Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Introduction to the Special Issue on Cognitive Neuroscience of Mindfulness","authors":"Todd S. Braver , Sara W. Lazar","doi":"10.1016/j.bpsc.2025.02.009","DOIUrl":"10.1016/j.bpsc.2025.02.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 337-341"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Neurophenomenological Approaches to Meditation and Their Relevance to Clinical Research","authors":"Antoine Lutz ,&nbsp;Oussama Abdoun ,&nbsp;Yair Dor-Ziderman ,&nbsp;Fynn-Mathis Trautwein ,&nbsp;Aviva Berkovich-Ohana","doi":"10.1016/j.bpsc.2024.11.008","DOIUrl":"10.1016/j.bpsc.2024.11.008","url":null,"abstract":"<div><div>There is a renewed interest in taking phenomenology seriously in consciousness research, contemporary psychiatry, and neurocomputation. The neurophenomenology research program, pioneered by Varela, rigorously examines subjective experience using first-person methodologies, inspired by phenomenology and contemplative practices. This review explores recent advancements in neurophenomenological approaches, particularly their application to meditation practices and potential clinical research translations. First, we examine innovative multidimensional phenomenological assessment tools designed to capture subtle, dynamic shifts in experiential content and structures of consciousness during meditation. These experience sampling approaches enable shedding new light on the mechanisms and dynamic trajectories of meditation practice and retreat. Second, we highlight how empirical studies in neurophenomenology leverage the expertise of experienced meditators to deconstruct aversive and self-related processes, providing detailed first-person reports that guide researchers in identifying novel behavioral and neurodynamic markers associated with pain regulation, self-dissolution, and acceptance of mortality. Finally, we discuss a recent framework, deep computational neurophenomenology, that updates the theoretical ambitions of neurophenomenology to naturalize phenomenology. This framework uses the formalism of deep parametric active inference, where parametric depth refers to a property of generative models that can form beliefs about the parameters of their own modeling process. Collectively, these methodological innovations, centered around rigorous first-person investigation, highlight the potential of epistemologically beneficial mutual constraints among phenomenological, computational, and neurophysiological domains. This could contribute to an integrated understanding of the biological basis of mental illness, its treatment, and its tight connections to the lived experience of the patient.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 411-424"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Confound to Clinical Tool: Mindfulness and the Observer Effect in Research and Therapy","authors":"Clemens C.C. Bauer ,&nbsp;Daniel A. Atad ,&nbsp;Norman Farb ,&nbsp;Judson A. Brewer","doi":"10.1016/j.bpsc.2025.01.012","DOIUrl":"10.1016/j.bpsc.2025.01.012","url":null,"abstract":"<div><div>The observer effect (OE), the idea that observing a phenomenon changes it, has important implications across scientific disciplines involving measurement and observation. While often viewed as a confounding variable to control for, this paper argues that the OE should be seriously accounted for, explored, and systematically leveraged in research and clinical settings. Specifically, mindfulness practices that cultivate present-moment, nonjudgmental awareness are proposed as a platform to account for, explore, and intentionally harness the OE. In research contexts, mindfulness training may allow participants to provide more precise self-reports by minimizing reactive biases that perturb the observed phenomena. Empirical evidence suggests that mindfulness enhances interoceptive awareness and reduces automatic judgment, potentially increasing measurement sensitivity, specificity, and validity. Clinically, psychotherapies often aim to make unconscious patterns explicitly observable to the client, capitalizing on the transformative potential of observation. Mindfulness directly cultivates this capacity for meta-awareness, allowing individuals to decenter from rigid cognitive-emotional patterns fueling psychopathology. Rather than avoiding unpleasant experiences such as cravings or anxiety, mindfulness guides individuals to simply observe these phenomena, reducing identification and reactivity. Mindfulness practices may leverage components of the OE, facilitating lasting psychological change. To further study the OE, developing an OE index to code observer influence is proposed. Overall, this paper highlights the ubiquity of the OE and advocates developing methods to intentionally account for and apply observer influences across research and therapeutic contexts.