Ultrasonography最新文献

{"title":"Combined fine-needle aspiration with core needle biopsy for assessing thyroid nodules: a more valuable diagnostic method?","authors":"Zhe Chen,&nbsp;Jia-Jia Wang,&nbsp;Dong-Ming Guo,&nbsp;Yu-Xia Zhai,&nbsp;Zhuo-Zhi Dai,&nbsp;Hong-Hui Su","doi":"10.14366/usg.22112","DOIUrl":"https://doi.org/10.14366/usg.22112","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic value of combined fine-needle aspiration (FNA) with core needle biopsy (CNB) in thyroid nodules.</p><p><strong>Methods: </strong>FNA and CNB were performed simultaneously on 703 nodules. We compared the proportions of inconclusive results and the diagnostic performance for malignancy among FNA, CNB, and combined FNA/CNB for different nodule sizes.</p><p><strong>Results: </strong>Combined FNA/CNB showed lower proportions of inconclusive results than CNB for all nodules (2.8% vs. 5.7%, P<0.001), nodules ≤1.0 cm (4.9% vs. 7.3%, P=0.063), nodules >1.0 cm (2.0% vs. 5.0 %, P<0.001), nodules ≤1.5 cm (3.8% vs. 7.9 %, P<0.001), and nodules >1.5 cm (2.1% vs. 3.9 %, P=0.016). The sensitivity of combined FNA/CNB in predicting malignancy was significantly higher than that of CNB (89.0% vs. 80.0%, P<0.001) and FNA (89.0% vs. 58.1%, P<0.001) for all nodules. Within American College of Radiology Thyroid and Imaging Reporting and Data System grades 4-5, in the subgroup of nodules ≤1.5 cm, combined FNA/ CNB showed the best sensitivity in predicting malignancy (91.4%), significantly higher than that of CNB (81.0%, P<0.001) and FNA (57.8%, P<0.001). However, in the subgroup of nodules >1.5 cm, the difference between combined FNA/CNB and CNB was not significant (84.2% vs. 78.9%, P=0.500).</p><p><strong>Conclusion: </strong>Regardless of nodule size, combined FNA/CNB tended to yield lower proportions of inconclusive results than CNB or FNA alone and exhibited higher performance in diagnosing malignancy. The combined FNA/CNB technique may be a more valuable diagnostic method for nodules ≤1.5 cm and nodules with a risk of malignancy than CNB and FNA alone.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"314-322"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/b7/usg-22112.PMC10071058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT.","authors":"Hyobin Seo,&nbsp;Kwang Nam Jin,&nbsp;Ji Sang Park,&nbsp;Koung Mi Kang,&nbsp;Eun Kyung Lee,&nbsp;Ji Ye Lee,&nbsp;Roh-Eul Yoo,&nbsp;Young Joo Park,&nbsp;Ji-Hoon Kim","doi":"10.14366/usg.22111","DOIUrl":"https://doi.org/10.14366/usg.22111","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated thyroid cancer risk in a lung cancer screening population according to the presence of an incidental thyroid nodule (ITN) detected on low-dose chest computed tomography (LDCT).</p><p><strong>Methods: </strong>Of 47,837 subjects who underwent LDCT, a lung cancer screening population according to the National Lung Screening Trial results was retrospectively enrolled. The prevalence of ITN on LDCT was calculated, and the ultrasonography (US)/fine-needle aspiration (FNA)-based risk of thyroid cancer according to the presence of ITN on LDCT was compared using the Fisher exact or Student t-test as appropriate.</p><p><strong>Results: </strong>Of the 2,329 subjects (female:male=44:2,285; mean age, 60.9±4.9 years), the prevalence of ITN on LDCT was 4.8% (111/2,329). The incidence of thyroid cancer was 0.8% (18/2,329, papillary thyroid microcarcinomas [PTMCs]) and was higher in the ITN-positive group than in the ITN-negative group (3.6% [4/111] vs. 0.6% [14/2,218], P=0.009). Among the 2,011 subjects who underwent both LDCT and thyroid US, all risks were higher (P<0.001) in the ITNpositive group than in the ITN-negative group: presence of thyroid nodule on US, 94.1% (95/101) vs. 48.6% (928/1,910); recommendation of FNA according to the American Thyroid Association guideline and Korean Thyroid Imaging Reporting and Data System guideline, 41.2% (42/101) vs. 2.4% (46/1,910) and 39.6% (40/101) vs. 1.9% (37/1,910), respectively.</p><p><strong>Conclusion: </strong>Despite a higher risk of thyroid cancer in the LDCT ITN-positive group than in the ITN-negative group in a lung cancer screening population, all cancers were PTMCs. A heavy smoking history may not necessitate thorough screening US for thyroid incidentalomas.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"275-285"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/64/usg-22111.PMC10071062.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonography of intrascrotal torsed appendages: size and interval between symptom onset and the ultrasonographic examination according to echogenicity.","authors":"Seung-Hyun Lim,&nbsp;Dal Mo Yang,&nbsp;Hyun Cheol Kim,&nbsp;Sang Won Kim,&nbsp;Hyunmin Kim,&nbsp;Da In Lee,&nbsp;Sung Kyung Moon,&nbsp;Seung Jin Park","doi":"10.14366/usg.22169","DOIUrl":"https://doi.org/10.14366/usg.22169","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the size of torsed appendages and the interval between symptom onset and the ultrasonographic examination according to the echogenicity of the torsed appendages.