Pasquale Arpaia;Renato Cuocolo;Allegra Fullin;Ludovica Gargiulo;Francesca Mancino;Nicola Moccaldi;Ersilia Vallefuoco;Paolo De Blasiis
{"title":"Executive Functions Assessment Based on Wireless EEG and 3D Gait Analysis During Dual-Task: A Feasibility Study","authors":"Pasquale Arpaia;Renato Cuocolo;Allegra Fullin;Ludovica Gargiulo;Francesca Mancino;Nicola Moccaldi;Ersilia Vallefuoco;Paolo De Blasiis","doi":"10.1109/JTEHM.2024.3357287","DOIUrl":"https://doi.org/10.1109/JTEHM.2024.3357287","url":null,"abstract":"Executive functions (EFs) are neurocognitive processes planning and regulating daily life actions. Performance of two simultaneous tasks, requiring the same cognitive resources, lead to a cognitive fatigue. Several studies investigated cognitive-motor task and the interference during walking, highlighting an increasing risk of falls especially in elderly and people with neurological diseases. A few studies instrumentally explored relationship between activation-no-activation of two EFs (working memory and inhibition) and spatial-temporal gait parameters. Aim of our study was to detect activation of inhibition and working memory during progressive difficulty levels of cognitive tasks and spontaneous walking using, respectively, wireless electroencephalography (EEG) and 3D-gait analysis. Thirteen healthy subjects were recruited. Two cognitive tasks were performed, activating inhibition (Go-NoGo) and working memory (N-back). EEG features (absolute and relative power in different bands) and kinematic parameters (7 spatial-temporal ones and Gait Variable Score for 9 range of motion of lower limbs) were analyzed. A significant decrease of stride length and an increase of external-rotation of foot progression were found during dual task with Go-NoGo. Moreover, a significant correlation was found between the relative power in the delta band at channels Fz, C4 and progressive difficulty levels of Go-NoGo (activating inhibition) during walking, whereas working memory showed no correlation. This study reinforces the hypothesis of the prevalent involvement of inhibition with respect to working memory during dual task walking and reveals specific kinematic adaptations. The foundations for EEG-based monitoring of cognitive processes involved in gait are laid. Clinical and Translational Impact Statement: Clinical and instrumental evaluation and training of executive functions (as inhibition), during cognitive-motor task, could be useful for rehabilitation treatment of gait disorder in elderly and people with neurological disease.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"268-278"},"PeriodicalIF":3.4,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10411910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139676113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NeuroDiag: Software for Automated Diagnosis of Parkinson’s Disease Using Handwriting","authors":"Quoc Cuong Ngo;Nicole McConnell;Mohammod Abdul Motin;Barbara Polus;Arup Bhattacharya;Sanjay Raghav;Dinesh Kant Kumar","doi":"10.1109/JTEHM.2024.3355432","DOIUrl":"https://doi.org/10.1109/JTEHM.2024.3355432","url":null,"abstract":"Objective: A change in handwriting is an early sign of Parkinson’s disease (PD). However, significant inter-person differences in handwriting make it difficult to identify pathological handwriting, especially in the early stages. This paper reports the testing of NeuroDiag, a software-based medical device, for the automated detection of PD using handwriting patterns. NeuroDiag is designed to direct the user to perform six drawing and writing tasks, and the recordings are then uploaded onto a server for analysis. Kinematic information and pen pressure of handwriting are extracted and used as baseline parameters. NeuroDiag was trained based on 26 PD patients in the early stage of the disease and 26 matching controls. Methods: Twenty-three people with PD (PPD) in their early stage of the disease, 25 age-matched healthy controls (AMC), and 7 young healthy controls were recruited for this study. Under the supervision of a consultant neurologist or their nurse, the participants used NeuroDiag. The reports were generated in real-time and tabulated by an independent observer. Results: The participants were able to use NeuroDiag without assistance. The handwriting data was successfully uploaded to the server where the report was automatically generated in real-time. There were significant differences in the writing speed between PPD and AMC (P<0.001). NeuroDiag showed 86.96% sensitivity and 76.92% specificity in differentiating PPD from those without PD. Conclusion: In this work, we tested the reliability of NeuroDiag in differentiating between PPD and AMC for real-time applications. The results show that NeuroDiag has the potential to be used to assist neurologists and for telehealth applications. Clinical and Translational Impact Statement — This pre-clinical study shows the feasibility of developing a community-wide screening program for Parkinson’s disease using automated handwriting analysis software, NeuroDiag.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"291-297"},"PeriodicalIF":3.4,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10403837","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mieli Luukinen;Henna Pitkänen;Timo Leppänen;Juha Töyräs;Anna Sigridur Islind;Samu Kainulainen;Henri Korkalainen