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 402-410"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00075-8","DOIUrl":"10.1016/S2451-9022(25)00075-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Cerebellar-Cortical Connectivity Induced by Modafinil and Its Relationship With Receptor and Transporter Expression","authors":"Stefano Delli Pizzi ,&nbsp;Federica Tomaiuolo ,&nbsp;Antonio Ferretti ,&nbsp;Giovanna Bubbico ,&nbsp;Valeria Onofrj ,&nbsp;Stefania Della Penna ,&nbsp;Carlo Sestieri ,&nbsp;Stefano L. Sensi","doi":"10.1016/j.bpsc.2024.11.010","DOIUrl":"10.1016/j.bpsc.2024.11.010","url":null,"abstract":"<div><h3>Background</h3><div>Modafinil is primarily used to treat narcolepsy but is also used as an off-label cognitive enhancer. Functional magnetic resonance imaging studies indicate that modafinil modulates the connectivity of neocortical networks primarily involved in attention and executive functions. However, much less is known about the drug’s effects on subcortical structures. Following preliminary findings, we evaluated modafinil’s activity on the connectivity of distinct cerebellar regions with the neocortex. We assessed the spatial relationship of these effects with the expression of neurotransmitter receptors/transporters.</div></div><div><h3>Methods</h3><div>Patterns of resting-state functional magnetic resonance imaging connectivity were estimated in 50 participants from scans acquired pre- and postadministration of a single (100 mg) dose of modafinil (<em>n</em> = 25) or placebo (<em>n</em> = 25). Using specific cerebellar regions as seeds for voxelwise analyses, we examined modafinil’s modulation of cerebellar-neocortical connectivity. Next, we conducted a quantitative evaluation of the spatial overlap between the modulation of cerebellar-neocortical connectivity and the expression of neurotransmitter receptors/transporters obtained by publicly available databases.</div></div><div><h3>Results</h3><div>Modafinil increased the connectivity of crus I and vermis IX with prefrontal regions. Crus I connectivity changes were associated with the expression of dopaminergic D₂ receptors. The vermis I–II showed enhanced coupling with the dorsal anterior cingulate cortex and matched the expression of histaminergic H₃ receptors. The vermis VII–VIII displayed increased connectivity with the visual cortex, an activity associated with dopaminergic and histaminergic neurotransmission.</div></div><div><h3>Conclusions</h3><div>Our study reveals modafinil’s modulatory effects on cerebellar-neocortical connectivity. The modulation mainly involves crus I and the vermis and spatially overlaps the distribution of dopaminergic and histaminergic receptors.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 304-313"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Amygdala Activation During Symptom Provocation Predicts Response to Combined Repetitive Transcranial Magnetic Stimulation and Exposure Therapy in Obsessive-Compulsive Disorder in a Randomized Controlled Trial","authors":"Milan Houben ,&nbsp;Tjardo S. Postma ,&nbsp;Sophie M.D.D. Fitzsimmons ,&nbsp;Chris Vriend ,&nbsp;Neeltje M. Batelaan ,&nbsp;Adriaan W. Hoogendoorn ,&nbsp;Ysbrand D. van der Werf ,&nbsp;Odile A. van den Heuvel","doi":"10.1016/j.bpsc.2024.10.020","DOIUrl":"10.1016/j.bpsc.2024.10.020","url":null,"abstract":"<div><h3>Background</h3><div>Repetitive transcranial magnetic stimulation (rTMS) combined with exposure and response prevention is a promising treatment modality for treatment-refractory obsessive-compulsive disorder (OCD). However, not all patients respond sufficiently to this treatment. We investigated whether brain activation during a symptom provocation task could predict treatment response.