SLAS Technology最新文献_第10页

CardioGuard: AI-driven ECG authentication hybrid neural network for predictive health monitoring in telehealth systems CardioGuard：用于远程医疗系统中预测性健康监测的人工智能驱动心电图验证混合神经网络。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-20 DOI: 10.1016/j.slast.2024.100193

Muhammad Jamal Ahmed , Urooj Afridi , Hasnain Ali Shah , Habib Khan , Mohammed Wasim Bhatt , Abdullah Alwabli , Inam Ullah

{"title":"CardioGuard: AI-driven ECG authentication hybrid neural network for predictive health monitoring in telehealth systems","authors":"Muhammad Jamal Ahmed , Urooj Afridi , Hasnain Ali Shah , Habib Khan , Mohammed Wasim Bhatt , Abdullah Alwabli , Inam Ullah","doi":"10.1016/j.slast.2024.100193","DOIUrl":"10.1016/j.slast.2024.100193","url":null,"abstract":"<div><div>The increasing integration of telehealth systems underscores the importance of robust and secure methods for patient data management. Traditional authentication methods, such as passwords and PINs, are prone to breaches, underscoring the need for more secure alternatives. Therefore, there is a need for alternative approaches that provide enhanced security and user convenience. Biometric-based authentication systems uses individuals unique physical or behavioral characteristics for identification, have emerged as a promising solution. Specifically, Electrocardiogram (ECG) signals have gained attention among various biometric modalities due to their uniqueness, stability, and non-invasiveness. This paper presents CardioGaurd, a deep learning-based authentication system that leverages ECG signals—unique, stable, and non-invasive biometric markers. The proposed system uses a hybrid Convolution and Long short-term memory based model to obtain rich characteristics from the ECG signal and classify it as authentic or fake. CardioGaurd not only ensures secure access but also serves as a predictive tool by analyzing ECG patterns that could indicate early signs of cardiovascular abnormalities. This dual functionality enhances patient security and contributes to AI-driven disease prevention and early detection. Our results demonstrate that CardioGaurd offers superior performance in both security and potential predictive health insights compared to traditional models, thus supporting a shift towards more proactive and personalized telehealth solutions.</div></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100193"},"PeriodicalIF":2.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S247263032400075X/pdfft?md5=c31468384bcd0ef166c3834aedba50a5&pid=1-s2.0-S247263032400075X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological correlation between eosinophils and thyroid nodules based on medical image testing 基于医学影像检测的嗜酸性粒细胞与甲状腺结节的病理相关性。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-19 DOI: 10.1016/j.slast.2024.100189

Mingjie He , Tianqi Zhang , Qing Huang , Xiukai Tang , Biaoliang Wu , Ying Liu

{"title":"Pathological correlation between eosinophils and thyroid nodules based on medical image testing","authors":"Mingjie He , Tianqi Zhang , Qing Huang , Xiukai Tang , Biaoliang Wu , Ying Liu","doi":"10.1016/j.slast.2024.100189","DOIUrl":"10.1016/j.slast.2024.100189","url":null,"abstract":"<div><div>Thyroid nodule is a common thyroid disease, but the study of its pathology and pathogenesis is still limited. As a non-invasive diagnostic method, medical image examination is of great value to study the pathological correlation of thyroid nodules. The purpose of this study was to investigate the expression of eosinophils in medical image examination and the pathological correlation between eosinophils and thyroid nodules. The study analyzed the pathological reports of a group of patients with thyroid nodules examined by medical images and performed corresponding imaging scans or examinations. The imaging data is processed, including image reconstruction, data transmission and other steps, to generate images that can be diagnosed by doctors. Thyroid function and parameters of leukocyte were collected and compared.The serum levels of TT4 and fT4 were observed lower in G2 group, while thyroid stimulating hormone (TSH) was higher compared to G1 group before surgery. Compared to G2 group, eosinophils count and percentage were lower in G1group (<em>p</em> < 0.05) post-surgery and lower ratio of eosinophils count with lymphocyte count (ELR) were observed in G1 group patients (<em>p</em> < 0.05).Elevated TSH is closely related to malignant TN per surgery, while lower ELR suggesting that TN removed thoroughly. Relevant cut-off values required further study to guide the diagnosis, treatment and follow-up of TN.</div></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100189"},"PeriodicalIF":2.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000712/pdfft?md5=b6c2a7e02c51750517a844e19045aa57&pid=1-s2.0-S2472630324000712-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Advances in Precise Diagnostics and Personalized Medicine 社论：精确诊断和个性化医疗的进展。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-18 DOI: 10.1016/j.slast.2024.100194

