World Journal of Mens Health最新文献

{"title":"Upregulation of the Nestin/NRF2/PRDX2 Signaling Pathway in Penile Tissues Ameliorates Erectile Function in Rats with Cavernous Nerve Injury.","authors":"Jian Zhou, Jun Jiang, Rui Jiang","doi":"10.5534/wjmh.260011","DOIUrl":"https://doi.org/10.5534/wjmh.260011","url":null,"abstract":"<p><strong>Purpose: </strong>Cavernous nerve injury (CNI) is a major cause of erectile dysfunction (ED), and oxidative stress plays a key role in the underlying molecular mechanisms. Nestin contributes to the maintenance of intracellular redox balance. However, whether CNI affects erectile function in rats <i>via</i> the Nestin-related pathway is unclear.</p><p><strong>Materials and methods: </strong>The GSE31247 dataset and a knowledge-guided gene selection approach were analyzed to identify key differentially expressed <i>Nestin</i> genes in cavernous tissue between CNI and Sham-operated rats. The effect of the Nestin, NRF2, and PRDX2 pathways on oxidative stress and pyroptosis-related markers was evaluated in PC-12 cells. <i>In vivo</i>, Nestin expression was examined in the corpus cavernosum of rats with bilateral CNI (BCNI). The effects of upregulated Nestin expression and icariin treatment on erectile function, as well as the underlying mechanisms, were evaluated.</p><p><strong>Results: </strong>Nestin was significantly downregulated in the CNI group versus the Sham group, thus indicating its potential involvement in neuropeptide hormone activity and neurotransmitter transport/signaling pathways. Icariin upregulates the expression of Nestin, NRF2, and PRDX2 in PC-12 cells, suppresses oxidative stress and pyroptosis markers, and increases nNOS expression. Conversely, <i>Prdx2</i> knockdown in PC-12 cells increased oxidative stress and pyroptosis-related markers while decreasing nNOS (p<0.05). Compared to the Sham group, the BCNI group showed lower Nestin, NRF2, and PRDX2 levels and a reduced ICP_max/MAP ratio (p<0.05). <i>Nestin</i> upregulation or icariin treatment in BCNI rats enhanced NRF2/PRDX2 expression, inhibited oxidative stress and pyroptosis-related markers, and increased nNOS, eNOS and the ICP_max/MAP ratio (p<0.05).</p><p><strong>Conclusions: </strong><i>Nestin</i> downregulation in the penile tissue of BCNI rats inhibits NRF2 and PRDX2 expression, contributing to ED. <i>Nestin</i> gene transfection or icariin treatment in the corpus cavernosum upregulates Nestin, NRF2, and PRDX2 pathway proteins, reduces oxidative stress and pyroptosis-related markers, increases nNOS and eNOS, and ultimately improves erectile function in BCNI rats.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varicocele Repair or Assisted Reproduction First? An Evidence-Based, Couple-Centered Decision Framework.","authors":"Selahittin Çayan, Imad Ziouziou, Amarnath Rambhatla, Christine Wyns, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.260130","DOIUrl":"https://doi.org/10.5534/wjmh.260130","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Associated Differences in Age-Related Sensorineural Hearing Loss: Why Are Men More Vulnerable?","authors":"Seokhwan Lee, Sung-Won Choi","doi":"10.5534/wjmh.260126","DOIUrl":"https://doi.org/10.5534/wjmh.260126","url":null,"abstract":"<p><p>Age-related hearing loss is a progressive bilateral sensorineural loss that increases steeply with age, contributing to communication disabilities and social isolation, impacting healthy aging. Across diverse cohorts, men tend to develop earlier and more severe high-frequency threshold elevations than age-matched women. This male disadvantage is partly explained by gender-related lifetime exposure (<i>e.g.</i>, occupational noise, smoking), likely reflecting interactions with biological sex factors, including steroid signaling and mitochondrial susceptibility. Sex differences in cochlear physiology are detectable from infancy, including larger otoacoustic emissions in female newborns, supporting developmental endocrine influences. Adult men usually exhibit earlier and steeper high-frequency declines. Conversely, studies in menopausal women have indicated heterogeneity rather than a uniform female inflection point. Mechanistic studies have demonstrated inner-ear estrogen receptor expression and context-dependent otoprotection. However, human epidemiology does not support uniform auditory benefits from menopausal hormone therapy; rather, long-term oral estrogen or estrogen