Current Medical Imaging Reviews最新文献

{"title":"Voxel-Based Specific Regional Analysis System for Alzheimer's Disease and Arterial Spin Labeling in Brain Magnetic Resonance Imaging: A Comparative Study.","authors":"Yukinori Okada, Norikazu Ohno, Yoshisuke Kitahara, Hirofumi Niioka, Koji Tanaka, Hiromitsu Ueda, Katsunori Tsujii, Masayuki Sato","doi":"10.2174/0115734056337828250526070304","DOIUrl":"https://doi.org/10.2174/0115734056337828250526070304","url":null,"abstract":"<p><p><p> Introduction: Magnetic resonance imaging can differentiate Alzheimer-type dementia from dementia with Lewy bodies using voxel-based specific regional analysis systems for Alzheimer's disease and arterial spin labeling, which reveal reduced blood flow from the posterior cingulate gyrus to the precuneus in Alzheimer-type dementia. However, the relationship between voxel-based specific regional analysis system scores and arterial spin labeling remains unclear. To investigate the relationship between brain atrophy scores and arterial spin labeling values in the posterior cingulate precuneus. </p> <p> Methods: Participants with suspected dementia who underwent brain magnetic resonance imaging using a voxel-based regional analysis system were included. They were classified as follows: Group 1 (suspected Alzheimer-type dementia) had atrophy ≥2 in the volume of interest; Group 2 (suspected dementia with Lewy body) had atrophy <2 in the volume of interest and ≥0.2 in the gray and white matter of the dorsal brainstem; and Group 3 included those not meeting these criteria. Correlation values among atrophy within the volume of interest, percentage of atrophic areas, atrophy ratio, percentage of total brain atrophy, age, and maximum arterial spin labeling value at the posterior cingulate precuneus were evaluated. </p> <p> Results: Groups 1, 2, and 3 comprised 179, 143, and 197 patients, respectively. Arterial spin labeling values at the posterior cingulate precuneus were 77.0±24.4-77.3±25.2, 78.3±81.3-80.2±23.6, and 80.2±22.3-80.4±22.8 mL/min/100 g, respectively. Group 1 had a correlation coefficient between total brain atrophy and arterial spin labeling of -0.189 to-0.214 (P<0.01). Group 2 had a correlation coefficient between total brain atrophy and arterial spin labeling of -0.215 to -0.223 (P<0.01). Group 3 showed no significant correlations. No statistically significant difference was observed in ASL 1 and 2 values between the Alzheimer-type dementia and other groups (ASL 1: 74.5 mL/min/100 g vs. 78.8 mL/min/100 g, P=0.08; ASL 2: 74.8 mL/min/100 g vs. 79.2 mL/min/100 g, P=0.101). No statistically significant difference was observed in ASL 1 and 2 values between the Alzheimer-type dementia and DLB groups (ASL 1: 74.5 mL/min/100 g vs. 69.3. mL/min/100 g, P=0.093; ASL 2: 74.8 mL/min/100 g vs. 78.9 mL/min/100 g, P=0.258). </p> <p> Discussion: Reduced blood flow in the posterior cingulate gyrus and precuneus shows only a weak correlation with brain atrophy in both Alzheimer-type dementia and dementia with Lewy bodies. Therefore, it is not a reliable marker for differentiating Alzheimer-type dementia from dementia with Lewy bodies and other groups. </p> <p> Conclusion: It is necessary to avoid using cerebral blood flow assessment alone when diagnosing dementia. </p>.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anal Extrusion of Ventriculoperitoneal Shunt Distal Catheter: A Case Report and Literature Review.","authors":"Jasmine Ahmed Alturaiki, Eissa Alousi, Mustafa Alhelal, Ali AlKhamees, Awn Alessa, Ibrahim Alahmed, Abdulsalam Mohammed Aleid","doi":"10.2174/0115734056392417250628194723","DOIUrl":"https://doi.org/10.2174/0115734056392417250628194723","url":null,"abstract":"<p><strong>Background: </strong>The standard treatment for hydrocephalus is often the placement of a ventriculoperitoneal shunt (VPS), especially in patients with myelomeningocele (MMC). This case report aimed to enrich the existing knowledge by presenting a rare instance of asymptomatic anal extrusion of a VPS catheter in an infant, along with a review of the relevant literature.