World Journal of Mens Health最新文献

{"title":"Analysis of Toxicity and Mechanisms of Bisphenol Analogs in Male Infertility: Insights from Network Toxicology and Molecular Docking Approaches.","authors":"Biao Ran, Hao Ran, Liangren Liu","doi":"10.5534/wjmh.240270","DOIUrl":"10.5534/wjmh.240270","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"721-724"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial FIS1 As a Novel Drug Target for the Treatment of Erectile Dysfunction: A Multi-Omic and Epigenomic Association Study.","authors":"Tianle Zhu, Pan Gao, Yukuai Ma, Peng Yang, Zhi Cao, Jingjing Gao, Junhua Du, Hui Jiang, Xiansheng Zhang","doi":"10.5534/wjmh.240131","DOIUrl":"10.5534/wjmh.240131","url":null,"abstract":"<p><strong>Purpose: </strong>Mitochondrial dysfunction may impact male erectile function, but the underlying genetic mechanisms remain unclear. The study aims to investigate the causal role for genetically regulated mitochondrial function in erectile dysfunction (ED) and to identify potential drug targets for the treatment of ED.</p><p><strong>Materials and methods: </strong>The data of gene methylation, gene expression and protein level related to mitochondria were extracted from the corresponding genome-wide association studies (GWAS) database. Discovery and validation datasets for ED were sourced from research by Bovijn et al, the FinnGen database, and the UK Biobank. We performed summary-data-based Mendelian randomization analysis, colocalization analysis, as well as molecular prediction and molecular docking analysis to assess the association between mitochondrial dysfunction and ED. We also identified relevant targets and potential molecules for the treatment of ED.</p><p><strong>Results: </strong>Through the integration of multi-omics results, we identified an inverse relationship between the expression of the mitochondrial-related gene <i>FIS1</i> and the risk of ED (odds ratio [OR]: 0.89, 95% confidence interval [CI]: 0.81-0.97, p-value of summary-data-based Mendelian randomization analysis [PSMR]=1.01×10⁻²). In FIS1, methylation of cg19802458 and cg08601038 was related to high expression of the <i>FIS1</i> gene, which is consistent with the protective effects of cg19802458 and cg08601038 methylation against ED. Additionally, elevated levels of FIS1 protein displayed a negative association with ED risk (OR: 0.71, 95% CI: 0.55-0.92, PSMR=1.00×10⁻²). Molecular prediction and molecular docking analysis revealed that resveratrol and quercetin had protective effects against ED by targeting FIS1, and had good affinity and binding mode with FIS1, respectively.</p><p><strong>Conclusions: </strong>This study demonstrated the causal relationship between the mitochondrial <i>FIS1</i> gene and ED risk and found that resveratrol and quercetin may have therapeutic effects on ED. These discoveries offer fresh perspectives on the pathogenesis of ED and propose preliminary candidate targets and drugs for future treatment of ED.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"669-685"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Hormonal Changes Following Microdissection Testicular Sperm Extraction among Men with Non-Obstructive Azoospermia: Findings from a Large Longitudinal Prospective Multicentric Study.","authors":"Fausto Negri, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Federico Belladelli, Alessandro Bertini, Francesco Cattafi, Eugenio Ventimiglia, Rayan Matloob, Antonino Saccà, Luca Boeri, Alessia d'Arma, Francesco Montorsi, Andrea Salonia","doi":"10.5534/wjmh.240184","DOIUrl":"10.5534/wjmh.240184","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate possible hormonal changes following microdissection testicular sperm extraction (mTESE) in men with non-obstructive azoospermia (NOA) across three referral centers.