World Journal of Mens Health最新文献

{"title":"Artificial Intelligence in Scientific Writing: Balancing Innovation and Efficiency with Integrity: Perspectives and Position Statements of Global Andrology Forum Expert Group.","authors":"Taha Abo-Almagd Hamoda, Christine Wyns, Germar-Michael Pinggera, Hiva Alipour, Tomer Avidor-Reiss, Taymour Mostafa, Eric Chung, Jonathan Ramsay, Selahittin Çayan, Amarnath Rambhatla, Ralf Reinhold Henkel, Giovanni Maria Colpi, Ramadan Saleh, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.250007","DOIUrl":"10.5534/wjmh.250007","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"217-226"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential NRF2 Methylation and PD-1 Expression in Normal Tissues of Colorectal Adenoma and Carcinoma across Sexes.","authors":"Chin-Hee Song, Yonghoon Choi, Nayoung Kim, Ryoung Hee Nam, Jin Won Kim, Jae Young Jang, Eun Hye Kim, Sungchan Ha, Ha-Na Lee","doi":"10.5534/wjmh.250061","DOIUrl":"10.5534/wjmh.250061","url":null,"abstract":"<p><strong>Purpose: </strong>Metachronous cancer following the cure of the primary cancer could be related with the tumor microenvironment. Recently it has been known that nuclear factor erythroid 2-related factor 2 (<i>NRF2</i>), a key transcription factor regulates immune checkpoint expression, including programmed cell death-ligand 1 (PD-L1), a well-known checkpoint molecule. The aim of this study was to investigate the roles of <i>NRF2</i> and <i>PD-1</i> in the tumor microenvironment using the normal colon tissue, with a focus on sex-specific differences.</p><p><strong>Materials and methods: </strong>A total of 280 participants were enrolled including 66 healthy controls (HC), 109 patients with colorectal adenoma (AD), and 105 patients with colorectal cancer (CRC). Quantitative real-time polymerase chain reaction (PCR) for <i>NRF2</i> and <i>PD-1</i> and methylation-specific PCR for <i>NRF2</i> were performed with normal mucosal tissue above the 20 cm from anal verge.</p><p><strong>Results: </strong><i>NRF2</i> methylation levels were significantly lower in the AD and CRC groups compared to the HC in both sexes. <i>PD-1</i> mRNA expression was significantly reduced in the AD and CRC groups compared to the HC group. In terms of sex males showed significantly lower <i>PD-1</i> mRNA levels in the AD and CRC groups, whereas females displayed significantly higher <i>PD-1</i> expression in the AD group but significantly lower levels in the CRC group. In conclusion there were significant differences in <i>NRF2</i> methylation and <i>PD-1</i> expression in the normal mucosal tissue among CRC, AD, and HC groups, suggesting that metachronous lesions might arise from this underlying tumor microenvironment.</p><p><strong>Conclusions: </strong>Our results suggest that mRNA expressions of <i>NRF2</i> and <i>PD-L1</i> in the normal colon tissue may serve as early molecular markers in colorectal carcinogenesis with distinct sex-specific patterns.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"322-333"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Adipose Stem Cells Engineered to Express Carboxylesterase Confer Anti-Tumoral Efficacy of Irinotecan in Castration-Resistant Prostate Cancer Bone Metastasis Growth and Osteolysis.","authors":"Da Hyun Yun, Jae Heon Kim, Sang Hun Lee, Eun Jung Lee, Serk In Park, Yun Seob Song","doi":"10.5534/wjmh.240284","DOIUrl":"10.5534/wjmh.240284","url":null,"abstract":"<p><strong>Purpose: </strong>Castration-resistant prostate cancer (CRPC) presents a significant clinical challenge, particularly when it metastasizes to bone, leading to skeletal-related events such as osteolysis. Conventional therapies offer limited efficacy and high toxicity, highlighting the need for innovative treatments. This study investigates the use of human telomerase reverse transcriptase-immortalized adipose-derived stem cells engineered to express carboxylesterase (hTERT-ADSC.CE) to enhance the local activation and efficacy of irinotecan (CPT-11) in targeting CRPC.</p><p><strong>Materials and methods: </strong>hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells were generated by lentiviral transduction with two genes encoding carboxylesterase enzymes <i>CES1</i> or <i>CES2</i> (referred to as CE1 or CE2 in this manuscript), respectively. The migration of hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells toward prostate cancer cells was evaluated in a transwell migration assay. The cytotoxicity of irinotecan in combination with hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells on PC3 prostate cancer cells was assessed <i>via</i> MTT viability and apoptosis assays. An <i>in vivo</i> CRPC bone metastasis model in mice was used to examine the therapeutic effects of co-administered hTERT-ADSC.CE2 cells and CPT-11 on tumor growth and tumor-induced osteolysis.