World Journal of Mens Health最新文献

{"title":"A Highly Sensitive Methylation Assay for Prostate Cancer Diagnosis.","authors":"Xingyu Zhong, Zhihao Ming, Haodong He, Yifan Xiong, Shaogang Wang, Qidong Xia","doi":"10.5534/wjmh.240182","DOIUrl":"https://doi.org/10.5534/wjmh.240182","url":null,"abstract":"<p><strong>Purpose: </strong>Prostate cancer is a prevalent malignancy among males, necessitating precise diagnosis for effective treatment and prognosis. However, there is a lack of accurate, reliable, and cost-effective methods for precise diagnosis of prostate cancer.</p><p><strong>Materials and methods: </strong>The bisulfite-treated DNA was amplified by a blocker strand-assisted methylation-specific PCR method, and the signal was amplified by a guiding strand-assisted enzyme/probe detection system. On this basis, an Optimized DNA Methylation Detection Assay was developed. Fifty-five prostate cancer patients and 24 healthy patients were selected for blood/urine sample testing to evaluate the clinical value of the assay.</p><p><strong>Results: </strong>The experimental results showed that the detection limit of the Tri-Component Liquid Biopsy Assay reached 0.002%. Assays for six prostate cancer methylation variants were constructed and finally three sites, GSTP1, ADCY4, and HOXA7, were selected for the design of prostate cancer diagnostic panel. The differences in methylation were statistically significant. Additionally, evaluating this approach on liquid biopsies from prostate cancer patients, we obtained a sensitivity and specificity of 89% and 76% respectively. Meanwhile, the cost of a single test on this platform is about $7.5, and the testing time is only about 5 hours.</p><p><strong>Conclusions: </strong>Here we have successfully developed a highly sensitive methylation assay for prostate cancer diagnosis that features both accuracy, efficiency, and low cost. Combined with the established detection panel, this method can realize accurate and non-invasive early diagnosis of prostate cancer, which substantially augments the pragmatic utility of liquid biopsy.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Toxicity and Mechanisms of Bisphenol Analogs in Male Infertility: Insights from Network Toxicology and Molecular Docking Approaches.","authors":"Biao Ran, Hao Ran, Liangren Liu","doi":"10.5534/wjmh.240270","DOIUrl":"https://doi.org/10.5534/wjmh.240270","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Hypogonadism: The Korean Society of Men's Health and Aging Position Statement.","authors":"Sun Tae Ahn, Young-Sang Kim, Sung Hoon Yu, Yoon-Sok Chung","doi":"10.5534/wjmh.240266","DOIUrl":"https://doi.org/10.5534/wjmh.240266","url":null,"abstract":"<p><p>The Korean Society of Men's Health and Aging (KSMHA) acknowledges the necessity for an updated statement on testosterone therapy driven by evolving clinical practices and new research findings. The primary purpose of this position statement is to provide a tailored, evidence-based framework that aligns with international best practices while addressing the unique needs of the Korean population. Additionally, this statement addresses the growing recognition of both organic and functional hypogonadism, particularly given the rising rates of obesity and metabolic syndrome, which affect testosterone levels and overall health. The position statement addresses key areas, including the clinical and laboratory diagnosis of male hypogonadism, with a focus on appropriate cut-off values for testosterone levels in Korean men, and provides guidance on assessing treatment outcomes. In this statement, we present an objective position on testosterone therapy based on recent studies that have carefully evaluated its effectiveness and safety. By providing a tailored framework for the management of male hypogonadism, KSMHA aims to enhance patient care and align Korean practices with global standards.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Andrology Forum Clinical Practice Guidelines on the Management of Premature Ejaculation.","authors":"Taymour Mostafa, Germar-Michael Pinggera, Manaf Al Hashimi, Bahadır Sahin, Selahittin Çayan, Rupin Shah, Eric Chung, Amarnath Rambhatla, Mohamed Arafa, Widi Atmoko, Omer Raheem, Ayman Rashed, Tan V Le, Nicholas Tadros, Hiva Alipour, Edmund Ko, Baris Altay, Shedeed Ashour, Mohamad Moussa, Ricky Adriansjah, Giorgio Ivan Russo, Gian Maria Busetto, Iman Shamohammadi, Ioannis Sokolakis, Muhammad Ujudud Musa, Fahmi Bahar, Gökhan Çeker, Tuncay Toprak, Massimiliano Timpano, Nguyen Quang, Manh Nguyen Truong, Sang Thanh Le, Rossella Cannarella, Ahmad Motawi, Kadir Bocu, Luca Boeri, Giovanni M Colpi, Gianmaria Salvio, Kareim Mohamed Khalafalla, Marco Falcone, Nazim Gherabi, Sunil Jindal, Taha Hamoda, Kasonde Bowa, Teng Aik Ong, Sedigheh Bahmyari, Ahmed El-Sakka, Amr El Meliegy, Emad Taha, Christopher Chee Kong Ho, Gokhan Calik, Aldo E Calogero, Niwanda Yogiswara, Walter D Cardona Maya, Hussain Al Najjar, Maged Ragab, Ashok Agarwal","doi":"10.5534/wjmh.240260","DOIUrl":"10.5534/wjmh.240260","url":null,"abstract":"<p><strong>Purpose: </strong>Premature ejaculation (PE) is a commonly encountered male sexual dysfunction (MSD) with various definitions, diagnostic criteria, and treatment options, leading to significant heterogeneity and controversy in its management. This study aimed to explore the global practice patterns of the diagnosis and management of PE.