Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression","authors":"Elisa Xu ,&nbsp;Samantha Pitts ,&nbsp;Jacob Dahill-Fuchel ,&nbsp;Sara Scherrer ,&nbsp;Tanya Nauvel ,&nbsp;Jacqueline Guerra Overton ,&nbsp;Patricio Riva-Posse ,&nbsp;Andrea Crowell ,&nbsp;Martijn Figee ,&nbsp;Sankaraleengam Alagapan ,&nbsp;Christopher J. Rozell ,&nbsp;Ki Sueng Choi ,&nbsp;Helen S. Mayberg ,&nbsp;Allison C. Waters","doi":"10.1016/j.bpsc.2024.11.021","DOIUrl":"10.1016/j.bpsc.2024.11.021","url":null,"abstract":"<div><h3>Background</h3><div>Symptoms of depression are associated with impaired interoceptive processing of bodily sensation. The antidepressant effects of subcallosal cingulate deep brain stimulation (SCC DBS) include acute change in bodily sensation, and the SCC target is connected to cortical regions critically involved in interoception. This study tested whether cortical interoceptive processing is modulated by SCC DBS for treatment-resistant depression.</div></div><div><h3>Methods</h3><div>In 8 patients receiving SCC DBS for treatment-resistant depression, we used electroencephalography to measure the heartbeat-evoked potential (HEP), a putative readout of neural interoception, before surgery and over 6 months of treatment with DBS. We also examined the immediate effect of DBS on the HEP and correlated HEP change over time with outcomes of treatment for depression.</div></div><div><h3>Results</h3><div>HEP amplitude increased from baseline to 6 months of DBS treatment, and this increase was associated with faster antidepressant response. Recording with stimulation on (vs. off) had an immediate effect on HEP in the laboratory. Overall, modulation of the HEP was most pronounced in sensors over the left parietal cortex.</div></div><div><h3>Conclusions</h3><div>Brain-based evidence implies an interoceptive element in the mechanism of treatment efficacy with DBS for treatment-resistant depression and substantiates a theorized connection between interoception and depression.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages 495-503"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Functional Interactions Among Cognitive Control Networks Support the Onset of Adolescent Substance Use?","authors":"Ashley C. Parr ,&nbsp;Daniel J. Petrie ,&nbsp;Finnegan J. Calabro","doi":"10.1016/j.bpsc.2025.03.001","DOIUrl":"10.1016/j.bpsc.2025.03.001","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages 447-449"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Cognition and Functional Connectivity in Early and Chronic Schizophrenia","authors":"Saige Rutherford ,&nbsp;Carly A. Lasagna ,&nbsp;Scott D. Blain ,&nbsp;Andre F. Marquand ,&nbsp;Thomas Wolfers ,&nbsp;Ivy F. Tso","doi":"10.1016/j.bpsc.2024.07.024","DOIUrl":"10.1016/j.bpsc.2024.07.024","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with schizophrenia (SZ) experience impairments in social cognition that contribute to poor functional outcomes. However, mechanisms of social cognitive dysfunction in SZ remain poorly understood, which impedes the design of novel interventions to improve outcomes. In this preregistered project, we examined the representation of social cognition in the brain’s functional architecture in early and chronic SZ.</div></div><div><h3>Methods</h3><div>The study contains 2 parts: a confirmatory and an exploratory portion. In the confirmatory portion, we identified resting-state connectivity disruptions evident in early and chronic SZ. We performed a connectivity analysis using regions associated with social cognitive dysfunction in early and chronic SZ to test whether aberrant connectivity observed in chronic SZ (<em>n</em> = 47 chronic SZ and <em>n</em> = 52 healthy control participants) was also present in early SZ (<em>n</em> = 71 early SZ and <em>n</em> = 47 healthy control participants). In the exploratory portion, we assessed the out-of-sample generalizability and precision of predictive models of social cognition. We used machine learning to predict social cognition and established generalizability with out-of-sample testing and confound control.</div></div><div><h3>Results</h3><div>Results revealed decreases between the left inferior frontal gyrus and the intraparietal sulcus in early and chronic SZ, which were significantly associated with social and general cognition and global functioning in chronic SZ and with general cognition and global functioning in early SZ. Predictive modeling revealed the importance of out-of-sample evaluation and confound control.</div></div><div><h3>Conclusions</h3><div>This work provides insights into the functional architecture in early and chronic SZ and suggests that inferior frontal gyrus–intraparietal sulcus connectivity could be a prognostic biomarker of social impairments and a target for future interventions (e.g., neuromodulation) focused on improved social functioning.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages 542-553"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation During Childhood and Adolescence","authors":"Taylor J. Keding ,&nbsp;Justin D. Russell ,&nbsp;Xiaojin Zhu ,&nbsp;Quanfa He ,&nbsp;James J. Li ,&nbsp;Ryan J. Herringa","doi":"10.1016/j.bpsc.2024.08.003","DOIUrl":"10.1016/j.bpsc.