World Journal of Mens Health最新文献

{"title":"Benign Growth, Malignant Protection? Insights into Benign Prostatic Hyperplasia and Prostate Cancer.","authors":"Po-Jung Su, I-Hung Shao, Yu-Hsiang Lin","doi":"10.5534/wjmh.250314","DOIUrl":"10.5534/wjmh.250314","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"749-750"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for the Additional Health Benefits Associated with Phosphodiesterase 5 Inhibitors when Used for Treating Erectile Dysfunction, with a Focus on Prostate Cancer Patients and Other Associated Conditions.","authors":"Alexandra Naranjo, Geoffrey Ian Hackett, Sophie Smith, Harley Stephens, William Kinnaird, Mike Kirby","doi":"10.5534/wjmh.250313","DOIUrl":"10.5534/wjmh.250313","url":null,"abstract":"<p><p>Erectile dysfunction (ED) affects the majority of prostate cancer (PCa) patients. Although phosphodiesterase 5 inhibitors (PDE5i) are the first-line treatment for ED and are strongly supported by evidence as safe and effective, they remain underutilised in PCa patients. Furthermore, there is a large evidence base that supports the association of PDE5i with favourable clinical outcomes in several different health conditions that are also often considered co-morbidities for men with PCa. We present this review to examine the evidence on favourable clinical outcomes associated with PDE5i use in a range of urological, cardiovascular, metabolic, and skeletal conditions. In men who have been treated for PCa, these co-morbidities are common and may even be exacerbated by treatment itself. The evidence base suggests that PDE5i could potentially co-treat several comorbidities in men treated for PCa in addition to ED, provided high-quality randomised controlled trials replicate and confirm the findings of observational studies and animal models. If validated, PDE5i may be prescribed in appropriately selected patients and exert its beneficial effects in these men post PCa treatment, not only improving health outcomes but also quality of life.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"582-592"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Society of Sexual Medicine: Position Statement for the Potential Use of Enclomiphene in the Treatment of Male Hypogonadism.","authors":"Jeff Foster, Louis Choo, Anand Patel, Michael Kirby, Geoff Hackett","doi":"10.5534/wjmh.250395","DOIUrl":"10.5534/wjmh.250395","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"480-483"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGFL7 Inhibits the Immune Response in Metastatic Castration-Resistant Prostate Cancer by Deactivating Endothelial Intercellular Adhesion Molecule-1.","authors":"Seung Soo Lee, Ji Young Lee, Hyun Jung Lee, Sung-Woo Park","doi":"10.5534/wjmh.250111","DOIUrl":"10.5534/wjmh.250111","url":null,"abstract":"<p><strong>Purpose: </strong>Epidermal growth factor-like 7 (EGFL7) has been implicated in various cancers, but its role in different stages of prostate cancer (PCa), particularly metastatic castration-resistant prostate cancer (mCRPC), remains unclear. This study aimed to investigate the biological function of EGFL7 and its association with immune regulation in PCa.</p><p><strong>Materials and methods: </strong>We quantified EGFL7 and intercellular adhesion molecule-1 (ICAM-1) levels in serum and prostate tissue specimens from patients with benign prostatic hyperplasia (BPH), localized PCa, and mCRPC. To explore its functional role, EGFL7 expression was either silenced or overexpressed in DU145 and PC3 cells using siRNA or pCMV-GFP, respectively. Xenograft experiments were conducted in nude mice using transfected DU145/PC3 cells, followed by post-hoc microarray analysis of tumor tissues.</p><p><strong>Results: </strong>Our findings revealed that EGFL7 expression was significantly higher in both serum and tumor tissues of mCRPC patients compared to those with BPH or localized PCa. ICAM-1 levels were inversely correlated with EGFL7 expression. Knockdown of EGFL7 in DU145 cells suppressed cell proliferation, migration, and invasion, while <i>in vivo</i> studies demonstrated that EGFL7 silencing inhibited tumor growth and increased ICAM-1 expression along with CD4/8 lymphocyte infiltration. Conversely, overexpression of EGFL7 in PC3 cells promoted tumor progression and reduced ICAM-1 levels.</p><p><strong>Conclusions: </strong>These findings suggest that EGFL7 overexpression in mCRPC suppresses immune cell infiltration by downregulating endothelial ICAM-1. Our study highlights the potential of EGFL7 as a therapeutic target in advanced PCa.