Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Modulation of Cerebellar-Cortical Connectivity Induced by Modafinil and Its Relationship With Receptor and Transporter Expression","authors":"Stefano Delli Pizzi ,&nbsp;Federica Tomaiuolo ,&nbsp;Antonio Ferretti ,&nbsp;Giovanna Bubbico ,&nbsp;Valeria Onofrj ,&nbsp;Stefania Della Penna ,&nbsp;Carlo Sestieri ,&nbsp;Stefano L. Sensi","doi":"10.1016/j.bpsc.2024.11.010","DOIUrl":"10.1016/j.bpsc.2024.11.010","url":null,"abstract":"<div><h3>Background</h3><div>Modafinil is primarily used to treat narcolepsy but is also used as an off-label cognitive enhancer. Functional magnetic resonance imaging studies indicate that modafinil modulates the connectivity of neocortical networks primarily involved in attention and executive functions. However, much less is known about the drug’s effects on subcortical structures. Following preliminary findings, we evaluated modafinil’s activity on the connectivity of distinct cerebellar regions with the neocortex. We assessed the spatial relationship of these effects with the expression of neurotransmitter receptors/transporters.</div></div><div><h3>Methods</h3><div>Patterns of resting-state functional magnetic resonance imaging connectivity were estimated in 50 participants from scans acquired pre- and postadministration of a single (100 mg) dose of modafinil (<em>n</em> = 25) or placebo (<em>n</em> = 25). Using specific cerebellar regions as seeds for voxelwise analyses, we examined modafinil’s modulation of cerebellar-neocortical connectivity. Next, we conducted a quantitative evaluation of the spatial overlap between the modulation of cerebellar-neocortical connectivity and the expression of neurotransmitter receptors/transporters obtained by publicly available databases.</div></div><div><h3>Results</h3><div>Modafinil increased the connectivity of crus I and vermis IX with prefrontal regions. Crus I connectivity changes were associated with the expression of dopaminergic D₂ receptors. The vermis I–II showed enhanced coupling with the dorsal anterior cingulate cortex and matched the expression of histaminergic H₃ receptors. The vermis VII–VIII displayed increased connectivity with the visual cortex, an activity associated with dopaminergic and histaminergic neurotransmission.</div></div><div><h3>Conclusions</h3><div>Our study reveals modafinil’s modulatory effects on cerebellar-neocortical connectivity. The modulation mainly involves crus I and the vermis and spatially overlaps the distribution of dopaminergic and histaminergic receptors.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 304-313"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Amygdala Activation During Symptom Provocation Predicts Response to Combined Repetitive Transcranial Magnetic Stimulation and Exposure Therapy in Obsessive-Compulsive Disorder in a Randomized Controlled Trial","authors":"Milan Houben ,&nbsp;Tjardo S. Postma ,&nbsp;Sophie M.D.D. Fitzsimmons ,&nbsp;Chris Vriend ,&nbsp;Neeltje M. Batelaan ,&nbsp;Adriaan W. Hoogendoorn ,&nbsp;Ysbrand D. van der Werf ,&nbsp;Odile A. van den Heuvel","doi":"10.1016/j.bpsc.2024.10.020","DOIUrl":"10.1016/j.bpsc.2024.10.020","url":null,"abstract":"<div><h3>Background</h3><div>Repetitive transcranial magnetic stimulation (rTMS) combined with exposure and response prevention is a promising treatment modality for treatment-refractory obsessive-compulsive disorder (OCD). However, not all patients respond sufficiently to this treatment. We investigated whether brain activation during a symptom provocation task could predict treatment response.</div></div><div><h3>Methods</h3><div>Sixty-one adults with OCD (39 female/22 male) underwent symptom provocation with OCD- and fear-related visual stimuli during functional magnetic resonance imaging prior to an 8-week combined rTMS and exposure and response prevention treatment regimen. Participants received one of the following 3 rTMS treatments as part of a randomized controlled trial: 1) 10-Hz rTMS (110% resting motor threshold) to the left dorsolateral prefrontal cortex, 2) 10-Hz rTMS (110% resting motor threshold) to the left presupplementary motor area, or 3) 10-Hz control rTMS (60% resting motor threshold) to the vertex. Multiple regression and correlation were used to examine the predictive value of task-related brain activation for treatment response in the following regions of interest: the dorsomedial prefrontal cortex, amygdala, dorsolateral prefrontal cortex, and left presupplementary motor area.</div></div><div><h3>Results</h3><div>The different treatment groups responded equally to treatment. Higher pretreatment task-related activation of the right amygdala to OCD-related stimuli showed a positive association with treatment response in all groups. Exploratory whole-brain analyses showed positive associations between activation in multiple task-relevant regions and treatment response. Only dorsal anterior cingulate cortex activation to fear-related stimuli showed a negative association with treatment outcome.