Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Testosterone Administration Increases the Computational Impact of Social Evaluation on the Updating of State Self-Esteem","authors":"Jixin Long ,&nbsp;Junsong Lu ,&nbsp;Yang Hu ,&nbsp;Philippe N. Tobler ,&nbsp;Yin Wu","doi":"10.1016/j.bpsc.2025.02.008","DOIUrl":"10.1016/j.bpsc.2025.02.008","url":null,"abstract":"<div><h3>Background</h3><div>High self-esteem promotes well-being and buffers against anxiety. However, state self-esteem (SSE) is not stable but rather is dynamically updated based on evaluations received from others. Particularly in men, decreased SSE is related to aberrant behaviors and clinical symptoms. A critical physiological mechanism that underlies these associations may involve a sex hormone, testosterone. However, the causal relationship between testosterone and the process of updating SSE in men remains unknown.</div></div><div><h3>Methods</h3><div>The study had a double-blind, placebo-controlled, between-participants design. First, we administered a single dose (150 mg) of testosterone or placebo gel to healthy young men (<em>N</em> = 120). Subsequently, the participants completed a social evaluation task in which they adjusted their prediction of potential evaluation by others and dynamically reported their SSE based on the social feedback they received. Meanwhile, we applied a computational modeling approach to investigate the dynamic changes in their SSE.</div></div><div><h3>Results</h3><div>Exogenous testosterone significantly influenced the participants’ expectation of receiving positive social feedback from raters with different approval rates and separately amplified the changes in average SSE when the participants received positive or negative feedback from the raters. Even more importantly, computational modeling showed that the participants who received testosterone (vs. the placebo) assigned a higher weight to expected social feedback and social prediction errors when updating their SSE.</div></div><div><h3>Conclusions</h3><div>The findings provide potential clinical implications for combining exogenous testosterone with interventions aimed at enhancing SSE through positive social feedback as a preclinical treatment for aberrant behaviors and clinical symptoms.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 406-415"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulcal Depth and Genetic Susceptibility Influence Initial Treatment Response in Adults With Attention-Deficit/Hyperactivity Disorder","authors":"Jonathan Laatsch ,&nbsp;Friederike S. David ,&nbsp;Frederike Stein ,&nbsp;Carlo Maj ,&nbsp;Andreas J. Forstner ,&nbsp;Simon Maier ,&nbsp;Swantje Matthies ,&nbsp;Esther Sobanski ,&nbsp;Barbara Alm ,&nbsp;Ludger Tebartz van Elst ,&nbsp;Axel Krug ,&nbsp;Alexandra Philipsen","doi":"10.1016/j.bpsc.2025.09.012","DOIUrl":"10.1016/j.bpsc.2025.09.012","url":null,"abstract":"<div><h3>Background</h3><div>As neurobiological markers gain prominence in guiding personalized treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remains unclear. In this study, we investigated whether pretreatment SD predicts symptom alleviation in adults with attention-deficit/hyperactivity disorder (ADHD) and explored moderating effects of genetic susceptibility for ADHD and cross-disorder influences.</div></div><div><h3>Methods</h3><div>Using structural neuroimaging data from COMPAS (Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study), we examined associations between SD and treatment response following a 12-week intervention involving either group psychotherapy or clinical management with methylphenidate or placebo. Pretreatment SD was derived from 119 T1-weighted anatomical scans and analyzed using linear regression models to assess its predictive value for posttreatment symptom severity. Subsequently, we explored the moderating role of polygenic scores for ADHD and cross-disorder susceptibility. Structural analyses were performed using the threshold-free cluster enhancement approach in CAT, with moderation analyses conducted in SPSS.</div></div><div><h3>Results</h3><div>Results revealed that SD in parietal, temporal, and occipital regions significantly predicted symptom alleviation, linking deeper sulci with greater treatment efficacy. Moreover, genetic predisposition to ADHD and cross-disorder traits influenced these relationships, highlighting an interaction between cortical structure and genetic susceptibility in determining treatment outcomes.