npj Regenerative Medicine最新文献

Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing. 具有时空控制生长因子递送和环糊精激活的生长因子受体隔离拮抗作用的支架可促进皮肤伤口愈合。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-09-29 DOI: 10.1038/s41536-025-00431-0

Jelena Marjanovic, Veronika Jurczuk, Lilian Valadares Tose, Yarixa Cintron Diaz, Francisco Fernandez Lima, Beatriz Abdo Abujamra, Sara Danker, Sinan Jabori, Devinder Singh, Jamie L Burgess, Joshua Tam, Mohamadmahdi Samandari, Rivka C Stone, Stephen C Davis, Robert S Kirsner, Marjana Tomic-Canic, Fotios M Andreopoulos, Ivan Jozic

{"title":"Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing.","authors":"Jelena Marjanovic, Veronika Jurczuk, Lilian Valadares Tose, Yarixa Cintron Diaz, Francisco Fernandez Lima, Beatriz Abdo Abujamra, Sara Danker, Sinan Jabori, Devinder Singh, Jamie L Burgess, Joshua Tam, Mohamadmahdi Samandari, Rivka C Stone, Stephen C Davis, Robert S Kirsner, Marjana Tomic-Canic, Fotios M Andreopoulos, Ivan Jozic","doi":"10.1038/s41536-025-00431-0","DOIUrl":"10.1038/s41536-025-00431-0","url":null,"abstract":"Chronic wounds present a major burden to patients, health care professionals, and health care systems worldwide, yet treatment options remain limited and often ineffective. Although initially promising, growth factor-based therapies displayed limited and underwhelming effectiveness largely due to poor bioavailabilbioity and impaired receptor function within the chronic wound microenvironment. Here we demonstrate that chronic wounds exhibit elevated cholesterol synthesis, which disrupts growth factor signaling by sequestering receptors within lipid rafts. To address this, we developed a novel therapy combining growth factors with cyclodextrin in an ECM-mimetic scaffold, enabling localized cholesterol modulation and improved receptor accessibility. We demonstrate that this approach enhances growth factor bioavailability and functionality, creating a regenerative environment. In both human ex vivo and diabetic mouse wound models, this targeted co-delivery strategy significantly improved healing outcomes by stimulating angiogenesis and re-epithelialization, supporting a promising new direction for chronic wound therapy through localized metabolic modulation of the wound niche.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"42"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome injection as a prevention strategy for early postoperative mesh complications in a porcine model of sacrocolpopexy. 外泌体注射作为预防猪骶髋固定模型术后早期补片并发症的策略。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-09-29 DOI: 10.1038/s41536-025-00432-z

Cassandra K Kisby, Sam Faraguna, Abigail Hitt, Ilya Y Shadrin, Hunter Newman, Anna Gilpin, Cindy L Amundsen, Shyni Varghese

{"title":"Exosome injection as a prevention strategy for early postoperative mesh complications in a porcine model of sacrocolpopexy.","authors":"Cassandra K Kisby, Sam Faraguna, Abigail Hitt, Ilya Y Shadrin, Hunter Newman, Anna Gilpin, Cindy L Amundsen, Shyni Varghese","doi":"10.1038/s41536-025-00432-z","DOIUrl":"10.1038/s41536-025-00432-z","url":null,"abstract":"Exosomes, an acellular regenerative biologic, have demonstrated success in resolving vaginal mesh exposures after pelvic reconstructive surgery; little data exists for their use for prevention of mesh-based complications. This study evaluated the early efficacy of purified exosome product (PEP) for preventing mesh exposures. Ten Yorkshire-crossed pigs underwent mesh sacrocolpopexy with two high-risk-for-exposure configurations: mesh fold ventrally, vaginotomy dorsally. PEP in hyaluronic acid (HA) or HA-only (control) was injected at baseline. Twelve weeks later, animals were euthanized and evaluated for mesh exposure and histologic changes. None of the PEP-treated tissues demonstrated mesh exposure (0/6); all control group animals experienced a mesh exposure (4/4 mesh fold configuration, 2/4 vaginotomy configuration). Control tissues exhibited higher fibrosis (vaginotomy fibrosis score: median(IQR); 3(3,3) control, 2(1,2) PEP; p = 0.03) and greater epithelial apoptosis (mesh fold TUNEL+area fraction: median 18.9 control vs 0.43 PEP; p = 0.02). Our study demonstrated that PEP treatment mitigated the risk of early mesh exposure.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"43"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts. 来自巨噬细胞的V型胶原调节梗死后心脏的初始胶原组装和排列。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-09-29 DOI: 10.1038/s41536-025-00430-1