</p><p><strong>Methods: </strong>This was a retrospective analysis of 54 cases in 46 patients with torsion of the testicular appendages between December 2008 and July 2021. Eight patients received follow-up ultrasonography 7-48 days after initial ultrasonography. The echogenicity of torsed appendages was classified into three groups: hypoechoic, hyperechoic, or isoechoic.</p><p><strong>Results: </strong>The 54 torsed appendages were hypoechoic (n=40), hyperechoic (n=9), or isoechoic (n=5). The size of the torsed appendages ranged from 4 to 14 mm (8.0±3.1 mm) in hypoechoic torsed appendages and from 2.6 to 5.0 mm (3.7±0.9 mm) in hyperechoic torsed appendages. The interval between symptom onset and the ultrasonographic examination ranged from 0 to 17 days (4.2±4.4 days) in hypoechoic torsed appendages and from 8 to 48 days (29.8±16.0 days) in hyperechoic torsed appendages. The hyperechoic torsed appendages were smaller and had longer intervals between symptom onset and the ultrasonographic examination than the hypoechoic torsed appendages (P<0.05). Three hypoechoic torsed appendages and a single isoechoic torsed appendage on initial ultrasonography became hyperechoic on follow-up ultrasonography.</p><p><strong>Conclusion: </strong>The size of the torsed appendages and the interval between symptom onset and the ultrasonographic examination varied according to the echogenicity of the torsed appendages. The hyperechoic torsed appendages were smaller and had longer intervals until the examination than the hypoechoic torsed appendages.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"259-264"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/b4/usg-22169.PMC10071070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9637997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top applications of dermatologic ultrasonography that can modify management.","authors":"Ximena Wortsman","doi":"10.14366/usg.22130","DOIUrl":"https://doi.org/10.14366/usg.22130","url":null,"abstract":"Dermatologic ultrasonography is a new field that has been growing exponentially in the last 10 years. It has multiple applications that can modify patient management, such as the assessment of benign and malignant cutaneous tumors, vascular anomalies, inflammatory dermatologic entities, aesthetic complications, and nail lesions. Compared with other imaging techniques such as computed tomography or magnetic resonance imaging, ultrasonography has the highest axial spatial resolution and has benefited from the development of high- and ultra-high-frequency probes that could even reach 70 MHz. The daily use of ultrasonography in dermatology has been reported to improve the accuracy of diagnoses, the tracking of activity, and the assessment of severity in common dermatologic conditions, which certainly can support better treatment of patients.","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"183-202"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/5a/usg-22130.PMC10071066.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How many times should we repeat measurements of the ultrasound-guided attenuation parameter for evaluating hepatic steatosis?","authors":"Duck Min Seo,&nbsp;Sang Min Lee,&nbsp;Ji Won Park,&nbsp;Min-Jeong Kim,&nbsp;Hong Il Ha,&nbsp;Sun-Young Park,&nbsp;Kwanseop Lee","doi":"10.14366/usg.22122","DOIUrl":"https://doi.org/10.14366/usg.22122","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective study aimed to determine the number of times the ultrasound-guided attenuation parameter (UGAP) should be measured during the evaluation of hepatic steatosis.</p><p><strong>Methods: </strong>Patients with suspected nonalcoholic fatty liver disease who underwent two UGAP repetition protocols (six-repetition [UGAP_6] and 12-repetition [UGAP_12]) and measurement of the controlled attenuation parameter (CAP) using transient elastography between October 2020 and June 2021 were enrolled. The mean attenuation coefficient (AC), interquartile range (IQR)/median, and coefficient of variance (CV) of the two repetition protocols were compared using the paired t test. Moreover, the diagnostic performances of UGAP_6 and UGAP_12 were compared using the area under the receiver operating characteristic (AUROC) curve, considering the CAP value as a reference standard.</p><p><strong>Results: </strong>The study included 160 patients (100 men; mean age, 50.9 years). There were no significant differences between UGAP_6 and UGAP_12 (0.731±0.116 dB/cm/MHz vs. 0.734±0.113 dB/cm/MHz, P=0.156) and mean CV (7.6±0.3% vs. 8.0±0.3%, P=0.062). However, the mean IQR/median of UGAP_6 was significantly lower than that of UGAP_12 (8.9%±6.0% vs. 9.8%±5.2%, P=0.012). In diagnosing the hepatic steatosis stage, UGAP_6 and UGAP_12 yielded comparable AUROCs (≥S1, 0.908 vs. 0.897, P=0.466; ≥S2, 0.883 vs. 0.897, P=0.126; S3, 0.832 vs. 0.834, P=0.799).