World Journal of Mens Health最新文献

{"title":"Regenerative Therapy for Erectile Dysfunction: Paradigm Shift or Premature Promise?","authors":"Manaf Al Hashimi, Mohamed Arafa, Germar-Michael Pinggera, Widi Atmoko, Tuncay Toprak, Marco Falcone, Rupin Shah, Ashok Agarwal","doi":"10.5534/wjmh.260216","DOIUrl":"https://doi.org/10.5534/wjmh.260216","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silent Progression Gap in Benign Prostatic Hyperplasia Management.","authors":"Yu-Hsiang Lin, Jau-Yuan Chen, Horng-Heng Juang","doi":"10.5534/wjmh.260182","DOIUrl":"https://doi.org/10.5534/wjmh.260182","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammation Is Associated with the Relationship between Benign Prostatic Hyperplasia and Rheumatoid Arthritis.","authors":"Qinglong Yang, Haolin Chen, Zexuan Liu, Gaoming Hou, Wenqiang Liao, Xuxia Sui, Qingtao Yang","doi":"10.5534/wjmh.260053","DOIUrl":"https://doi.org/10.5534/wjmh.260053","url":null,"abstract":"<p><strong>Purpose: </strong>Benign prostatic hyperplasia (BPH) and rheumatoid arthritis (RA) have both been associated with inflammatory processes; however, their association remains unclear. This study explored the prospective association between BPH and the subsequent risk of RA using data from the UK Biobank, and further evaluated whether the systemic immune-inflammation index (SII) and the neutrophil-to-lymphocyte ratio (NLR) are associated with this relationship.</p><p><strong>Materials and methods: </strong>A total of 222,891 males without RA or prostate cancer at baseline were included. BPH was identified through self-report, hospital ICD-10 codes (N40), and primary care records. Incident RA was defined using hospital ICD-10 codes (M05 to M06). Multivariable Cox proportional hazards models were applied to assess the association between BPH and risk of incident RA. Mediation analyses were used to explore the potential role of SII and NLR in this association. Sensitivity analyses, including subgroup analyses, multiple imputation, exclusion of early RA cases, and competing risk models, were performed to test robustness.</p><p><strong>Results: </strong>During a median follow-up of 14 years, 2,252 incident RA cases were documented. After multivariable adjustment, BPH was associated with a higher risk of RA (hazard ratio=1.19, 95% confidence interval: 1.03 to 1.37). The association remained consistent across sensitivity analyses. Mediation analyses suggested that SII and NLR may partly account for the observed association between BPH and RA (4.28% and 7.25%, respectively).</p><p><strong>Conclusions: </strong>BPH was associated with an increased risk of RA, and systemic inflammatory markers were also associated with this relationship.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Symptom Relief: A Dual-Mechanism Hypothesis Linking Definitive Bladder Outlet Obstruction Relief to Bladder Cancer Control.","authors":"Yu-Hsiang Lin","doi":"10.5534/wjmh.260171","DOIUrl":"https://doi.org/10.5534/wjmh.260171","url":null,"abstract":"","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Glucagon-Like Peptide-1 Receptor Agonists or Sodium-Glucose Cotransporter 2 Inhibitors Be Considered New Treatment Options for Male Hypogonadism and Sexual Dysfunction?","authors":"Giovanni Corona, Clotilde Sparano, Marilina Romeo, Omid Sedigh, Carlo Bettocchi, Giulia Rastrelli, Linda Vignozzi, Mario Maggi","doi":"10.5534/wjmh.260045","DOIUrl":"https://doi.org/10.5534/wjmh.260045","url":null,"abstract":"<p><p>The use of glucagon-like peptide-1 receptor agonists (GLP1-RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) resulted in weight loss and long-term cardiovascular (CV) and renal safety preservation. Their role in male sexual hormones and behavior is still not sufficiently investigated. This paper aims at summarizing the effects of GLP1-RA and SGLT2i on obesity-associated hypogonadism and sexual dysfunctions. Both GLP1-RA and SGLT2i resulted in an improvement of body composition and metabolic profile, supporting erectile function amelioration. Only GLP1-RA showed a weight loss dependent increase in total and calculated free testosterone with lower effects on gonadotropin levels, while for SGLT2i, the data are contradictory. Finally, the use of testosterone replacement therapy showed better results as compared to GLP1-RA when orgasm and sexual satisfaction domains were investigated. In conclusion considering the beneficial effects of GLP1-RA on long-term CV mortality and morbidity, compared to the substantially neutral effects derived from the use of testosterone replacement therapy, we support the use of this class of medications for improving sexual dysfunction and its underlying CV problems in overweight and obese patients with erectile dysfunction.