World Journal of Mens Health最新文献

{"title":"Water Vapor Thermal Therapy for Benign Prostatic Hyperplasia: An Umbrella Review and Updated Meta-Analysis.","authors":"Zhuoxin Li, Chenrui Wang, Yupeng Wu, Begoña Ballesta Martínez, Jiahe Liu, Jingjing Xiang, Xingshi Zhang, Xiaoxu Zhao, Yan Lu, Shigeo Horie, Di Gu, Qi Hou","doi":"10.5534/wjmh.250104","DOIUrl":"10.5534/wjmh.250104","url":null,"abstract":"<p><strong>Purpose: </strong>Water vapor thermal therapy (WVTT) is an emerging minimally invasive therapy for benign prostatic hyperplasia (BPH). This umbrella review and updated meta-analysis aims to evaluate the comprehensive outcomes of WVTT for the management of BPH.</p><p><strong>Materials and methods: </strong>Up to January 2025, randomized clinical trials and observational studies were included in the updated meta-analysis, while systematic reviews and meta-analyses were included in the umbrella review. Both were conducted in accordance with PRISMA criteria. The umbrella review protocol was pre-registered under registration identifier CRD42024514038. The research compared outcomes including International Prostate Symptom Score (IPSS), peak urinary flow (Qmax), postvoid residual volume (PVR), sexual function, retreatment rates, adverse events and cost-effectiveness. Outcomes were analyzed using a random effects meta-analysis model. The source of heterogeneity was identified by meta-regression.</p><p><strong>Results: </strong>The umbrella review comprised 6 systematic reviews and the updated meta-analysis included 25 primary studies involving 3,308 patients. The meta-analysis revealed, at 3 months post-operation, a mean reduction of 10.96 points in IPSS (95% confidence interval [CI], 9.71 to 12.20; I²=89%), a mean increase of 4.70 mL/s in Qmax (95% CI, 4.22 to 5.19; I²=31%), and a mean reduction of 69.52 mL in PVR (95% CI, 52.15 to 86.89; I²=84%). At 12 months, the analysis revealed a mean reduction of 12.35 points in IPSS (95% CI, 10.74 to 13.95; I²=94%), a mean increase of 5.27 mL/s in Qmax (95% CI, 4.46 to 6.07; I²=84%), and a mean reduction of 37.07 mL in PVR (95% CI, 18.29 to 55.85; I²=97%). Our umbrella review showed that WVTT also resulted in low retreatment rates and preserved sexual function. Adverse events were mostly mild and self-limiting.</p><p><strong>Conclusions: </strong>WVTT is an effective and safe treatment for BPH leading to symptom relief with low retreatment rates and wide application scenarios. Clinicians should consider WVTT as a viable minimally invasive alternative for BPH patients who are not suitable for more invasive therapies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"883-900"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intratesticular Platelet-Rich Plasma Injection on Sperm Retrieval Rates in Non-Obstructive Azoospermia Male after Failed Testicular Sperm Extraction: An Inception Cohort.","authors":"Satvir S Basran, Fausto Negri, Ashkan P Langroudi, Nicholas Sellke, James Stinson, Albert Ha, Wade Muncey, Federico Belladelli, Chiyuan A Zhang, Francesco Del Giudice, Lusine Aghajanova, Michael L Eisenberg","doi":"10.5534/wjmh.250281","DOIUrl":"10.5534/wjmh.250281","url":null,"abstract":"<p><strong>Purpose: </strong>While sperm recovery was demonstrated in males who failed prior testicular sperm extractions, the role and efficacy of autologous platelet-rich plasma (PRP) in males with non-obstructive azoospermia (NOA) undergoing salvage microdissection testicular sperm extraction (mTESE) still need to be determined.</p><p><strong>Materials and methods: </strong>Patients with a history of NOA and at least one previous failed surgical sperm extraction were invited to participate in this study. We analyzed data from an inception cohort of 29 infertile males from January 2023 to February 2025. The primary endpoint was sperm retrieval (SR) rate at surgery. An Arteriocyte Magellan kit was used for the PRP preparation. After injecting local anesthesia as a spermatic cord block, up to 1.5 mL of the PRP mixture was injected into each testicle. After at least 90 days post-injection, microscopic-assisted testicular sperm extraction was performed. We assessed changes in serum hormone levels-specifically circulating total testosterone (TT), follicle-stimulating hormone, luteinizing hormone, and estradiol-following intratesticular PRP injection.