</p><p><strong>Conclusion: </strong>UGAP had high diagnostic performance in diagnosing hepatic steatosis, regardless of the number of repetitions (six repetitions vs. 12 repetitions), with maintained reliability. Therefore, six UGAP measurements seem sufficient for evaluating hepatic steatosis using UGAP.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"227-237"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/12/usg-22122.PMC10071056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound findings of subpial hemorrhage in neonates.","authors":"Yun-Jung Lim,&nbsp;Su-Mi Shin,&nbsp;Hyeri Kim,&nbsp;Mi Lim Chung,&nbsp;Seok Hahn,&nbsp;Yeon Jin Cho","doi":"10.14366/usg.22199","DOIUrl":"https://doi.org/10.14366/usg.22199","url":null,"abstract":"<p><strong>Purpose: </strong>Subpial hemorrhage (SPH) is a subtype of intracranial hemorrhage characterized by damage to the adjacent brain parenchyma. The aim of this study was to describe the sonographic features of SPH in neonates.</p><p><strong>Methods: </strong>The cranial ultrasound (US) findings of neonates with SPH confirmed by brain magnetic resonance imaging (MRI) were analyzed retrospectively. Initial and follow-up US and MRI scans were reviewed by two pediatric radiologists who were blinded to both clinical history and outcomes. The US features were compared with the MRI findings.</p><p><strong>Results: </strong>Sixteen patients were included (median gestational age, 38 weeks; range, 26 to 40 weeks; 69% term). SPH was detected most often in the temporal lobe (63%), and multiple SPHs were found in seven of 16 neonates, based on MRI. Acute SPH with an underlying venous infarct (UVI) was detected on US in 15 of 16 patients: small or large fan-shaped hyperechoic lesions (n=7 and 4, respectively) and gyriform hyperechoic lesions (n=4). The sonographic yin-yang sign was observed in three of the four large fan-shaped SPH cases. The accompanying findings on US were intraventricular hemorrhage (four out of six MRI-confirmed cases), and concurrent periventricular venous infarcts (five out of nine MRI-confirmed cases). In five patients, subpial cysts were observed on follow-up US or MRI (n=4 and n=4, respectively).</p><p><strong>Conclusion: </strong>Acute SPH with UVI can appear as a peripheral fan-shaped or gyriform hyperechoic lesion on cranial US. SPH can be detected and suspected based on the US features of SPH with the accompanying findings.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"333-342"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/b4/usg-22199.PMC10071067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9252016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Noninvasive assessment of hepatic steatosis using a pathologic reference standard: comparison of CT, MRI, and US-based techniques.","authors":"Jae Seok Bae,&nbsp;Dong Ho Lee,&nbsp;Kyung-Suk Suh,&nbsp;Haeryoung Kim,&nbsp;Kyung Bun Lee,&nbsp;Jae Young Lee,&nbsp;Joon Koo Han","doi":"10.14366/usg.21150.ER","DOIUrl":"https://doi.org/10.14366/usg.21150.ER","url":null,"abstract":"","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"356"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/73/usg-21150.ER.PMC10071061.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-observer and intra-observer reliability between manual segmentation and semi-automated segmentation for carotid vessel wall volume measurements on three-dimensional ultrasonography.","authors":"Chun Wai Chan,&nbsp;Sze Chai Christy Chow,&nbsp;Man Hei Kwok,&nbsp;Ka Ching Tiffany Ngan,&nbsp;Tsun Hei Or,&nbsp;Simon Takadiyi Gunda,&nbsp;Michael Ying","doi":"10.14366/usg.22123","DOIUrl":"https://doi.org/10.14366/usg.22123","url":null,"abstract":"<p><strong>Purpose: </strong>Carotid vessel wall volume (VWV) measurement on three-dimensional ultrasonography (3DUS) outperforms conventional two-dimensional ultrasonography for carotid atherosclerosis evaluation. Although time-saving semi-automated algorithms have been introduced, their clinical availability remains limited due to a lack of validation, particularly an extensive reliability analysis. This study compared inter-observer and intra-observer reliability between manual segmentation and semi-automated segmentation for carotid VWV measurements on 3DUS.</p><p><strong>Methods: </strong>Thirty-one 3DUS volume datasets were prospectively acquired from 20 healthy subjects, aged >18 years, without previous stroke, transient ischemic attack, or cardiovascular disease. Five observers segmented all volume datasets both manually and semi-automatically. The process was repeated five times. Reliability was expressed by the intraclass correlation coefficient, supplemented by the coefficient of variation.