</p><p><strong>Materials and methods: </strong>A cross-sectional, global, online survey on PE was conducted using a questionnaire developed by an international cohort of experts. Results were analyzed using R version 4.1.2. Additionally, expert recommendations were formulated using a modified Delphi method.</p><p><strong>Results: </strong>The survey was completed by 264 participants from 41 countries. The majority of respondents were below the age of 45 years and were urologists focusing on andrology and sexual health. PE diagnosis was primarily based (by 61.5%) on an intravaginal ejaculatory latency time of less than one minute. Lifelong PE was the most common category reported (47.7%), and most respondents (84.2%) observed ante-portas PE in less than 25% of cases. Distinguishing PE from erectile dysfunction was challenging for many respondents (60.7%). Diabetes mellitus was the most common comorbidity (17.1%). Pharmacological therapy was the most common treatment method (34.3%), with dapoxetine being the most preferred medication (37.9%). Surgical methods were infrequently used. Emerging treatments like hyaluronic acid gel glans augmentation were favored by only 11.7%. Patient satisfaction was the primary criterion for successful PE treatment (55.9%), and cost was a significant concern for many (35.5%).</p><p><strong>Conclusions: </strong>This global survey highlights significant diversity in the diagnostic and treatment strategies for PE. Standard diagnostic criteria are generally accepted, off-label medication is widely used in therapy, and the role of surgery is still controversial. A multi-modal therapy approach, tailored to the patient's specific needs, is favored. Further research into the neurobiology of PE and the development of effective and safe options is crucial for improving the management of PE.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis.","authors":"Weizhuo Wang, Kang Chen, Yi Yu, Mingwei Chen, Lu Wang, Ying Pang, Meiqi Ren, Hong Zhang, Kai Fu","doi":"10.5534/wjmh.240252","DOIUrl":"https://doi.org/10.5534/wjmh.240252","url":null,"abstract":"<p><strong>Purpose: </strong>In recent decades, the incidence of male infertility has been increasing annually. In clinical practice, the question of whether to supplement folic acid is common among patients. Given the limited guidelines and research on the impact of folic acid on male infertility, this study aims to assess the effect of folic acid on male infertility using Mendelian randomization (MR) analysis.</p><p><strong>Materials and methods: </strong>We conducted a two-sample bidirectional MR study using IEU database data for folate levels and supplementation. Male infertility genome-wide association study (GWAS) data were obtained from the FinnGen Consortium R8 dataset. To evaluate the causal relationship between folate, folate supplementation, and the risk of male infertility, we employed various MR methods, including inverse-variance weighted (IVW), MR-Egger, and Maximum Likelihood. The analysis results were assessed using MR-PRESSO, MR-Egger, and leave-one-out analysis. Genes related to folate metabolism were sourced from the MSigDB database, and the Expression Quantitative Trait Loci (eQTL) information of related genes was obtained from the IEU database. Single nucleotide polymorphism data for other male infertility risk factors, such as diabetes and obesity, were also analyzed.</p><p><strong>Results: </strong>According to the MR analysis, there is no causal relationship between serum folate levels and male infertility in the general population. However, reverse Mendelian analysis indicated that male infertility may promote elevated serum folate levels. Folate supplementation appears to act as a protective factor against male infertility, while reverse MR analysis shows no causal relationship between male infertility and folate supplementation. Furthermore, we identified SERPINE1 and LDLR as potential causal genes in the folate metabolism pathway related to male infertility. Hypertension and hyperlipidemia also showed causal relationships with these two genes.