</div></div><div><h3>Methods</h3><div>Sixty-one adults with OCD (39 female/22 male) underwent symptom provocation with OCD- and fear-related visual stimuli during functional magnetic resonance imaging prior to an 8-week combined rTMS and exposure and response prevention treatment regimen. Participants received one of the following 3 rTMS treatments as part of a randomized controlled trial: 1) 10-Hz rTMS (110% resting motor threshold) to the left dorsolateral prefrontal cortex, 2) 10-Hz rTMS (110% resting motor threshold) to the left presupplementary motor area, or 3) 10-Hz control rTMS (60% resting motor threshold) to the vertex. Multiple regression and correlation were used to examine the predictive value of task-related brain activation for treatment response in the following regions of interest: the dorsomedial prefrontal cortex, amygdala, dorsolateral prefrontal cortex, and left presupplementary motor area.</div></div><div><h3>Results</h3><div>The different treatment groups responded equally to treatment. Higher pretreatment task-related activation of the right amygdala to OCD-related stimuli showed a positive association with treatment response in all groups. Exploratory whole-brain analyses showed positive associations between activation in multiple task-relevant regions and treatment response. Only dorsal anterior cingulate cortex activation to fear-related stimuli showed a negative association with treatment outcome.</div></div><div><h3>Conclusions</h3><div>Higher pretreatment right amygdala activation during symptom provocation predicts better treatment response to combined rTMS and exposure and response prevention in OCD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 295-303"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Frontiers in Computational Metabolic Psychiatry","authors":"Anthony G. Chesebro ,&nbsp;Botond B. Antal ,&nbsp;Corey Weistuch ,&nbsp;Lilianne R. Mujica-Parodi","doi":"10.1016/j.bpsc.2024.10.011","DOIUrl":"10.1016/j.bpsc.2024.10.011","url":null,"abstract":"<div><div>One of the primary challenges in metabolic psychiatry is that the disrupted brain functions that underlie psychiatric conditions arise from a complex set of downstream and feedback processes that span multiple spatiotemporal scales. Importantly, the same circuit can have multiple points of failure, each of which results in a different type of dysregulation, and thus elicits distinct cascades downstream that produce divergent signs and symptoms. Here, we illustrate this challenge by examining how subtle differences in circuit perturbations can lead to divergent clinical outcomes. We also discuss how computational models can perform the spatially heterogeneous integration and bridge in vitro and in vivo paradigms. By leveraging recent methodological advances and tools, computational models can integrate relevant processes across scales (e.g., tricarboxylic acid cycle, ion channel, neural microassembly, whole-brain macrocircuit) and across physiological systems (e.g., neural, endocrine, immune, vascular), providing a framework that can unite these mechanistic processes in a manner that goes beyond the conceptual and descriptive to the quantitative and generative. These hold the potential to sharpen our intuitions toward circuit-based models for personalized diagnostics and treatment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 258-266"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder","authors":"Margaret T. Davis ,&nbsp;Ruth H. Asch ,&nbsp;Emily R. Weiss ,&nbsp;Ashley Wagner ,&nbsp;Sarah K. Fineberg ,&nbsp;Nabeel Nabulsi ,&nbsp;David Matuskey ,&nbsp;Richard E. Carson ,&nbsp;Irina Esterlis","doi":"10.1016/j.bpsc.2024.11.014","DOIUrl":"10.1016/j.bpsc.2024.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is a serious psychiatric condition that is associated with a high risk for suicide attempts (SAs) and death by suicide. However, relatively little is known about the pathophysiology of BPD. The metabotropic glutamate 5 receptor (mGlu₅) has been specifically implicated in the pathophysiology of BPD and SAs, with more general roles in emotion regulation, social and cognitive functioning, and pain processing. Here, we examined the relationship between mGlu₅ availability, BPD, and SAs in vivo for the first time.