</p><p><strong>Results: </strong>Carotid VWV measurements using the common carotid artery (CCA) were more reliable than those using the internal carotid artery (ICA) or external carotid artery (ECA) for both manual and semiautomated segmentation (manual segmentation, CCA: inter-observer, 0.935; intra-observer, 0.934 to 0.966; ICA: inter-observer, 0.784; intra-observer, 0.756 to 0.878; ECA: inter-observer, 0.732; intraobserver, 0.919 to 0.962; semi-automated segmentation, CCA: inter-observer, 0.986; intra-observer, 0.954 to 0.993; ICA: inter-observer, 0.977; intra-observer, 0.958 to 0.978; ECA: inter-observer, 0.966; intra-observer, 0.884 to 0.937). Total carotid VWV measurements by manual (inter-observer, 0.922; intra-observer, 0.927 to 0.961) and semi-automated segmentation (inter-observer, 0.987; intra-observer, 0.968 to 0.989) were highly reliable. Semi-automated segmentation showed higher reliability than manual segmentation for both individual and total carotid VWV measurements.</p><p><strong>Conclusion: </strong>3DUS carotid VWV measurements of the CCA are more reliable than measurements of the ICA and ECA. Total carotid VWV measurements are highly reliable. Semi-automated segmentation has higher reliability than manual segmentation.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"214-226"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/d1/usg-22123.PMC10071063.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive singular value decomposition filtering of high-intensity focused ultrasound interference enables real-time ultrasound-guided therapy.","authors":"Hunjong Lee,&nbsp;Euisuk Chung,&nbsp;Heechul Yoon,&nbsp;Tai-Kyong Song","doi":"10.14366/usg.22144","DOIUrl":"https://doi.org/10.14366/usg.22144","url":null,"abstract":"<p><p>High-intensity focused ultrasound (HIFU) is an emerging therapeutic tool for the effective thermal ablation of pathological tissue. For accurate localization of the target and safe control of the HIFU dosage, real-time imaging guidance during the HIFU exposure is desired. Ultrasound imaging has the capability to guide clinicians toward a lesion in real time, but is not an ideal option, as HIFU application causes strong interference, thereby substantially distorting the images used for guidance. Thus, this study introduces singular value decomposition-based filtering capable of restoring ultrasound harmonic images from HIFU interference without undesirable spectral distortion. The results were experimentally validated with a custom-made phantom, indicating that this approach effectively eliminates HIFU-induced artifacts, which is essential for real-time monitoring of the therapeutic process.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"343-353"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/49/usg-22144.PMC10071068.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9251520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation.","authors":"Yoon Seong Lee,&nbsp;Seunghyun Lee,&nbsp;Young Hun Choi,&nbsp;Yeon Jin Cho,&nbsp;Seul Bi Lee,&nbsp;Jung-Eun Cheon,&nbsp;Kyung Taek Hong,&nbsp;Hyoung Jin Kang","doi":"10.14366/usg.22107","DOIUrl":"https://doi.org/10.14366/usg.22107","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients.</p><p><strong>Methods: </strong>This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) between November 2019 and January 2021. All 34 patients (8.7±5.0 years) were examined using 2D-SWE for an initial diagnosis. A subgroup analysis was performed using the data from follow-up examinations of patients diagnosed with VOD. The characteristics of the initial VOD diagnosis were compared with the longitudinal changes observed in VOD patients who underwent multiple ultrasound examinations.</p><p><strong>Results: </strong>In total, 19 patients were diagnosed with VOD at 17.6±9.4 days after HSCT. All VOD patients showed hepatomegaly, ascites, and gallbladder wall thickening. Liver stiffness was higher in VOD patients than in non-VOD patients (12.4±1.1 vs. 6.3±0.8 kPa, P<0.001). Liver stiffness values above 7.2 kPa showed 84.2% sensitivity and 93.3% specificity in distinguishing VOD from non-VOD (area under the curve, 0.925; 95% confidence interval, 0.780 to 0.987; P<0.001). A subgroup analysis of 11 patients showed a linear decrease in liver stiffness values after VOD diagnosis with treatment (first, second, and third follow-ups; 13.5±1.7, 11.3±1.4, and 9.5±0.8 kPa, respectively), but without statistical significance in the pairwise analysis.</p><p><strong>Conclusion: </strong>Liver stiffness measured using 2D-SWE increased in pediatric patients who develop VOD after HSCT. Therefore, liver stiffness can be a predictive and quantitative parameter for diagnosing VOD.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"286-296"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/8d/usg-22107.PMC10071064.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}