</p><p><strong>Conclusions: </strong>This study used MR to discover that folate supplementation is a protective factor against male infertility, and that SERPINE1 and LDLR may be influential genes in folate metabolism affecting male infertility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prostate Cancer Treatment on Quality of Life of LGBTQ+ Patients: A Systematic Review.","authors":"Liliana Vartolomei, Patrik Petrov, Mihai Dorin Vartolomei, Shahrokh F Shariat","doi":"10.5534/wjmh.240203","DOIUrl":"https://doi.org/10.5534/wjmh.240203","url":null,"abstract":"<p><p>The gay, bisexual, transgender, and queer + (LGBTQ+) community is underserved, and their needs are often misunderstood and/or overlooked. We aimed to analyze the current literature regarding prostate cancer's (PCa) impact on the quality of life (QoL) of LGBTQ+ patients with a focus on sexuality, identity, and psychosocial support. In June 2024, we searched the following databases, PubMed, Embase, and Clinicaltrials.gov, for relevant data regarding sexuality, identity, and psychosocial support of LGBTQ+ suffering from PCa using the keywords \"Prostate Cancer AND Gay or Prostate Cancer AND LGBTQ+.\" In sum, there were only a few records on the subject with very few clinical trials. Major concerns of inadequate care included the impact on sexual intercourse, sexual identity and role, mental health, and psychological support. Two U.S. trials reported on the deep health-related quality of LGBTQ+ community members in dealing with PCa. These revealed significant sufferings and disparities in care access, delivery, perception, and satisfaction in the LGBTQ+ patients affected by PCa. Current data suggest that LGBTQ+ patients with PCa are an under-researched population whose QoL concerns and needs are often overlooked. PCa has a significant impact on the sexual, emotional, and social well-being of the LGBTQ+ community; this impact seems different than the non-LGBTQ+ community, underlying the need for focused research and interventions.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescen.","authors":"Fang Yang, Xiaoya Li, Meijing Wang, Xiucheng Lan, Jingyi Zhang, Junjun Li, Degui Chang, Xujun Yu","doi":"10.5534/wjmh.240254","DOIUrl":"https://doi.org/10.5534/wjmh.240254","url":null,"abstract":"<p><p>Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the past half-century. Genetic defects alone cannot explain the rapid increase in incidence, and there is growing evidence that environmental factors or lifestyle changes are responsible for the high incidence in recent years. Testicular Leydig cells occupy an important role in the male reproductive system. In this study, we review the mechanisms by which environmental endocrine disruptors promote both death and senescence of testicular Leydig cells, refine the former into two programmed death modes, apoptosis, and autophagy, and further explore the interactions among them, thus summarizing the advances of the toxic effects of environmental endocrine disruptors on testicular Leydig cells, and expecting to provide a new therapeutic idea.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Rates of Sex Hormone Receptors with Their Clinical Correlates in Gastric Cancer Patients and Normal Controls.","authors":"Yonghoon Choi, Nayoung Kim, Ji Hyun Park, Chin-Hee Song, Hyeon Jeong Oh","doi":"10.5534/wjmh.240272","DOIUrl":"https://doi.org/10.5534/wjmh.240272","url":null,"abstract":"<p><strong>Purpose: </strong>Sex hormones affect development and prognosis of gastric cancer (GC). This study aimed to compare the sex hormone receptor expression between control and GC, and to evaluate its correlation with patient characteristics.</p><p><strong>Materials and methods: </strong>110 patients (74 with GC, 36 controls) underwent immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) for estrogen receptors (ERs) α and β and androgen receptor (AR). The effect of ERs and AR on the clinicopathological and tumor characteristics were analyzed.</p><p><strong>Results: </strong>The positive rate of ERα, ERβ, and AR in GC tissue was 64.9%, 78.4%, and 60.8% by IHC and 41.4%, 27.6%, and 48.3% in RT-PCR respectively. In control, the positive rate of those was 16.7%, 80.6%, and 38.9% by IHC and 22.2%, 58.3%, and 19.4% in RT-PCR respectively. The IHC and RT-PCR results showed concordance with each other, and ERα and AR expressions were positively correlated with cancer, while ERβ showed the opposite pattern. ERα expression was correlated with <i>Helicobacter pylori</i> negativity (p<0.001), diffuse or mixed-type histology (p=0.014), and undifferentiated histology (p<0.001), and AR expression was related to <i>H. pylori</i> negativity (p<0.001), cardiac cancer (p=0.040), and undifferentiated histology (p<0.001). The higher expression rate of ERα in males and that of AR in females seemed to be related with cancer, showing sex differences.