</div></div><div><h3>Conclusions</h3><div>These findings highlight SD as a promising neurobiological marker of ADHD treatment response and emphasize the importance of integrating neurobiological and genetic factors into predictive models of therapeutic efficacy in psychiatry.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 450-462"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(26)00062-5","DOIUrl":"10.1016/S2451-9022(26)00062-5","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Page A2"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear Learning and Memory in the Aging Brain: Neural Mechanisms of Posttraumatic Stress Disorder Risk and Resilience in Older Adults","authors":"Katherine L. Barlis,&nbsp;Jamie Terner,&nbsp;Nancy X. Huynh,&nbsp;Ashley Ann Huggins","doi":"10.1016/j.bpsc.2025.12.003","DOIUrl":"10.1016/j.bpsc.2025.12.003","url":null,"abstract":"<div><div>With a rapidly growing population of older adults worldwide, understanding how aging shapes mental and cognitive health is an urgent public health priority. Although older age has been considered protective against the development of posttraumatic stress disorder (PTSD), this pattern is far from universal. Emerging evidence indicates that older adults with a history of trauma may experience delayed-onset PTSD or a reemergence of symptoms after years of dormancy. In this review, we examine how age-related changes in the brain intersect with known PTSD mechanisms to influence trajectories of risk and resilience in later life. We focus on the canonical fear network—comprising the amygdala, hippocampus, and ventromedial prefrontal cortex—which is central to fear learning, memory, and emotion regulation. These regions are also highly vulnerable to aging and neurodegenerative processes; however, older adults remain underrepresented in both neurobiological and treatment studies of PTSD. We argue that the structural and functional aging of these systems may exacerbate difficulties with associative learning and emotion regulation while also interacting with psychosocial stressors unique to aging. At the same time, age-related strengths (such as positivity bias) may promote resilience. These insights carry important implications for clinical care; existing empirically supported psychotherapies may benefit from adaptations to account for age-related neural and cognitive shifts. A lifespan neuroscience framework is essential for identifying the shared mechanisms between PTSD and aging, with the goal of informing tailored, mechanism-driven interventions that promote the mental and cognitive health of trauma-exposed older adults.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 385-394"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward an Understanding of the Neural Mechanisms That Underlie Human Preference for the Freedom to Choose","authors":"Michael T. Treadway","doi":"10.1016/j.bpsc.2026.02.002","DOIUrl":"10.1016/j.bpsc.2026.02.002","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 383-384"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(26)00061-3","DOIUrl":"10.1016/S2451-9022(26)00061-3","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Page A1"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Functional Connectivity of Right Dorsolateral Prefrontal Cortex and Hippocampus Subregions Relates to Emotional and Sensory-Perceptual Properties of Intrusive Trauma Memories","authors":"Quentin Devignes ,&nbsp;Kevin J. Clancy ,&nbsp;Boyu Ren ,&nbsp;Yara Pollmann ,&nbsp;Justin T. Baker ,&nbsp;Isabelle M. Rosso","doi":"10.1016/j.bpsc.2025.03.004","DOIUrl":"10.1016/j.bpsc.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div><span>Trauma-related intrusive memories (TR-IMs) are core symptoms of posttraumatic stress disorder<span> (PTSD). Prior research links reexperiencing symptoms with resting-state functional coupling between the right dorsolateral prefrontal cortex (dlPFC) and </span></span>right hippocampus<span> (HPC). However, prior work has not examined whether this negative coupling relates to TR-IMs or has differentiated between the anterior and posterior HPC (aHPC/pHPC). This study examined relationships of TR-IM frequency and properties with resting-state negative coupling between the right dlPFC and right aHPC/pHPC in symptomatic trauma-exposed individuals with TR-IMs.</span></div></div><div><h3>Methods</h3><div>Participants (<em>N</em><span> = 109; 88 female) completed 2 weeks of ecological momentary assessments capturing TR-IM frequency and properties (intrusiveness, emotional intensity, vividness, visual properties, and reliving). Using resting-state functional magnetic resonance imaging, participant-specific 4-mm spheres were placed at the right dlPFC voxel most anticorrelated with the right aHPC/pHPC. Quasi-Poisson and linear mixed-effect models assessed relationships of TR-IM frequency and properties with right dlPFC–right aHPC/pHPC anticorrelation.