Hui Li , Kun Yin

引用次数: 0

Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis 连接蛋白 43 通过 TGFβ1-Smad3 介导的 αV 信号轴控制三阴性乳腺癌的转移行为基于光学图像诊断的研究

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-17 DOI: 10.1016/j.slast.2024.100190

Yun Fu , Xiaoyin Sun , Qizhi He , Zhangyuan Gu , Xiaoqing Jia , Zhigang Zhuang

{"title":"Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis","authors":"Yun Fu , Xiaoyin Sun , Qizhi He , Zhangyuan Gu , Xiaoqing Jia , Zhigang Zhuang","doi":"10.1016/j.slast.2024.100190","DOIUrl":"10.1016/j.slast.2024.100190","url":null,"abstract":"<div><p>Abnormal expression of connexin 43 (Cx43) contributes to the development and progression of cancer. However, its regulation is complex and dependent on the environment. The expression of Cx43 in triple-negative cancer lesions was analyzed by immunohistochemistry and optical coherence tomography using experimental models and clinical samples. The model of TGFβ1-SMad3-in-αv signal axis was established and verified by experiments. The results show that Cx43 plays a key role in the regulation of triple-negative cancer metastasis. <em>In vivo</em>, over-expressed Cx43 decreased tumor volume and inhibited ITGαV, TGF-β1, Smad3 and N-cadherin expressions, but enhanced the E-cadherin. Cx43 had the lowest expression in the TNBC samples, especially in lymph node metastatic TNBC patients and had a negative correlation with ITG alpha V, TGF-β1 and Smad3.The study demonstrated Cx43 controlled metastatic behavior through TGF-β1 -Smad3-ITG αV signaling axis in MDA-MB-231 cells, providing evidence for Cx43’s function in TNBC. The optical image diagnosis method can realize the identification and quantitative evaluation of early cancer triple negative, and provide a new strategy and means for the treatment of cancer triple negative.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100190"},"PeriodicalIF":2.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000724/pdfft?md5=078cde3938fa2345741f49254d0dc81a&pid=1-s2.0-S2472630324000724-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical MRI imaging based on computer vision for extracting and analyzing morphological features of renal tumors 基于计算机视觉的光学磁共振成像，用于提取和分析肾肿瘤的形态特征。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-16 DOI: 10.1016/j.slast.2024.100192

Wu Deng , Xiaohai He , Jia Xu , Boyuan Ding , Songcen Dai , Chao Wei , Hui Pu , Yi Wei , Xinpeng Ren

{"title":"Optical MRI imaging based on computer vision for extracting and analyzing morphological features of renal tumors","authors":"Wu Deng , Xiaohai He , Jia Xu , Boyuan Ding , Songcen Dai , Chao Wei , Hui Pu , Yi Wei , Xinpeng Ren","doi":"10.1016/j.slast.2024.100192","DOIUrl":"10.1016/j.slast.2024.100192","url":null,"abstract":"<div><p>Computer vision technology is more and more widely used in the market. Target detection and feature extraction are two important auxiliary means of this technique, which are helpful to analyze target motion data. However, in the field of biology, there are some data limitations in the analysis of targets such as bacteria and tumors, which need to be further explored. Optical MRI imaging technology based on computer vision provides a new way to extract and analyze morphological features of renal tumors. In this paper, an optical MRI imaging method based on computer vision is designed and developed for the extraction and analysis of morphological features of kidney tumors. By using optical MRI imaging technology based on computer vision, the morphological characteristics of kidney tumors were extracted by analyzing the optical characteristics and MRI images of kidney tumors, and a simulation model was established to simulate the morphological characteristics of different types of kidney tumors, and feature extraction and analysis were carried out by computer algorithm. Through the analysis of the simulation model, the morphological characteristics of renal tumors were extracted and analyzed, which provided a new and non-invasive method for clinical diagnosis and treatment of renal tumors.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100192"},"PeriodicalIF":2.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000748/pdfft?md5=a2a8b1de98cd33816bde3cd2c8ae7b4f&pid=1-s2.0-S2472630324000748-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience in the diagnosis and treatment of non-invasive bilateral carotid cavernous sinus fistula based on CT image examination 根据 CT 图像检查诊断和治疗无创双侧颈动脉海绵窦瘘的经验。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-16 DOI: 10.1016/j.slast.2024.100191