</p><p><strong>Case presentation: </strong>A 2-month-old male infant with myelomeningocele (MMC) and hydrocephalus presented with asymptomatic anal extrusion of his ventriculoperitoneal shunt (VPS) catheter, discovered by his mother. Emergency imaging revealed distal catheter migration through the rectosigmoid junction. Surgical management included (1) laparoscopic-assisted catheter removal with bowel repair using Vicryl sutures, (2) intraoperative external ventricular drain (EVD) placement, and (3) 14-day antibiotic prophylaxis. Cerebrospinal fluid analysis remained normal throughout the treatment. Following three weeks of infection monitoring, contralateral VPS replacement was performed successfully, with postoperative imaging confirming optimal shunt function and resolved hydrocephalus. This case highlighted the importance of caregiver vigilance in identifying this rare but serious complication, even in asymptomatic patients (Fig. 1).</p><p><strong>Conclusion: </strong>Although anal extrusion of a VPS catheter is an uncommon but serious complication, primarily seen in pediatric patients, it can lead to lifethreatening infections if untreated. Prompt surgical intervention along with broad-spectrum antibiotic therapy is critical. This report highlights the need for recognizing classic symptoms of intestinal perforation and catheter migration in pediatric patients.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of Heart-related Imaging from Lung Electrical Impedance Tomography Using Semi-Siamese U-Net.","authors":"Yen-Fen Ko, Yue-Der Lin, Po-Lan Su","doi":"10.2174/0115734056408077250610070821","DOIUrl":"https://doi.org/10.2174/0115734056408077250610070821","url":null,"abstract":"<p><strong>Introduction: </strong>Electrical Impedance Tomography (EIT) is widely used for bedside ventilation monitoring but is limited in reconstructing cardiac-related signals due to the dominance of lung impedance changes. This study aims to reconstruct heart-related impedance imaging from lung EIT using a novel semi-Siamese U-Net architecture.</p><p><strong>Methods: </strong>A deep learning model was developed with a shared encoder and two decoders designed to segment lung and heart regions independently. The model was trained and validated on FEM-based EIT simulations and tested on real human EIT data. A weighted binary cross-entropy loss was applied to emphasize cardiac-related learning.</p><p><strong>Results: </strong>The model achieved a Dice coefficient >0.99 and MAE <0.1% on simulation data. It successfully separated lung and heart regions on human EIT frames without additional fine-tuning, demonstrating strong generalization capacity.</p><p><strong>Discussion: </strong>These findings reveal that the semi-Siamese U-Net can overcome signal dominance and improve cardiac-related EIT reconstruction. However, promising results are currently limited to qualitative evaluation of real data and simulation-based training.</p><p><strong>Conclusion: </strong>The proposed method offers a potential pathway for simultaneous lung-heart monitoring in ICU settings. Future work will focus on clinical validation and real-time implementation.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dark Corner of the Pituitary Gland: A Case Report and Literature Review of Primary Melanocytoma.","authors":"Jiajing Ni, Jianhua Wang","doi":"10.2174/0115734056359260250623115500","DOIUrl":"https://doi.org/10.2174/0115734056359260250623115500","url":null,"abstract":"<p><strong>Background: </strong>Primary pituitary melanocytoma, an exceedingly rare tumor, may resemble pituitary adenoma with apoplexy owing to its heterogeneous melanin concentration and possible hemorrhagic events. An accurate diagnosis of melanocytoma is, therefore, essential.</p><p><strong>Case presentation: </strong>We present a case of a 31-year-old female patient who exhibited a progressively worsening headache that commenced one month prior. MRI showed a significantly enlarged sella turcica with a gourd-shaped lesion that had a mixture of short T1 and T2 signals. In conjunction with the MRI findings, CT scans, both non-contrast and contrast-enhanced, revealed a circular, dense region in the sellar area, exhibiting heightened enhancement post-contrast administration. Subsequently, this patient was scheduled for endoscopic transnasal skull base tumor resection and skull base reconstruction. Later, histopathological assessment showed red-S-100 (+), red-melanin A (+), red-KI-67 (+5%), red-melanoma (+), P53 (+), red-P53 (+) and Ki-67 (+) and suggested an intermediate-grade melanocytoma, positioning this lesion between benign and malignant on the spectrum of melanocytic neoplasms.