Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Resolving Uncertainties in a Social World","authors":"Joseph M. Barnby","doi":"10.1016/j.bpsc.2024.09.005","DOIUrl":"10.1016/j.bpsc.2024.09.005","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1079-1080"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological Pathways of Unconscious Emotion Processing in Depression: Insights From a Simultaneous Electroencephalography–Functional Magnetic Resonance Imaging Measurement","authors":"Julia Schräder ,&nbsp;Lennard Herzberg ,&nbsp;Han-Gue Jo ,&nbsp;Lucia Hernandez-Pena ,&nbsp;Julia Koch ,&nbsp;Ute Habel ,&nbsp;Lisa Wagels","doi":"10.1016/j.bpsc.2024.07.005","DOIUrl":"10.1016/j.bpsc.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is characterized by strong emotional dysregulation. Mechanisms driving the negative affect in depression may be fast processes existing on an unconscious level.</div></div><div><h3>Methods</h3><div>A priming task was conducted using simultaneous electroencephalography–functional magnetic resonance imaging measurement involving presentation of facial expressions (happy, sad, and neutral) to examine the neurophysiological pathway of biased unconscious emotion processing in MDD. Priming prior to a target emotion created unconscious (16.7-ms primer) and conscious (150-ms primer) trials. A large sample (<em>N</em> = 126) was recruited, containing healthy control participants (<em>n</em> = 66; 37 women) and participants with MDD (<em>n</em> = 60; 31 women).</div></div><div><h3>Results</h3><div>The healthy control group showed a shorter reaction time in happy but not in sad or neutral trials compared with the MDD group. N170 amplitudes were lower in trials with unconscious than conscious primer presentation. N170 amplitudes correlated with cortical (right fusiform gyrus, right middle temporal gyrus, right inferior temporal gyrus, left supplementary motor area, right middle frontal gyrus) and subcortical brain regions (right amygdala). The strength of N170 and brain activity correlation increased when the stimulus was consciously presented. Presented emotions did not affect the correlation of N170 values and brain activity.</div></div><div><h3>Conclusions</h3><div>Our findings show that MDD may exhibit biased emotion regulation abilities at a behavioral and neurophysiological level. Face-sensitive event-related potentials demonstrate a correlation with heightened brain activity in regions associated with both face recognition (fusiform gyrus) and emotion processing (amygdala). These findings are evident in both MDD and healthy control groups, with lower effect sizes in the MDD group indicating reduced emotion recognition and processing abilities.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1121-1131"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(24)00287-8","DOIUrl":"10.1016/S2451-9022(24)00287-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Profiles in Treatment-Resistant Late-Life Depression and Their Impact on Treatment Outcomes","authors":"Katharina Göke ,&nbsp;Shawn M. McClintock ,&nbsp;Linda Mah ,&nbsp;Tarek K. Rajji ,&nbsp;Hyewon H. Lee ,&nbsp;Sean M. Nestor ,&nbsp;Jonathan Downar ,&nbsp;Yoshihiro Noda ,&nbsp;Zafiris J. Daskalakis ,&nbsp;Benoit H. Mulsant ,&nbsp;Daniel M. Blumberger","doi":"10.1016/j.bpsc.2024.07.009","DOIUrl":"10.1016/j.bpsc.2024.07.009","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression (LLD) is associated with cognitive impairment, but substantial heterogeneity exists among patients. Data on the extent of cognitive impairments are inconclusive, particularly in patients with treatment-resistant depression (TRD). We investigated the cognitive profiles of patients with treatment-resistant versus nonresistant LLD and aimed to identify distinct cognitive subgroups. We also examined whether cognitive subgroups responded differentially to treatment with bilateral repetitive transcranial magnetic stimulation (rTMS).</div></div><div><h3>Methods</h3><div>A total of 165 patients with LLD were divided into treatment-resistant and nonresistant groups and compared with healthy control participants on measures of executive function, information processing speed, verbal learning, and memory. Cluster analysis identified subgroups based on cognitive scores. Demographic and clinical variables, as well as outcomes with bilateral rTMS, were compared between cognitive subgroups.