</p><p><strong>Conclusions: </strong>The expression rates of ERα, ERβ, and AR were different depending on sex, histologic type and <i>H. pylori</i> infection status, which may explain sex-based differences in GC.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer and Suicide Risk: A Systematic Review and Meta-Analysis.","authors":"Yun Jin Kim, Eun Ji Lee, Sung Ryul Shim, Jae Heon Kim","doi":"10.5534/wjmh.240168","DOIUrl":"https://doi.org/10.5534/wjmh.240168","url":null,"abstract":"<p><strong>Purpose: </strong>Suicide is a substantial public health concern, and there are a variety of contributing factors. Prostate cancer is known to be a disease at high risk of suicide regardless of country and age. Nonetheless, comprehensive information about associated risk levels and underlying determinants remains limited. To systematically evaluate the suicide risk in prostate cancer patients compared to control by systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>PubMed, Embase, and the Cochrane Library were searched from the earliest available indexing date through May 2024. The criteria for selecting the subjects were as follows: (1) studies including patients who had prostate cancer, (2) intervention was not specified, (3) comparison was made with people without prostate cancer selected as the control group, and (4) outcomes were measured as standardized mortality ratio (SMR) or relative risk (RR), or hazard ratio (HR) of suicide in prostate cancer. Random-effects model were used to estimate pooled effect sizes. Meta-regression analyses were conducted to identify the potential moderator effects between prostate cancer and the risk of suicide.</p><p><strong>Results: </strong>A systematic review and meta-analysis of these 25 studies that included a total of 4,987,941 participants were performed. The pooled SMR for overall suicide risk in prostate cancer compared with control groups was 1.251 (95% confidence interval [95% CI]: 1.120-1.383). The pooled RR or HR was 1.712 (95% CI: 1.306-2.243). The suicide risk of prostate cancer patients showed statistically significant in all cases of SMR and RR or HR. The suicide risk was also significantly higher in most subgroup analyses according to age and research follow-up period.</p><p><strong>Conclusions: </strong>The findings of this systematic review and meta-analysis support the association between prostate cancer and increased risk of suicidal tendencies. Follow-up for prostate cancer patients should be highly integrated with psychiatric and psychological care to improve the psychosocial function of patients.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Clinical Features and Survival Outcomes of Esophageal Cancer: A Comparative Study in the Korean Population.","authors":"Jin Hee Noh, Hyungchul Park, Do Hoon Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung","doi":"10.5534/wjmh.240192","DOIUrl":"https://doi.org/10.5534/wjmh.240192","url":null,"abstract":"<p><strong>Purpose: </strong>Esophageal cancer is a predominantly male disease. However, the sex differences associated with esophageal cancer have not been thoroughly investigated. This study aimed to evaluate the differences between esophageal cancer in males and females in the Korean population.</p><p><strong>Materials and methods: </strong>We assessed patients diagnosed with esophageal cancer between 2005 and 2015 at a tertiary referral center. The clinical features of patients, histopathologic characteristics of tumors, and treatment and survival outcomes were compared between male and female patients.</p><p><strong>Results: </strong>We enrolled 2,068 patients, comprising 1,924 (93.0%) males and 144 (7.0%) females. The median age at diagnosis was younger for females than males (65 <i>vs.</i> 63 years, p=0.004). Squamous cell carcinoma was the predominant pathological type (99.0% in males and 93.1% in females); however, the proportion of adenocarcinoma cases was higher in females than males (0.8% <i>vs.</i> 5.6%, p<0.001). Multivariate analysis indicated favorable overall survival for female patients (hazard ratio [HR], 0.685; 95% confidence interval [CI], 0.548-0.857) and patients with high body mass index (≥25 kg/m², HR, 0.432; 95% CI, 0.355-0.526), and in early tumor stage (Stage 4, HR, 12.684; 95% CI, 7.451-21.591). The 5-year overall survival (44.8% <i>vs.</i> 53.5%, p=0.016) and recurrence-free survival rates (74.0% <i>vs.</i> 84.3%, p=0.036) were higher in females than in males.</p><p><strong>Conclusions: </strong>We found significant sex differences in esophageal cancer among the Korean population, with female patients demonstrating distinct clinical characteristics and more favorable survival outcomes compared to male patients. These findings underscore the importance of considering sex-specific factors in the management and prognosis of esophageal cancer.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}