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"702-712"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of High-Normal Fasting Blood Glucose on Semen Quality, Embryonic Development, and Pregnancy Outcomes.","authors":"Lina Wang, Huanhuan Li, Wenhui Zhou","doi":"10.5534/wjmh.250083","DOIUrl":"10.5534/wjmh.250083","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between male high-normal fasting blood glucose (FBG) and semen quality, embryonic development, and pregnancy outcomes of <i>in vitro</i> fertilization (IVF)/intracytoplasmic sperm injection (ICSI).</p><p><strong>Materials and methods: </strong>This retrospective cohort study included 921 couples undergoing their first single blastocyst frozen-thawed embryo transfer cycles. Participants were divided into 4 groups depending on quartiles of male FBG (3.90-6.10 mmol/L): from the lowest Quartile 1 (Q1) to the highest Q4. Firstly, semen quality and reproductive outcomes were compared across groups. Next, based on male FBG quartiles, logistic regression models were performed to explore associations between FBG with semen quality and IVF/ICSI outcomes. Finally, with male FBG considered as continuous variables, generalized additive models (GAMs) were conducted to visualize the non-linear relationship of FBG with the outcomes. Primary outcome: live birth rate (LBR). Secondary outcomes: semen quality, embryonic development parameters, biochemical pregnancy rate (BPR), clinical pregnancy rate, miscarriage rate, and other pregnancy outcomes.</p><p><strong>Results: </strong>Higher FBG quartiles exhibited significantly reduced sperm total motility, progressive motility, and progressive sperm count, alongside increased asthenozoospermia prevalence (p<0.05). BPRs rose from Q1 (4.4%) to Q4 (11.0%) (p=0.033), while LBR showed a declining trend from Q1 (46.7%) to Q4 (36.0%) (p=0.102). Regression analysis indicated that males in Q4 had a higher biochemical pregnancy risk and lower live birth likelihood (p-trend<0.05). GAMs revealed a dose-dependent increase in both asthenozoospermia and biochemical pregnancy risks with rising FBG levels.</p><p><strong>Conclusions: </strong>High-normal male FBG is significantly associated with both impaired semen quality (particularly asthenozoospermia) and adverse IVF/ICSI outcomes, including increased biochemical pregnancy risk and reduced LBRs. These findings highlight the significance of assessing paternal metabolic health and suggest that FBG screening may serve as a valuable tool for optimizing IVF/ICSI strategies and improving reproductive success.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"634-645"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Cadmium Telluride Quantum Dots on Male Reproductive Health: A Systematic Review of Toxicological Effects and Mechanisms.","authors":"Amir Reza Firouzabadi, Amir Masoud Firouzabadi, Mohammad Reza Shayesteh","doi":"10.5534/wjmh.250107","DOIUrl":"10.5534/wjmh.250107","url":null,"abstract":"<p><p>Cadmium telluride (CdTe) quantum dots (QDs) are widely utilized in biomedical applications because of their unique optical properties. However, concerns regarding their potential reproductive toxicity have emerged, necessitating comprehensive toxicological evaluations. Evidence suggests that Cd-based QDs can traverse the blood-testis barrier, accumulate in testicular tissue, and impair male fertility. Studies have reported detrimental effects, including reduced sperm quality, endocrine disruption, and oxidative stress-induced cellular damage. Moreover, multigenerational toxicity has been observed, with adverse effects on offspring, such as developmental delays, lower body weights, and biochemical markers of hepatic and renal dysfunction. To mitigate these toxic effects, various protective strategies have been investigated. Antioxidants, including astaxanthin nanoparticles and N-acetylcysteine, have demonstrated efficacy in reducing oxidative stress by neutralizing reactive oxygen species and restoring the cellular balance. Additionally, surface modifications, particularly zinc sulfide coatings, have shown promise in limiting cadmium ion release, thereby decreasing cytotoxicity and reproductive harm. The potential reproductive toxicity of CdTe QDs underscores the importance of developing safer nanomaterials. Future research should prioritize optimizing nanoparticle design, refining exposure parameters, and elucidating the molecular mechanisms underlying their toxicity to increase biocompatibility while minimizing reproductive risk.