plus progestogen use may increase the risk of hearing loss. Evidence for androgen pathways is emerging, albeit limited. In older men, higher serum testosterone, but not dehydroepiandrosterone sulfate, is associated with lower odds of high-frequency hearing loss. The precise mechanisms and clinical effects of exogenous hormone therapies on auditory aging remain uncertain. This review synthesizes current evidence using a life-course \"multi-hit\" framework. Rather than pointing to a single biological driver, we describe how innate susceptibilities such as the aging endocrine axis and mitochondrial variation interact with male-predominant ototoxic exposure and cardiometabolic comorbidities to shape auditory dimorphisms. Addressing current knowledge gaps requires sex-stratified longitudinal research integrating precise endocrine profiling with functional auditory outcomes. Clinically, although endocrine pathways are not yet therapeutic targets, understanding this multidimensional vulnerability highlights the utility of risk-stratified screening. Incorporating proactive hearing assessment into routine evaluations of aging men, particularly those with late-onset hypogonadism, can facilitate early detection, timely rehabilitation, and possible downstream cognitive benefit.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen Parameters among Transgender and Gender Diverse Individuals Assigned Male at Birth Compared to Cisgender Men.","authors":"Justin White, Vincent Nguyen, Yong Tao, Samantha Torrance, Anna Dion, Irena Druce, Daniel J Corsi, Matthew Roberts, Jenna Gale","doi":"10.5534/wjmh.250235","DOIUrl":"https://doi.org/10.5534/wjmh.250235","url":null,"abstract":"<p><strong>Purpose: </strong>Limited literature suggests that transgender and gender diverse (TGD) individuals assigned male at birth may have poorer semen parameters than cisgender persons. It is well known that gender-affirming hormone therapy (GAHT) can have a detrimental impact on sperm parameters; however, some studies suggest a higher proportion of sperm abnormalities, even among TGD individuals who had never initiated GAHT. Our objective was to compare semen parameters among TGD individuals to cis-gender men.</p><p><strong>Materials and methods: </strong>A retrospective cohort study included all patients who attempted to cryopreserve sperm at a fertility center from January 1, 2017 to June 30, 2022 for TGD indications (n=124). Baseline demographic information and pre- and post-freeze semen parameters before GAHT (n=111) were reviewed and compared to cis-gender controls (n=301) who provided semen samples for <i>in vitro</i> fertilization. Semen parameters among patients with prior exposure to GAHT (n=13) are also described.</p><p><strong>Results: </strong>TGD individuals had a higher likelihood of abnormal sperm concentration and/or motility compared to cisgender controls (odds ratio, 7.10; 95% confidence interval, 2.64 to 19.59; p<0.001). Despite no prior GAHT, almost half of the TGD patients had sperm concentration and/or motility below the 5th percentile. Significant between group difference in alcohol, cannabis and tobacco use was observed, with cisgender controls pursuing more of these behaviors (p<0.05). Despite this, mean sperm concentration (million/mL) and motility (%) were significantly lower in the TGD cohort, with higher volume (mL), with exclusion of patients with prior GAHT use.</p><p><strong>Conclusions: </strong>TGD individuals had poorer semen characteristics at baseline compared to cis controls, prior to GAHT initiation. Semen parameter differences could not be attributed to behavioural patterns of substance use, highlighting the importance of identifying other causes of poorer semen parameters in the TGD population.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Serum Testosterone and 25-Hydroxyvitamin D with Bone Mineral Density in Aging Men.","authors":"Woong Jin Bae, Soomin Kim, Hwa Jong Lee, Wonseok Huh, Dong Sup Lee","doi":"10.5534/wjmh.260018","DOIUrl":"https://doi.org/10.5534/wjmh.260018","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate the relationships among testosterone levels, vitamin D levels and bone mineral density (BMD) in elderly men.