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Violence exposure during childhood and adolescence is associated with increased prevalence and severity of psychopathology. Neurobiological correlates suggest that abnormal maturation of emotion-related brain circuitry, such as the amygdala-prefrontal cortex (PFC) circuit, may underlie the development of psychiatric symptoms after exposure. However, it remains unclear how amygdala-PFC circuit maturation is related to psychiatric risk in the context of violence.</div></div><div><h3>Methods</h3><div>In this study, we analyzed individual differences in amygdala-PFC circuit maturity using data collected from the PNC (Philadelphia Neurodevelopmental Cohort) (<em>n</em> = 1133 youths). Neurodevelopment models of amygdala-PFC resting-state functional connectivity were built using deep learning and trained to predict chronological age in typically developing youths (not violence exposed and without a psychiatric diagnosis). Using the brain age gap estimate, an index of relative circuit maturation, patterns of atypical neurodevelopment were investigated.</div></div><div><h3>Results</h3><div>Violence exposure was associated with delayed maturation of basolateral amygdala (BLA)–PFC circuits, driven by increased BLA–medial orbitofrontal cortex functional connectivity. In contrast, increased psychiatric symptoms were associated with advanced maturation of BLA-PFC functional connectivity, driven by decreased BLA–dorsolateral PFC functional connectivity.</div></div><div><h3>Conclusions</h3><div>Delayed frontoamygdala maturation after exposure to violence suggests atypical, but adaptive, development of threat appraisal processes, potentially reflecting a greater threat generalization characteristic of younger children. Advanced circuit maturation with increasing symptoms suggests divergent neurodevelopmental mechanisms underlying illness after emotion circuits have adapted to adversity, exacerbated by preexisting vulnerabilities to early maturation. Disentangling the effects of adversity and psychopathology on neurodevelopment is crucial for helping youths recover from violence and preventing illness from continuing into adulthood.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages 450-462"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifold Learning Uncovers Nonlinear Interactions Between the Adolescent Brain and Environment That Predict Emotional and Behavioral Problems","authors":"Erica L. Busch ,&nbsp;May I. Conley ,&nbsp;Arielle Baskin-Sommers","doi":"10.1016/j.bpsc.2024.07.001","DOIUrl":"10.1016/j.bpsc.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>To progress adolescent mental health research beyond our present achievements—a complex account of brain and environmental risk factors without understanding neurobiological embedding in the environment—we need methods to uncover relationships between the developing brain and real-world environmental experiences.</div></div><div><h3>Methods</h3><div>We investigated associations between brain function, environments, and emotional and behavioral problems using participants from the Adolescent Brain Cognitive Development (ABCD) Study (<em>n</em> = 2401 female). We applied manifold learning, a promising technique for uncovering latent structure from high-dimensional biomedical data such as functional magnetic resonance imaging. Specifically, we developed exogenous PHATE (potential of heat-diffusion for affinity-based trajectory embedding) (E-PHATE) to model brain-environment interactions. We used E-PHATE embeddings of participants’ brain activation during emotional and cognitive processing tasks to predict individual differences in cognition and emotional and behavioral problems both cross-sectionally and longitudinally.</div></div><div><h3>Results</h3><div>E-PHATE embeddings of participants’ brain activation and environments at baseline showed moderate-to-large associations with total, externalizing, and internalizing problems at baseline, across several subcortical regions and large-scale cortical networks, compared with the zero-to-small effects achieved by voxelwise data or common low-dimensional embedding methods. E-PHATE embeddings of the brain and environment at baseline were also related to emotional and behavioral problems 2 years later. These longitudinal predictions showed a consistent moderate effect in the frontoparietal and attention networks.</div></div><div><h3>Conclusions</h3><div>The embedding of the adolescent brain in the environment yields enriched insight into emotional and behavioral problems. Using E-PHATE, we demonstrated how the harmonization of cutting-edge computational methods with longstanding developmental theories advances the detection and prediction of adolescent emotional and behavioral problems.