</div></div><div><h3>Results</h3><div>Patients with LLD, particularly TRD, exhibited significantly worse cognitive performance than healthy controls. A 3-cluster solution was found, including cognitively intact (<em>n</em> = 89), cognitively diminished (<em>n</em> = 29), and impaired memory (<em>n</em> = 47) subgroups. Both the cognitively diminished and impaired memory subgroups had more anxiety symptoms and a higher proportion of patients with TRD than the cognitively intact group, although the latter difference did not survive multiple comparison correction. No significant differences were observed in outcomes to rTMS treatment.</div></div><div><h3>Conclusions</h3><div>Patients with LLD exhibited impairments across cognitive domains, which were more pronounced in TRD. Three cognitive subgroups responded similarly to rTMS treatment, indicating its effectiveness across cognitive profiles, especially when medications are not tolerated. Future research should examine the relationships among cognitive subgroups, cognitive decline, and neurodegeneration.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1199-1210"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis","authors":"Tim J. Hartung ,&nbsp;Nina von Schwanenflug ,&nbsp;Stephan Krohn ,&nbsp;Tommy A.A. Broeders ,&nbsp;Harald Prüss ,&nbsp;Menno M. Schoonheim ,&nbsp;Carsten Finke","doi":"10.1016/j.bpsc.2024.07.021","DOIUrl":"10.1016/j.bpsc.2024.07.021","url":null,"abstract":"<div><h3>Background</h3><div>Anti-NMDA receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxelwise and time-resolved estimation of network importance—beyond changes in classical static functional connectivity.</div></div><div><h3>Methods</h3><div>To assess changes in functional brain network organization, we applied EC mapping in 73 patients with NMDARE and 73 matched healthy control participants. Areas with significant group differences were further investigated using 1) spatial clustering analyses, 2) time series correlation to assess synchronicity between the hippocampus and cortical brain regions, and 3) correlation with cognitive and clinical parameters.</div></div><div><h3>Results</h3><div>Dynamic, time-resolved EC showed significantly higher variability in 13 cortical areas (familywise error <em>p</em> &lt; .05) in patients with NMDARE compared with healthy control participants. Areas with dynamic EC group differences were spatially organized in centrality clusters resembling resting-state networks. Importantly, variability of dynamic EC in the frontotemporal cluster was associated with impaired verbal episodic memory in patients (<em>r =</em> −0.25, <em>p =</em> .037). EC synchronicity between the hippocampus and the medial prefrontal cortex was reduced in patients compared with healthy control participants (familywise error <em>p</em> &lt; .05, <em>t</em>_max = 3.76) and associated with verbal episodic memory in patients (<em>r =</em> 0.28, <em>p =</em> .019). Static EC analyses showed group differences in only one brain region (left intracalcarine cortex).</div></div><div><h3>Conclusions</h3><div>Widespread changes in network dynamics and reduced hippocampal-medial prefrontal synchronicity were associated with verbal episodic memory deficits and may thus represent a functional neural correlate of cognitive dysfunction in NMDARE. Importantly, dynamic EC detected substantially more network alterations than traditional static approaches, highlighting the potential of this method to explain long-term deficits in NMDARE.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1222-1229"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impairment of Visual Fixation and Preparatory Saccade Control in Borderline Personality Disorder With and Without Comorbid Attention-Deficit/Hyperactivity Disorder","authors":"Olivia G. Calancie ,&nbsp;Ashley C. Parr ,&nbsp;Don C. Brien ,&nbsp;Brian C. Coe ,&nbsp;Linda Booij ,&nbsp;Sarosh Khalid-Khan ,&nbsp;Doug P. Munoz","doi":"10.1016/j.bpsc.2024.07.003","DOIUrl":"10.1016/j.bpsc.2024.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is associated with heightened impulsivity, evidenced by increased substance abuse, self-harm, and suicide attempts. Addressing impulsivity in individuals with BPD is a therapeutic objective, but its underlying neural basis in this clinical population remains unclear, partly due to its frequent comorbidity with attention-deficit/hyperactivity disorder (ADHD).