Xin Sun, Sarah Sigal, Maria-Alexa Cosma, Carla de Villiers, Michael Weinberger, Paul R Riley

{"title":"Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts.","authors":"Xin Sun, Sarah Sigal, Maria-Alexa Cosma, Carla de Villiers, Michael Weinberger, Paul R Riley","doi":"10.1038/s41536-025-00430-1","DOIUrl":"10.1038/s41536-025-00430-1","url":null,"abstract":"Previous work has revealed that macrophages directly contribute collagen to the fibrotic scar in the injured hearts of zebrafish and mice. However, the functional impact of this contribution has not been investigated. Here, we characterised the deposition and ultrastructure of collagen fibrils in the forming scar of neonatal regenerative post-natal day (P)1 hearts and fibrotic P7 and adult mouse hearts after myocardial infarction (MI). Collagen type V (Col V) was the earliest deposited fibrillar collagen, coincident with macrophage recruitment to the site of injury and prior to cardiac myo-fibroblast activation. Deletion of COL5A1 in CD68+ macrophages resulted in disarrayed collagen fibrils within the nascent scar that was associated with a trend toward chamber dilation, wall thinning and compromised cardiac function. Our findings shed light on a role for macrophage-deposited Col V in establishing collagen deposition, alignment and scar stability prior to myofibroblast activation in the immediate acute phase post-MI.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"44"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix. 细胞外基质治疗体积性肌肉损失损伤后细胞动力学的解构。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-09-29 DOI: 10.1038/s41536-025-00429-8

Adrienne A Giannone, Shanae A-M Butler, Jacqueline A Larouche, Paula M Fraczek, Grace Kenney, Scott A Johnson, Clint D Skillen, Pranav Rao, Jessie Jin, Teja Chaparala, Mangesh Kulkarni, Robert J Tower, Benjamin Levi, Stephen F Badylak, Bryan N Brown, Carlos A Aguilar

{"title":"Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix.","authors":"Adrienne A Giannone, Shanae A-M Butler, Jacqueline A Larouche, Paula M Fraczek, Grace Kenney, Scott A Johnson, Clint D Skillen, Pranav Rao, Jessie Jin, Teja Chaparala, Mangesh Kulkarni, Robert J Tower, Benjamin Levi, Stephen F Badylak, Bryan N Brown, Carlos A Aguilar","doi":"10.1038/s41536-025-00429-8","DOIUrl":"10.1038/s41536-025-00429-8","url":null,"abstract":"The acute loss of critical skeletal muscle volume or volumetric muscle loss (VML) results in persistent inflammation, fibrotic scarring, permanent strength deficits and long-term disability. The molecular mechanisms that drive fibrosis following VML injury have primarily been evaluated in rodent models, however, translation of these findings to large animals remains underexplored. Herein, we utilized a canine model of VML and a mesoscopic approach to evaluate how treatment with an extracellular matrix hydrogel impacts the early cellular circuitry regulating inflammation, fibrosis and muscle regeneration. We observed treatment with extracellular matrix dampens inflammation and fibrosis by spatially confining the immune reaction to the superficial surface of the wound. Simultaneously, extracellular matrix treatment improved muscle stem cell and regenerative progenitor infiltration into the VML defect and limited degeneration of intact myofibers. These results establish a spatially informed framework for understanding how extracellular matrix hydrogel treatment impacts regenerative trajectories and cellular communities post-VML.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"45"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids. FGF9治疗可减少ipsc衍生肾类器官的脱靶软骨细胞。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-30 DOI: 10.1038/s41536-025-00428-9

Virginie Joris, Anika Schumacher, Maria Paula Marks, Maria Eischen-Loges, Sofia Fallo, Martijn van Griensven, Vanessa L S LaPointe