</p><p><strong>Materials and methods: </strong>We prospectively analyzed data from 102 consecutive NOA men. Patients with prior hormonal therapies were excluded. Preoperative serum hormone levels (total testosterone [tT], luteinizing hormone [LH], follicle-stimulating hormone [FSH], and 17β-estradiol) were collected, with repeat measurements at 3-month post-surgery. We divided the cohort into two groups using a tT cut-off value of 3 ng/mL: 1) men who kept eugonadal status; and, 2) men who were initially eugonadal but became testosterone deficient (TD) after surgery.</p><p><strong>Results: </strong>Overall, median (interquartile range [IQR]) age was 37 years (32-40 years). Positive sperm retrieval during mTESE was observed in 34 (33.3%) patients, and 48 (47.1%) underwent bilateral mTESE. Compared to baseline, 3-month postoperative median (IQR) hormonal levels were as follows: tT: 3.71 ng/mL (2.76-5.24 ng/mL) <i>vs.</i> 4.27 ng/mL (3.25-6.07 ng/mL), p=0.32; FSH: 22.0 mIU/mL (12.65-31.47 mIU/mL) <i>vs.</i> 19.5 mIU/mL (11.63-25.8 mIU/mL), p=0.25; LH: 9.0 mIU/mL (5.11-12.4 mIU/mL) <i>vs.</i> 7.6 mIU/mL (5.04-13.4 mIU/mL), p=0.73, respectively. Twelve (13.5%) eugonadal men at baseline showed TD after mTESE. Median (IQR) tT values at baseline and 3-month follow-up were compared between those who preserved eugonadal status after surgery and those who became TD after surgery: baseline levels were 4.46 ng/mL (4.1-6.27 ng/mL) <i>vs.</i> 4.14 ng/mL (3.24-4.98 ng/mL), p=0.09; and, 3-month follow-up levels were 4.58 ng/mL (3.58-5.56 ng/mL) <i>vs.</i> 2.51 ng/mL (2.31-2.76 ng/mL), p<0.001, respectively. Men who developed TD had lower testicular volume (TV) (6 [4-10] vs. 10 [8-12.25] Prader, p=0.001) and karyotype abnormalities (4 [33.3] <i>vs.</i> 1 [1.3], p=0.006).</p><p><strong>Conclusions: </strong>This multicentric study shows that mTESE in men with NOA does not significantly impact short-time postoperative follow-up tT, LH, and FSH levels. A substantial proportion of men who were initially eugonadal demonstrated tT suggestive for TD at 3-month follow-up. These men had lower TV at baseline and abnormal karyotype.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"702-709"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Testosterone Levels Following Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia: Systematic Review and Meta-Analysis.","authors":"Wael Zohdy, Rupin Shah, Christopher Chee Kong Ho, Gokhan Calik, Vineet Malhotra, Bircan Kolbaşı Erkan, Mesut Berkan Duran, Georgios Tsampoukas, Garaz Radion, Ramadan Saleh, Ahmed M Harraz, Parviz Kavoussi, Eric Chung, Edmund Ko, Luca Boeri, Naveen Kumar, Selahittin Çayan, Amarnath Rambhatla, Osvaldo Rajmil, Mohamed Arafa, Rossella Cannarella, Omer Raheem, Taymour Mostafa, Widi Atmoko, Taha Abo-Almagd Abdel-Meguid Hamoda, Armand Zini, Ashok Agarwal","doi":"10.5534/wjmh.240129","DOIUrl":"10.5534/wjmh.240129","url":null,"abstract":"<p><strong>Purpose: </strong>Surgical sperm retrieval (SSR) is used to extract spermatozoa for use with intracytoplasmic sperm injection in men with obstructive and non-obstructive azoospermia (NOA). The procedure may lead to segmental devascularization, postoperative fibrosis, and atrophy with a subsequent decrease in testosterone. The aim of the study is to investigate the impact of SSR on serum levels of total testosterone (TT), follicle-stimulating hormone (FSH), luteinizing hormone (LH) testicular volume, and sexual function in infertile azoospermic men.</p><p><strong>Materials and methods: </strong>In this systematic review and meta-analysis (SRMA), we searched articles in \"PubMed\" and \"Scopus\" exploring the impact of SSR on TT, FSH, LH, and testicular volume. The full-text articles were screened to assess eligibility before data extraction, quality assessment, and meta-analysis.