</p><p><strong>Results: </strong>In total, 4 out of 25 males (16.0%) had positive SR (3/20 [15.0%] with a single previous procedure, 1/3 [33.3%] with two prior procedures, and 0/2 [0%] with three prior procedures). No change in TT was noted after PRP treatment. Patients with successful SR had higher body mass index at baseline (30.1 [29.1 to 36.1] <i>vs.</i> 27.1 [24.8 to 27.8], p=0.011). Four patients (13.8%) withdrew from the study.</p><p><strong>Conclusions: </strong>Autologous intratesticular PRP injection is a feasible, well tolerated procedure with a low complication rate and rapid recovery. However, the current scientific evidence is not yet sufficient to establish its efficacy in the context of mTESE.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1058-1065"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Centralizing Artificial Urinary Sphincter Implantation Services in France: A National Population-Based Model on Travel Times, Equity, and Patient Outcomes.","authors":"Louis Lenfant, Yoann Taillé, Emmanuel Chartier-Kastler, Bertrand Lukacs, Thomas Seisen, Morgan Roupret, Aurélien Beaugerie, Eric Vicaut, Pierre C Mozer","doi":"10.5534/wjmh.250127","DOIUrl":"10.5534/wjmh.250127","url":null,"abstract":"<p><strong>Purpose: </strong>Higher annual center volume for artificial urinary sphincter (AUS) implantation is associated with improved survival without device removal. We assessed the impact of four centralization scenarios on AUS removal rates, patient travel burden, and workload redistribution to inform healthcare policy.</p><p><strong>Materials and methods: </strong>We conducted a national, population-based cohort study using the Observapur database, which includes all men in France treated for prostate cancer or benign prostatic hyperplasia who underwent their first AUS implantation between 2006 and 2018. Patients were identified using reimbursement codes; 7,776 had complete geographic data. We modeled four centralization scenarios: (A) closure of very low-volume centers (<1 AUS procedure/year); (B) closure of low-volume centers (<5 procedures/year); (C) closure of centers performing <10 procedures/year with reallocation to high-volume centers (>20 procedures/year); and (D) closure of centers with the highest AUS removal rates. The primary outcome was the predicted 1- and 2-year AUS removal rate. Secondary outcomes included changes in travel distances and workload redistribution.</p><p><strong>Results: </strong>Annual closures ranged from 25 centers (Scenario A) to 138 centers (Scenario C), affecting 381 (Scenario A) to 3,250 (Scenario C) patients. Travel distances increased from -1.8 km (Scenario A) to +43.6 km (Scenario C). AUS removal risk was reduced across all scenarios at 2 years: Scenario A (24.0%), B (25.2%), C (33.8%), and D (19.3%). Workload redistribution was highest in Scenario C, where 65 centers experienced a >50% increase in procedures.</p><p><strong>Conclusions: </strong>Centralizing AUS implantation improves patient outcomes by reducing device removal rates, but the impact on additional workload varies. Scenario C offers the greatest survival benefit but imposes the highest travel and workload burden. Moderate centralization (Scenarios A or B) provides a balanced approach, improving outcomes while maintaining accessibility and feasibility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"916-924"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biomolecular Effects of Finasteride on Male Rat Brain During Administration and After Discontinuation.","authors":"Young Hyo Choi, Hee Youn Kim, Seung Ho Yang, Jun Sung Koh, Jin Bong Choi, Dong Sup Lee","doi":"10.5534/wjmh.250105","DOIUrl":"10.5534/wjmh.250105","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the biomolecular effects of finasteride on rat brain tissue during and after discontinuation.</p><p><strong>Materials and methods: </strong>Twenty-four 14-week-old male Wistar rats were randomly assigned to three groups: Group 1 (control), Group 2 (finasteride-treated), and Group 3 (finasteride-withdrawn). Serum testosterone and dihydrotestosterone levels were measured at the end of the study period. Brain tissues were analyzed using real-time polymerase chain reaction (RT-PCR), western blotting, and immunohistochemistry, with c-Fos employed as a non-specific biomarker of neural cellular activity.