical practice on a broader scale.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Dynamic Online Nomogram Prediction Model for Assessing the Risk of Erectile Dysfunction.","authors":"Guodong Liu, Yuyang Zhang, Xu Wu, Hui Gao, Hui Jiang, Xiansheng Zhang","doi":"10.5534/wjmh.250018","DOIUrl":"https://doi.org/10.5534/wjmh.250018","url":null,"abstract":"<p><strong>Purpose: </strong>Erection dysfunction (ED) represents a globally prevalent men's health problem and affected by a variety of factors. This study aimed to develop a dynamic nomogram model to assess the probability of ED in a population through a multitude of factors.</p><p><strong>Materials and methods: </strong>A total of 2,668 subjects from the National Health and Nutrition Examination Survey were included in this study. The entire dataset was randomly divided into training and validation sets, with the training set comprising 70% of the data and the validation set comprising 30%. The Least Absolute Shrinkage and Selection Operator and multivariate logistic regression analysis determined the predictors for constructing the nomogram, and the model was evaluated by Concordance Index (C-index), calibration curve, Hosmer-Lemeshow test, and decision curve analysis.</p><p><strong>Results: </strong>The nomogram model consisted of 9 predictors, which were age, education, stroke, lymphocyte, diabetes, poverty income ratio, prostate disease, activity, and hypertension. The C-index for the training set was 0.828 and for the validation set was 0.825, indicating that the model shows good clinical applicability and calibration of the model on both the training and validation sets. Additionally, we created an online dynamic nomogram (https://wvknly-liu-guodong.shinyapps.io/dynnomapp/) that anyone can evaluate on a web page.</p><p><strong>Conclusions: </strong>Our dynamic nomogram can integrate multiple risk factors to provide a personalized risk assessment that is highly clinically predictive and provides a valuable tool for early intervention and prospective management of ED. This could help physicians to identify and manage high-risk populations early and provide personalized treatment plans.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Factors Associated with Premature Ejaculation in Japan: First Nationwide Cross-Sectional Survey by the Japanese Society for Sexual Medicine.","authors":"Masato Shirai, Akira Tsujimura, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Yoshikazu Sato, Atsushi Nagai, Koichi Nagao, Haruaki Sasaki","doi":"10.5534/wjmh.250094","DOIUrl":"https://doi.org/10.5534/wjmh.250094","url":null,"abstract":"<p><strong>Purpose: </strong>Premature ejaculation (PE) is a most common sexual complaint among men worldwide, but its prevalence and associated factors in Japan remain underexplored. This study aimed to determine the prevalence of self-reported PE, lifelong PE (LPE), and acquired PE (APE) among Japanese men, as well as to identify associated factors, distress levels, and healthcare-seeking behaviors through a nationwide cross-sectional survey.</p><p><strong>Materials and methods: </strong>This internet-based nationwide cross-sectional survey was conducted among Japanese men from 20 to 79 years old by the Clinical Research Promotion Committee of the Japanese Society for Sexual Medicine (JSSM). Data were collected using validated questionnaires, including the International Society for Sexual Medicine (ISSM) criteria for LPE and APE.</p><p><strong>Results: </strong>Of 37,485 invited participants, 6,228 provided valid responses (response rate: 16.61%), with 5,331 sexually active men included in the analysis. The prevalence of self-reported PE distress was 23.39%. ISSM-defined LPE and APE were observed in 0.54% and 3.47% of respondents, respectively. Univariate analysis identified erectile dysfunction (ED), psychotropic drug use, neurological diseases, trauma, aortic aneurysm surgery, and partnership dissatisfaction as significant associated factors for both LPE and APE. Multivariate analysis confirmed ED as the common associated factor. Despite 51.00% of respondents expressing a desire for treatment, only 4.81% had sought medical help.</p><p><strong>Conclusions: </strong>This study provides the first epidemiological insights into PE in Japan, revealing a notable prevalence and identifying ED as a key associated factor. Despite significant distress, most affected individuals do not seek medical help, highlighting the necessity for greater public awareness and better access to treatment options. Future research should focus on longitudinal assessments to explore causal relationships and evaluate potential interventions.