</p><p><strong>Materials and methods: </strong>A bicentered, cross-sectional study was performed using data from men aged 60 years or older who visited the clinic for general check-ups from January 2020 to December 2024. The T-score of BMD was measured using dual-energy X-ray absorptiometry. Measurements of serum testosterone and 25(OH) vitamin D levels were mandatory. After the exclusion of patients who received cancer-related chemotherapy/radiotherapy, testosterone replacement therapy, androgen deprivation therapy or hyperparathyroidism, correlations among testosterone levels, vitamin D levels and T-scores were tested.</p><p><strong>Results: </strong>In total, 557 men were ultimately analyzed. Among the baseline parameters, the T-score of spine BMD was associated with the body mass index (BMI) and testosterone level, whereas the T-score of hip BMD was related to age, BMI, testosterone level and 25(OH) vitamin D level; age was inversely correlated with the T-score of hip BMD, and the other parameters were positively correlated with hip BMD. After all adjustments were made, testosterone (B=0.058, p=0.015, 95% confidence interval [CI]=0.012-0.105) and 25(OH) vitamin D (B=0.008, p=0.004, 95% CI=0.003-0.014) levels were independently associated with the T-score of hip BMD. With a cutoff value for testosterone deficiency of 3.5 ng/mL and a cutoff value for vitamin D insufficiency of 30 ng/mL, both testosterone deficiency and vitamin D insufficiency were associated with a T-score ≤-1.0 for hip BMD.</p><p><strong>Conclusions: </strong>Both testosterone deficiency and vitamin D insufficiency should be considered in elderly men with a low hip joint BMD.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Digital Communication Tools in Enhancing Collaboration and Research Productivity: The Global Andrology Forum Model.","authors":"Asli Metin Mahmutoglu, Ayad Palani, Taymour Mostafa, Bahadir Sahin, Nadia Sheibak, Shalaka Ramgir-Naidu, Sofya Bushueva, Tuncay Toprak, Walter D Cardona Maya, Jean de la Rosette, Celeste Manfredi, Mohammed Abdulgabbar Noman, Abiodun Oyerinde, Ashok Agarwal","doi":"10.5534/wjmh.260074","DOIUrl":"https://doi.org/10.5534/wjmh.260074","url":null,"abstract":"<p><strong>Purpose: </strong>Research productivity is a key indicator of academic performance and is shaped by access to resources, collaborative engagement, and effective communication. This study aimed to evaluate the impact of resource availability, research collaboration, and the use of digital communication tools (DCTs) on researchers' productivity.</p><p><strong>Materials and methods: </strong>This cross-sectional study used an online questionnaire to evaluate the influence of DCTs on research productivity among eligible Global Andrology Forum members. The questionnaire collected data on demographics, research output, collaboration patterns, DCT preferences, and institutional support. The productivity data of participants were extracted from Scopus and Google Scholar. The economic status of the participants' country was obtained from the World Bank. Two-group comparisons used the Mann-Whitney U test, while multi-group comparisons used the Kruskal-Wallis test with post hoc analyses when significant. Spearman's correlation analysis and a multivariable robust linear regression model were used to assess associations and evaluate the robustness of the findings, respectively.</p><p><strong>Results: </strong>A total of 141 of 144 researchers completed the survey, representing 37 countries across diverse economic settings. Researchers from high-income countries demonstrated significantly higher productivity than those from middle-income countries. DCTs (WhatsApp and Zoom) were widely used for messaging and virtual meetings. Time spent on WhatsApp was positively correlated with research performance, including number of publications (ρ=0.224, p=0.008), total citations (ρ=0.259, p=0.002), most cited article (ρ=0.215, p=0.011), h-index (ρ=0.289, p=0.001), co-authorship (ρ=0.223, p=0.008), and international collaboration (ρ=0.274, p=0.001). Researchers who spent more than 4 hours per week on WhatsApp demonstrated significantly higher productivity indicators.</p><p><strong>Conclusions: </strong>DCTs and structured global research networks are essential for strengthening research capacity and promoting equitable participation across regions. While economic constraints may limit productivity, effective use of digital collaboration platforms can help narrow these gaps by expanding networking opportunities, enabling meaningful collaboration, and enhancing overall research output.