</div></div><div><h3>Conclusions</h3><div>Higher pretreatment right amygdala activation during symptom provocation predicts better treatment response to combined rTMS and exposure and response prevention in OCD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 295-303"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Frontiers in Computational Metabolic Psychiatry","authors":"Anthony G. Chesebro ,&nbsp;Botond B. Antal ,&nbsp;Corey Weistuch ,&nbsp;Lilianne R. Mujica-Parodi","doi":"10.1016/j.bpsc.2024.10.011","DOIUrl":"10.1016/j.bpsc.2024.10.011","url":null,"abstract":"<div><div>One of the primary challenges in metabolic psychiatry is that the disrupted brain functions that underlie psychiatric conditions arise from a complex set of downstream and feedback processes that span multiple spatiotemporal scales. Importantly, the same circuit can have multiple points of failure, each of which results in a different type of dysregulation, and thus elicits distinct cascades downstream that produce divergent signs and symptoms. Here, we illustrate this challenge by examining how subtle differences in circuit perturbations can lead to divergent clinical outcomes. We also discuss how computational models can perform the spatially heterogeneous integration and bridge in vitro and in vivo paradigms. By leveraging recent methodological advances and tools, computational models can integrate relevant processes across scales (e.g., tricarboxylic acid cycle, ion channel, neural microassembly, whole-brain macrocircuit) and across physiological systems (e.g., neural, endocrine, immune, vascular), providing a framework that can unite these mechanistic processes in a manner that goes beyond the conceptual and descriptive to the quantitative and generative. These hold the potential to sharpen our intuitions toward circuit-based models for personalized diagnostics and treatment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 258-266"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder","authors":"Margaret T. Davis ,&nbsp;Ruth H. Asch ,&nbsp;Emily R. Weiss ,&nbsp;Ashley Wagner ,&nbsp;Sarah K. Fineberg ,&nbsp;Nabeel Nabulsi ,&nbsp;David Matuskey ,&nbsp;Richard E. Carson ,&nbsp;Irina Esterlis","doi":"10.1016/j.bpsc.2024.11.014","DOIUrl":"10.1016/j.bpsc.2024.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is a serious psychiatric condition that is associated with a high risk for suicide attempts (SAs) and death by suicide. However, relatively little is known about the pathophysiology of BPD. The metabotropic glutamate 5 receptor (mGlu₅) has been specifically implicated in the pathophysiology of BPD and SAs, with more general roles in emotion regulation, social and cognitive functioning, and pain processing. Here, we examined the relationship between mGlu₅ availability, BPD, and SAs in vivo for the first time.</div></div><div><h3>Methods</h3><div>Eighteen individuals with BPD, 18 healthy control participants matched on age, sex, and smoking status, and 18 clinical comparison control participants with major depressive disorder completed comprehensive clinical assessments and participated in an [¹⁸F]FPEB positron emission tomography scan to measure mGlu₅ availability. The volume of distribution (<em>V</em>_T) in the frontolimbic circuit implicated in BPD pathophysiology was the positron emission tomography outcome measure.</div></div><div><h3>Results</h3><div>We observed significantly higher frontolimbic mGlu₅ availability in the BPD group than in both the healthy control group (<em>p</em> = .009, <em>d</em> = 0.84, 18.43% difference) and the major depressive disorder group (<em>p</em> = .03, <em>d</em> = 0.69, 15.21% difference). In the BPD, but not the major depressive disorder group, higher mGlu₅ availability was also associated with a history of SAs (19–25% higher, <em>p</em>s = .02–.005). Furthermore, mGlu₅ availability was positively correlated with risk factors for suicide (e.g., sexual victimization, perceived burdensomeness) in individuals with BPD and a history of SA.</div></div><div><h3>Conclusions</h3><div>Results show higher mGlu₅ availability in BPD and SA for the first time. Our preliminary findings suggest that mGlu₅ may be a critical treatment target for BPD symptoms, including SAs, and warrant additional investigation in larger samples.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 324-332"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00040-0","DOIUrl":"10.1016/S2451-9022(25)00040-0","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Insulin Increases Brain Glutathione and Enhances Antioxidant Capacity in Healthy Participants but Not in Those With Early Psychotic Disorders","authors":"Virginie-Anne Chouinard ,&nbsp;Wirya Feizi ,&nbsp;Xi Chen ,&nbsp;Boyu Ren ,&nbsp;Kathryn E. Lewandowski ,&nbsp;Jacey Anderson ,&nbsp;Steven Prete ,&nbsp;Emma Tusuzian ,&nbsp;Kyle Cuklanz ,&nbsp;Shuqin Zhou ,&nbsp;Paula Bolton ,&nbsp;Abigail Stein ,&nbsp;Bruce M. Cohen ,&nbsp;Fei Du ,&nbsp;Dost Öngür","doi":"10.1016/j.bpsc.2024.11.018","DOIUrl":"10.1016/j.bpsc.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>We examined the acute effects of intranasal insulin on cognitive function and brain glutathione (GSH), a central factor in resistance to oxidative stress, in both participants with early psychosis and healthy control (HC) participants.