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Management of Leydig Cell Tumors: 27-Year Experience of Avoiding Frozen Sections Guided by Expert Radiological Assessment.","authors":"Peter Beniac, Laetitia Lonca, Sophie Ferlicot, Jacques Irani, Thomas Bessede, Bernard Akl, Samba Faye, Valentine Frydman, Alexandre Ifrah, Andrei Tise, Vincent Izard, Cédric Lebâcle, Laurence Rocher","doi":"10.5534/wjmh.260098","DOIUrl":"https://doi.org/10.5534/wjmh.260098","url":null,"abstract":"<p><strong>Purpose: </strong>Leydig cell tumors (LCTs) are rare, usually benign testicular tumors for which frozen section examination is commonly recommended during testis-sparing surgery (TSS). We report a 27-year single-center experience, emphasizing the role of imaging for conservative surgery decision-making. It shows our experience using expert radiology assessment to direct TSS without frozen section examination.</p><p><strong>Materials and methods: </strong>In this retrospective observational study, we reviewed our institutional database of testicular tumors treated between 1998 and 2025. Patients with histologically confirmed LCTs were included. Clinical presentation, hormonal profile, imaging characteristics, surgery type, and intraoperative frozen section use were analyzed.</p><p><strong>Results: </strong>Among 481 testicular tumors, 68 (14.14%) were LCTs. Within the histologically confirmed LCTs cohort, preoperative expert radiology assessment achieved 97% (66/68) concordance with the final pathology. Partial orchiectomy was performed in 62 cases (91.18%), total orchiectomy in 6 (8.82%). Median age was 36 years. Median follow-up was 75 months. No malignant LCTs were observed. All patients remained in complete remission. The most common reasons for consultation were infertility (n=41, 60.29%) where systematic ultrasound screening discovered the lesion, gynecomastia (n=4, 5.88%), Klinefelter syndrome work-up (n=4, 5.88%; 2 additional cases identified within the infertility group, total n=6) and palpable nodule (n=4, 5.88%). Median ultrasound tumor size was 7 mm (range: 2 to 32 mm).</p><p><strong>Conclusions: </strong>Radiological characteristics effectively differentiated LCTs, suggesting that direct TSS without frozen section examination might be feasible when expert radiological evaluation is available. Our findings reflect radiology-pathology concordance within histologically confirmed LCTs rather than diagnostic accuracy in an unselected population. This approach optimizes surgical workflow, preserves endocrine function and fertility. No recurrence was observed. Frozen section examination should be maintained where expert radiology consultation is unavailable or diagnostic uncertainty exists. Prospective validation is required before omitting frozen section examination outside expert centers.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adiposity Change Patterns and Prostate Cancer Risk: Age- and Smoking-Specific Associations in 1,332,372 Korean Males.","authors":"Su Youn Nam, Junwoo Jo","doi":"10.5534/wjmh.250399","DOIUrl":"https://doi.org/10.5534/wjmh.250399","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence linking body mass index (BMI) change to prostate cancer risk remains inconsistent despite known associations between adiposity and prostate carcinogenesis.</p><p><strong>Materials and methods: </strong>We conducted a population-based cohort study of 1,332,372 Korean males who completed health examinations in 2009 and 2013 and were followed through 2017. BMI was classified using Asia-Pacific criteria, and changes between 2009 and 2013 defined 25 groups. Prostate cancers were ascertained by ICD-10 (International Classification of Diseases, 10th Revision) codes. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) controlling for demographics, lifestyle factors, and comorbidities.</p><p><strong>Results: </strong>Over 12.7 million person-years, 9,147 prostate cancers were identified. BMI trajectories displayed distinct risk patterns. Remaining underweight (aHR, 0.76; 95% CI, 0.61 to 0.96) or moving from underweight to normal (aHR, 0.65; 95% CI, 0.47 to 0.91) was associated with lower risk, whereas persistent overweight (aHR, 1.18; 95% CI, 1.10 to 1.27), persistent obesity I (aHR, 1.19; 95% CI, 1.12 to 1.27), and transition from overweight to obesity I (aHR, 1.14; 95% CI, 1.03 to 1.27) were associated with higher risk compared with persistent normal BMI. Among males with obesity I, weight loss to normal BMI was associated with reduced risk compared to persistent obesity I (aHR, 0.63; 95% CI, 0.46 to 0.87). Smoking amplified the adverse associations of persistent overweight and obesity. However, persistent obesity II (≥30 kg/m²) was associated with lower risk among males <60 years (aHR, 0.62; 95% CI, 0.44 to 0.89), though this finding should be interpreted with caution as it may reflect detection bias.