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Noble On-Site Dual Screening System for Male Fertility of Sperm Count and Hyaluronidase Activity.","authors":"Jisuk Lee, Seung-Hun Song, Jin Hyun Jun, Il-Hoon Cho","doi":"10.5534/wjmh.250110","DOIUrl":"10.5534/wjmh.250110","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a noble on-site dual screening system for sperm concentration and hyaluronidase (HAdase) activity of male fertility based on lateral-flow assay methods, and to evaluate the effectiveness of this dual screening system.</p><p><strong>Materials and methods: </strong>A chromogenic reaction for sperm count was established using a sperm-specific antibody against sperm antigen-10 (SP-10). Substrate-enzyme reaction was developed in which the activity of sperm HAdase on hyaluronic acid (HA) substrates could be measured through a color reaction. The colored HA substrates were degraded and the color faded by the sperm HAdase. To evaluate the validity of the developed methods, the results were compared using 49 semen samples (normozoospermia, 20; oligozoospermia, 9; azoospermia, 20) whose sperm counts were confirmed by the conventional method.</p><p><strong>Results: </strong>Using color reaction by SP-10, no signal was observed in azoospermia and low count of sperm (<16×10⁶/mL), and the color signal increased as the count of sperm increased in normal and high count of sperm (≥16×10⁶/mL). The assay system for sperm HAdase activity was successfully developed. In the HAdase assay, the stronger the enzyme activity, the lower the color signal. Through statistical analysis, it was confirmed that there was a statistically significant correlation between sperm count and HAdase activity.</p><p><strong>Conclusions: </strong>It was successfully developed that a novel on-site dual screening system for sperm count and HAdase activity, simultaneously. We are expecting that this novel dual assay system will provide the accessible and useful information about male fertility at on-site or home.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"669-677"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Varicocele Repair on Testicular Sperm Retrieval, Sperm Recovery in the Ejaculate and Clinical Pregnancy Rates in Non-Obstructive Azoospermic Men with Clinical Varicocele: A Systematic Review and Meta-Analysis.","authors":"Selahittin Çayan, Germar-Michael Pinggera, Hiva Alipour, Baris Altay, Rupin Shah, Carlo Giulioni, Taymour Mostafa, Taha Hamoda, Diana Carolina Angel Alarcon, Fereshteh Dardmeh, Salima Daoud, Noor Fathalla, Sezgin Gunes, Tan V Le, Ranjit Babulal Vishwakarma, Ahmed Mohamed Harraz, Mohamed Arafa, Rossella Cannarella, Amarnath Rambhatla, Armand Zini, Eric Chung, Widi Atmoko, Ayad Palani, Luca Boeri, Aldo E Calogero, Taras Shatylko, Manaf Al Hashimi, Ashok Agarwal","doi":"10.5534/wjmh.250065","DOIUrl":"10.5534/wjmh.250065","url":null,"abstract":"<p><strong>Purpose: </strong>The role of varicocele repair (VR) in infertile men with non-obstructive azoospermia (NOA) and varicocele is controversial in the current guidelines, despite available studies. This study aims to assess the impact of VR on testicular sperm retrieval, sperm recovery from the ejaculate, and clinical pregnancy rates in infertile men with NOA and clinical varicocele through a systematic review and meta-analysis (SRMA) of controlled studies.</p><p><strong>Materials and methods: </strong>A systematic literature search was conducted using the Scopus and PubMed databases up to November 2023. Among the 1,847 articles retrieved, five observational controlled studies comparing reproductive outcomes between infertile men with NOA and clinical varicocele who underwent VR, and a control group that received no treatment, met the inclusion criteria for this SRMA.</p><p><strong>Results: </strong>The selected studies included 269 men with NOA who underwent VR before the testicular sperm extraction (TESE) procedure and 364 men who did not undergo VR. The pooled estimate demonstrated a significantly higher odds ratio (OR) of 2.17 (95% confidence interval [95% CI]: 1.17-4.01, p=0.01) for surgical sperm retrieval in the VR group. VR significantly increased the likelihood of sperm appearance in the ejaculate, with an OR of 7.8 (95% CI: 3.59-16.94, p<0.001). Besides, VR provided a significantly greater clinical pregnancy rate with intracytoplasmic sperm injection (ICSI) compared to non-operated men (OR: 2.18, 95% CI: 1.03-4.60; p=0.04).