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Adipose Stem Cells Engineered to Express Carboxylesterase Confer Anti-Tumoral Efficacy of Irinotecan in Castration-Resistant Prostate Cancer Bone Metastasis Growth and Osteolysis.","authors":"Da Hyun Yun, Jae Heon Kim, Sang Hun Lee, Eun Jung Lee, Serk In Park, Yun Seob Song","doi":"10.5534/wjmh.240284","DOIUrl":"https://doi.org/10.5534/wjmh.240284","url":null,"abstract":"<p><strong>Purpose: </strong>Castration-resistant prostate cancer (CRPC) presents a significant clinical challenge, particularly when it metastasizes to bone, leading to skeletal-related events such as osteolysis. Conventional therapies offer limited efficacy and high toxicity, highlighting the need for innovative treatments. This study investigates the use of human telomerase reverse transcriptase-immortalized adipose-derived stem cells engineered to express carboxylesterase (hTERT-ADSC.CE) to enhance the local activation and efficacy of irinotecan (CPT-11) in targeting CRPC.</p><p><strong>Materials and methods: </strong>hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells were generated by lentiviral transduction with two genes encoding carboxylesterase enzymes <i>CES1</i> or <i>CES2</i> (referred to as CE1 or CE2 in this manuscript), respectively. The migration of hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells toward prostate cancer cells was evaluated in a transwell migration assay. The cytotoxicity of irinotecan in combination with hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells on PC3 prostate cancer cells was assessed via MTT viability and apoptosis assays. An <i>in vivo</i> CRPC bone metastasis model in mice was used to examine the therapeutic effects of co-administered hTERT-ADSC.CE2 cells and CPT-11 on tumor growth and tumor-induced osteolysis.</p><p><strong>Results: </strong>hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells demonstrated selective migration toward PC3 cells and significantly enhanced the cytotoxic effects of CPT-11 on prostate cancer cells <i>in vitro</i>. <i>In vivo</i>, the combined treatment with hTERT-ADSC.CE2 and CPT-11 significantly reduced tumor growth and osteolytic activity in the bone metastasis model. Histological analysis confirmed increased apoptosis in tumor cells and reduced osteolysis, indicating effective local drug activation by hTERT-ADSC.CE1 and/or hTERT-ADSC.CE2.</p><p><strong>Conclusions: </strong>Our findings suggest that hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells combined with irinotecan offer a promising targeted therapy for CRPC, enhancing drug efficacy while minimizing systemic toxicity. This cell-based enzyme-prodrug therapy could address the limitations of current therapies, especially in bone metastatic CRPC, and warrants further investigation for clinical translation.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum Clinical Practice Guidelines: Because Male Reproductive Health Matters! Introducing a Novel Approach to Address Common Yet Controversial Aspects of Male Infertility.","authors":"Edoardo Pescatori, Rupin Shah, Germar-Michael Pinggera, Eric Chung, Selahittin Çayan, Widi Atmoko, Ramadan Saleh, Giovanni Colpi, Mohamed Arafa, Taha Hamoda, Manaf Al Hashimi, Taymour Mostafa, Amarnath Rambhatla, Jonathan Ramsay, Ashok Agarwal","doi":"10.5534/wjmh.250088","DOIUrl":"https://doi.org/10.5534/wjmh.250088","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Medical Traveling for Radical Prostatectomy in the Era of Robotic Surgery: A Nationwide Cohort Study in Korea.","authors":"Jinhyung Jeon, Jee Soo Ha, Hye Sun Lee, Soyoung Jeon, Jae Heon Kim, Kang Su Cho","doi":"10.5534/wjmh.250028","DOIUrl":"https://doi.org/10.5534/wjmh.250028","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the trends in medical travel for radical prostatectomy (RP) in Korea during the robotic surgery era over a 10-year period. Regional self-sufficiency rates (SSR) for RP were analyzed, and factors associated with medical travel were identified.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed nationwide claims data from 2009 to 2019. Among 161,385 men newly diagnosed with prostate cancer, 57,096 (35.4%) underwent RP, including 6,482 laparoscopic RP (LRP), 16,092 open RP (ORP), and 34,522 robot-assisted RP (RARP). The regional SSR was defined as the proportion of patients undergoing RP within the same region of diagnosis, whereas medical travel was defined as RP performed outside the region of diagnosis. Logistic regression analysis was used to identify the factors associated with medical travel, and SSR trends were assessed using chi-square trend analysis.</p><p><strong>Results: </strong>In 2009, 2,983 RPs (ORP: 1,163, LRP: 358, RARP: 1,462) were performed, increasing to 8,332 (ORP: 1,449, LRP: 670, RARP: 6,213) by 2019. The proportion of patients who underwent RARP increased from 49% to 75%. Nationwide SSR for overall RP showed a significant increasing trend (χ²_trend=73.413, p_trend<0.001). Non-Seoul regions exhibited a significant upward trend (χ²_trend=7.19, p_trend=0.007), whereas Seoul showed no significant trend (χ²_trend=1.905, p_trend=0.168). Non-Seoul SSR for RARP demonstrated the most pronounced growth (χ²_trend=156.085, p_trend<0.001). However, nationwide SSR for RARP showed no significant increasing trend (χ²_trend=1.888, p_trend=0.169). Younger age, lower Charlson comorbidity index score, non-Seoul residence, and preference for robotic surgery were associated with medical travel.