{"title":"FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids.","authors":"Virginie Joris, Anika Schumacher, Maria Paula Marks, Maria Eischen-Loges, Sofia Fallo, Martijn van Griensven, Vanessa L S LaPointe","doi":"10.1038/s41536-025-00428-9","DOIUrl":"10.1038/s41536-025-00428-9","url":null,"abstract":"Renal failure due to drug nephrotoxicity or disease is frequently observed in patients. The development of in vitro models able to recapitulate kidney biology offers new possibilities to study drug toxicity or model diseases. Induced pluripotent stem cell-derived kidney organoids already show promise, but several drawbacks must be overcome to maintain them in culture, among which is the presence of non-renal cell populations such as cartilage. We modified the culture protocol and maintained kidney organoids in medium containing FGF9 for 1 additional week compared to the control protocol (Takasato). In comparison to the control, the FGF9-treated kidney organoids had reduced cartilage at day 7 + 25 and diminished chondrocyte marker expression. Importantly, the renal structures assessed by immunofluorescence were unaffected by the FGF9 treatment. This reduction of cartilage produces a higher quality kidney organoid that can be maintained longer in culture to improve their maturation for further in vivo work.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"41"},"PeriodicalIF":6.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing. 人类ipscs衍生的间充质干细胞促进皮肤再生和烧伤创面愈合。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-30 DOI: 10.1038/s41536-025-00427-w

Mahmoud Farahat, Sophie Brosset, Yufei Chen, Ayesha Aijaz, Graham Rix, Bhavishya Challagundla, Margarita Elloso, Maria Fernanda Hutter, Ian M Rogers, Marc G Jeschke

{"title":"Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing.","authors":"Mahmoud Farahat, Sophie Brosset, Yufei Chen, Ayesha Aijaz, Graham Rix, Bhavishya Challagundla, Margarita Elloso, Maria Fernanda Hutter, Ian M Rogers, Marc G Jeschke","doi":"10.1038/s41536-025-00427-w","DOIUrl":"10.1038/s41536-025-00427-w","url":null,"abstract":"The key to surviving severe burns is rapid burn wound excision and closure, yet extensive wounds often surpass natural healing capacity. Alternative treatments, such as synthetic skin substitutes, have not emerged as a standard, optimal solution. Stem cell therapies, especially using allogenic sources, show promise in enhancing wound repair. Induced mesenchymal stem cells (iMSCs) have demonstrated vast possibilities to overcome traditional stem cell therapy limitations. This study utilized Cord tissue-derived iMSCs (CT-iMSCs) incorporated into well-established epidermal-dermal substitutes Integra® Dermal Regeneration Template (DRT) at 5000-20,000 cells/cm2 in a porcine full-thickness burn model to test their regenerative capabilities. We evaluated healing outcomes, inflammation, neovascularization, collagen levels, and fibrosis markers. Wounds treated with CT-iMSCs showed notable improvements, including faster wound healing, better epithelialization, and marked improvements in healing markers compared to controls. These data support the potential of iMSCs as an ideal cell source for autologous skin regeneration.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"40"},"PeriodicalIF":6.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desmoglein-driven dynamic signaling in pemphigus vulgaris: a systematic review of pathogenic pathways. 寻常型天疱疮的粘粒蛋白驱动的动态信号：对致病途径的系统回顾。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-22 DOI: 10.1038/s41536-025-00426-x

Siavash Rahimi, William V J Hariton, Fattaneh Khalaj, Ralf J Ludwig, Luca Borradori, Eliane J Müller

{"title":"Desmoglein-driven dynamic signaling in pemphigus vulgaris: a systematic review of pathogenic pathways.","authors":"Siavash Rahimi, William V J Hariton, Fattaneh Khalaj, Ralf J Ludwig, Luca Borradori, Eliane J Müller","doi":"10.1038/s41536-025-00426-x","DOIUrl":"10.1038/s41536-025-00426-x","url":null,"abstract":"Epithelial tissue integrity is maintained through specialized intercellular junctions known to coordinate homeostatic processes. In this context, outside-in signaling and mechanotransduction through desmosomal cadherins, the building blocks of desmosomes and main stress bearers in epithelial tissue, are only starting to emerge. To better understand the dual function of desmosomal cadherins in structural integrity and cellular signaling, we here performed a systematic, unbiased review on pathogenic signaling effectors identified in models and patients with pemphigus vulgaris (PV). PV is an autoimmune blistering disorder characterized by disruption of desmosomal transadhesion through autoantibodies mainly targeting the desmosomal cadherins desmoglein (Dsg) 3 or Dsg1 and Dsg3. The survey of functionally validated pathogenic pathways published since inception in 1977 up to mid-2024 identifies 128 studies and 128 signaling molecules, highlighting a coherent network of biomechanical, bioelectrical, and biochemical signaling events. This in-depth analysis will stimulate future research as well as development of potential therapeutic applications beyond PV.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"39"},"PeriodicalIF":6.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prx1⁺ progenitors give rise to new articular cartilage when conditions are permissive for endogenous regeneration. 当条件允许内源性再生时，Prx1+祖细胞产生新的关节软骨。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-09 DOI: 10.1038/s41536-025-00425-y