</div></div><div><h3>Methods</h3><div>Twenty-one patients with early-stage psychotic disorders and 18 HC participants underwent magnetic resonance spectroscopy (MRS) scans and cognitive assessments before and after administration of intranasal insulin 40 IU. We conducted proton MRS (¹H-MRS) in the prefrontal cortex at 4T to measure GSH and glutamate metabolites. We assessed cognition using the Brief Assessment of Cognition in Schizophrenia symbol coding, digit sequencing, and verbal fluency tasks, in addition to the Stroop task.</div></div><div><h3>Results</h3><div>The mean (SD) age of participants was 25.7 (4.6) years; 51.3% were female. There were no significant group differences at baseline in age, sex, body mass index, homeostatic model assessment of insulin resistance (HOMA-IR), or cognition. Patients had higher baseline GSH (<em>p</em> &lt; .001) and glutamate (<em>p</em> = .007). After insulin administration, GSH increased in HC participants (mean change, 0.15; 95% CI 0.03 to 0.26; <em>p</em> = .015), but not in patients. Symbol coding improved in both patients (0.74; 95% CI 0.37 to 1.11; <em>p</em> &lt; .001) and HC participants (0.83; 95% CI 0.58 to 1.09; <em>p</em> &lt; .001), and verbal fluency improved in HC participants (0.43; 95% CI 0.14 to 0.72; <em>p</em> = .006). Lower baseline HOMA-IR was associated with greater change in GSH (coefficient −0.22; 95% CI −0.40 to −0.04; <em>p</em> = .017).</div></div><div><h3>Conclusions</h3><div>Intranasal insulin increased brain GSH in HC participants, but not in patients with early psychotic disorders. These novel findings demonstrate that intranasal insulin enhances antioxidant capacity and resilience to oxidative stress in HC individuals in contrast to an absent antioxidant response in those with early psychotic disorders.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 286-294"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Status Modulates Global and Local Brain Age Estimates in Overweight and Obese Adults","authors":"Shalaila S. Haas ,&nbsp;Fahim Abbasi ,&nbsp;Kathleen Watson ,&nbsp;Thalia Robakis ,&nbsp;Alison Myoraku ,&nbsp;Sophia Frangou ,&nbsp;Natalie Rasgon","doi":"10.1016/j.bpsc.2024.11.017","DOIUrl":"10.1016/j.bpsc.2024.11.017","url":null,"abstract":"<div><h3>Background</h3><div>As people live longer, maintaining brain health becomes essential for extending health span and preserving independence. Brain degeneration and cognitive decline are major contributors to disability. In this study, we investigated how metabolic health influences the brain age gap estimate (brainAGE), which measures the difference between neuroimaging-predicted brain age and chronological age.</div></div><div><h3>Methods</h3><div>K-means clustering was applied to fasting metabolic markers including insulin, glucose, leptin, cortisol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, steady-state plasma glucose, and body mass index of 114 physically and cognitively healthy adults. The homeostatic model assessment for insulin resistance served as a reference. T1-weighted brain magnetic resonance imaging was used to calculate voxel-level and global brainAGE. Longitudinal data were available for 53 participants over a 3-year interval.</div></div><div><h3>Results</h3><div>K-means clustering divided the sample into 2 groups, those with favorable (<em>n</em> = 58) and those with suboptimal (<em>n</em> = 56) metabolic health. The suboptimal group showed signs of insulin resistance and dyslipidemia (false discovery rate–corrected <em>p</em> &lt; .05) and had older global brainAGE and local brainAGE, with deviations most prominent in cerebellar, ventromedial prefrontal, and medial temporal regions (familywise error–corrected <em>p</em> &lt; .05). Longitudinal analysis revealed group differences but no significant time or interaction effects on brainAGE measures.</div></div><div><h3>Conclusions</h3><div>Suboptimal metabolic status is linked to accelerated brain aging, particularly in brain regions rich in insulin receptors. These findings highlight the importance of metabolic health in maintaining brain function and suggest that promoting metabolic well-being may help extend health span.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 278-285"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00044-8","DOIUrl":"10.1016/S2451-9022(25)00044-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism Matters in Mental Health","authors":"Zachary Freyberg ,&nbsp;Judith M. Ford ,&nbsp;Mary L. Phillips","doi":"10.1016/j.bpsc.2024.12.009","DOIUrl":"10.1016/j.bpsc.2024.12.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 239-240"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Connectivity Between Glutamate Receptor Antagonism and Insulin Pathways: Implications for Modeling Mechanism of Action of Ketamine/Esketamine and Dextromethorphan in Depression Treatment","authors":"Sabrina Wong ,&nbsp;Gia Han Le ,&nbsp;Rodrigo B. Mansur ,&nbsp;Joshua D. Rosenblat ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.bpsc.2024.10.004","DOIUrl":"10.1016/j.bpsc.2024.10.004","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 3","pages":"Pages 241-243"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}