Renal Doppler ultrasonography for predicting non-diabetic kidney disease in patients with diabetes.

IF 2.4 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Ultrasonography Pub Date : 2023-07-01 DOI:10.14366/usg.23028

Sung Il Jung, Min Hoan Moon, Chang Kyu Sung, Myoung Seok Lee, Jeong Hwan Park, Sohee Oh

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Abstract

Purpose: This study was conducted to assess the role of renal Doppler ultrasonography (US) in predicting non-diabetic kidney disease (NDKD) in patients with diabetes, using histologic findings as the reference standard.

Methods: Fifty-nine consecutive patients with diabetes who underwent renal Doppler US and native kidney biopsy were included in this retrospective, single-institutional study. Based on histologic findings, patients were classified as having diabetic nephropathy (DN) or NDKD. Renal Doppler US findings, including cortical echogenicity, corticomedullary differentiation, and the resistive index (RI), were compared between DN and NDKD. A subgroup analysis according to chronic kidney disease (CKD) status was also performed.

Results: Cortical echogenicity and corticomedullary differentiation showed no significant differences between DN and NDKD (P=0.887 and P>0.99, respectively), whereas the RI was significantly higher in patients with DN than in those with NDKD (P=0.032). The subgroup analysis revealed a significant difference in the RI between DN and NDKD in patients with diabetes and CKD (P=0.010), but a significant difference was not found in those without CKD (P=0.713). When limited to patients with diabetes and CKD, the RI had an area under the curve value of 0.759, sensitivity of 57.1%, specificity of 81.0%, positive likelihood ratio of 3.0, and negative LR of 0.5 for predicting NDKD, using a cutoff value of ≤0.69.

Conclusion: Renal Doppler US may be useful in predicting NDKD in patients with diabetes and CKD.

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肾多普勒超声对糖尿病患者非糖尿病肾病的预测价值。

目的:本研究以组织学表现为参考标准，探讨肾多普勒超声(US)对糖尿病患者非糖尿病性肾病(NDKD)的预测作用。方法:这项回顾性、单机构研究纳入了59例连续接受肾多普勒超声检查和原生肾活检的糖尿病患者。根据组织学结果，将患者分为糖尿病肾病(DN)或NDKD。比较DN和NDKD的肾多普勒超声表现，包括皮质回声性、皮质髓质分化和阻力指数(RI)。根据慢性肾脏疾病(CKD)状态进行亚组分析。结果:DN与NDKD患者的皮质回声性和皮质髓质分化差异无统计学意义(P=0.887、P>0.99)，而DN患者的RI明显高于NDKD患者(P=0.032)。亚组分析显示糖尿病合并CKD患者DN和NDKD的RI差异有统计学意义(P=0.010)，而非CKD患者的RI差异无统计学意义(P=0.713)。当限定于糖尿病和CKD患者时，预测NDKD的RI曲线下面积为0.759，敏感性为57.1%，特异性为81.0%，阳性似然比为3.0，阴性LR为0.5，临界值≤0.69。结论:肾多普勒超声可用于预测糖尿病和CKD患者的NDKD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.10

自引率

6.50%

发文量

审稿时长

15 weeks

期刊介绍： Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.