</p><p><strong>Results: </strong>hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells demonstrated selective migration toward PC3 cells and significantly enhanced the cytotoxic effects of CPT-11 on prostate cancer cells <i>in vitro</i>. <i>In vivo</i>, the combined treatment with hTERT-ADSC.CE2 and CPT-11 significantly reduced tumor growth and osteolytic activity in the bone metastasis model. Histological analysis confirmed increased apoptosis in tumor cells and reduced osteolysis, indicating effective local drug activation by hTERT-ADSC.CE1 and/or hTERT-ADSC.CE2.</p><p><strong>Conclusions: </strong>Our findings suggest that hTERT-ADSC.CE1 and hTERT-ADSC.CE2 cells combined with irinotecan offer a promising targeted therapy for CRPC, enhancing drug efficacy while minimizing systemic toxicity. This cell-based enzyme-prodrug therapy could address the limitations of current therapies, especially in bone metastatic CRPC, and warrants further investigation for clinical translation.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"359-369"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Anesthesia for Holmium Laser Enucleation of the Prostate: Does Spinal Anesthesia Improve Recovery?","authors":"Yu Seob Shin, Ho Seok Chung","doi":"10.5534/wjmh.250090","DOIUrl":"10.5534/wjmh.250090","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"469-470"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Perirectal Hydrogel Spacer Placement with Clinical Outcomes in Patients with Prostate Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis.","authors":"Jong Kyou Kwon, Jinhyung Jeon, Sungun Bang, Kyo Chul Koo, Kang Su Cho, Do Kyung Kim","doi":"10.5534/wjmh.250043","DOIUrl":"10.5534/wjmh.250043","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the relationship between perirectal hydrogel spacer placement and the clinical outcomes in men undergoing radiotherapy (RT) for prostate cancer.</p><p><strong>Materials and methods: </strong>An extensive literature review was conducted using the PubMed/Medline, Embase, Cochrane Library, and Web of Science databases, encompassing studies published through June 2024. Group comparisons were performed using the weighted mean difference for continuous variables and the risk ratio for dichotomous measures. The primary endpoint was to compare rectal radiation doses with or without a perirectal spacer. Secondary outcomes included gastrointestinal (GI) and genitourinary (GU) toxicities (acute/late and any/grade ≥2, with subgroup analyses for hypofractionated RT.</p><p><strong>Results: </strong>We reviewed 35 studies comprising 4,664 males. Rectal spacers effectively reduced the mean and maximum rectal radiation exposure, with reductions of 51.8% in V50 (mL) and 56.8% in V70 (mL). Furthermore, the percentage-based analysis showed reductions of 54.5% in V50 (%) and 62.2% in V70 (%). Acute GU toxicities (any grade and grade ≥2) showed no significant difference between the spacer and no-spacer groups, with no subgroup differences by fractionation. Late GU toxicities (any grade) were lower in the spacer group, while grade ≥2 toxicities showed no difference. Acute GI toxicities (any grade) were significantly reduced with spacers, particularly in hypofractionated RT, while grade ≥2 toxicities showed no difference. Late GI toxicities (any grade) were lower in the spacer group, with a stronger protective effect in hypofractionated RT. No significant difference was observed in grade ≥2 late GI toxicities.</p><p><strong>Conclusions: </strong>Hydrogel spacers significantly reduced rectal radiation exposure and overall GI toxicity. However, their limited impact on severe toxicity highlights the need for further research on high-risk treatments and advanced RT techniques.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"301-321"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgens are a Key Factor Affecting Immune Related Diseases.","authors":"Hede Zou, Jiayou Zhao, Haoran Xu, Wenkang Chen, Rui Cao, Yongjie Ma","doi":"10.5534/wjmh.240292","DOIUrl":"10.5534/wjmh.240292","url":null,"abstract":"<p><p>Androgens mainly have suppressing effects on immune function, affecting the different progression of immune diseases in males and females, but their main mechanisms are still unclear. Bibliometric methods are used to analyze relevant literature in the Web of Science Core Collection (WoSCC) database over the past decade, with a focus on key and hot topics. The results show that prostate cancer, triple negative breast cancer, and sex differences in respiratory diseases, etc. are hot topics in the interdisciplinary field of androgen and immunology. In males, androgens are mainly synthesized and secreted by the testes, indicating the important role of male reproduction in immunity and providing a reproductive perspective for the prevention and treatment of immune diseases.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"237-252"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Dynamic Online Nomogram Prediction Model for Assessing the Risk of Erectile Dysfunction.","authors":"Guodong Liu, Yuyang Zhang, Xu Wu, Hui Gao, Hui Jiang, Xiansheng Zhang","doi":"10.5534/wjmh.250018","DOIUrl":"10.5534/wjmh.250018","url":null,"abstract":"<p><strong>Purpose: </strong>Erection dysfunction (ED) represents a globally prevalent men's health problem and affected by a variety of factors. This study aimed to develop a dynamic nomogram model to assess the probability of ED in a population through a multitude of factors.