SLAS Technology最新文献

{"title":"Exploring cognitive behavioral aspects in educational psychology: A rigorous analysis of reliability and validity measures","authors":"","doi":"10.1016/j.slast.2024.100144","DOIUrl":"10.1016/j.slast.2024.100144","url":null,"abstract":"<div><p>The purpose of this study is to verify the reliability and effectiveness of an educational psychology scale, which is explored by using the methods of literature, interview, questionnaire survey and mathematical statistics. The research object is the education psychology data of undergraduate students in local undergraduate colleges and universities.The data are collected and analyzed through the scale. The results show that the educational psychology scale contains six dimensions, including self-efficacy, learning motivation, hope trait, psychological resilience, physical self-esteem and emotional management, with a total of 27 items. The kmo sampling appropriateness of the scale is 0.800. The load of six dimensions in the total amount table is between 0.58 and 0.73. The fitting coefficient of each item of the structural model is between 0.45–0.73, and the correlation between each dimension and the total table is between 0.24–0.52. Scale cronbach's α The coefficient was 0.83 and the test-retest reliability was 0.90. The content validity of the scale ranged from 0.554 to 0.775. The scale has good reliability and validity, and can be used to evaluate undergraduate students' educational psychology.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100144"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000268/pdfft?md5=63ba18db754a7fdbb3df198a940437b4&pid=1-s2.0-S2472630324000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life sciences discovery and technology highlights","authors":"Tal Murthy ,&nbsp;Jamien Lim","doi":"10.1016/j.slast.2024.100169","DOIUrl":"10.1016/j.slast.2024.100169","url":null,"abstract":"","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100169"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000517/pdfft?md5=35f375d5eff4a81b52c95c1c1eaadae1&pid=1-s2.0-S2472630324000517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the affinity selection mass spectrometry workflow for efficient identification and ranking of potent USP1 inhibitors","authors":"Yi Zhao,&nbsp;Meixian Liu,&nbsp;Tian Qin,&nbsp;Yongqiang Peng,&nbsp;Guang Lin,&nbsp;Chao Che,&nbsp;Zhendong Zhu","doi":"10.1016/j.slast.2024.100174","DOIUrl":"10.1016/j.slast.2024.100174","url":null,"abstract":"<div><p>An optimized Affinity Selection-Mass Spectrometry (AS-MS) workflow has been developed for the efficient identification of potent USP1 inhibitors. USP1 was immobilized on agarose beads, ensuring low small molecule retention, efficient protein capture, and protein stability. The binding affinity of 49 compounds to USP1 was evaluated using the optimized AS-MS method, calculating binding index (BI) values for each compound. Biochemical inhibition assays validated the AS-MS results, revealing a potential correlation between higher BI values and lower IC₅₀ values. This optimized workflow enables rapid identification of high-quality USP1 inhibitor hits, facilitating structure-activity relationship studies and accelerating the discovery of potential cancer therapeutics.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100174"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000566/pdfft?md5=04d32317879afbb2ecd681a335b9fb7b&pid=1-s2.0-S2472630324000566-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of combined detection of three gastric functions and Helicobacter pylori typing in chronic gastritis and gastric cancer","authors":"","doi":"10.1016/j.slast.2024.100141","DOIUrl":"10.1016/j.slast.2024.100141","url":null,"abstract":"<div><p>This research attempted to clarify the clinical diagnostic value of combined detection of gastric function and Helicobacter pylori (Hp) serotyping in chronic gastritis and gastric cancer (GC). The 80 chronic non atrophic gastritis (CNAG) patients treated in our hospital from October 2021 to October 2022 received selection as the CNAG group. The 96 chronic atrophic gastritis (CAG) patients diagnosed by gastroscopy and pathology in the same period received selection as CAG group. During the same period, 50 patients diagnosed with GC received inclusion in GC group. Pepsin I (PG I), PG II (PG II), gastrin-17 (G-17) and Hp serotyping received detection and comparison in three groups. The diagnostic efficacy of PG Ⅰ, PG Ⅱ, G-17, the ratio of serum PG I to PG II (PGR), and Hp serotyping in chronic gastritis and GC received evaluation by receiver operating characteristic (ROC). Relative to in the CNAG group, PG I and PGR levels in the other two groups exhibited depletion (<em>P</em> &lt; 0.05); no statistical significance was observed in the PG II level among the three groups (<em>P</em> &gt; 0.05); relative to the CNAG group, the G-17 level in the other two groups exhibited elevation (<em>P</em> &lt; 0.05). Total Hp positive rate was 61.06 %, among which GC group exhibited the highest positive rate (72.00 %), and type I Hp positive rate also exhibited the highest in GC group (60.00 %). The type II Hp positive rate exhibited the highest in CNAG group (15.00 %). The PG I and PGR levels in type I Hp positive patients exhibited depletion relative to those in type II Hp positive patients, whereas PG II and G-17 levels exhibited elevation. When testing each indicator alone, the area under the curve (AUC) of PG I exhibited the highest in CNAG group, which was 0.874. When testing each indicator alone, AUC of Hp typing exhibited the highest in CAG group, which was 0.515. When testing each indicator alone, AUC of G-17 exhibited the highest in GC group, which was 0.787. The performance of combined detection was better than that of individual detection, with AUCs greater than 0.9 in three groups. In conclusion, changes in PG I, PG II, PGR and G-17 levels and Hp serotyping can receive application as screening indicators for chronic gastritis and GC, which can reflect relevant status of gastric mucosa to varying degrees. Combined detection of indicators has higher diagnostic performance and can receive application as an auxiliary diagnostic indicator in addition to gastroscopy biopsy, providing a reference basis for the formulation of clinical diagnosis and treatment plans.