Association between dietary fiber intake and gallstone disease in US adults: Data from NHANES 2017–2020

IF 2.5 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology Pub Date : 2025-02-28 DOI:10.1016/j.slast.2025.100259

Tian Liu, Huimin Lv, Jia Li, Yusheng Chen, Mengnan Chen

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引用次数: 0

Abstract

Background

Gallstone disease is a widespread condition affecting the gastrointestinal tract, and poor diet is believed to be one of the reasons for its occurrence. Previous studies of dietary fiber intake and gallstones have limitations. The study's goal is to investigate the relationship between dietary fiber intake and gallstone prevalence in US adults.

Materials and methods

Data from NHANES 2017 to March 2020 is used for the study. The association between fiber intake and gallstone prevalence was analyzed using multivariate logistic regression. To confirm the results’ robustness, we performed sensitivity analyses also.

Results

Among the 6,051 U.S. adults aged over 20 with complete information, the prevalence of gallstones was 10.8 % (651/6051). After adjusting for relevant covariates, an increase in fiber intake of 5 g/day was associated with an 11 % decrease in the prevalence of gallstones (fully adjusted OR = 0.89, 95 % CI: 0.83–0.95). Participants were divided into high (>25 g/d) and low (≤25 g/d) fiber intake groups. Still significant negative association between dietary fiber intake and gallstones (fully adjusted OR = 0.66, 95 % CI: 0.49–0.91). Further dividing dietary fiber intake level into quintiles sustained this negative relationship, particularly showing the lowest gallstone occurrence in the highest dietary fiber group (OR = 0.63, 95 % CI: 0.44–0.91). While the stratified analyses indicated variability in the relationship between dietary fiber intake and the prevalence of gallstones, no interactive effects were identified in this association according to the interaction analysis.

Conclusions

This study confirms that dietary fiber intake is negatively associated with the prevalence of gallstones. Sufficient dietary fiber intake might protect from gallstones. In order to formulate dietary recommendations, it is important to carry out prospective studies to validate the observed associations.

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美国成年人膳食纤维摄入量与胆结石疾病之间的关系：来自NHANES 2017-2020的数据

背景：胆结石病是一种广泛影响胃肠道的疾病，不良饮食被认为是其发生的原因之一。先前关于膳食纤维摄入和胆结石的研究存在局限性。该研究的目的是调查膳食纤维摄入量与美国成年人胆结石患病率之间的关系。材料和方法：研究使用NHANES 2017至2020年3月的数据。使用多元逻辑回归分析纤维摄入量与胆结石患病率之间的关系。为了确认结果的稳健性，我们还进行了敏感性分析。结果：在6051名信息完整的20岁以上美国成年人中，胆结石患病率为10.8%（651/6051）。在调整相关协变量后，每天增加5克纤维摄入量与胆结石患病率降低11%相关（完全调整OR = 0.89,95% CI: 0.83-0.95）。参与者被分为高纤维摄取量组（25克/天）和低纤维摄取量组（≤25克/天）。膳食纤维摄入量与胆结石之间仍然存在显著的负相关（完全校正OR = 0.66,95% CI: 0.49-0.91）。进一步将膳食纤维摄入水平按五分位数划分，这种负相关关系仍然存在，特别是在膳食纤维摄入量最高的一组中，胆结石发生率最低（OR = 0.63,95% CI: 0.44-0.91）。虽然分层分析表明膳食纤维摄入量与胆结石患病率之间的关系存在差异，但根据相互作用分析，没有发现这种关联中的相互作用。结论：本研究证实膳食纤维摄入量与胆结石患病率呈负相关。摄入足够的膳食纤维可以预防胆结石。为了制定饮食建议，进行前瞻性研究来验证观察到的关联是很重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SLAS Technology Computer Science-Computer Science Applications

CiteScore

6.30

自引率

7.40%

发文量

审稿时长

106 days

期刊介绍： SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.