</p><p><strong>Conclusions: </strong>This is the first SRMA, consisting of only controlled studies, to demonstrate that VR performed prior to TESE in men with NOA significantly improves sperm production as reflected in the spontaneous appearance of sperm in the semen and higher odds of surgical sperm retrieval and clinical pregnancy compared with non-operated men. Thus, these findings highlight the potentially beneficial impact of VR in men with NOA and clinical varicocele.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"593-607"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminal Plasma Exosomes in Male Infertility: Roles, Mechanisms, and Applications-A Double-Edged Sword.","authors":"Meijing Wang, Xiaoya Li, Xiucheng Lan, Junjun Li, Liang Dong, Fang Yang, Degui Chang, Xujun Yu","doi":"10.5534/wjmh.250115","DOIUrl":"10.5534/wjmh.250115","url":null,"abstract":"<p><p>Exosomes, which are membrane-bound vesicles with diameters of 30 to 150 nanometers, are secreted by nearly all cell types and serve as key mediators of intercellular communication. In the male reproductive system, exosomes originating from reproductive glands, including the testes, epididymis, and prostate, transport proteins, lipids, and nucleic acids, thereby regulating sperm function, maturation, and fertilization. Exosomes facilitate intercellular communication by transporting bioactive molecules (particularly microRNAs), and are instrumental in sperm maturation, motility, and fertilization capacity. However, exosomes exhibit dual roles in male reproductive processes, as their mechanisms of action are highly context-dependent, depending on the molecules they carry and the microenvironment in which they function. This review aims to summarize the dual regulatory functions of seminal plasma exosomes in male infertility, with a focus on their roles in spermatogenesis, sperm maturation, and fertilization. Furthermore, the potential of exosomes as biomarkers for diagnosing and treating male infertility is examined. Despite the promising application of exosomes in male reproductive health, further studies are required to elucidate their mechanisms, offering new perspectives for precise interventions in male infertility and enhancing assisted reproductive technologies.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"491-507"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global State of Contemporary Andrology Practice: A Comprehensive Analysis of Clinical Practice, Training Pathways, and Emerging Challenges.","authors":"Rupin Shah, Taymour Mostafa, Manaf Al Hashimi, Germar-Michael Pinggera, Wael Zohdy, Bahadır Şahin, Hiva Alipour, Ayad Faeq Palani, Mohamed Arafa, Eric Chung, Ayman Rashed, Edmund Ko, Baris Altay, Amarnath Rambhatla, Tuncay Toprak, Hussein Kandil, Edoardo Pescatori, Ahmed El-Sakka, Haitham Ali Elbardisi, Juan Manuel Corral Molina, Marco Falcone, Edouard Harry Amar, Taiwo Crossby Omotoriogun, Selcuk Sarikaya, Nguyen Ho Vinh Phuoc, Mounir Jamali, Oğuzhan Kahraman, Ahmet Cihan, Sava Micic, Muslim Dogan Deger, Muhammad Ujudud Musa, Gökhan Çeker, Umut Cagin Ari, Cevahir Ozer, Huda Mossa Omran, Saleh Binsaleh, Rossella Cannarella, Mohamad Ahmad Moussa, Iman Shamohammadi, Andrian Japari, Francesco Gaggia, Aria Danurdoro, Nasser Mogharabian, Mohamed Elmahdy Toiema, Hisanori Taniguchi, Missy Savira, Christopher Chee Kong Ho, Keerti Singh, Manh Truong Nguyen, Parviz K Kavoussi, Shingai Bertrand Angelo Mutambirwa, Ishan Merchant, Dharani Moorthy, Vijay Kumar, Arif Kalkanli, Faiza Rao, Fatih Gokalp, Nicolas Garrido, Charalampos Konstantinidis, David Pening, Sedigheh Bahmyari, Parisa Dolati, Aldo E Calogero, Ramadan Saleh, Birute Zilaitiene, Giorgio Ivan Russo, Nadia Kazdar, Ricky Adriansjah, Gianmaria Salvio, Giancarlo Balercia, Catalina Zenoaga-Barbarosie, Balantine Ugochukwu Eze, Widi Atmoko, Deniz Kulaksiz, Amina Benabbou, Siu King Mak, Luca Boeri, Sang Thanh Le, Ajay Kumar Jain, Amr El Meliegy, Kadir Böcü, Nur Dokuzeylül Güngör, Gokhan Calik, Konstantinos Makarounis, Mesut Berkan Duran, Hisham Ahmed Arab, Luigi Montano, Gulfam Ahmad, Trang Thi Minh Nguyen, Hyun Jun Park, Eko Arianto, Krishna Chaitanya Mantravadi, Andrea Crafa, Tahsin Turunc, Fotios Dimitriadis, Umut Arslan, Sk Mizanur Rahman, Andri Rezano, Ryan Patrick Smith, Erman Ceyhan, Naveen Kumar, Dyandra Parikesit, Mehmet Serkan Özkent, Rosadi Putra, Haocheng Lin, Osvaldo Rajmil, Sanjay Prakash Jayaprakash, Tan V Le, Satish Pundlik