{"title":"Variation in the Photoplethysmogram Response to Arousal From Sleep Depending on the Cause of Arousal and the Presence of Desaturation","authors":"Mieli Luukinen;Henna Pitkänen;Timo Leppänen;Juha Töyräs;Anna Sigridur Islind;Samu Kainulainen;Henri Korkalainen","doi":"10.1109/JTEHM.2024.3349916","DOIUrl":"10.1109/JTEHM.2024.3349916","url":null,"abstract":"Objective: The aim of this study was to assess how the photoplethysmogram frequency and amplitude responses to arousals from sleep differ between arousals caused by apneas and hypopneas with and without blood oxygen desaturations, and spontaneous arousals. Stronger arousal causes were hypothesized to lead to larger and faster responses. Methods and procedures: Photoplethysmogram signal segments during and around respiratory and spontaneous arousals of 876 suspected obstructive sleep apnea patients were analyzed. Logistic functions were fit to the mean instantaneous frequency and instantaneous amplitude of the signal to detect the responses. Response intensities and timings were compared between arousals of different causes. Results: The majority of the studied arousals induced photoplethysmogram responses. The frequency response was more intense (\u0000<inline-formula> <tex-math>${p} < 0.001$ </tex-math></inline-formula>\u0000) after respiratory than spontaneous arousals, and after arousals caused by apneas compared to those caused by hypopneas. The amplitude response was stronger (\u0000<inline-formula> <tex-math>${p} < 0.001$ </tex-math></inline-formula>\u0000) following hypopneas associated with blood oxygen desaturations compared to those that were not. The delays of these responses relative to the electroencephalogram arousal start times were the longest (\u0000<inline-formula> <tex-math>${p} < 0.001$ </tex-math></inline-formula>\u0000) after arousals caused by apneas and the shortest after spontaneous arousals and arousals caused by hypopneas without blood oxygen desaturations. Conclusion: The presence and type of an airway obstruction and the presence of a blood oxygen desaturation affect the intensity and the timing of photoplethysmogram responses to arousals from sleep. Clinical impact: The photoplethysmogram responses could be used for detecting arousals and assessing their intensity, and the individual variation in the response intensity and timing may hold diagnostically significant information.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"328-339"},"PeriodicalIF":3.4,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10380637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139953793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hojjat Salehinejad;Anne M. Meehan;Pedro J. Caraballo;Bijan J. Borah
{"title":"Contrastive Transfer Learning for Prediction of Adverse Events in Hospitalized Patients","authors":"Hojjat Salehinejad;Anne M. Meehan;Pedro J. Caraballo;Bijan J. Borah","doi":"10.1109/JTEHM.2023.3344035","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3344035","url":null,"abstract":"Objective: Deterioration index (DI) is a computer-generated score at a specific frequency that represents the overall condition of hospitalized patients using a variety of clinical, laboratory and physiologic data. In this paper, a contrastive transfer learning method is proposed and validated for early prediction of adverse events in hospitalized patients using DI scores. Methods and procedures: An unsupervised contrastive learning (CL) model with a classifier is proposed to predict adverse outcome using a single temporal variable (DI scores). The model is pretrained on an unsupervised fashion with large-scale time series data and fine-tuned with retrospective DI score data. Results: The performance of this model is compared with supervised deep learning models for time series classification. Results show that unsupervised contrastive transfer learning with a classifier outperforms supervised deep learning solutions. Pretraining of the proposed CL model with large-scale time series data and fine-tuning that with DI scores can enhance prediction accuracy. Conclusion: A relationship exists between longitudinal DI scores of a patient and the corresponding outcome. DI scores and contrastive transfer learning can be used to predict and prevent adverse outcomes in hospitalized patients. Clinical impact: This paper successfully developed an unsupervised contrastive transfer learning algorithm for prediction of adverse events in hospitalized patients. The proposed model can be deployed in hospitals as an early warning system for preemptive intervention in hospitalized patients, which can mitigate the likelihood of adverse outcomes.