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100141"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000232/pdfft?md5=07b1ba1bf167a228cc89bde86f817183&pid=1-s2.0-S2472630324000232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic fermentation environment control under intelligent data monitoring","authors":"","doi":"10.1016/j.slast.2024.100153","DOIUrl":"10.1016/j.slast.2024.100153","url":null,"abstract":"<div><p>Probiotic fermentation studies are vital in many areas, particularly when it comes to feeding applications. This work examines probiotic fermentation in oil tea crops. The assessment of tea saponin-degrading bacteria and optimization of fermentation conditions using fermented oil tea cake under natural conditions, screening out six strains with strong ability to degrade tea saponin; selection of the best tea saponin degradation strain L.2 and recognition of its morphological features and ITS sequence to obtain L.2 strain is Aspergillus Niger. Oil tea is rich in tea saponin. Aspergillus Niger degraded tea saponins in oil teacakes at a rate of 93.96 % under the ideal conditions of 31.3 oC, 103.5 h, and 4.57 mL of initial acid addition. This has been accomplished via solid-state fermentation of L.2 using single factor studies and surface response optimization experiments. Moreover, Aspergillus Niger degraded tea saponins in oil tea cakes at a rate of 93.96% at the ideal circumstances of 31.3 C, 103.5 h, and 4.57 mL of initial acid addition.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100153"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000359/pdfft?md5=8354d8af9ecab492cf279c36e558de99&pid=1-s2.0-S2472630324000359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing robustness to adversarial attacks in attention-based networks: Case of EEG-based motor imagery classification","authors":"","doi":"10.1016/j.slast.2024.100142","DOIUrl":"10.1016/j.slast.2024.100142","url":null,"abstract":"<div><p>The classification of motor imagery (MI) using Electroencephalography (EEG) plays a pivotal role in facilitating communication for individuals with physical limitations through Brain-Computer Interface (BCI) systems. Recent strides in Attention-Based Networks (ATN) have showcased remarkable performance in EEG signal classification, presenting a promising alternative to conventional Convolutional Neural Networks (CNNs). However, while CNNs have been extensively analyzed for their resilience against adversarial attacks, the susceptibility of ATNs in comparable scenarios remains largely unexplored. This paper aims to fill this gap by investigating the robustness of ATNs in adversarial contexts. We propose a high-performing attention-based deep learning model specifically designed for classifying Motor Imagery (MI) brain signals extracted from EEG data. Subsequently, we conduct a thorough series of experiments to assess various attack strategies targeting ATNs employed in EEG-based BCI tasks. Our analysis utilizes the widely recognized BCI Competition 2a dataset to demonstrate the effectiveness of attention mechanisms in BCI endeavors. Despite achieving commendable classification results in terms of accuracy (87.15%) and kappa score (0.8287), our findings reveal the vulnerability of attention-based models to adversarial manipulations (accuracy: 9.07%, kappa score: -0.21), highlighting the imperative for bolstering the robustness of attention architectures for EEG classification tasks.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100142"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000244/pdfft?md5=4562ff680af5d6240601ccadf780b2fa&pid=1-s2.0-S2472630324000244-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of intelligent nursing system based on big data in maintenance hemodialysis patients","authors":"","doi":"10.1016/j.slast.2024.100160","DOIUrl":"10.1016/j.slast.2024.100160","url":null,"abstract":"<div><p>Maintenance hemodialysis (MHD) is one of the most important renal replacement therapies for patients with end-stage renal disease. However, long-term and frequent treatment not only damages the physiological functions of patients but also leads to serious economic burdens and mental stress. This can easily cause a series of psychological disorders in patients, resulting in severe rejection and fear of MHD. To reduce patient resistance and improve the quality of life of MHD, this article built an intelligent nursing system based on big data and then used the constructed intelligent nursing system to research MHD. Through experiments, it has been found that compared to self-efficacy intervention, intelligent nursing systems can control the concurrent rate of MHD patients below 14 %, and self-efficacy intervention methods can control the concurrent rate of MHD patients above 13 %. Moreover, using intelligent nursing systems can improve the ability of MHD patients to self-care. At the same time, before the use of intelligent nursing systems, the nursing satisfaction of MHD patients also varied greatly, with the overall satisfaction rate after use being 70 % higher than before. Using intelligent nursing systems can improve the satisfaction of MHD patients with nursing outcomes.