</span></div></div><div><h3>Results</h3><div>TR-IM emotional intensity was positively associated with right dlPFC-aHPC connectivity, while vividness and visual properties correlated with right dlPFC-pHPC connectivity. These associations remained significant after controlling for PTSD symptom severity and time since trauma. No significant associations emerged between TR-IM frequency, intrusiveness, or reliving and anticorrelation with either hippocampal subregion.</div></div><div><h3>Conclusions</h3><div>This study provides novel insights into the neural correlates of TR-IMs, highlighting the relevance of intrinsic negative coupling between the right dlPFC and aHPC/pHPC to their phenomenology. Further research on this circuit could advance understanding of component processes of trauma reexperiencing, a severe and treatment-refractory PTSD symptom.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 476-484"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(26)00064-9","DOIUrl":"10.1016/S2451-9022(26)00064-9","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages A5-A11"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Testosterone Effects on Self-Esteem: A Long Hill to Climb","authors":"Owen Carmichael","doi":"10.1016/j.bpsc.2026.01.010","DOIUrl":"10.1016/j.bpsc.2026.01.010","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 381-382"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White Matter Microstructure Alterations in Social Anxiety Disorder: A Mega-Analysis Across Twelve Cohorts in the ENIGMA-Anxiety Working Group","authors":"Eline F. Roelofs ,&nbsp;Nynke A. Groenewold ,&nbsp;Kinga Farkas ,&nbsp;Alyssa H. Zhu ,&nbsp;Si Gao ,&nbsp;Tiana Borgers ,&nbsp;Udo Dannlowski ,&nbsp;Kira Flinkenflügel ,&nbsp;Dominik Grotegerd ,&nbsp;Tim Hahn ,&nbsp;Andreas Jansen ,&nbsp;Elisabeth J. Leehr ,&nbsp;Tilo T.J. Kircher ,&nbsp;Hannah Meinert ,&nbsp;Igor Nenadić ,&nbsp;Frederike Stein ,&nbsp;Benjamin Straube ,&nbsp;Tamer Demiralp ,&nbsp;Raşit Tükel ,&nbsp;P. Michiel Westenberg ,&nbsp;Janna Marie Bas-Hoogendam","doi":"10.1016/j.bpsc.2025.11.007","DOIUrl":"10.1016/j.bpsc.2025.11.007","url":null,"abstract":"<div><h3>Background</h3><div>Studies investigating social anxiety disorder (SAD) have reported inconsistent alterations in white matter (WM) microstructure. The ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)-Anxiety Working Group investigated differences in the microstructure of 25 WM tracts between individuals with SAD and healthy control (HC) participants in a mega-analysis.</div></div><div><h3>Methods</h3><div>We analyzed data from 487 individuals with SAD and 1604 HC participants (ages 8–65 years) from 12 cohorts worldwide. Analyses and quality control were performed using standardized ENIGMA diffusion tensor imaging protocols. We primarily examined fractional anisotropy (FA) as the main parameter of WM microstructure. Linear mixed-effects analyses were conducted to compare individuals with SAD with HC participants in the total sample. Next, adult (age &gt;21) and adolescent (age ≤21) samples were analyzed separately. In sensitivity analyses, additional effects of sex, medication, symptom severity, and comorbid psychiatric disorders were investigated.</div></div><div><h3>Results</h3><div>In the total sample, individuals with SAD showed lower FA in several tracts, including the corpus callosum and fornix, compared with HC participants. Widespread sex × diagnosis interactions were observed, mostly driven by lower FA in females with SAD. Adults with SAD showed lower FA in multiple tracts, while age × diagnosis interactions were observed in adolescents.</div></div><div><h3>Conclusions</h3><div>Using a mega-analytic approach, several differences in WM microstructure were found between individuals with SAD and HC participants, both in the full sample and in age group–specific sensitivity analyses. Some neurobiological changes in WM tracts in individuals with SAD may vary with age and sex, whereas others may relate to broader transdiagnostic neurobiological features underlying psychopathology. Further research should investigate these issues in more detail.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 4","pages":"Pages 438-449"},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}