</p><p><strong>Conclusions: </strong>The proportion of RARPs steadily increased with the expansion of robotic surgical systems for prostate cancer in Korea. Despite improvements in the SSR for RARP in non-Seoul regions, disparities remain, with Seoul being the primary location for robotic surgery.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Ginseng Berry Extract (SIRTBERRY™) in Treating Andropause Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Sun-Young Park, Yong Seong Lee, In Heo, Soon Chul Myung, Sang Jun Lee, Jin Wook Kim","doi":"10.5534/wjmh.240311","DOIUrl":"https://doi.org/10.5534/wjmh.240311","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy and safety of ginseng berry extract (GBE) (SIRTBERRY™) in treating andropause symptoms in aging men.</p><p><strong>Materials and methods: </strong>In this randomized, double-blind, placebo-controlled trial, 116 men with andropause symptoms were assigned to receive either 700 mg/day GBE or placebo for 8 weeks. The primary efficacy variables included changes in the aging male symptoms (AMS) scale and improvement rate as per the androgen deficiency in aging male (ADAM) questionnaire, from the baseline. Secondary efficacy measurements included changes in the total and free testosterone levels, serum lipid levels, International Index of Erectile Function (IIEF) scores, International Prostate Symptom Score (IPSS), and various hormonal and metabolic markers.</p><p><strong>Results: </strong>The GBE group exhibited significant improvements in AMS scores, ADAM improvement rates, and IIEF scores compared to the placebo group. Specifically, the GBE group showed a 70% improvement in ADAM scores versus a 47.83% improvement in the placebo group (p=0.0376), and a greater reduction in AMS scores (p=0.0205). Significant enhancements were observed in erectile function, with the IIEF scores improved more in the GBE group (p=0.0334), particularly in the erectile function domain (p=0.0290). No serious adverse event was reported, and the safety profile of GBE was found to be comparable to that of placebo.</p><p><strong>Conclusions: </strong>GBE significantly improved andropause symptoms, including sexual function, and demonstrated a favorable safety profile, suggesting its potential as a safe and effective alternative treatment for testosterone deficiency syndrome. Further research regarding its long-term benefits and applicability to broader populations is warranted.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Intake-Induced Aggravation of Chronic Prostatitis/Chronic Pelvic Pain Syndrome is Associated with Reduced Gut Microbiota-Driven Short-Chain Fatty Acid Propionate and Butyrate.","authors":"Chang Liu, Shaoyu Yue, Di Niu, Ligang Zhang, Jing Chen, Yang Chen, Yu Guan, Xiaoliang Hua, Xianguo Chen, Li Zhang, Hexi Du, Chaozhao Liang","doi":"10.5534/wjmh.240223","DOIUrl":"https://doi.org/10.5534/wjmh.240223","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic prostatitis (CP) is a common urological disease and about 8.4% to 13.5% of men suffer from prostatitis symptoms in China. This study was conducted to evaluate the effect of alcohol usage on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and the role of the gut microbiome in this course.</p><p><strong>Materials and methods: </strong>A total of 151 individuals were recruited when they were diagnosed with CP/CPPS. Eventually, 38 patients were enrolled and grouped into three groups: the CP/CPPS group, alcohol group, and quitter group. 16S ribosomal ribonucleic acid sequencing was used to investigate the fecal samples, and a liquid chromatograph-mass spectrometer was used to analyze untargeted metabolomics. Next, targeted identification of short-chain fatty acids was carried out. T helper 17 (Th17) cells and cytokines were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively. Furthermore, the associations among intestinal microbiota, short-chain fatty acids, and clinical symptoms were evaluated through correlation analysis.</p><p><strong>Results: </strong>Alcohol consumption results in different microbial composition in patients with CP. Higher symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the alcohol group. Notably, correlation analysis revealed that several gut microbes were correlated with propionate and butyrate contents and patient's symptoms. Contrarily, lower symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the quitter group.</p><p><strong>Conclusions: </strong>This study preliminarily explores the potential association between alcohol and CP/CPPS, in which short-chain fatty acid-producing gut flora may play a key role. This study may enhance the understanding of the effect of alcohol on CP/CPPS and provide a preliminary foundation for formulating prevention strategies. The main limitation of this study is the small sample size, and further large-scale plus in-depth research ought to be carried out in the future.