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100160"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000426/pdfft?md5=f75086df0b13447a6a9022c6f4bd58b0&pid=1-s2.0-S2472630324000426-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards robotic laboratory automation plug & play: Reference architecture model for robot integration","authors":"Ádám Wolf ,&nbsp;Panna Zsoldos ,&nbsp;Károly Széll ,&nbsp;Péter Galambos","doi":"10.1016/j.slast.2024.100168","DOIUrl":"10.1016/j.slast.2024.100168","url":null,"abstract":"<div><p>Supportive robotic solutions take over mundane, but essential tasks from human workforce in biomedical research and development laboratories. The newest technologies in collaborative and mobile robotics enable the utilization in the human-centered and low-structured environment. Their adaptability, however, is hindered by the additional complexity that they introduce. In our paper we aim to entangle the convoluted laboratory robot integration architectures. We begin by hierarchically decomposing the laboratory workflows, and mapping the activity representations to layers and components of the automation control architecture. We elaborate the framework in detail on the example of pick-and-place labware transportation - a crucial supportive step, which we identified as the number one area of interest among experts of the field. Our concept proposal serves as a reference architecture model, the key principles of which were used in reference implementations, and are in line with international standardization efforts.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 4","pages":"Article 100168"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000505/pdfft?md5=9191d8fa8d8188d7f293c9c7602492fa&pid=1-s2.0-S2472630324000505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A duplexed high-throughput mass spectrometry assay for bifunctional POLB polymerase and lyase activity","authors":"Zachary A. Gurard-Levin ,&nbsp;Brian McMillan ,&nbsp;Douglas A. Whittington ,&nbsp;Brian Doyon ,&nbsp;Michael D. Scholle ,&nbsp;Jacques Ermolieff ,&nbsp;Madhavi Bandi ,&nbsp;Mu-Sen Liu ,&nbsp;Alvaro Amor ,&nbsp;William D. Mallender","doi":"10.1016/j.slast.2024.100173","DOIUrl":"10.1016/j.slast.2024.100173","url":null,"abstract":"<div><p>Polymerase β (POLB), with dual functionality as a lyase and polymerase, plays a critical role in the base excision repair (BER) pathway to maintain genomic stability. POLB knockout and rescue studies in BRCA1/2-mutant cancer cell lines revealed that inhibition of lyase and polymerase activity is required for the synthetic lethal interaction observed with PARP inhibitors, highlighting POLB as a valuable therapeutic target. Traditional biochemical assays to screen for enzyme inhibitors focus on a single substrate to product relationship and limit the comprehensive analysis of enzymes such as POLB that utilize multiple substrates or catalyze a multi-step reaction. This report describes the first high-throughput mass spectrometry-based screen to measure the two distinct biochemical activities of POLB in a single assay using a duplexed self-assembled monolayer desorption ionization (SAMDI) mass spectrometry methodology. A multiplexed assay for POLB dual enzymatic activities was developed optimizing for kinetically balanced conditions and a collection of 200,000 diverse small molecules was screened in the duplexed format. Small molecule modulators identified in the screen were confirmed in a traditional fluorescence-based polymerase strand-displacement assay and an orthogonal label-free binding assay using SAMDI affinity selection mass spectrometry (ASMS). This work demonstrates the flexibility of high-throughput mass spectrometry approaches in drug discovery and highlights a novel application of SAMDI technology that opens new avenues for multiplexed high-throughput screening.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100173"},"PeriodicalIF":2.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000554/pdfft?md5=98c7fdf63e41ea96bdacfbf8869f2053&pid=1-s2.0-S2472630324000554-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromechanical proficiency in elite performance decision-making: An event-related potential (ERP) analysis","authors":"Qiang Xiong ,&nbsp;Dan-Li Song","doi":"10.1016/j.slast.2024.100171","DOIUrl":"10.1016/j.slast.2024.100171","url":null,"abstract":"<div><p>This research focuses intensively on the neural mechanisms of action selection responses in elite athletes during high-stakes decision-making. It emphasizes the neuromechanical dimensions of these processes, contrasting the responses of expert and novice players within a theoretical framework of neural information processing in high-performance contexts. Utilizing advanced EEG technologies, including event-related potential (ERP) analysis, the study captures a comprehensive view of both behavioral and neurophysiological data. The central aim is to unravel the intricate neural underpinnings that distinguish elite athletes in their decision-making strategies. Key findings highlight: (1) Enhanced accuracy and swifter reaction times in elite athletes during the action selection phase; (2) Significant neurophysiological differences, marked by pronounced N1 peak amplitudes with prolonged latencies, reduced P2 peak amplitudes with stable latencies, decreased P3 peak amplitudes with reduced latencies, and increased average PSW amplitudes. These discoveries significantly advance our understanding of the neural foundations of expert decision-making in high-performance sports. This study not only sheds light on the cognitive and neural dynamics of elite sports performance but also provides a foundation for developing training and performance enhancement techniques in various high-stakes domains.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100171"},"PeriodicalIF":2.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000530/pdfft?md5=e72a6a82179683da8675cc91d2f3dbbe&pid=1-s2.0-S2472630324000530-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}