</p><p><strong>Results: </strong>Seventeen studies meeting the inclusion criteria were finally analyzed and included 1,685 infertile, azoospermic men. Patients underwent SSR and were followed in the postoperative period (one week to 32 months). The analysis showed a significant reduction in TT (mean difference [MD] 3.81 nmol/L, 95% confidence interval [CI] 0.55:7.06; p=0.02) compared to pre-SSR values. We also observed insignificant differences in serum FSH (MD 5.08 IU/L, 95% CI -5.6:15.8; p=0.35), LH (MD -2.96 IU/L, 95% CI -6.31:0.39; p=0.08), and no change in testicular volume (MD 0.07 mL, 95% CI -1.92:2.07; p=0.94) after SSR. Sexual dysfunction was associated with hypogonadism, depression, and anxiety, especially in men with unsuccessful SSR and Klinefelter syndrome.</p><p><strong>Conclusions: </strong>The results of this SRMA indicate a significant reduction in TT after SSR. Sexual dysfunction after testicular sperm extraction and the potential negative impact of future SSR repeat should be considered during preoperative counseling.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"523-538"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study).","authors":"Kazuyoshi Shigehara, Yuki Kato, Rei Shinzawa, Hiroyuki Konaka, Shohei Kawaguchi, Takahiro Nohara, Kouji Izumi, Mikio Namiki, Atsushi Mizokami","doi":"10.5534/wjmh.240066","DOIUrl":"10.5534/wjmh.240066","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated the effects of testosterone replacement therapy (TRT) on the Fibrosis-4 (FIB-4) index among hypogonadal patients who were extracted from a randomized controlled study in Japan (the EARTH study).</p><p><strong>Materials and methods: </strong>Data of 186 patients (88 in the TRT group; 98 in the control group) were collected. The patients in the TRT group received intramuscular administration of testosterone enanthate (250 mg) every 4 weeks for 12 months. The patients' background information such as current medical history and lifestyle habits were collected. Waist circumference, body mass index, and body fat volume were measured at baseline and 12-month visit. Fasting blood sugar (FBS), hemoglobin A1c, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol levels were collected at baseline and 12-month visit. The FIB-4 index was calculated according to age, aspartate aminotransferase, alanine transaminase, and platelet count.</p><p><strong>Results: </strong>Except for serum FBS values, most of baseline characteristics were comparable between the TRT and control groups. When comparing the changes of each variable from baseline at 12-month visit in both groups, significant differences were found in waist circumference (p=0.00248), fat volume (p=0.00812), and platelet counts (p=0.0478), whereas a FIB-4 index did not change. On the contrary, in a subanalysis including only patients with a FIB-4 index ≥1.30 at baseline, a significant difference in a FIB-4 index (-0.10±0.39 <i>vs.</i> 0.04±0.44; p=0.0311) was observed with significant decreases in waist circumference, body fat volume, and TG levels, and an increase in platelet counts. The FIB-4 index was significantly decreased by TRT from 1.98±0.52 to 1.87±0.60 (p=0.0277).</p><p><strong>Conclusions: </strong>TRT for 12 months improved the FIB-4 index among hypogonadal men with a higher baseline FIB-4 index.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"661-668"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgens Are a Key Factor Affecting Immune Related Diseases.","authors":"Hede Zou, Jiayou Zhao, Haoran Xu, Wenkang Chen, Rui Cao, Yongjie Ma","doi":"10.5534/wjmh.240292","DOIUrl":"https://doi.org/10.5534/wjmh.240292","url":null,"abstract":"<p><p>Androgens mainly have suppressing effects on immune function, affecting the different progression of immune diseases in males and females, but their main mechanisms are still unclear. Bibliometric methods are used to analyze relevant literature in the Web of Science Core Collection (WoSCC) database over the past decade, with a focus on key and hot topics. The results show that prostate cancer, triple negative breast cancer, and sex differences in respiratory diseases, etc. are hot topics in the interdisciplinary field of androgen and immunology. In males, androgens are mainly synthesized and secreted by the testes, indicating the important role of male reproduction in immunity and providing a reproductive perspective for the prevention and treatment of immune diseases.