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"215-224"},"PeriodicalIF":3.4,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10363391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139034302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multitask and Transfer Learning Approach for Joint Classification and Severity Estimation of Dysphonia","authors":"Dosti Aziz;Sztahó Dávid","doi":"10.1109/JTEHM.2023.3340345","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3340345","url":null,"abstract":"Objective: Despite speech being the primary communication medium, it carries valuable information about a speaker’s health, emotions, and identity. Various conditions can affect the vocal organs, leading to speech difficulties. Extensive research has been conducted by voice clinicians and academia in speech analysis. Previous approaches primarily focused on one particular task, such as differentiating between normal and dysphonic speech, classifying different voice disorders, or estimating the severity of voice disorders. Methods and procedures: This study proposes an approach that combines transfer learning and multitask learning (MTL) to simultaneously perform dysphonia classification and severity estimation. Both tasks use a shared representation; network is learned from these shared features. We employed five computer vision models and changed their architecture to support multitask learning. Additionally, we conducted binary ‘healthy vs. dysphonia’ and multiclass ‘healthy vs. organic and functional dysphonia’ classification using multitask learning, with the speaker’s sex as an auxiliary task. Results: The proposed method achieved improved performance across all classification metrics compared to single-task learning (STL), which only performs classification or severity estimation. Specifically, the model achieved F1 scores of 93% and 90% in MTL and STL, respectively. Moreover, we observed considerable improvements in both classification tasks by evaluating beta values associated with the weight assigned to the sex-predicting auxiliary task. MTL achieved an accuracy of 77% compared to the STL score of 73.2%. However, the performance of severity estimation in MTL was comparable to STL. Conclusion: Our goal is to improve how voice pathologists and clinicians understand patients’ conditions, make it easier to track their progress, and enhance the monitoring of vocal quality and treatment procedures. Clinical and Translational Impact Statement: By integrating both classification and severity estimation of dysphonia using multitask learning, we aim to enable clinicians to gain a better understanding of the patient’s situation, effectively monitor their progress and voice quality.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"233-244"},"PeriodicalIF":3.4,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10347235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139034042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Wearable Fluorescence Imaging Device for Intraoperative Identification of Human Brain Tumors","authors":"Mehrana Mohtasebi;Chong Huang;Mingjun Zhao;Siavash Mazdeyasna;Xuhui Liu;Samaneh Rabienia Haratbar;Faraneh Fathi;Jinghong Sun;Thomas Pittman;Guoqiang Yu","doi":"10.1109/JTEHM.2023.3338564","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3338564","url":null,"abstract":"Malignant glioma (MG) is the most common type of primary malignant brain tumors. Surgical resection of MG remains the cornerstone of therapy and the extent of resection correlates with patient survival. A limiting factor for resection, however, is the difficulty in differentiating the tumor from normal tissue during surgery. Fluorescence imaging is an emerging technique for real-time intraoperative visualization of MGs and their boundaries. However, most clinical grade neurosurgical operative microscopes with fluorescence imaging ability are hampered by low adoption rates due to high cost, limited portability, limited operation flexibility, and lack of skilled professionals with technical knowledge. To overcome the limitations, we innovatively integrated miniaturized light sources, flippable filters, and a recording camera to the surgical eye loupes to generate a wearable fluorescence eye loupe (FLoupe) device for intraoperative imaging of fluorescent MGs. Two FLoupe prototypes were constructed for imaging of Fluorescein and 5-aminolevulinic acid (5-ALA), respectively. The wearable FLoupe devices were tested on tumor-simulating phantoms and patients with MGs. Comparable results were observed against the standard neurosurgical operative microscope (PENTERO® 900) with fluorescence kits. The affordable and wearable FLoupe devices enable visualization of both color and fluorescence images with the same quality as the large and expensive stationary operative microscopes. The wearable FLoupe device allows for a greater range of movement, less obstruction, and faster/easier operation. Thus, it reduces surgery time and is more easily adapted to the surgical environment than unwieldy neurosurgical operative microscopes. Clinical and Translational Impact Statement—The affordable and wearable fluorescence imaging device developed in this study enables neurosurgeons to observe brain tumors with the same clarity and greater flexibility compared to bulky and costly operative microscopes.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"225-232"},"PeriodicalIF":3.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10339301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaya Kuru;Darren Ansell;Dave Hughes;Benjamin Jon Watkinson;Fabrizio Gaudenzi;Martin Jones;David Lunardi;Noreen Caswell;Adela Rabella Montiel;Peter Leather;Daniel Irving;Kina Bennett;Corrin McKenzie;Paula Sugden;Carl Davies;Christian Degoede