</p><p><strong>Results: </strong>In Group 2, serum dihydrotestosterone levels, 5-alpha reductase type 1 protein expression, and c-Fos phosphorylation showed a decreasing trend (p=0.067, p=0.015, p=0.123, respectively, versus Group 1), but rebounded in Group 3 (p=0.044, p=0.033, p=0.049, respectively, versus Group 2). In contrast, 5-alpha reductase type 2 protein expression was significantly reduced in Group 2 (p=0.017 <i>vs.</i> group 1) and remained suppressed in Group 3 (p=0.029 versus Group 1, p>0.999 versus Group 2). The mean intensity of immunohistochemistry revealed decreased 5-alpha reductase type 2 and c-Fos protein levels in Group 2 (p=0.008 and p=0.017, respectively). After withdrawal, c-Fos protein levels recovered in Group 3 (p=0.031 versus Group 2), whereas 5-alpha reductase type 2 levels remained unchanged (p=0.682 versus Group 2).</p><p><strong>Conclusions: </strong>Suppression of c-Fos-related neural activity in rat brain tissue could be temporarily maximized by both type 1 and type 2 5-alpha reductase inhibition by finasteride administration, and this suppression could be relieved by the restoration of 5-alpha reductase type 1 expression after finasteride discontinuation.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"925-933"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and Readability Analysis of Artificial Intelligence-Generated Medical Information Related to Prostate Cancer: A Cross-Sectional Study of ChatGPT and DeepSeek.","authors":"Zhao Luo, Chuan Lin, Tae Hyo Kim, Yu Seob Shin, Sun Tae Ahn","doi":"10.5534/wjmh.250144","DOIUrl":"10.5534/wjmh.250144","url":null,"abstract":"<p><strong>Purpose: </strong>Artificial intelligence (AI) tools have demonstrated considerable potential for the dissemination of medical information. However, variability may exist in the quality and readability of prostate-cancer-related content generated by different AI platforms. This study aimed to evaluate the quality, accuracy, and readability of prostate-cancer-related medical information produced by ChatGPT and DeepSeek.</p><p><strong>Materials and methods: </strong>Frequently asked questions related to prostate cancer were collected from the American Cancer Society website, ChatGPT, and DeepSeek. Three urologists with over 10 years of clinical experience reviewed and confirmed the relevance of the selected questions. The Patient Education Materials Assessment Tool for Printable Materials (PEMAT-P) was used to assess the understandability and actionability of AI-generated content. The DISCERN instrument was used to evaluate the quality of the treatment-related information. Additionally, readability was assessed using four established indices: Automated Readability Index (ARI), Flesch Reading Ease Score, Gunning Fog Index, and Flesch-Kincaid Grade Level.</p><p><strong>Results: </strong>No statistically significant differences were observed between ChatGPT and DeepSeek in PEMAT-P scores (70.66±8.13 <i>vs</i>. 69.35±8.83) or DISCERN scores (59.07±3.39 <i>vs</i>. 58.88±3.66) (p>0.05). However, the ARI for DeepSeek was higher than that for ChatGPT (12.63±1.42 <i>vs</i>. 10.85±1.93, p<0.001), indicating greater textual complexity and reading difficulty.</p><p><strong>Conclusions: </strong>AI tools, such as ChatGPT and DeepSeek, hold significant potential for enhancing patient education and disseminating medical information on prostate cancer. Nevertheless, further refinement of content quality and language clarity is needed to prevent potential misunderstandings, decisional uncertainty, and anxiety among patients due to difficulty in comprehension.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"942-951"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Prunella vulgaris</i> on Male Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Tae Hyung Kim, Soomin Kim, Hwajong Lee, Sae Woong Kim, Youn Gil Kwak, Mi Ran Jang, Dongho Shin, Woong Jin Bae","doi":"10.5534/wjmh.250154","DOIUrl":"10.5534/wjmh.250154","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of <i>Prunella vulgaris</i> (PV) extract in men with lower urinary tract symptoms (LUTS).