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vitamin B₆ in Testosterone Synthesis.","authors":"Saleem Ali Banihani","doi":"10.5534/wjmh.240250","DOIUrl":"https://doi.org/10.5534/wjmh.240250","url":null,"abstract":"<p><p>Boosting testosterone production and maintaining its adequate concentrations in males is still a critical area of the ongoing research. Vitamin B₆ (VB6), also named pyridoxine, is an essential nutrient and biochemically an organic cofactor in various enzymatic reactions that activate several catabolic and anabolic processes, including energy production, neurotransmitter synthesis, immune system function. While various studies have revealed an indirect association between testosterone and VB6, a collective and comprehensive review of its role in testosterone synthesis has been lacking. Here, we review and summarize the involvement of VB6 in testosterone production and regulation. To achieve this, a thorough search of the PubMed and Scopus databases was conducted, identifying English-language articles published from August 1956 to the present using the keywords \"vitamin B₆\" and \"pyridoxine\" versus testosterone. Relevant studies contributing to a mechanistic understanding of this relationship were also included. In summary, VB6 is essential for testosterone production and regulation through various indirect mechanisms. These include its impact on hormonal signaling pathways like GnRH and prolactin, its role in activating enzymatic processes that affect testosterone synthesis, its modulation of androgen receptor sensitivity, and its protection against oxidative stress and homocysteine toxicity. Such critical role of VB6 in regulating testosterone levels in men is considered a strong incentive for researchers to conduct interventional studies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global State of Contemporary Andrology Practice: A Comprehensive Analysis of Clinical Practice, Training Pathways, and Emerging Challenges.","authors":"Rupin Shah, Taymour Mostafa, Manaf Al Hashimi, Germar-Michael Pinggera, Wael Zohdy, Bahadır Şahin, Hiva Alipour, Ayad Faeq Palani, Mohamed Arafa, Eric Chung, Ayman Rashed, Edmund Ko, Baris Altay, Amarnath Rambhatla, Tuncay Toprak, Hussein Kandil, Edoardo Pescatori, Ahmed El-Sakka, Haitham Ali Elbardisi, Juan Manuel Corral Molina, Marco Falcone, Edouard Harry Amar, Taiwo Crossby Omotoriogun, Selcuk Sarikaya, Nguyen Ho Vinh Phuoc, Mounir Jamali, Oğuzhan Kahraman, Ahmet Cihan, Sava Micic, Muslim Dogan Deger, Muhammad Ujudud Musa, Gökhan Çeker, Umut Cagin Ari, Cevahir Ozer, Huda Mossa Omran, Saleh Binsaleh, Rossella Cannarella, Mohamad Ahmad Moussa, Iman Shamohammadi, Andrian Japari, Francesco Gaggia, Aria Danurdoro, Nasser Mogharabian, Mohamed Elmahdy Toiema, Hisanori Taniguchi, Missy Savira, Christopher Chee Kong Ho, Keerti Singh, Manh Truong Nguyen, Parviz K Kavoussi, Shingai Bertrand Angelo Mutambirwa, Ishan Merchant, Dharani Moorthy, Vijay Kumar, Arif Kalkanli, Faiza Rao, Fatih Gokalp, Nicolas Garrido, Charalampos Konstantinidis, David Pening, Sedigheh Bahmyari, Parisa Dolati, Aldo E Calogero, Ramadan Saleh, Birute Zilaitiene, Giorgio Ivan Russo, Nadia Kazdar, Ricky Adriansjah, Gianmaria Salvio, Giancarlo Balercia, Catalina Zenoaga-Barbarosie, Balantine Ugochukwu Eze, Widi Atmoko, Deniz Kulaksiz, Amina Benabbou, Siu King Mak, Luca Boeri, Sang Thanh Le, Ajay Kumar Jain, Amr El