</div></div><div><h3>Methods</h3><div>Eighteen individuals with BPD, 18 healthy control participants matched on age, sex, and smoking status, and 18 clinical comparison control participants with major depressive disorder completed comprehensive clinical assessments and participated in an [¹⁸F]FPEB positron emission tomography scan to measure mGlu₅ availability. The volume of distribution (<em>V</em>_T) in the frontolimbic circuit implicated in BPD pathophysiology was the positron emission tomography outcome measure.</div></div><div><h3>Results</h3><div>We observed significantly higher frontolimbic mGlu₅ availability in the BPD group than in both the healthy control group (<em>p</em> = .009, <em>d</em> = 0.84, 18.43% difference) and the major depressive disorder group (<em>p</em> = .03, <em>d</em> = 0.69, 15.21% difference). In the BPD, but not the major depressive disorder group, higher mGlu₅ availability was also associated with a history of SAs (19–25% higher, <em>p</em>s = .02–.005). Furthermore, mGlu₅ availability was positively correlated with risk factors for suicide (e.g., sexual victimization, perceived burdensomeness) in individuals with BPD and a history of SA.</div></div><div><h3>Conclusions</h3><div>Results show higher mGlu₅ availability in BPD and SA for the first time. Our preliminary findings suggest that mGlu₅ may be a critical treatment target for BPD symptoms, including SAs, and warrant additional investigation in larger samples.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 324-332"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00040-0","DOIUrl":"10.1016/S2451-9022(25)00040-0","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Insulin Increases Brain Glutathione and Enhances Antioxidant Capacity in Healthy Participants but Not in Those With Early Psychotic Disorders","authors":"Virginie-Anne Chouinard ,&nbsp;Wirya Feizi ,&nbsp;Xi Chen ,&nbsp;Boyu Ren ,&nbsp;Kathryn E. Lewandowski ,&nbsp;Jacey Anderson ,&nbsp;Steven Prete ,&nbsp;Emma Tusuzian ,&nbsp;Kyle Cuklanz ,&nbsp;Shuqin Zhou ,&nbsp;Paula Bolton ,&nbsp;Abigail Stein ,&nbsp;Bruce M. Cohen ,&nbsp;Fei Du ,&nbsp;Dost Öngür","doi":"10.1016/j.bpsc.2024.11.018","DOIUrl":"10.1016/j.bpsc.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>We examined the acute effects of intranasal insulin on cognitive function and brain glutathione (GSH), a central factor in resistance to oxidative stress, in both participants with early psychosis and healthy control (HC) participants.</div></div><div><h3>Methods</h3><div>Twenty-one patients with early-stage psychotic disorders and 18 HC participants underwent magnetic resonance spectroscopy (MRS) scans and cognitive assessments before and after administration of intranasal insulin 40 IU. We conducted proton MRS (¹H-MRS) in the prefrontal cortex at 4T to measure GSH and glutamate metabolites. We assessed cognition using the Brief Assessment of Cognition in Schizophrenia symbol coding, digit sequencing, and verbal fluency tasks, in addition to the Stroop task.</div></div><div><h3>Results</h3><div>The mean (SD) age of participants was 25.7 (4.6) years; 51.3% were female. There were no significant group differences at baseline in age, sex, body mass index, homeostatic model assessment of insulin resistance (HOMA-IR), or cognition. Patients had higher baseline GSH (<em>p</em> &lt; .001) and glutamate (<em>p</em> = .007). After insulin administration, GSH increased in HC participants (mean change, 0.15; 95% CI 0.03 to 0.26; <em>p</em> = .015), but not in patients. Symbol coding improved in both patients (0.74; 95% CI 0.37 to 1.11; <em>p</em> &lt; .001) and HC participants (0.83; 95% CI 0.58 to 1.09; <em>p</em> &lt; .001), and verbal fluency improved in HC participants (0.43; 95% CI 0.14 to 0.72; <em>p</em> = .006). Lower baseline HOMA-IR was associated with greater change in GSH (coefficient −0.22; 95% CI −0.40 to −0.04; <em>p</em> = .017).</div></div><div><h3>Conclusions</h3><div>Intranasal insulin increased brain GSH in HC participants, but not in patients with early psychotic disorders. These novel findings demonstrate that intranasal insulin enhances antioxidant capacity and resilience to oxidative stress in HC individuals in contrast to an absent antioxidant response in those with early psychotic disorders.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 286-294"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}