</p><p><strong>Materials and methods: </strong>In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 80 men aged 40-75 years with moderate LUTS (International Prostate Symptom Score [IPSS] ≥8 and ≤19) were randomized to receive PV extract (600 mg/day) or placebo. The primary outcome was the change in total IPSS from baseline to week 12. Secondary outcomes included changes in IPSS subscores, quality of life (QoL), uroflowmetry, and prostate volume. Safety was assessed by adverse events and laboratory parameters.</p><p><strong>Results: </strong>A total of 75 participants completed the trial (PV group, n=39; placebo group, n=36). At week 12, the PV group showed a significantly greater reduction in total IPSS compared to placebo (-5.2±4.6 <i>vs.</i> -2.8±4.3; p=0.014). Significant improvements were also observed in voiding subscore (-3.3±3.7 <i>vs.</i> -1.6±3.2; p=0.020) and QoL (-1.2±1.4 <i>vs.</i> -0.7±1.3; p=0.044). There were no significant differences in maximum flow rate or prostate volume. The incidence of adverse events was low and similar between groups.</p><p><strong>Conclusions: </strong>PV extract improved LUTS and QoL in men with LUTS was well tolerated. These findings suggest its potential as a safe and effective phytotherapeutic option for managing male LUTS.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"1028-1036"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Areas of Controversy and Confusion in Male Infertility: A Call for Clarity.","authors":"Mohamed Arafa, Tuncay Toprak, Edmund Ko, Rupin Shah, Armand Zini, Eric Chung, Selahittin Cayan, Germar-Michael Pinggera, Widi Atmoko, Tan Le, Ayman Rashed, Taras Shatylko, Akira Tsujimura, Hyun Jun Park, Hussein Kandil, Manaf Al Hashmi, Marco Falcone, Celeste Manfredi, Haocheng Lin, Andrian Japari, Manh Nguyen Truong, Mohammed Abdulgabbar Noman, Jean de la Rosette, Walter D Cardona Maya, Ashok Agarwal","doi":"10.5534/wjmh.250269","DOIUrl":"10.5534/wjmh.250269","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"751-759"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Gender Perspective in Obesity and Gastric Cancer.","authors":"Nayoung Kim","doi":"10.5534/wjmh.260087","DOIUrl":"10.5534/wjmh.260087","url":null,"abstract":"<p><p>There is sex difference of obesity and it might be related with sex hormones. For instance, estrogen regulates adipose tissue function and fat deposition by activation of the sympathetic nervous system, which leads to more adiposity in subcutaneous fat instead of visceral fat. There are strong evidences for the association between obesity and cancer, predominantly cancers of digestive organs including cardia gastric cancer (GC) and cancers of hormone sensitive organs in females. The main pathways linking obesity and cancer are hyperinsulinemia/insulin resistance and abnormalities of the insulin-like growth factor (IGF)-I system, sex hormone biosynthesis and pathway, and subclinical chronic low-grade inflammation and oxidative stress. There have been several reports regarding the effect of obesity on the development of cardia GC, especially in males. The body mass index (BMI) changes from underweight or normal to overweight (23.0-24.9 kg/m²) decrease the development of non-cardia GC in males but not in females. The prognosis of GC is the better as the BMI is higher, especially in males. Estrogen can explain for the sex difference of non-cardia cancer (mainly intestinal type) regarding obesity. The peripheral adipose tissue is responsible for the process of steroid aromatization to produce sex hormones including estrogen which can explain why the obese males have better survival or less development of non-cardia GC. In terms of cardia GC, the main cause is related with frequent gastroesophageal reflux in obese males. In addition, metabolic factors such as cholesterol, glucose and IGFs are related with GC similar to other obesity related cancers.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"766-778"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring NAD⁺-Sirtuins Signaling: A Novel Approach to Combat Male Reproductive Aging.","authors":"Lu Zhou, Xiucheng Lan, Meijing Wang, Xiaoya Li, Xin Zeng, Sixue Peng, Jingyi Zhang, Junjun Li, Liang Dong, Xujun Yu, Fang Yang","doi":"10.5534/wjmh.250248","DOIUrl":"10.5534/wjmh.250248","url":null,"abstract":"<p><p>Male reproductive aging manifests as progressive declines in testosterone synthesis, spermatogenic efficiency, and fertility, driven by multi-system dysfunction. This review synthesizes evidence establishing the nicotinamide adenine