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a New Diagnostic Tool (LUTS/BPH Score) for Male Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia.","authors":"Seong Uk Jeh, Chanho Park, Min Sung Choi, Chang Seok Kang, Dae Hyun Kim, Jae Hwi Choi, See Min Choi, Jeong Seok Hwa, Sung Won Kwon, Sae Cheol Kim, Dong Deuk Kwon, Tae Gyun Kwon, Myung Ki Kim, Sun Jin Kim, Young Gon Kim, Tae Hyung Kim, Yong Gil Na, Dong Soo Park, Hyun Jun Park, Rak Hee Seong, Sang Guk Yang, Gyeong Seop Lee, Dong Hyun Lee, Sang Eun Lee, Hyun Chul Jung, Jae Hung Jung, Hoon Choi, Yun Soo Lee, Jong Hyun Tae, Seung Il Jung, Sung Chul Kam, Chang Wan Kang, Jae Seog Hyun","doi":"10.5534/wjmh.240306","DOIUrl":"https://doi.org/10.5534/wjmh.240306","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a new diagnostic tool, the LUTS/BPH score, for male lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH), which integrates the International Prostate Symptom Score (IPSS), prostate size, and urinary flow rate.</p><p><strong>Materials and methods: </strong>From an initial pool of 75,199 subjects, 12,891 patients met the inclusion criteria. For the statistical analysis used to develop the new LUTS/BPH score, data were refined through outlier removal, normalization, and the collection of relevant variables. Weights for the relevant variables were determined using principal component analysis (PCA).</p><p><strong>Results: </strong>The new LUTS/BPH score was developed using the three variables: IPSS, prostate size, and maximum urinary flow rate (Qmax). The LUTS/BPH score was calculated by normalizing these variables and applying PCA to determine the weights, resulting in weights of 0.62 for IPSS, -0.64 for Qmax, and 0.46 for prostate size (PCA score=0.62×IPSS -0.64×Qmax+0.46×prostate size). To simplify the LUTS/BPH score calculation in practice, weights were adjusted using IPSS as the reference variable (weight set to 1) and rounded to the first decimal place. The final LUTS/BPH score formula is \"LUTS/BPH score=IPSS-Qmax+0.7×prostate size\". Based on this distribution, the LUTS/BPH score can classify symptom severity into three categories: (1) Mild symptoms <2, (2) Moderate symptoms: 2-42, and (3) Severe symptoms ≥43.</p><p><strong>Conclusions: </strong>The newly developed LUTS/BPH score is an objective and quantifiable diagnostic tool for male LUTS due to BPH, supplementing the currently used IPSS with additional key diagnostic indicators such as prostate size and urinary flow rate.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted <i>versus</i> Open Radical Prostatectomy in the Treatment of Localized Prostate Cancer: 3-Year Results from a Prospective Cohort Study.","authors":"Chang Wook Jeong, Sang Hyun Yoo, Jang Hee Han, Seung-Hwan Jeong, Hyeong Dong Yuk, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak","doi":"10.5534/wjmh.240090","DOIUrl":"https://doi.org/10.5534/wjmh.240090","url":null,"abstract":"<p><strong>Purpose: </strong>Radical prostatectomy remains the primary treatment for localized prostate cancer (PCa). Despite its use for over two decades, the benefits of robot-assisted radical prostatectomy (RARP) remain unclear. We evaluated the surgical, functional, and oncological outcomes between RARP and open radical retropubic prostatectomy (RRP).</p><p><strong>Materials and methods: </strong>This prospective cohort study included men who underwent radical prostatectomy between March 2016 and April 2020. We excluded patients who received preoperative androgen-deprivation therapy, had an initial prostate-specific antigen level of >50 ng/mL, had a clinical T stage of ≥T3b, and those aged under 50 or over 80 years. The primary outcome was the 90-day complication rate. Surgical and oncologic outcomes were compared. Continence and potency recovery were depicted using Kaplan-Meier curves and assessed using the log-rank test. To balance baseline characteristics, stabilized inverse probability of treatment weighting (sIPTW) was used.</p><p><strong>Results: </strong>Among the 1,306 patients assessed, 1,055 were included after exclusion and adjustment using the sIPTW (RARP, n=835; RRP, n=220), with a median follow-up of 39 months. The RARP group had a significantly lower 90-day complication rate than the RRP group (8.9% <i>vs.</i> 26.4%; p<0.001). The RARP group showed significantly better surgical outcomes, including estimated blood loss and surgical margins. At 36 months, the pad-free rates were 86.1% and 88.4% for the RARP and RRP groups, respectively (log-rank test, p=0.642). Potency recovery was superior in the RARP group (11.4% <i>vs.</i> 5.2%; log-rank test, p=0.001). Biochemical recurrence (RARP, 23.7%; RRP, 27.9%; p=0.246) and rates of additional treatment (RARP, 23.5%; RRP, 28.1%; p=0.202) were not different. Single-institution study is a potential limitation.</p><p><strong>Conclusions: </strong>The findings indicate that RARP is associated with a better safety profile and surgical outcomes without compromising short-term oncologic outcomes than RRP. While continence recovery was comparable between the methods, RARP may offer superior potency recovery.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}