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages 463-474"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00100-4","DOIUrl":"10.1016/S2451-9022(25)00100-4","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 5","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices","authors":"Saampras Ganesan ,&nbsp;Fernando A. Barrios ,&nbsp;Ishaan Batta ,&nbsp;Clemens C.C. Bauer ,&nbsp;Todd S. Braver ,&nbsp;Judson A. Brewer ,&nbsp;Kirk Warren Brown ,&nbsp;Rael Cahn ,&nbsp;Joshua A. Cain ,&nbsp;Vince D. Calhoun ,&nbsp;Lei Cao ,&nbsp;Gaël Chetelat ,&nbsp;Christopher R.K. Ching ,&nbsp;J. David Creswell ,&nbsp;Paulina Clara Dagnino ,&nbsp;Svend Davanger ,&nbsp;Richard J. Davidson ,&nbsp;Gustavo Deco ,&nbsp;Janine M. Dutcher ,&nbsp;Anira Escrichs ,&nbsp;Anthony P. King","doi":"10.1016/j.bpsc.2024.10.015","DOIUrl":"10.1016/j.bpsc.2024.10.015","url":null,"abstract":"<div><div>Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the field of meditation and contemplative neuroscience.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 425-436"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness as a Way of Reducing Automatic Constraints on Thought","authors":"Kalina Christoff Hadjiilieva","doi":"10.1016/j.bpsc.2024.11.001","DOIUrl":"10.1016/j.bpsc.2024.11.001","url":null,"abstract":"<div><div>The number of mindfulness-based wellness promotion programs offered by institutions, by governments, and through mobile apps has grown exponentially in the last decade. However, the scientific understanding of what mindfulness is and how it works is still evolving. Here, I focus on 2 common mindfulness practices: focused attention (FA) and open monitoring (OM). First, I summarize what is known about FA and OM meditation at the psychological level. While they share similar emotion regulation goals, they differ in terms of some of their attention regulation goals. Second, I turn to the neuroscientific literature, showing that FA meditation is associated with consistent activations of cortical control network regions and deactivations of cortical default network regions. In contrast, OM meditation seems to be most consistently associated with changes in the functional connectivity patterns of subcortical structures, including the basal ganglia and cerebellum. Finally, I present a novel account of the mental changes that occur during FA and OM meditation as understood from within the Dynamic Framework of Thought—a conceptual framework that distinguishes between deliberate and automatic constraints on thought. Although deliberate self-regulation processes are often emphasized in scientific and public discourse on mindfulness, here I argue that mindfulness may primarily involve changes in automatic constraints on thought. In particular, I argue that mindfulness reduces the occurrence of automatized sequences of mental states or habits of thought. In this way, mindfulness may increase the spontaneity of thought and reduce automatically constrained forms of thought such as rumination and obsessive thought.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 393-401"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function","authors":"Vaibhav Tripathi ,&nbsp;Ishaan Batta ,&nbsp;Andre Zamani ,&nbsp;Daniel A. Atad ,&nbsp;Sneha K.S. Sheth ,&nbsp;Jiahe Zhang ,&nbsp;Tor D. Wager ,&nbsp;Susan Whitfield-Gabrieli ,&nbsp;Lucina Q. Uddin ,&nbsp;Ruchika S. Prakash ,&nbsp;Clemens C.C. Bauer","doi":"10.1016/j.bpsc.2024.12.016","DOIUrl":"10.1016/j.bpsc.2024.12.016","url":null,"abstract":"<div><div>The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind. In recent years, there has been a surge in the number of studies examining its functional connectivity, particularly its relationship with frontoparietal networks involved in top-down attention, executive function, and cognitive control. The fluidity in switching between these internal and external modes of processing, which is highlighted by anticorrelated functional connectivity, has been proposed as an indicator of cognitive health. Due to the ease of estimation of functional connectivity–based measures through resting-state functional magnetic resonance imaging paradigms, there is now a wealth of large-scale datasets, paving the way for standardized connectivity benchmarks. In this review, we explore the promising role of DMN connectivity metrics as potential biomarkers of cognitive state across attention, internal mentation, mind wandering, and meditation states and investigate deviations in trait-level measures across aging and in clinical conditions such as Alzheimer’s disease, Parkinson’s disease, depression, attention-deficit/hyperactivity disorder, and others. We also tackle the issue of reliability of network estimation and functional connectivity and share recommendations for using functional connectivity measures as a biomarker of cognitive health.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Pages 359-368"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(25)00076-X","DOIUrl":"10.1016/S2451-9022(25)00076-X","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 4","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}