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"554-571"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age Disparity in Couples Seeking First Medical Help for Infertility Has Changed Over the Last Twenty Years: A Socio-Demographic Analysis.","authors":"Federica Passarelli, Luca Boeri, Edoardo Pozzi, Massimiliano Raffo, Fausto Negri, Federico Belladelli, Christian Corsini, Alessandro Bertini, Gabriele Birolini, Alessia D'Arma, Emanuele Montanari, Francesco Montorsi, Andrea Salonia","doi":"10.5534/wjmh.250201","DOIUrl":"10.5534/wjmh.250201","url":null,"abstract":"<p><strong>Purpose: </strong>Epidemiological studies have suggested that men are usually coupled with younger women. Parental age at first child have steadily increased over last decades. Accordingly, the age gap within partners has changed in the real-life setting over the same time frame. To analyze differences in partners' age (delta [Δ] age [M-F]) over a 20-year time frame among 1,605 men and their partners, seeking medical help for primary couple's infertility at a single center (2005-2024).</p><p><strong>Materials and methods: </strong>Partners' age was recorded, Δage was calculated. Comorbidities were scored with Charlson Comorbidity Index (CCI). Educational status was recorded. Sexual dysfunctions were self-reported for all male patients. Descriptive statistics and linear regression analyses were applied.</p><p><strong>Results: </strong>Median (interquartile range) patient's and partner's age were 37 (34-41) and 34 (31-37) years. Median Δage was 3 (0-6) years. Δage decreased by 1 point for each decade, being similar between 2005-2010 and 2011-2015, then decreasing from 2016-2020 to 2011-2015 and from 2021-2024 to 2011-2015 (all p<0.01). Similar values were found between 2021-2024 and 2016-2020, suggesting 2015 as a cutoff after which Δage decreased compared to earlier years, thus remaining afterwards stable. Δage change was related to increasing age bands of the female partner since male age was similar across the time frame. Men with low education status, with CCI ≥1 and with sedentary lifestyle had higher Δage (all p<0.01). Infertile men who self-reported erectile dysfunction had higher Δage than those with normal erectile function (p=0.01).</p><p><strong>Conclusions: </strong>In infertile couples, age-difference relationships decreased over time due to female ageing at first parenthood. Greater Δage was linked to lower education, higher comorbidities, and a sedentary lifestyle in male partners. Erectile dysfunction was more common in couples with higher Δage.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"713-720"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N6-Methyladenosine RNA Methylation: A Key Regulator in Male Reproductive Disorders and Urological Cancers.","authors":"Xiaopeng Huang, Xiaoya Li, Xiucheng Lan, Meijing Wang, Jingyi Zhang, Liang Dong, Junjun Li, Xujun Yu, Renbin Yuan, Fang Yang","doi":"10.5534/wjmh.250125","DOIUrl":"10.5534/wjmh.250125","url":null,"abstract":"<p><p>In the field of male health, disorders of the reproductive and urological systems present significant challenges. The global increase in male infertility, primarily attributed to environmental and lifestyle factors, along with the high incidence of urological cancers, not only places a significant socio-economic burden but also emphasizes the urgent need for in-depth research. Epigenetic modifications, especially N6-methyladenosine (m6A) methylation, are of great importance in these conditions. m6A, which is regulated by specific \"writer\", \"eraser\", and \"reader\" proteins, has an impact on various RNA-related processes. This review summarizes the regulatory functions of m6A in male reproductive health and urological cancers. In male reproduction, it explores how m6A affects somatic cell functions, steroidogenesis, and the blood-testis barrier. It also delves into its role in diabetic erectile dysfunction and benign prostatic hyperplasia. In urological cancers, the review examines m6A's influence on metabolic reprogramming, programmed cell death, and tumor immunity. Furthermore, this review discusses the potential of targeting m6A as a therapeutic approach for these conditions. By integrating recent research findings, it offers new perspectives on the role of m6A in male reproductive and urological disorders, laying a foundation for future research.