Dan Zhu , Zhenyang Yu , Weiguang Zhang , Shuai Zhang

{"title":"Experience in the diagnosis and treatment of non-invasive bilateral carotid cavernous sinus fistula based on CT image examination","authors":"Dan Zhu , Zhenyang Yu , Weiguang Zhang , Shuai Zhang","doi":"10.1016/j.slast.2024.100191","DOIUrl":"10.1016/j.slast.2024.100191","url":null,"abstract":"<div><p>Carotid cavernous fistula is a rare but clinically important vascular abnormality that is challenging to diagnose and treat. The clinical data of a patient with bilateral carotid cavernous fistula diagnosed by CT images were retrospectively analyzed. Through the analysis of CT images, the patient was accurately located and the diagnosis was confirmed. CT images can provide detailed anatomical information and accurately show the location, morphology and hemodynamic characteristics of carotid cavernous fistula. Through CT image examination, we successfully diagnosed bilateral carotid cavernous fistula patients, and can provide an important reference for surgical treatment. Therefore, CT image examination can provide accurate diagnosis and surgical planning information, and provide support for the formulation of individual treatment plans for patients. The application of this method is helpful to improve the early diagnosis rate and treatment effect of carotid cavernous fistula.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100191"},"PeriodicalIF":2.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000736/pdfft?md5=1928739854258fac5740430b1b53f767&pid=1-s2.0-S2472630324000736-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life sciences discovery and technology highlights 生命科学发现与技术亮点。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-09-13 DOI: 10.1016/j.slast.2024.100188

Jamien Lim, Tal Murthy

引用次数: 0

Breast cancer promotes the expression of neurotransmitter receptor related gene groups and image simulation of prognosis model 乳腺癌促进神经递质受体相关基因组的表达及预后模型的图像模拟。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-08-31 DOI: 10.1016/j.slast.2024.100183

Shuting Qin , Linjie Lu , Xi Tang , Shenli Huang , Zhongxin Guo , Guohe Tan

{"title":"Breast cancer promotes the expression of neurotransmitter receptor related gene groups and image simulation of prognosis model","authors":"Shuting Qin , Linjie Lu , Xi Tang , Shenli Huang , Zhongxin Guo , Guohe Tan","doi":"10.1016/j.slast.2024.100183","DOIUrl":"10.1016/j.slast.2024.100183","url":null,"abstract":"<div><p>Breast cancer (BC), a prevalent and severe malignancy, detrimentally affects women globally. Its prognostic implications are profoundly influenced by gene expression patterns. This study retrieved 509 BCE-associated oncogenes and 1,012 neurotransmitter receptor-related genes from the GSEA and KEGG databases, intersecting to identify 98 relevant genes. Clinical and transcriptomic expression data related to BC were downloaded from the TCGA, and differential genes were identified based on an FDR value <0.05 & |log2FC| ≥ 0.585. Univariate analysis of these genes revealed that high expression of NSF and low expression of HRAS, KIF17, and RPS6KA1 are closely associated with BC survival prognosis. A prognostic model constructed for these four genes demonstrated significant prognostic relevance for BC-TCGA patients (<em>P</em> < 0.001). Subsequently, an immunofunctional analysis of the BC oncogene-neurotransmitter receptor-related gene cluster revealed the involvement of immune cells such as T cells CD8, T cells CD4 memory resting, and Macrophages M2. Further analysis indicated that immune functions were primarily concentrated in APC_co_inhibition, APC_co_stimulation, CCR, and Check-point, among others. Lastly, a prognostic nomogram model was established, and ROC curve analysis revealed that the nomogram is a vital indicator for assessing BC prognosis, with 1-year, 3-year, and 5-year survival rates of 0.981, 0.897, and 0.802, respectively. This model demonstrates high calibration, clinical utility, and predictive capability, promising to offer an effective preliminary tool for clinical diagnostics.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100183"},"PeriodicalIF":2.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000657/pdfft?md5=d7ce4b1eeca3a088e2432aaafca8d962&pid=1-s2.0-S2472630324000657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep integration of low-cost liquid handling robots in an industrial pharmaceutical development environment 在工业制药开发环境中深度集成低成本液体处理机器人。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-08-31 DOI: 10.1016/j.slast.2024.100180

