Seong Soo Jeon, Chan Kyo Kim, Sung Yoon Park, Jae Hoon Chung, Minyong Kang, Hyun Hwan Sung, Byong Chang Jeong
{"title":"The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study.","authors":"Seong Soo Jeon, Chan Kyo Kim, Sung Yoon Park, Jae Hoon Chung, Minyong Kang, Hyun Hwan Sung, Byong Chang Jeong","doi":"10.14366/usg.22202","DOIUrl":"https://doi.org/10.14366/usg.22202","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa).</p><p><strong>Methods: </strong>In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biopsy with and without a targeted biopsy. Tissue stiffness on SWE was measured in the target lesion and in 12 regions of the systematic biopsies, and the maximum (Emax), mean (Emean), and minimum (Emin) values of stiffness were generated. The area under the receiver operating characteristic curve (AUROC) for predicting clinically significant cancer (CSC) was calculated. Interobserver reliability and variability were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman plots, respectively.</p><p><strong>Results: </strong>PCa was found in 78 of 488 regions (16%) in 17 patients. In region-based and patientbased analyses, the Emax, Emean, and Emin values of PCa were significantly higher than those of benign prostate tissue (P<0.001). For the prediction of CSC, the AUROCs of Emax, Emean, and Emin in the patient-based analysis were 0.865, 0.855, and 0.828, while that of prostate-specific antigen density was 0.749. In the region-based analysis, the AUROCs of Emax, Emean, and Emin values were 0.772, 0.776, and 0.727, respectively. The interobserver reliability for the SWE parameters was moderate to good (ICC, 0.542 to 0.769), and the mean percentage differences on Bland-Altman plots were less than 7.0%.</p><p><strong>Conclusion: </strong>The 2D-SWE method appears to be a reproducible and useful tool for the prediction of PCa. A larger study is warranted for further validation.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"400-409"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/19/usg-22202.PMC10331058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jung Wook Seo, Youe Ree Kim, Jong Keon Jang, So Yeon Kim, Young Youn Cho, Eun Sun Lee, Dong Ho Lee
{"title":"Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD.","authors":"Jung Wook Seo, Youe Ree Kim, Jong Keon Jang, So Yeon Kim, Young Youn Cho, Eun Sun Lee, Dong Ho Lee","doi":"10.14366/usg.22212","DOIUrl":"https://doi.org/10.14366/usg.22212","url":null,"abstract":"Purpose This study compared the controlled attenuation parameter (CAP) to attenuation imaging (ATI) in the diagnosis of steatosis and transient elastography (TE) to two-dimensional shear wave elastography (2D-SWE) for the diagnosis of fibrosis in a prospectively constructed nonalcoholic fatty liver disease (NAFLD) patient cohort. Methods Participants who underwent TE with CAP were included from a previously constructed NAFLD cohort with multiparametric ultrasound data. The degree of hepatic steatosis and stage of liver fibrosis were assessed. Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUROC) for the grades of steatosis (S1-3) and fibrosis (F0-F4). Results There were 105 participants. The distribution of hepatic steatosis grades (S0-S3) and liver fibrosis stages (F0-F4) was as follows: S0, n=34; S1, n=41; S2, n=22; S3, n=8; F0, n=63; F1, n=25; F2, n=5; F3, n=7; and F4, n=5. No significant difference was found between CAP and ATI in detecting ≥S1 (AUROC: 0.93 vs. 0.93, P=0.956) or ≥S2 (0.94 vs. 0.94, P=0.769). However, the AUROC of ATI in detecting ≥S3 was significantly higher than that of CAP (0.94 vs. 0.87, P=0.047). Regarding the detection of liver fibrosis, no significant difference was found between TE and 2D-SWE. The AUROCs of TE and 2D-SWE were as follows: ≥F1, 0.94 vs. 0.89 (P=0.107); ≥F2, 0.89 vs. 0.90 (P=0.644); ≥F3, 0.91 vs. 0.90 (P=0.703); and ≥F4, 0.88 vs. 0.92 (P=0.209). Conclusion 2D-SWE and TE showed comparable diagnostic performance in assessing liver fibrosis, and ATI provided significantly better performance in detecting ≥S3 steatosis than CAP.","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"421-431"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/8e/usg-22212.PMC10331060.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jae Seok Bae, Jae Young Lee, Dong Ho Lee, Sae-Won Han, Yoojoo Lim, Tae-You Kim
{"title":"Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography.","authors":"Jae Seok Bae, Jae Young Lee, Dong Ho Lee, Sae-Won Han, Yoojoo Lim, Tae-You Kim","doi":"10.14366/usg.22214","DOIUrl":"https://doi.org/10.14366/usg.22214","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to assess the role of the shear-wave velocity (SWV) value in predicting chemotherapeutic response and progression-free survival (PFS) in patients with colorectal cancer liver metastasis (CRLM).</p><p><strong>Methods: </strong>In this prospective single-center study, participants with CRLM scheduled for chemotherapy were enrolled between May 2018 and June 2021. SWV measurements were obtained using shear-wave elastography at the CRLM site before and after initiating chemotherapy. Based on the Response Evaluation Criteria in Solid Tumors, the participants were categorized by chemotherapeutic response into responders (complete remission and partial remission) and non-responders (stable disease and progressive disease). Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the performance of changes in SWV measurements in predicting the chemotherapeutic response of CRLM. In addition, a Cox proportional hazards model was used to identify variables associated with PFS.</p><p><strong>Results: </strong>In total, 67 participants (40 men; mean age, 62.3±10.1 years) were enrolled, including 34 responders and 33 non-responders. The area under the ROC curve, sensitivity, and negative predictive value of the SWV measurement in predicting non-responders were 0.840, 97.0%, and 95.2%, respectively, using a cutoff value of a 13% decrease. Additionally, a change in SWV values was independently associated with PFS (hazard ratio, 1.020), non-responder status, and the presence of five or more CRLMs.</p><p><strong>Conclusion: </strong>A change in SWV values measured after chemotherapy demonstrated meaningful diagnostic performance in predicting non-responsiveness among patients with CRLM. Additionally, a change in SWV values was independently associated with PFS.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"457-465"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/b3/usg-22214.PMC10331051.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sung Il Jung, Min Hoan Moon, Chang Kyu Sung, Myoung Seok Lee, Jeong Hwan Park, Sohee Oh
{"title":"Renal Doppler ultrasonography for predicting non-diabetic kidney disease in patients with diabetes.","authors":"Sung Il Jung, Min Hoan Moon, Chang Kyu Sung, Myoung Seok Lee, Jeong Hwan Park, Sohee Oh","doi":"10.14366/usg.23028","DOIUrl":"https://doi.org/10.14366/usg.23028","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to assess the role of renal Doppler ultrasonography (US) in predicting non-diabetic kidney disease (NDKD) in patients with diabetes, using histologic findings as the reference standard.</p><p><strong>Methods: </strong>Fifty-nine consecutive patients with diabetes who underwent renal Doppler US and native kidney biopsy were included in this retrospective, single-institutional study. Based on histologic findings, patients were classified as having diabetic nephropathy (DN) or NDKD. Renal Doppler US findings, including cortical echogenicity, corticomedullary differentiation, and the resistive index (RI), were compared between DN and NDKD. A subgroup analysis according to chronic kidney disease (CKD) status was also performed.</p><p><strong>Results: </strong>Cortical echogenicity and corticomedullary differentiation showed no significant differences between DN and NDKD (P=0.887 and P>0.99, respectively), whereas the RI was significantly higher in patients with DN than in those with NDKD (P=0.032). The subgroup analysis revealed a significant difference in the RI between DN and NDKD in patients with diabetes and CKD (P=0.010), but a significant difference was not found in those without CKD (P=0.713). When limited to patients with diabetes and CKD, the RI had an area under the curve value of 0.759, sensitivity of 57.1%, specificity of 81.0%, positive likelihood ratio of 3.0, and negative LR of 0.5 for predicting NDKD, using a cutoff value of ≤0.69.</p><p><strong>Conclusion: </strong>Renal Doppler US may be useful in predicting NDKD in patients with diabetes and CKD.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"440-445"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/bc/usg-23028.PMC10331050.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modified CEUS LI-RADS using Sonazoid for the diagnosis of hepatocellular carcinoma.","authors":"Katsutoshi Sugimoto, Naohisa Kamiyama, Tatsuya Kakegawa, Hiroshi Takahashi, Takuya Wada, Masakazu Abe, Yu Yoshimasu, Hirohito Takeuchi, Takao Itoi","doi":"10.14366/usg.23065","DOIUrl":"https://doi.org/10.14366/usg.23065","url":null,"abstract":"<p><p>This review outlines several modified versions of the contrast-enhanced ultrasonography Liver Imaging Reporting and Data System (CEUS LI-RADS) that utilize Sonazoid. Furthermore, it discusses the advantages and challenges of diagnosing hepatocellular carcinoma using these guidelines, as well as the authors' expectations and opinions regarding the next CEUS LI-RADS version. It is possible that Sonazoid could be incorporated into the next version of CEUS LI-RADS.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"388-399"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/b3/usg-23065.PMC10331059.