Meliegy, Kadir Böcü, Nur Dokuzeylül Güngör, Gokhan Calik, Konstantinos Makarounis, Mesut Berkan Duran, Hisham Ahmed Arab, Luigi Montano, Gulfam Ahmad, Trang Thi Minh Nguyen, Hyun Jun Park, Eko Arianto, Krishna Chaitanya Mantravadi, Andrea Crafa, Tahsin Turunc, Fotios Dimitriadis, Umut Arslan, Sk Mizanur Rahman, Andri Rezano, Ryan Patrick Smith, Erman Ceyhan, Naveen Kumar, Dyandra Parikesit, Mehmet Serkan Özkent, Rosadi Putra, Haocheng Lin, Osvaldo Rajmil, Sanjay Prakash Jayaprakash, Tan V Le, Satish Pundlik Dipankar, Charalampos Thomas, Carlo Giulioni, Danh Cong Nguyen, Vinod K V, Zaid Qureshi, Filippo Giacone, Ashish Reddy, Sujoy Dasgupta, Divyanu Jain, Ciro Salzano, Federica Finocchi Finocchi, Lucia Rocco, Ateş Kadıoğlu, Akeem Babatunde Sikiru, Ali Said Kilicalp, Mezbahul Moker Rabin, Giovanni Liguori, Jose Arturo Mora Rodriguez, Jesus Fernando Solorzano Vazquez, Angelo Alessandro Marino, Taha Hamoda, Vilvapathy Senguttuvan Karthikeyan, Bircan Kolbaşı Erkan, Mikhail Ruzaev, Manel Nezzal, Giovanni M Colpi, Fahmi Bahar, Tamilselvi Sethupathy, Guadalupe Del Carmen Hernández Hebrard, Mohamed S Al-Marhoon, Ahmad Tarek Motawi, Sotiris Andreadakis, Coskun Kaya, Alessandro Franceschelli, Fikri Rizaldi, Shubhadeep Roychoudhury, Pedro Cuapio Padilla, Ahmad Ateyah Awwad, Daniel Suslik Zylbersztejn, Nazim Gherabi, Abdallah Bensouda, Naufal Nandita Firsty, Giorgio Franco, Neha Shreyas Goswami, B Aanantha Lakshmi, Frédéric Romain Santer, Ege Can Serefoglu, Vahid Esmaeili, Ioannis Sokolakis, Mustafa Kadihasanoglu, Marion Bendayan, Petronela Naghi, Sofia Ines Leonardi Diaz, Saviana Adriana Buhlea, Alireza Kheradmand, Tulay Irez, Tiago Cesar Mierzwa, Silvia Werdhy Lestari, Riffat Bibi, Quang Nguyen, Ranjit Babulal Vishwakarma, Pietro Salacone, Stamatis Papaharitou, Saad Mohammed Abumelha, Elango Kamaraj, Robyn Amanda Van Staden, Damayanthi Durairajanayagam, Ramazan Asci, Gustavo Marquesine Paul, Abiodun Oyerinde, Akhmad Mustafa, Chirag Gupta, Yudhistira Pradnyan Kloping, Marjan Sabbaghian, Isaac Ardianson Deswanto, Moungala Lionel Wildy, Teng Aik Ong, Sann Lin Ko, Sheryl Toni Homa, Rahul Gajbhiye, Mara Simopoulou, Mohamed Abdelfatah Farag, Vineet Malhotra, Ekom Monday Etukudo, Hazem Meteb Al-Rumaih, Ninad Chandrakant Tamboli, Awaj Kafle, Mohamed Elkhouly, Ashok Agarwal","doi":"10.5534/wjmh.250039","DOIUrl":"https://doi.org/10.5534/wjmh.250039","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the current state of andrology practice worldwide, identifies challenges faced by clinicians, and explores training, certification, and research opportunities. It also seeks to redefine the qualifications necessary to be recognized as an andrologist and to propose areas for standardization and improvement.</p><p><strong>Materials and methods: </strong>A global, cross-sectional survey was conducted using a 48-question online questionnaire designed by international experts. The survey, distributed in English, covered various domains of modern andrology practice. Responses from 405 participants across 59 countries were analyzed using R version 4.1.2, with categorical variables reported as frequencies and percentages.</p><p><strong>Results: </strong>Among respondents, 47.3% held medical doctor (MD) degrees, with urologists (31.1%) and clinical andrologists (25.3%) being the most represented specialties. Formal, board-certified andrological training was reported as available in only 48.1% of countries. While half of the respondents identified as andrologists based on experience, only one-third did so through certification, obtained from diverse, nationally recognized organizations. The primary areas of practice included male infertility (36.7%), male sexual dysfunction (27.2%), and sexually transmitted infections (14.5%). Many participants were actively engaged in assisted reproductive technologies, imaging, and andrological surgical emergencies. Despite strong interest in clinical, basic, and translational research, respondents highlighted significant challenges, including inconsistent training pathways, insufficient certification standards, and the complexity of managing diverse andrological conditions.