Dipankar, Charalampos Thomas, Carlo Giulioni, Danh Cong Nguyen, Vinod K V, Zaid Qureshi, Filippo Giacone, Ashish Reddy, Sujoy Dasgupta, Divyanu Jain, Ciro Salzano, Federica Finocchi Finocchi, Lucia Rocco, Ateş Kadıoğlu, Akeem Babatunde Sikiru, Ali Said Kilicalp, Mezbahul Moker Rabin, Giovanni Liguori, Jose Arturo Mora Rodriguez, Jesus Fernando Solorzano Vazquez, Angelo Alessandro Marino, Taha Hamoda, Vilvapathy Senguttuvan Karthikeyan, Bircan Kolbaşı Erkan, Mikhail Ruzaev, Manel Nezzal, Giovanni M Colpi, Fahmi Bahar, Tamilselvi Sethupathy, Guadalupe Del Carmen Hernández Hebrard, Mohamed S Al-Marhoon, Ahmad Tarek Motawi, Sotiris Andreadakis, Coskun Kaya, Alessandro Franceschelli, Fikri Rizaldi, Shubhadeep Roychoudhury, Pedro Cuapio Padilla, Ahmad Ateyah Awwad, Daniel Suslik Zylbersztejn, Nazim Gherabi, Abdallah Bensouda, Naufal Nandita Firsty, Giorgio Franco, Neha Shreyas Goswami, B Aanantha Lakshmi, Frédéric Romain Santer, Ege Can Serefoglu, Vahid Esmaeili, Ioannis Sokolakis, Mustafa Kadihasanoglu, Marion Bendayan, Petronela Naghi, Sofia Ines Leonardi Diaz, Saviana Adriana Buhlea, Alireza Kheradmand, Tulay Irez, Tiago Cesar Mierzwa, Silvia Werdhy Lestari, Riffat Bibi, Quang Nguyen, Ranjit Babulal Vishwakarma, Pietro Salacone, Stamatis Papaharitou, Saad Mohammed Abumelha, Elango Kamaraj, Robyn Amanda Van Staden, Damayanthi Durairajanayagam, Ramazan Asci, Gustavo Marquesine Paul, Abiodun Oyerinde, Akhmad Mustafa, Chirag Gupta, Yudhistira Pradnyan Kloping, Marjan Sabbaghian, Isaac Ardianson Deswanto, Moungala Lionel Wildy, Teng Aik Ong, Sann Lin Ko, Sheryl Toni Homa, Rahul Gajbhiye, Mara Simopoulou, Mohamed Abdelfatah Farag, Vineet Malhotra, Ekom Monday Etukudo, Hazem Meteb Al-Rumaih, Ninad Chandrakant Tamboli, Awaj Kafle, Mohamed Elkhouly, Ashok Agarwal","doi":"10.5534/wjmh.250039","DOIUrl":"10.5534/wjmh.250039","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the current state of andrology practice worldwide, identifies challenges faced by clinicians, and explores training, certification, and research opportunities. It also seeks to redefine the qualifications necessary to be recognized as an andrologist and to propose areas for standardization and improvement.</p><p><strong>Materials and methods: </strong>A global, cross-sectional survey was conducted using a 48-question online questionnaire designed by international experts. The survey, distributed in English, covered various domains of modern andrology practice. Responses from 405 participants across 59 countries were analyzed using R version 4.1.2, with categorical variables reported as frequencies and percentages.</p><p><strong>Results: </strong>Among respondents, 47.3% held medical doctor (MD) degrees, with urologists (31.1%) and clinical andrologists (25.3%) being the most represented specialties. Formal, board-certified andrological training was reported as available in only 48.1% of countries. While half of the respondents identified as andrologists based on experience, only one-third did so through certification, obtained from diverse, nationally recognized organizations. The primary areas of practice included male infertility (36.7%), male sexual dysfunction (27.2%), and sexually transmitted infections (14.5%). Many participants were actively engaged in assisted reproductive technologies, imaging, and andrological surgical emergencies. Despite strong interest in clinical, basic, and translational research, respondents highlighted significant challenges, including inconsistent training pathways, insufficient certification standards, and the complexity of managing diverse andrological conditions.</p><p><strong>Conclusions: </strong>Andrology is an evolving multidisciplinary specialty where board-certified urologists, clinical andrologists, and reproductive medicine specialists collaborate to address male reproductive and sexual health challenges. Despite their advanced competencies in medical, surgical, and laboratory interventions, specialists face significant global disparities in training and certification. This survey highlights the urgent need for standardized training, evidence-based guidelines, and unified certification to ensure consistency, enhance patient care, and advance andrology's academic and clinical excellence worldwide.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":"608-633"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13302941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}