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"533-553"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Contusion Injury-Induced Ejaculatory Dysfunction Is Reduced by Intrathecal Infusions of Gastrin Releasing Peptide in Male Rats.","authors":"Siddharth S Gaikwad, Kiran Kumar Soni, Tej Nakashe, Neha Bhavani, Zhao Luo, Sung Chul Kam, Geum Hwa Lee, Yu Seob Shin","doi":"10.5534/wjmh.250279","DOIUrl":"https://doi.org/10.5534/wjmh.250279","url":null,"abstract":"<p><strong>Purpose: </strong>Spinal cord injury (SCI) has devastating effects on urogenital functions, including severe deficits in ejaculation. SCI treatment development is hindered by limited understanding of effects of SCI on the spinal ejaculation generator (SEG). The SEG consists of a population of lumbar spinothalamic (LSt) cells that control ejaculation. LSt cells control ejaculation via release of neuropeptides, notably gastrin releasing peptide (GRP). In control male rats, intrathecal infusions of GRP strongly facilitate ejaculatory reflexes, while GRP antagonists prevent ejaculation triggered by stimulation of the dorsal penile nerve (DPN). Moreover, ejaculatory dysfunction was associated with significantly reduced expression of GRP mRNA and protein in LSt cells. Here, we test the hypothesis that GRP infusions may restore ejaculatory reflexes in SCI males.</p><p><strong>Materials and methods: </strong>In a first study, male Sprague Dawley rats received either controlled spinal contusion at 200 Kdynes (n=8) or sham treatment (n=8). Four weeks later, animals received an acute spinal transection to remove remaining supraspinal influence on the SEG and subsequent intrathecal infusions (10 µL) of Saline and GRP 20 to 29 (0.2 nmol) while parameters of ejaculatory reflexes were recorded. In addition, DPN was stimulated at frequencies that normally trigger ejaculation in control males (30 Hz) or subthreshold (5 Hz) and reflexes were recorded. GRP, but not Saline triggered ejaculatory reflexes and facilitated DPN-stimulated reflexes equally in Sham and SCI groups. In a second study, the procedures were repeated, but without the acute spinal transection prior to infusions. Again, GRP, but not Saline, triggered and facilitated ejaculatory reflexes with no differences between Sham and SCI groups.</p><p><strong>Results: </strong>These results indicate that a reduction of GRP in LSt cells following SCI may contribute to ejaculatory dysfunction.</p><p><strong>Conclusions: </strong>GRP may be a target for development of treatment options for sexual dysfunction following SCI.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study.","authors":"Ashley Kieran Clift, Hans Johnson, David R Huang, Ranjith Ramasamy","doi":"10.5534/wjmh.250422","DOIUrl":"https://doi.org/10.5534/wjmh.250422","url":null,"abstract":"<p><strong>Purpose: </strong>Men with testosterone deficiency (TD) aiming to preserve testicular function can be treated with strategies including testosterone replacement therapy (TRT) combined with human chorionic gonadotropin (hCG) or clomiphene citrate (CC), or CC monotherapy. Evidence regarding these strategies on the pituitary axis and quality of life is limited.</p><p><strong>Materials and methods: </strong>This retrospective cohort study compared the effects of hCG+TRT, CC+TRT, and CC monotherapy on pituitary axis function, testosterone levels and quality of life during TD treatment. Changes in serum luteinising hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, and quality of life (QADAM scores) from baseline to 6 months were calculated using mixed models.</p><p><strong>Results: </strong>6,999 adult men were included: 6,364 men (91%) prescribed hCG+TRT, 552 (8%) prescribed CC+TRT, 83 (1%) prescribed CC monotherapy. hCG+TRT suppressed LH and FSH (p<0.05), whereas CC+TRT was associated with reduction in FSH only (p=0.02). At 6 months, CC monotherapy was associated with significant increases in LH and FSH (p<0.001). All treatments were associated with substantial increases in total and free testosterone with rapid attainment of physiological levels (ranging from 23.58 nmol/L to 26.52 nmol/L). Similar changes in QADAM scores were observed across the three approaches (from 7.86 points to 9.50 points, all p<0.001).</p><p><strong>Conclusions: </strong>This study revealed distinct patterns in the natural history of pituitary hormone levels across different fertility-sparing strategies for TD, while observing comparable benefits in testosterone levels and quality of life. Future studies should prospectively correlate longitudinal trends in pituitary hormones with semen parameters and other fertility outcomes to enable personalised treatment selection.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}