{"title":"Treatment of Nocturnal Enuresis Using Miniaturised Smart Mechatronics With Artificial Intelligence","authors":"Kaya Kuru;Darren Ansell;Dave Hughes;Benjamin Jon Watkinson;Fabrizio Gaudenzi;Martin Jones;David Lunardi;Noreen Caswell;Adela Rabella Montiel;Peter Leather;Daniel Irving;Kina Bennett;Corrin McKenzie;Paula Sugden;Carl Davies;Christian Degoede","doi":"10.1109/JTEHM.2023.3336889","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3336889","url":null,"abstract":"Our study was designed to develop a customisable, wearable, and comfortable medical device – the text so-called “MyPAD” that monitors the fullness of the bladder, triggering an alarm indicating the need to void, in order to prevent badwetting – i.e., treating Nocturnal Enuresis (NE) at the text pre-void stage using miniaturised mechatronics with Artificial Intelligence (AI). The developed features include: multiple bespoke ultrasound (US) probes for sensing, a bespoke electronic device housing custom US electronics for signal processing, a bedside alarm box for processing the echoed pulses and generating alarms, and a phantom to mimic the human body. The validation of the system is conducted on the text tissue-mimicking phantom and volunteers using Bidirectional Long Short-Term Memory Recurrent Neural Networks (Bi-LSTM-RNN) and Reinforcement Learning (RL). A Se value of 99% and a Sp value of 99.5% with an overall accuracy rate of 99.3% are observed. The obtained results demonstrate successful empirical evidence for the viability of the device, both in monitoring bladder expansion to determine voiding need and in reinforcing the continuous learning and customisation of the device for bladder control through consecutive uses. Clinical impact: MyPAD will treat the NE better and efficiently against other techniques currently used (e.g., post-void alarms) and will i) replace those techniques quickly considering sufferers’ condition while being treated by other approaches, and ii) enable children to gain control of incontinence over time and consistently have dry nights. Category: Early/Pre-Clinical Research","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"204-214"},"PeriodicalIF":3.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10328832","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138485029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Moglia;Luca Marsilio;Matteo Rossi;Maria Pinelli;Emanuele Lettieri;Luca Mainardi;Alfonso Manzotti;Pietro Cerveri
{"title":"Mixed Reality and Artificial Intelligence: A Holistic Approach to Multimodal Visualization and Extended Interaction in Knee Osteotomy","authors":"Andrea Moglia;Luca Marsilio;Matteo Rossi;Maria Pinelli;Emanuele Lettieri;Luca Mainardi;Alfonso Manzotti;Pietro Cerveri","doi":"10.1109/JTEHM.2023.3335608","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3335608","url":null,"abstract":"Objective: Recent advancements in augmented reality led to planning and navigation systems for orthopedic surgery. However little is known about mixed reality (MR) in orthopedics. Furthermore, artificial intelligence (AI) has the potential to boost the capabilities of MR by enabling automation and personalization. The purpose of this work is to assess Holoknee prototype, based on AI and MR for multimodal data visualization and surgical planning in knee osteotomy, developed to run on the HoloLens 2 headset. Methods: Two preclinical test sessions were performed with 11 participants (eight surgeons, two residents, and one medical student) executing three times six tasks, corresponding to a number of holographic data interactions and preoperative planning steps. At the end of each session, participants answered a questionnaire on user perception and usability. Results: During the second trial, the participants were faster in all tasks than in the first one, while in the third one, the time of execution decreased only for two tasks (“Patient selection” and “Scrolling through radiograph”) with respect to the second attempt, but without statistically significant difference (respectively \u0000<inline-formula> <tex-math>$p$ </tex-math></inline-formula>\u0000 = 0.14 and \u0000<inline-formula> <tex-math>$p$ </tex-math></inline-formula>\u0000 = 0.13, \u0000<inline-formula> <tex-math>$p < 0.05$ </tex-math></inline-formula>\u0000). All subjects strongly agreed that MR can be used effectively for surgical training, whereas 10 (90.9%) strongly agreed that it can be used effectively for preoperative planning. Six (54.5%) agreed and two of them (18.2%) strongly agreed that it can be used effectively for intraoperative guidance. Discussion/Conclusion: In this work, we presented Holoknee, the first holistic application of AI and MR for surgical planning for knee osteotomy. It reported promising results on its potential translation to surgical training, preoperative planning, and surgical guidance. Clinical and Translational Impact Statement - Holoknee can be helpful to support surgeons in the preoperative planning of knee osteotomy. It has the potential to impact positively the training of the future generation of residents and aid surgeons in the intraoperative stage.