dinucleotide (NAD⁺)-Sirtuins axis as a central regulator of testicular homeostasis and its age-related dysregulation. Mechanistically, NAD⁺ depletion impairs energy metabolism (glycolysis/TCA cycle), antioxidant defenses, and steroidogenesis, while reduced Sirtuins activity (SIRT1/SIRT3/SIRT6) disrupts spermatogonial stem cell maintenance, blood-testis barrier (BTB) integrity, epigenetic programming, and immune privilege. Key pathological features include: (1) Structural compromise (lysosomal dysfunction in Sertoli cells, BTB disruption); (2) Metabolic-oxidative stress (lipid accumulation, mitochondrial failure, reactive oxygen species overproduction); (3) Chronic inflammation (NLRP3 inflammasome activation, T-cell infiltration); (4) Epigenetic dysregulation (aberrant histone acetylation, ncRNA imbalances); and (5) hormonal synthesis disorder. Interventions targeting this axis-NAD⁺ precursors (NMN/NR), Sirtuin activators (resveratrol/quercetin), and lifestyle strategies (intermittent fasting/exercise)-demonstrate efficacy in preclinical models: NMN restores sperm quality (+40% normality) and testosterone synthesis; resveratrol reduces sperm DNA fragmentation by 45% via SIRT3 activation. Clinical data suggest improved physiological parameters (<i>e.g.</i>, muscle function, biological age) with NMN supplementation. Critical knowledge gaps persist regarding tissue-specific Sirtuin functions, long-term safety of NAD⁺ boosters, and individualized intervention protocols. Future research should prioritize testicular-targeted delivery systems, NAD⁺-based biomarkers, and randomized trials. Restoring NAD⁺-Sirtuins signaling represents a promising therapeutic strategy against age-related male infertility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"788-806"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Statistical Competence in Andrology: Outcomes of an Online Medical Statistics Training Program.","authors":"Nicolás Garrido, Asli Metin Mahmutoglu, Bahadir Sahin, Durairajanayagam Damayanthi, Rossella Cannarella, Ayad Palani, Ashok Agarwal","doi":"10.5534/wjmh.250161","DOIUrl":"10.5534/wjmh.250161","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the impact of a structured online medical statistics webinar on researchers in andrology, both clinicians and non-clinicians. The objectives were to: 1) emphasize the critical role of statistical literacy in medical and biomedical research, 2) evaluate participants' baseline knowledge, 3) determine the impact of the webinar on knowledge acquisition and satisfaction, and 4) analyze the influence of gender and institutional setting on learning outcomes.</p><p><strong>Materials and methods: </strong>The Global Andrology Forum (GAF) conducted a webinar comprising four expert-led lectures on medical statistics and male infertility research. Participants completed three online surveys evaluating baseline characteristics, pre- and post-course knowledge, and satisfaction.</p><p><strong>Results: </strong>Post-webinar analysis showed a significant improvement in statistical knowledge, with the mean percentage of correct responses rising from 55.6% (95% confidence interval [95% CI]: 51.35-59.86) to 66.8% (95% CI: 62.48-71.14) (p<0.05). Female participants demonstrated over twice as much a greater average score increase (16.1) compared to males (7.9), though the difference was not statistically significant (p=0.092). Participants from public institutions showed the most substantial improvement (p<0.001), while private sector participants had a more modest and non-significant increase (p=0.054). Overall satisfaction was high, with 77.6% of participants indicating that they would recommend the course to their colleagues.</p><p><strong>Conclusions: </strong>This structured online webinar significantly improved the participants' statistical knowledge, highlighting the importance of such training in medical research. The high levels of participant satisfaction and positive feedback regarding the course underscore the webinar's success. This study highlights the potential for future targeted online statistical educational initiatives and the need for such training for researchers in andrology and biomedicine.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"901-915"},"PeriodicalIF":4.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}