</p><p><strong>Materials and methods: </strong>A total of 2,668 subjects from the National Health and Nutrition Examination Survey were included in this study. The entire dataset was randomly divided into training and validation sets, with the training set comprising 70% of the data and the validation set comprising 30%. The Least Absolute Shrinkage and Selection Operator and multivariate logistic regression analysis determined the predictors for constructing the nomogram, and the model was evaluated by Concordance Index (C-index), calibration curve, Hosmer-Lemeshow test, and decision curve analysis.</p><p><strong>Results: </strong>The nomogram model consisted of 9 predictors, which were age, education, stroke, lymphocyte, diabetes, poverty income ratio, prostate disease, activity, and hypertension. The C-index for the training set was 0.828 and for the validation set was 0.825, indicating that the model shows good clinical applicability and calibration of the model on both the training and validation sets. Additionally, we created an online dynamic nomogram (https://wvknly-liu-guodong.shinyapps.io/dynnomapp/) that anyone can evaluate on a web page.</p><p><strong>Conclusions: </strong>Our dynamic nomogram can integrate multiple risk factors to provide a personalized risk assessment that is highly clinically predictive and provides a valuable tool for early intervention and prospective management of ED. This could help physicians to identify and manage high-risk populations early and provide personalized treatment plans.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"347-358"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Training Program for Meta-Analytical Research: A Novel Approach to Minimizing Errors in Medical Systematic Reviews and Meta-Analyses.","authors":"Ayad Palani, Hiva Alipour, Ashok Agarwal, Andrea Crafa, Ramadan Saleh, Bahadır Şahin, Wael Zohdy, Damayanthi Durairajanayagam, Fotios Dimitriadis, Erman Ceyhan, Rossella Cannarella, Tuncay Toprak, Widi Atmoko, Marco Falcone, Naveen Kumar, Giorgio Ivan Russo, Trang Nguyen, Gokhan Calik, Deniz Kulaksiz, Konstantinos Makarounis, Kadir Böcü, Fikri Rizaldi, Ricky Adriansjah, Hakan Keskin, Vineet Malhotra, Nguyen Phuoc, Sezgin Gunes, Carlo Giulioni, Ahmad Motawi, Germar-M Pinggera, Imad Ziouziou, Gökhan Çeker, Christopher Ho, Fereshteh Dardmeh, Fahmi Bahar, Nazim Gherabi, Parisa Dolati, Priyank Kothari, Aram Adamyan, Rupin Shah","doi":"10.5534/wjmh.250008","DOIUrl":"10.5534/wjmh.250008","url":null,"abstract":"<p><strong>Purpose: </strong>The Global Andrology Forum (GAF) has developed an innovative training method to equip novice researchers with the fundamental skills to conduct high-quality systematic reviews and meta-analyses (SRMAs) under the supervision of senior experts. This article aims to describe and evaluate the effectiveness of the GAF training program in enhancing these skills.</p><p><strong>Materials and methods: </strong>A six-module training program was designed to cover the key steps in SRMA studies, enabling GAF members to conduct high-quality SRMAs. Initially launched as a synchronous (remote) training program, it was later transitioned into an asynchronous format and implemented on the Moodle platform. Trainees participating in the synchronous training program were asked to evaluate the course using a specially designed questionnaire. Participants' assessments of the asynchronous course were collected at various stages. Data from both training models were statistically analyzed.</p><p><strong>Results: </strong>Among the trainees who participated in the questionnaire on the original synchronous course (n=101), the majority rated the material and assessments as clear, helpful, and effective in enhancing their knowledge. Additionally, the trainees indicated that the features offered in the training made them feel comfortable and engaged. Of the 29 participants enrolled in the asynchronous program, 22 took part in the assessment. Among them, 12 (54.5%) completed all course requirements, achieving an average score of 83.7%, qualifying them for conducting SRMAs.</p><p><strong>Conclusions: </strong>The GAF SRMA online training program has proven to be an effective and well-received initiative for equipping researchers with essential skills to conduct high-quality SRMAs. By addressing the diverse needs of trainees through its innovative and flexible design, the program has demonstrated its capacity to enhance knowledge and engagement. The successful implementation of this training program highlights its potential to significantly improve the quality of SRMAs in medical research, thereby contributing to the advancement of evidence-based medical practice on a broader scale.