</p><p><strong>Conclusion: </strong>This case report evaluated the presentation, key imaging findings, and histopathological features that help differentiate primary melanocytoma from other tumors and discussed key management and prognostic considerations following diagnosis.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationshıp between Condylar and Ramal Asymmetrıes and Abo and Rh Blood Groups.","authors":"Mehmet Emrah Polat, Halil Ibrahim Durmus, Mehmet Gul","doi":"10.2174/0115734056378135250618150104","DOIUrl":"https://doi.org/10.2174/0115734056378135250618150104","url":null,"abstract":"<p><strong>Objective: </strong>The association between ABO and Rh blood groups and diseases is an intriguing topic that continues to be studied, but their potential influence on mandibular asymmetry has not been explored. Temporomandibular joint (TMJ) disorders are multifactorial, and subtle anatomical variations may be linked to genetic predispositions. Our study aims to investigate the relationship between ABO and Rh blood groups and mandibular condylar and ramal asymmetries in a healthy adult Turkish population.</p><p><strong>Materials and methods: </strong>This study included 149 adult patients (67 males, 82 females) who had no history of systemic diseases, craniofacial deformities, or TMJ-related complaints. Asymmetry was assessed in panoramic radiographic images using a formula developed in a previous study. The chi-square and Kruskal-Wallis tests were used to analyze differences among ABO groups while the Mann-Whitney U test was used for Rh groups.</p><p><strong>Results: </strong>No significant difference was found in terms of gender distribution, Rh factor or age between ABO or Rh groups. However, there was a significant difference in condylar asymmetry index (CAI) between ABO groups (p < 0.05). Pairwise comparisons revealed that individuals with AB blood type exhibited significantly higher CAI values compared to those with B blood type. No statistically significant differences in asymmetry indices were observed between Rh groups.</p><p><strong>Conclusion: </strong>The findings of our study indicate the existence of a significant relationship between blood groups and asymmetry indices in a healthy population. The significant differences in condylar asymmetry between AB and B blood groups indicate a possible association between blood type and mandibular anatomical variations, rather than a causal relationship. Further studies are needed to confirm these findings and to understand the underlying mechanisms of the relationship between blood groups and mandibular asymmetry.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis.","authors":"Zhengjun Li, Fan Zhang, Weiting Lu, Chao Lu, Zheng Yuan, Zhongqiu Wang","doi":"10.2174/0115734056379090250611073434","DOIUrl":"https://doi.org/10.2174/0115734056379090250611073434","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to detect the performance of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for assessing primary biliary cholangitis (PBC).</p><p><strong>Methods: </strong>Seventy-five patients with PBC were included in this prospective study. Shear wave elastography (SWE) and Gd-EOB-DTPA-enhanced MRI were conducted, and then the signal intensity ratio (SIR) and contrast enhancement index (CEI) in different phases, including portal venous phase (PVP), equilibrium phase (EP), and hepatobiliary phase (HBP), were calculated. Afterward, the results were compared with Child-Pugh grading and non-invasive liver fibrosis models using the Kruskal-Wallis H test or Chi-squared test. The area under the curve (AUC) was applied to evaluate the diagnostic performance of SIR_HBP, CEI_HBP, and SWE across different Child-Pugh grades.