</div></div><div><h3>Methods</h3><div>We used a response inhibition paradigm—the interleaved pro-/antisaccade task—among adolescents diagnosed with BPD with and without comorbid ADHD (<em>n</em> = 25 and <em>n</em> = 24, respectively) during concomitant video-based eye tracking. We quantified various eye movement response parameters reflective of impulsive action during the task, including delay to fixation acquisition, fixation breaks, anticipatory saccades, and direction errors with express saccade (saccade reaction time: 90–140 ms) and regular saccade latencies (saccade reaction time &gt; 140 ms).</div></div><div><h3>Results</h3><div>Individuals with BPD exhibited deficient response preparation, as evidenced by reduced visual fixation on task cues and greater variability of saccade responses (i.e., saccade reaction time and peak velocity). The ADHD/BPD group shared these traits and made more anticipatory responses and direction errors with express saccade latencies and reduced error correction.</div></div><div><h3>Conclusions</h3><div>Saccadic deficits in BPD and ADHD/BPD stemmed not from an inability to execute antisaccades but rather from inadequate preparation for the upcoming task set. These distinctions may arise due to abnormal signaling in cortical areas like the frontal eye fields, posterior parietal cortex, and anterior cingulate cortex. Understanding these mechanisms could provide insights into targeted interventions focusing on task set preparation to manage response inhibition deficits in BPD and ADHD/BPD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1178-1187"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak Alpha Frequency in Schizophrenia, Bipolar Disorder, and Healthy Volunteers: Associations With Visual Information Processing and Cognition","authors":"","doi":"10.1016/j.bpsc.2024.06.004","DOIUrl":"10.1016/j.bpsc.2024.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) and bipolar disorder (BD) are associated with information processing abnormalities, including visual perceptual and cognitive impairments, that impact daily functioning. Recent work with healthy samples suggests that peak alpha frequency (PAF) is an electrophysiological index of visual information processing speed that is correlated with cognitive ability. There is evidence that PAF is slowed in SCZ, but it remains unclear whether PAF is reduced in BD or whether slower PAF is associated with impaired visual perception and cognition in these clinical disorders.</div></div><div><h3>Methods</h3><div>We recorded resting-state brain activity (both eyes open and closed) with electroencephalography in 90 participants with SCZ, 62 participants with BD, and 69 healthy control participants. Most participants also performed a visual perception task (backward masking) and cognitive testing (MATRICS Concensus Cognitive Battery).</div></div><div><h3>Results</h3><div>We replicated previous findings of reduced PAF in patients with SCZ compared with healthy control participants. In contrast, PAF in patients with BD did not differ significantly from that in healthy control participants. Furthermore, PAF was significantly correlated with performance on the perceptual and cognitive measures in SCZ but not BD. PAF was also correlated with visual perception in the healthy control group and showed a trend-level correlation with cognition.</div></div><div><h3>Conclusions</h3><div>Together, these results suggest that PAF deficits characterize SCZ, but not BD, and that individual differences in PAF are related to abnormalities in visual information processing and cognition in SCZ.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1132-1140"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(24)00290-8","DOIUrl":"10.1016/S2451-9022(24)00290-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak Alpha Frequency, Visual Perception, and Cognition in Schizophrenia","authors":"Victor J. Pokorny","doi":"10.1016/j.bpsc.2024.09.007","DOIUrl":"10.1016/j.bpsc.2024.09.007","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1077-1078"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents","authors":"McKinley Pawlak ,&nbsp;Jennifer Kemp ,&nbsp;Signe Bray ,&nbsp;Sneha Chenji ,&nbsp;Melanie Noel ,&nbsp;Kathryn A. Birnie ,&nbsp;Frank P. MacMaster ,&nbsp;Jillian Vinall Miller ,&nbsp;Daniel C. Kopala-Sibley","doi":"10.1016/j.bpsc.2024.07.002","DOIUrl":"10.1016/j.bpsc.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.</div></div><div><h3>Methods</h3><div>Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.</div></div><div><h3>Results</h3><div>Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.</div></div><div><h3>Conclusions</h3><div>Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1141-1177"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}