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9769540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation.","authors":"Wei-Che Lin, Wen-Chieh Chen, Pei-Wen Wang, Yi-Chia Chan, Yen-Hsiang Chang, Harn-Shen Chen, Szu-Tah Chen, Wei-Chih Chen, Kai-Lun Cheng, Shun-Yu Chi, Pi-Ling Chiang, Chen-Kai Chou, Feng-Fu Chou, Shun-Chen Huang, Feng-Hsuan Liu, Sheng-Dean Luo, Fen-Yu Tseng, Chih-Yuan Wang, Wen-Hung Wang, Ming-Hsun Wu","doi":"10.14366/usg.22126","DOIUrl":"https://doi.org/10.14366/usg.22126","url":null,"abstract":"<p><p>Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies for specialists in interventional radiology, endocrinology, and endocrine surgery collaborated to develop the first consensus regarding thyroid RFA in Taiwan. The modified Delphi method was used to reach a consensus. Based on a comprehensive review of recent and valuable literature and expert opinions, the recommendations included indications, pre-procedural evaluations, procedural techniques, post-procedural monitoring, efficacy, and safety, providing a comprehensive review of the application of RFA. The consensus effectively consolidates advice regarding thyroid RFA in clinical practice for local experts.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 3","pages":"357-375"},"PeriodicalIF":3.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/c8/usg-22126.PMC10331054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"US features of normal parathyroid glands: a comparison with metastatic lymph nodes in thyroid cancer.","authors":"Seong Ju Kim, Dong Gyu Na, Byeong-Joo Noh","doi":"10.14366/usg.22119","DOIUrl":"https://doi.org/10.14366/usg.22119","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the ultrasound (US) features of normal parathyroid glands (PTGs) and to evaluate whether normal PTGs can be differentiated from metastatic lymph nodes (LNs) in thyroid cancer.</p><p><strong>Methods: </strong>This retrospective study included 10 normal PTGs and 95 metastatic LNs from thyroid cancer showing suspicious US features. The echogenicity, echotexture, echogenic foci (calcifications), cystic change, abnormal vascularity, size, shape, and location were retrospectively assessed and compared between normal PTGs and metastatic LNs.</p><p><strong>Results: </strong>The echogenicity of normal PTGs was significantly different from that of metastatic LNs (P<0.001). Normal PTGs exhibited marked hyperechogenicity (100%), homogeneous echotexture (80%), focal intraglandular hypoechogenicity (20%), ovoid shape (90%), and focal cystic change in one case (10%). The echogenicity of metastatic LNs was markedly hyperechoic (0%), moderately hyperechoic (15.8%), mildly hyperechoic (53.7%), and hypoechoic (28.4%). The size and long axis/short axis ratios of normal PTGs were significantly smaller and larger than those of metastatic LNs (P<0.01 and P=0.022, respectively).</p><p><strong>Conclusion: </strong>Marked hyperechogenicity was found only in normal PTGs, and small, ovoid, markedly hyperechoic structures in the paramedian central neck characterized normal PTGs. Normal PTGs may be differentiated from metastatic LNs in thyroid cancer.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"203-213"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/b6/usg-22119.PMC10071065.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soo-Yeon Kim, Han-Byoel Lee, Wonshik Han, Su Hyun Lee, Jung Min Chang, Nariya Cho
{"title":"Role of Doppler US and elastography prior to biopsy to identify candidates for avoidance of surgery following neoadjuvant chemotherapy for breast cancer.","authors":"Soo-Yeon Kim, Han-Byoel Lee, Wonshik Han, Su Hyun Lee, Jung Min Chang, Nariya Cho","doi":"10.14366/usg.22185","DOIUrl":"https://doi.org/10.14366/usg.22185","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the role of Doppler ultrasound (US) and elastography to identify residual breast cancer for patients showing near complete response following chemotherapy on magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Between September 2016 and January 2018, 40 breast cancer patients who showed near complete response (either tumor size ≤0.5 cm or lesion-to-background parenchymal signal enhancement ratio ≤1.6) on MRI following neoadjuvant chemotherapy were prospectively enrolled. After excluding seven women who did not undergo Doppler US and elastography, 33 women (median age, 49 years; range, 32 to 67 years) were analyzed. On the day of surgery, women underwent Doppler US and elastography for tumor bed prior to US-guided core needle biopsy. Histopathologic results of biopsy and surgery were evaluated. Negative predictive value (NPV) and false negative rate (FNR) of biopsy and the combined Doppler US and elastography were analyzed, respectively.</p><p><strong>Results: </strong>After surgery, nine women had residual cancers and 24 women had pathologic complete response. The NPV and FNR of biopsy were 92% (24 of 26) and 22% (2 of 9), respectively. The NPV and FNR of combined Doppler US and elastography were 100% (14 of 14) and 0% (0 of 9), respectively. All of nine women with residual cancers had positive vascularity or elasticity. Two women with false-negative biopsy results, having 0.3 cm or 2.5 cm ductal carcinoma in situ at surgery, showed positive vascularity or elasticity.</p><p><strong>Conclusion: </strong>Tumor bed showing positive vascularity or elasticity indicates residual breast cancer for patients showing near complete response on MRI following chemotherapy.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"42 2","pages":"323-332"},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/00/usg-22185.PMC10071055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9637995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}