Christina L Jablonski, Dora Modrcin, John Cobb, Donna-Marie McCafferty, Paul T Salo, Roman J Krawetz

{"title":"Prx1+ progenitors give rise to new articular cartilage when conditions are permissive for endogenous regeneration.","authors":"Christina L Jablonski, Dora Modrcin, John Cobb, Donna-Marie McCafferty, Paul T Salo, Roman J Krawetz","doi":"10.1038/s41536-025-00425-y","DOIUrl":"10.1038/s41536-025-00425-y","url":null,"abstract":"It is widely acknowledged that articular cartilage lacks the ability to regenerate. However, if such regeneration were possible, which cell type would generate new tissue? The p21-/- mouse provides an excellent platform to explore this question, hence, we conducted lineage tracing on Paired related homeobox 1 (Prrx1/Prx1) cells post-injury to determine whether endogenous Prx1+ cells contribute to regenerated tissues post-injury. p21-/- mice displayed enhanced endogenous cartilage regeneration, accompanied by notable differences in the number and kinetics of Prx1+ cells within and around the injury site. In p21-/- mice, Prx1+ cells underwent chondrogenesis, ultimately contributing to the regenerated articular cartilage layer. These findings underscore the impact of tissue-resident cells on cartilage regeneration, albeit under abnormal conditions. If the conditions within the joint could be manipulated to favor such a regenerative environment, these endogenous cell types might be recruited to facilitate the formation of a new articular cartilage surface post-injury.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"38"},"PeriodicalIF":6.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons. 超分子纳米结构体外模拟GDNF对人多巴胺能神经元的营养作用。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-08 DOI: 10.1038/s41536-025-00424-z

Oscar A Carballo-Molina, Alexandra N Kolberg-Edelbrock, Matías Alvarez-Saavedra, Zaida Álvarez, Timmy Fyrner, Tamara Perez-Rosello, Zois Syrgiannis, Stacey M Chin, Nozomu Takata, Madison Strong, Liam C Palmer, D James Surmeier, Samuel I Stupp

{"title":"Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons.","authors":"Oscar A Carballo-Molina, Alexandra N Kolberg-Edelbrock, Matías Alvarez-Saavedra, Zaida Álvarez, Timmy Fyrner, Tamara Perez-Rosello, Zois Syrgiannis, Stacey M Chin, Nozomu Takata, Madison Strong, Liam C Palmer, D James Surmeier, Samuel I Stupp","doi":"10.1038/s41536-025-00424-z","DOIUrl":"10.1038/s41536-025-00424-z","url":null,"abstract":"Peptide-based supramolecular nanostructures offer a versatile platform with substantial promise for clinical translation in regenerative medicine. These systems allow for the incorporation of biologically active sequences and can be engineered to modulate tissue-specific parameters such as stiffness, diffusivity, and biodegradability. We developed here a bioactive supramolecular nanostructure containing a peptide designed based on glial cell-derived neurotrophic factor. These nanostructures form scaffolds that mimic important trophic effects provided by this growth factor on iPSC-derived human dopaminergic neurons. Our in vitro data show that the nanostructures promote cell viability, confer neuroprotection against 6-hydroxydopamine toxicity, enhance neuronal morphology, facilitate electrophysiological maturation, and induce genes involved in neuronal survival. We also found that the scaffold promoted axonal extension in midbrain human organoids. These findings suggest that the supramolecular system could be useful to improve outcomes in cell-based therapies for Parkinson's disease, where progressive dopaminergic degeneration is a hallmark.","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"37"},"PeriodicalIF":6.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From fragment to form: whole-body regeneration in a model urochordate. 从碎片到形态：尾脊索动物模型的全身再生。

IF 6.5 1区医学

npj Regenerative Medicine Pub Date : 2025-08-01 DOI: 10.1038/s41536-025-00423-0

Yuval Rinkevich, Baruch Rinkevich

引用次数: 0