Anton Thieme , Sean Renwick , Michaela Marschmann , Pedro Ivo Guimaraes , Susanne Weissenborn , Jamie Clifton

{"title":"Deep integration of low-cost liquid handling robots in an industrial pharmaceutical development environment","authors":"Anton Thieme , Sean Renwick , Michaela Marschmann , Pedro Ivo Guimaraes , Susanne Weissenborn , Jamie Clifton","doi":"10.1016/j.slast.2024.100180","DOIUrl":"10.1016/j.slast.2024.100180","url":null,"abstract":"<div><p>The pharmaceutical industry is increasingly embracing laboratory automation to enhance experimental efficiency and operational resilience, particularly through the integration of automated liquid handlers (ALHs). This paper explores the integration of the low-cost Opentrons OT-2 liquid handling robot with F. Hoffmann-La Roche AG's in-house workflow orchestration software, AutoLab, to overcome barriers to lab automation. By leveraging the OT-2′s development-oriented interfaces and AutoLab's modular architecture, we achieved a user-friendly, cost-efficient, and flexible automation solution that aligns with FAIR (findable, accessible, interoperable, reusable) data principles. We demonstrate an advanced workflow development methodology, utilizing the software architecture, that facilitates the creation of two flexible pipetting protocols and medium complexity assays. This deep integration approach diminishes the learning curve for novice users while simultaneously enhancing the overall efficiency and reliability of the experimental workflow. Our findings suggest that such integrations can significantly mitigate the challenges associated with lab automation, including cost, complexity, and adaptability, paving the way for more accessible and robust automated systems in pharmaceutical research.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100180"},"PeriodicalIF":2.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000621/pdfft?md5=d145d30056e4716d7085335eaf583030&pid=1-s2.0-S2472630324000621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation of predicting atrial fibrosis in patients with paroxysmal atrial fibrillation during sinus node recovery time in optical imaging 在光学成像中模拟预测窦房结恢复时间内阵发性心房颤动患者的心房纤维化。

IF 2.5 4区医学

SLAS Technology Pub Date : 2024-08-29 DOI: 10.1016/j.slast.2024.100186

Zhisong Chen, Hongwei Liu, Xuebo Liu, Haoming Song

{"title":"Simulation of predicting atrial fibrosis in patients with paroxysmal atrial fibrillation during sinus node recovery time in optical imaging","authors":"Zhisong Chen, Hongwei Liu, Xuebo Liu, Haoming Song","doi":"10.1016/j.slast.2024.100186","DOIUrl":"10.1016/j.slast.2024.100186","url":null,"abstract":"<div><p>Paroxysmal atrial fibrillation is a common arrhythmia, and its development process and prediction of the degree of atrial fibrosis are of great significance for treatment and management. Optical imaging technology provides a new means for non-invasive observation of atrial electrical activity. The aim of this study is to investigate the predictive effect of sinus node recovery time on the degree of atrial fibrosis in patients with paroxysmal atrial fibrillation, and to provide a basis for the application of optical imaging technology in the study of atrial fibrosis. The study collected clinical and optical imaging data from a group of patients with paroxysmal atrial fibrillation, and used statistical analysis methods to investigate the relationship between sinus node recovery time and the degree of atrial fibrosis. The research results indicate that there is a significant correlation between the recovery time of the sinus node and the degree of atrial fibrosis, that is, there is a positive correlation between the prolonged recovery time of the sinus node and the aggravation of atrial fibrosis. SNRT can serve as an effective indicator for evaluating atrial matrix and can be applied to predict recurrence after catheter ablation of paroxysmal atrial fibrillation. Shortening SNRT through catheter ablation can become an important predictor of effective catheter ablation.</p></div>","PeriodicalId":54248,"journal":{"name":"SLAS Technology","volume":"29 5","pages":"Article 100186"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2472630324000682/pdfft?md5=a03223c271f7af58ee50d8e9c11b38c8&pid=1-s2.0-S2472630324000682-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0