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"279-290"},"PeriodicalIF":3.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10325506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139676277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inertial Measurement Unit-Based Romberg Test for Assessing Adults With Vestibular Hypofunction","authors":"Kuan-Chung Ting;Yu-Chieh Lin;Chia-Tai Chan;Tzong-Yang Tu;Chun-Che Shih;Kai-Chun Liu;Yu Tsao","doi":"10.1109/JTEHM.2023.3334238","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3334238","url":null,"abstract":"This work aims to explore the utility of wearable inertial measurement units (IMUs) for quantifying movement in Romberg tests and investigate the extent of movement in adults with vestibular hypofunction (VH). A cross-sectional study was conducted at an academic tertiary medical center between March 2021 and April 2022. Adults diagnosed with unilateral vestibular hypofunction (UVH) or bilateral vestibular hypofunction (BVH) were enrolled in the VH group. Healthy controls (HCs) were recruited from community or outpatient clinics. The IMU-based instrumented Romberg and tandem Romberg tests on the floor were applied to both groups. The primary outcomes were kinematic body metrics (maximum acceleration [ACC], mean ACC, root mean square [RMS] of ACC, and mean sway velocity [MV]) along the medio-lateral (ML), cranio-caudal (CC), and antero-posterior (AP) axes. A total of 31 VH participants (mean age, 33.48 [SD 7.68] years; 19 [61%] female) and 31 HCs (mean age, 30.65 [SD 5.89] years; 18 [58%] female) were recruited. During the eyes-closed portion of the Romberg test, VH participants demonstrated significantly higher maximum ACC and increased RMS of ACC in head movement, as well as higher maximum ACC in pelvic movement along the ML axis. In the same test condition, individuals with BVH exhibited notably higher maximum ACC and RMS of ACC along the ML axis in head and pelvic movements compared with HCs. Additionally, BVH participants exhibited markedly increased maximum ACC along the ML axis in head movement during the eyes-open portion of the tandem Romberg test. Conversely, no significant differences were found between UVH participants and HCs in the assessed parameters. The instrumented Romberg and tandem Romberg tests characterized the kinematic differences in head, pelvis, and ankle movement between VH and healthy adults. The findings suggest that these kinematic body metrics can be useful for screening BVH and can provide goals for vestibular rehabilitation.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"245-255"},"PeriodicalIF":3.4,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10322744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139034303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Navigation Device for Precise Percutaneous Placement of the Guidewire in Femoral Neck Fracture Cannulated Screw Fixation Surgery","authors":"Yutao Cui;Guangkai Ren;Chuangang Peng;Baoming Yuan;Dankai Wu","doi":"10.1109/JTEHM.2023.3332453","DOIUrl":"https://doi.org/10.1109/JTEHM.2023.3332453","url":null,"abstract":"The accuracy of screw placement is a key factor for the stability of the cannulated screws used in the fixation of femoral neck fractures. In this study we designed a navigation device for ensuring the screw reaches the ideal position for optimal fixation. From March 2019 to September 2020, 66 patients with femoral neck fracture were enrolled and divided into 2 groups, one group was treated using the traditional free-hand cannulated screw fixation and the other using the new navigation device with assisted fixation. The effectiveness of the 2 methods was compared based on surgery duration, intraoperative bleeding, number of fluoroscopic examination and guidewire insertion attempts, screw parallelism, and effective fixation area. Fracture healing, complications and hip joint function were assessed after operation. The new navigation device reduced the duration of surgery without causing additional intraoperative bleeding, and significantly reduced number of fluoroscopy examination and guidewire insertion attempts (4.00±1.58 vs. 6.09±1.94 with traditional surgery). The accuracy of screw implantation was improved, as demonstrated by increased screw parallelism (0.71±0.57° vs. 1.66 ±1.01° with traditional surgery) and higher effective fixed area (64.88±10.52 vs. 58.61±9.19 mm2 with traditional surgery). In the postoperative follow-up, except for one case of femoral head necrosis and one case of bone nonunion in the traditional surgical group, the other patients showed fracture healing. There was no significant difference in hip joint function between the 2 groups. The new navigation device enables rapid and accurate guidewire positioning for cannulated screw fixation through simple operation procedures, resulting in good prospect for clinical transformation.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"162-170"},"PeriodicalIF":3.4,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10319461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138485009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}