</p><p><strong>Results: </strong>SWE (p<0.001), SIR _HBP (p<0.001), CEI_HBP (p<0.001), APRI (p=0.002), and FIB-4(p<0.001) showed significant differences in different Child-Pugh grades. Statistically significant differences were found in SIRHBP (p=0.005), CEI_HBP (p=0.010), and FIB-4 (p=0.001) of different SWE levels. For the diagnosis of Child-Pugh C, the AUC of SWE, SIR_HBP, and CEI_HBP were 0.889, 0.778, and 0.761, respectively. Correspondingly, the sensitivity was 75.0%, 64.4%, and 54.2%, and the specificity was 94.9%, 100%, and 100%, respectively. For the diagnosis of Child-Pugh B+C, the AUC of SWE, SIR_HBP, and CEI_HBP were 0.919, 0.809, and 0.814, respectively.</p><p><strong>Discussion: </strong>Our study confirmed that Gd-EOB-DTPA-enhanced MRI is an effective and objective method for assessing liver function in patients with PBC.</p><p><strong>Conclusion: </strong>SIR_HBP and CEI_HBP could be regarded as a novel imaging biomarker to evaluate liver function. Gd-EOB-DTPA-enhanced MRI and SWE outperformed serum-based models in sensitivity and specificity, strengthening the value of imaging in clinical decision-making.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Related Factors of Ultrasound-guided Lauromacrogol Injection in Treating Symptomatic Hepatic Cysts with a Diameter of <10cm: A Retrospective Study.","authors":"Qingyin Fu, Bin Hu, Jixian Lin, Qiping Liu, Tonghui Yang, Qiong Chen","doi":"10.2174/0115734056356792250610102812","DOIUrl":"https://doi.org/10.2174/0115734056356792250610102812","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to retrospectively analyze the curative effect and influencing factors of lauromacrogol in the treatment of symptomatic hepatic cysts of <10 cm.</p><p><strong>Methods: </strong>In this study, a total of 51 patients with symptomatic hepatic cysts (maximum diameter ranging from 5 cm to 10 cm) were included. Polycystic Liver Disease Questionnaire (PLD-Q) was used to evaluate the symptoms of patients prior to treatment. The patients were followed up at 1, 3, 6, and 12 months after treatment. At the 12-month follow-up, patients were asked to fill out the PLD-Q to assess their symptoms. The improvement rate of patients' symptoms was evaluated using a 5-point Likert scale (worse, 1; slight difference, 2; roughly the same, 3; good, and 4; better, 5. Volume reduction rate (VRR) was calculated by measuring the volume of the cyst cavity via ultrasound. Treatment success at the 12-month follow-up was determined using two criteria: symptom improvement and changes in cyst volume. Symptom improvement was assessed using a Likert Scale, with a score greater than 3 points indicating significant improvement. Additionally, a volume reduction rate (VRR) of 50% or more in cyst size (VRR ≥ 50%) was considered an effective treatment outcome. The relationship between the clinical factors and the ultrasonographic manifestations of hepatic cysts, including the initial maximum diameter of the cyst (measured using ultrasound before operation), the initial volume of the cyst, and the formation of septa after sclerosis of the cyst, was analyzed.</p><p><strong>Results: </strong>All patients completed at least 12 months of follow-up. After a 12-month follow-up, the effective and ineffective rates were 96.1% (49/51) and 3.9% (2/51), respectively. The logistic regression univariate analysis showed significant differences in the initial cyst volume (p = 0.001), the initial maximum diameter of the cyst (p = 0.005), and the interval formation after cyst sclerosis (p = <0.001) between VRR ≥ 50% and VRR < 50%. Logistic regression analysis demonstrated that septa formation after cyst sclerosis was an independent factor related to treatment failure, with an odds ratio of 3.246 (95% confidence interval, 0.784-4.148).</p><p><strong>Conclusion: </strong>Lauromacrogol is an effective method for hepatic cyst treatment. Septa formation after cyst sclerosis is an independent factor related to ineffective treatment.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Field MRI: A Paradigm Shift in Medical Imaging.","authors":"Ayush Dogra","doi":"10.2174/0115734056397346250609162719","DOIUrl":"https://doi.org/10.2174/0115734056397346250609162719","url":null,"abstract":"","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimised Convolution Layers of DnCNN Using Vedic Multiplier and Hyperparameter Tuning in Cancer Detection on Field Programmable Gate Array.","authors":"S Roobini Priya, Prema Vanaja Ranjan, Shanker Nagalingam Rajediran","doi":"10.2174/0115734056400656250616073019","DOIUrl":"https://doi.org/10.2174/0115734056400656250616073019","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, deep learning (DL) algorithms use Arithmetic Units (AU) in CPU/GPU hardware for processing images/data. AU operates in fixed precision and limits the representation of weights and activations in DL. The problem leads to quantization errors, which reduce accuracy during cancer cell segmentation.