</p><p><strong>Conclusions: </strong>Andrology is an evolving multidisciplinary specialty where board-certified urologists, clinical andrologists, and reproductive medicine specialists collaborate to address male reproductive and sexual health challenges. Despite their advanced competencies in medical, surgical, and laboratory interventions, specialists face significant global disparities in training and certification. This survey highlights the urgent need for standardized training, evidence-based guidelines, and unified certification to ensure consistency, enhance patient care, and advance andrology's academic and clinical excellence worldwide.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm DNA Fragmentation in Men with Varicocele: A Systematic Review and Meta-Analysis.","authors":"Ayad Palani, Selahittin Çayan, Rossella Cannarella, Ramadan Saleh, Baris Altay, Mustafa Kadihasanoglu, Ahmed Harraz, Fotios Dimitriadis, Erman Ceyhan, Andri Rezano, Ahmed Hussein Zwamel, Wael Ibrahim, Amina Benabbou, Ria Margiana, Essolakina Gnoneye, Md Mezbahul Moker Rabin, Jamiu Omirinde, Vahid Esmaeili, Armand Zini, Mohamed Arafa, Haitham Elbardisi, Tuncay Toprak, Murat Dursun, Kareim Khalafalla, Gianmaria Salvio, Eric Chung, Andrea Crafa, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250025","DOIUrl":"https://doi.org/10.5534/wjmh.250025","url":null,"abstract":"<p><strong>Purpose: </strong>In this systematic review and meta-analysis, we investigated the relationship between varicocele and sperm DNA fragmentation (SDF) alongside conventional semen parameters.</p><p><strong>Materials and methods: </strong>A comprehensive systematic search was conducted to identify articles on SDF in men with varicocele published in the Scopus and PubMed databases. This included observational studies investigating levels of SDF as a primary outcome and conventional semen parameters as secondary outcomes in men with varicocele compared to men without varicocele.</p><p><strong>Results: </strong>Out of 476 retrieved articles, 40 met our inclusion criteria, with 35 included in our quantitative synthesis. Our analysis revealed that men with varicocele showed significantly higher SDF than men without varicocele (mean difference [MD] 15.34, 95% confidence interval [95% CI]: 9.74-20.9; p<0.001). The evaluation of SDF using different assays did not affect the results (p=0.7). Our results indicated a significant effect of varicocele on sperm concentration (MD -29 million/mL, 95% CI: -37, -21; p<0.001), total sperm count (MD -188 million/ejaculate, 95% CI: -325, -52; p=0.007), sperm vitality (MD -5.7%, 95% CI: -8.6, -2.8; p<0.001), total sperm motility (MD -17%, 95% CI: -29.0, -5.3; p=0.004), progressive sperm motility (MD -17%, 95% CI: -23,-11, p<0.001), normal sperm forms (MD -3.1%, 95% CI: -4.3, -1.8, p<0.001) and abnormal sperm forms (MD 2.25%, 95% CI: 0.77, 3.73; p=0.003). However, semen volume and the total motile sperm count were not significantly different between both groups (MD -113 million/ejaculate, 95% CI: -244.0, 18.1; p=0.09).</p><p><strong>Conclusions: </strong>Varicocele negatively impacts male fertility by increasing SDF. Our study supports using SDF analysis in patients with varicocele to aid clinicians in deciding on varicocele repair.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Anesthesia for Holmium Laser Enucleation of the Prostate: Does Spinal Anesthesia Improve Recovery?","authors":"Yu Seob Shin, Ho Seok Chung","doi":"10.5534/wjmh.250090","DOIUrl":"https://doi.org/10.5534/wjmh.250090","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}