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"253-267"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Mirabegron and Tamsulosin Combination Therapy Compared to Tamsulosin Monotherapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Results of a Multicenter, Randomized, Double-Blind, Phase III Clinical Trial.","authors":"Sung Chul Kam, Yu Seob Shin, Doo Sang Kim, Won Ki Lee, Deok Hyun Han, Phil Hyun Song, Sung Hoo Hong, Young Seop Chang, Tae Hwan Kim, Sung Tae Cho, Sung Yul Park, Jae Hyun Bae, Kyung Jin Chung, Joon Hwa Noh, Kang Su Cho, Tae Nam Kim, Zhao Luo, Won Sik Ham, Tae Hyo Kim","doi":"10.5534/wjmh.250085","DOIUrl":"10.5534/wjmh.250085","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy and safety of mirabegron and tamsulosin combination therapy compared to tamsulosin monotherapy in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS).</p><p><strong>Materials and methods: </strong>This phase 3, randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of mirabegron/tamsulosin combination therapy versus tamsulosin monotherapy in men with LUTS. The trial, conducted across 25 centers from July 2021 to October 2023. Eligible participants were randomly assigned to either the combination or monotherapy group for 12 weeks. Primary efficacy endpoints included changes in total urinary frequency score (TUFS) and International Prostate Symptom Scores (IPSS), with secondary endpoints evaluating various urinary symptoms and changes in post void residual volume (PVR), maximum urinary flow rate (Qmax), and quality of life scores. Safety assessments included adverse events, PVR, Qmax, vital signs, electrocardiogram, and laboratory tests.</p><p><strong>Results: </strong>A total of 795 participants were randomized to monotherapy (n=397) and combination therapy (n=398) groups. After 12 weeks, 342 in the monotherapy and 339 in the combination therapy group completed the study, with no significant baseline differences. The combination therapy group showed a greater improvement in TUFS (-11.28) and IPSS (-10.85) scores compared to monotherapy (-8.30 and -9.85, respectively) with significant differences (p<0.0001, p=0.0325). Combination therapy showed significant improvements in storage symptoms and voiding diary variables, including daytime frequency, urgency, and incontinence, compared to monotherapy. The incidence of treatment-emergent adverse events was similar between the groups (13.10% <i>vs.</i> 16.58%, p=0.1943), with no serious drug-related adverse events, confirming an acceptable safety profile for combination therapy.</p><p><strong>Conclusions: </strong>Combination therapy with mirabegron and tamsulosin is more effective than monotherapy in improving LUTS in patients with BPH, particularly storage symptoms, with a comparable safety profile. A fixed-dose combination formulation in the future may further improve patient adherence and quality of life.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"427-437"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Genome-Wide Association Study Based Polygenic Risk Score for Prostate Cancer in an Asian Population.","authors":"Jiun-Hung Geng, Chia-Cheng Yu, Chao-Yuan Huang, Victor C Lin, Chia-Yang Li, Ming-Tsang Wu, Szu-Chia Chen, Bo-Ying Bao, Shu-Pin Huang","doi":"10.5534/wjmh.250056","DOIUrl":"10.5534/wjmh.250056","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to estimate genetic susceptibility to prostate cancer (PCa) by constructing a polygenic risk score (PRS) using single nucleotide polymorphisms (SNPs) identified from genome-wide association studies.</p><p><strong>Materials and methods: </strong>The study included 1,015 PCa patients from our institutions and 1,015 age-matched controls from the Taiwan Biobank (TWB). An independent external validation cohort of 188 PCa patients and 188 TWB controls (excluding those from the primary cohort) was assembled. DNA was extracted from blood samples, with approximately 690,000 SNPs genotyped (minor allele frequency ≥0.05) and 15 million additional SNPs imputed using the 1000 Genomes Project. After quality control, 958 PCa patients and 999 controls were included in the analysis. The PRS was developed using PRSice2 by dividing samples into a base dataset and a model-testing set. Model performance was assessed using receiver operating characteristic analysis and cross-validation (CV).</p><p><strong>Results: </strong>Of the 87,092 SNPs initially considered, 24 were used to construct the PRS, located in intronic regions of genes such as <i>KCNH7</i>, <i>HLA-DQA1</i>, and <i>PRNCR1</i>. The PRS significantly improved PCa prediction, achieving an area under the curve (AUC) of 0.824 (p=1.23×10⁻⁵⁰). Patients in the top 25th percentile of PRS had a 34-fold higher risk compared to those in the bottom 25th percentile (odds ratio=34.37, 95% confidence interval=22.93-51.68, p=1.96×10⁻⁵². The model showed stable performance with mean accuracies of 0.75 (3-fold CV) and 0.76 (10-fold CV) and achieved an AUC of 0.757 in the independent validation cohort.</p><p><strong>Conclusions: </strong>The developed PRS showed robust predictive ability for PCa in the Taiwanese population and may inform future risk stratification and personalized interventions.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"402-412"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}