Genetic compensation response contributes to Pleurodeles waltl limb regeneration.

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2025-05-31 DOI:10.1038/s41536-025-00417-y

Binxu Yin, Changhao Yu, Yang Liu, Hao Cai, Wencheng Wu, Tingting Ye, Lei Wang, Lujia Xiao, Yi Zhu, Huaijuan Guo, Kun Zhang, Heng Wang

引用次数: 0

Abstract

Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.

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遗传补偿反应促进侧柏肢体再生。

Hippo-Yap/Taz通路对多种物种的组织再生至关重要。然而，我们发现在高度再生的蝾螈中，由于遗传补偿反应（GCR）， Yap基因敲除不会损害肢体再生。具体来说，突变的Yap基因座衍生出无义mRNA， UPF3A识别该mRNA指导代偿性Taz诱导。阻断Yap mRNA或蛋白确实会抑制再生。GCR可用于维持肢体再生的稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.