</p><p><strong>Methods: </strong>In this study, arithmetic multiplication in convolution layers is replaced with Vedic multiplication in the proposed DnCNN algorithm. Next, Vedic multiplication-based convolution layers in the DnCNN architecture are optimized using POA (Pelican Optimization Algorithm), and the resulting POA-DnCNN is implemented on an FPGA device for breast cancer detection, segmentation, and classification of benign and malignant breast lesions.</p><p><strong>Discussion: </strong>In the convolution layer of DnCNN, floating-point operations are performed through the Hybrid-Vedic (HV) multiplier called 'CUTIN,' which is the combination of <i>Urdhva Tryambakam</i> and <i>Nikhilam Sutra</i> with the upasutra '<i>Anurupyena</i>.' Larger image sizes increase processor size and gate count.</p><p><strong>Results: </strong>The proposed HV-FPGA-based breast cancer detection system, employing Vedic multiplication in the convolution layers of DnCNN and hyperparameters optimized by POA, detects stages of breast cancer with an accuracy of 96.3%, precision of 94.54%, specificity of 92.37%, F-score of 93.56%, IoU of 94.78%, and DSC of 95.45%, outperforming existing methods.</p><p><strong>Conclusion: </strong>The proposed CUTIN multiplier uses a CSA (carry save adder) with simplified sum-carry generation logic (CSCGL), achieving lower area-delay, high speed, and improved precision.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Significance of Femoral and Tibial Anatomy for Anterior Cruciate Ligament Injury and Reconstruction.","authors":"Fong Fong Liew, Junqing Liang","doi":"10.2174/0115734056361050250605052447","DOIUrl":"https://doi.org/10.2174/0115734056361050250605052447","url":null,"abstract":"<p><p>The anterior cruciate ligament (ACL) is a crucial stabilizer of the knee joint, and its injury risk and surgical outcomes are closely linked to femoral and tibial anatomy. This review focuses on current evidence on how skeletal parameters, such as femoral intercondylar notch morphology, tibial slope, and insertion site variations-influence ACL biomechanics. A narrowed or concave femoral notch raises the risk of impingement, while a higher posterior tibial slope makes anterior tibial translation worse, which increases ACL strain. Gender disparities exist, with females exhibiting smaller notch dimensions, and hormonal fluctuations may contribute to ligament laxity. Anatomical changes that come with getting older make clinical management even harder. Adolescent patients have problems with epiphyseal growth, and older patients have to deal with degenerative notch narrowing and lower bone density. Preoperative imaging (MRI, CT, and 3D reconstruction) enables precise assessment of anatomical variations, guiding individualized surgical strategies. Optimal femoral and tibial tunnel placement during reconstruction is vital to replicate native ACL biomechanics and avoid graft failure. Emerging technologies, including AI-driven segmentation and deep learning models, enhance risk prediction and intraoperative precision. Furthermore, synergistic factors, such as meniscal integrity and posterior oblique ligament anatomy, need to be integrated into comprehensive evaluations. Future directions emphasize personalized approaches, combining advanced imaging, neuromuscular training, and artificial intelligence to optimize prevention, diagnosis, and rehabilitation. Addressing age-specific challenges, such as growth plate preservation in pediatric cases and osteoarthritis management in the elderly, will improve long-term outcomes. Ultimately, a nuanced understanding of skeletal anatomy and technological integration holds promise for reducing ACL reinjury rates and enhancing patient recovery.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}