</p><p><strong>Conclusions: </strong>The impact of longitudinal adiposity patterns varied by smoking status and age, supporting personalized, lifestage-specific prevention emphasizing weight management and lifestyle modification.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The Role of Reactive Oxygen Species, Inflammation, and Endoplasmic Reticulum Stress Response in the Finasteride Protective Effect against Benign Prostate Hyperplasia.","authors":"Geum-Hwa Lee, Hwa-Young Lee, Luo Zhao, Mohammad Mamun Ur Rashid, Myung Ki Kim, Young Beom Jeong, Han-Jung Chae, Yu Seob Shin","doi":"10.5534/wjmh.230122.e","DOIUrl":"https://doi.org/10.5534/wjmh.230122.e","url":null,"abstract":"<p><p>This corrects the article on p. 600 in vol. 42, PMID: 37853537.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Medical Interventions for Erectile Dysfunction after Prostate Cancer Treatment: A Systematic Review and Network Meta-Analysis.","authors":"Setegn Eshetie, Omena Ejekpokpo, Megan Charlick, Tenaw Tiruye, Alex Jay, Braden Higgs, Andrew Shepherd, Kerri Beckmann","doi":"10.5534/wjmh.260050","DOIUrl":"https://doi.org/10.5534/wjmh.260050","url":null,"abstract":"<p><strong>Purpose: </strong>Erectile dysfunction (ED) is a prevalent and distressing consequence of radical prostatectomy (RP) and radiotherapy (RT) for prostate cancer, profoundly impacting quality of life. Despite a wide array of available interventions, their comparative effectiveness remains uncertain in the absence of head-to-head trials.</p><p><strong>Materials and methods: </strong>We conducted a systematic review and network meta-analysis (NMA) of studies evaluating medical interventions for ED following RP or RT. MEDLINE, Embase, and Scopus were searched for eligible studies. Risk of bias (RoB) was assessed using the Cochrane RoB 2 and ROBINS-I tools. A random-effects NMA was performed, with efficacy expressed as odds ratios (ORs) and 95% confidence intervals (CIs). The certainty of evidence was evaluated using the GRADE framework. The primary outcome was recovery of erectile function, assessed using validated measures or the proportion achieving successful intercourse.</p><p><strong>Results: </strong>Forty-one studies (n=4,157 participants) met inclusion criteria. Following RP, combination therapies were most effective: tadalafil plus intraurethral alprostadil gel (OR 24.8), tadalafil plus vacuum erection device (OR 12.3), and tadalafil plus low-intensity shockwave therapy (OR 8.2) demonstrated the highest odds of functional recovery versus placebo. Following RT, on-demand tadalafil was the most effective intervention (OR 8.0). Pooled analysis of RP studies showed a significant mean improvement in International Index of Erectile Function scores favouring active interventions over control (mean difference 4.5, 95% CI: 2.4-6.5, I²=62%), with longer intervention duration associated with greater improvement. Overall certainty of evidence was low to very low due to RoB, imprecision, and inconsistency.</p><p><strong>Conclusions: </strong>Combination therapies appear most effective for ED recovery after RP, while on-demand phosphodiesterase type 5 inhibitors are most efficacious after RT. These findings provide novel comparative evidence; however, cautious clinical application and further high-quality research are warranted.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Defects in the Sperm Tail: Damaged Radial Spokes and Male Infertility.","authors":"Ji Yoon Lee, Jae Yeon Hwang","doi":"10.5534/wjmh.260051","DOIUrl":"https://doi.org/10.5534/wjmh.260051","url":null,"abstract":"<p><p>Male infertility is a global reproductive health issue, and sperm from the majority of infertile males exhibit motility defects. Although anatomical and endocrinological etiologies underlying male infertility have been identified and become targets for clinical treatment, approximately 15% to 40% of cases are still classified as idiopathic infertility, with causal factors remaining unresolved. Recent advances in genomic analyses have identified diverse genetic variants explaining idiopathic male infertility. In this review, we summarize the current understanding of infertility-causing genetic variants, particularly those encoding proteins that constitute the radial spoke complexes which are critical structural complexes in the sperm tail essential for motility.</p>","PeriodicalId":54261,"journal":{"name":"World Journal of Mens Health","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}