Retinal Cases and Brief Reports最新文献_第5页

DELAYED SPONTANEOUS CLOSURE OF A FULL-THICKNESS MYOPIC MACULAR HOLE WITH GOOD VISUAL RECOVERY. 全厚近视黄斑孔延迟自发闭合，视力恢复良好

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001535

Jin Kyun Oh, Stanley Chang

{"title":"DELAYED SPONTANEOUS CLOSURE OF A FULL-THICKNESS MYOPIC MACULAR HOLE WITH GOOD VISUAL RECOVERY.","authors":"Jin Kyun Oh, Stanley Chang","doi":"10.1097/ICB.0000000000001535","DOIUrl":"10.1097/ICB.0000000000001535","url":null,"abstract":"Purpose: The aim of this study was to present the longitudinal progression of a myopic macular hole with eventual closure and excellent visual recovery over a decade after initial full-thickness hole formation.Methods: The patient was monitored using time domain and spectral domain optical coherence tomography images over 16 years.Results: A 68-year-old man with high myopia was referred for surgical evaluation of a full-thickness macular hole and retinal detachment of his left eye, which were repaired. At the initial presentation, the fellow eye demonstrated a lamellar hole, which eventually also progressed to become a full-thickness macular hole. The patient subsequently declined surgery and was observed semiannually over the course of 16 years. At 10 years after the initial injury, the full-thickness macular hole closed spontaneously. The visual recovery was excellent with an acuity of 20/25.Conclusion: Although surgical intervention remains the mainstay of treatment for macular holes, patients who are not surgical candidates may still have good visual and anatomic outcomes even long after initial hole formation. Lamellar hole epiretinal proliferation material is frequently seen in myopic full-thickness macular holes and may be associated with eventually delayed hole closure because of their slow progression.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"244-247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PROGRESSIVE RETINOPATHY IN A PATIENT WITH MUCOPOLYSACCHARIDOSIS TYPE II UNDERGOING ENZYME REPLACEMENT THERAPY: A CASE REPORT. 一名接受酶替代疗法的 II 型黏多醣症患者的进行性视网膜病变：病例报告。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001537

Margot C Wouters, Michel Van Lint

引用次数: 0

HYDROXYCHLOROQUINE CAN BE RESUMED WITH CLOSE MONITORING AFTER RETINOPATHY HAS DEVELOPED, WITHOUT MAJOR VISUAL LOSS: CASE REPORT. 在视网膜病变发生后，可以在密切监测的情况下恢复使用羟氯喹，但不会造成严重的视力损失：病例报告。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001536

Janet S Sunness, Rivka Hadassah Sunness, David B Hellmann

{"title":"HYDROXYCHLOROQUINE CAN BE RESUMED WITH CLOSE MONITORING AFTER RETINOPATHY HAS DEVELOPED, WITHOUT MAJOR VISUAL LOSS: CASE REPORT.","authors":"Janet S Sunness, Rivka Hadassah Sunness, David B Hellmann","doi":"10.1097/ICB.0000000000001536","DOIUrl":"10.1097/ICB.0000000000001536","url":null,"abstract":"Purpose: The aim of this study was to present a patient with systemic lupus erythematosus on longstanding hydroxychloroquine (HCQ) use for whom HCQ was stopped because of signs of toxicity and then resumed four years later because of dire systemic need.Methods: This is a long-term retrospective study. Humphrey visual fields (10-2 and 24-2), fundus autofluorescence imaging, and spectral domain optical coherence tomography (OCT) were used to follow progression over time.Results: The patient was on HCQ for 26 years, with a cumulative dose over 3,000 g. HCQ was stopped in 2011 because of macular toxicity. She remained off HCQ for four years, during which time she developed type 1 diabetes due to an immunologic attack on the pancreas and then JC (John Cunningham) viremia after a period of treatment with mycophenolate, which put her at risk for progressive multifocal leukoencephalopathy. Mycophenolate was discontinued, and HCQ was resumed with careful follow-up over the next 7 years. The toxic maculopathy showed only mild slow progression since HCQ was resumed.Conclusion: Careful annual monitoring using Humphrey visual field 10-2 and spectral domain OCT imaging remains the standard of care for the patients on HCQ. However, it may be possible with close monitoring when there is compelling systemic need to resume HCQ after it has been stopped, with only slow progression of the retinopathy. This allowed the patient to have an improved quality of life and reduced the risk of severe morbidity and mortality.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"253-258"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASYMPTOMATIC RETINAL DYSFUNCTION AND RETINAL ABNORMALITIES IN A PATIENT WITH ALPHA-METHYLACYL-COA RACEMASE DEFICIENCY. 一名α-甲基乙酰-CoA消旋酶缺乏症患者无症状的视网膜功能障碍。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001549

Dimitrios Kalogeropoulos, Lilia Lagha, Andrew J Lotery

{"title":"ASYMPTOMATIC RETINAL DYSFUNCTION AND RETINAL ABNORMALITIES IN A PATIENT WITH ALPHA-METHYLACYL-COA RACEMASE DEFICIENCY.","authors":"Dimitrios Kalogeropoulos, Lilia Lagha, Andrew J Lotery","doi":"10.1097/ICB.0000000000001549","DOIUrl":"10.1097/ICB.0000000000001549","url":null,"abstract":"Purpose: The aim of this study was to present a case of a young female patient with asymptomatic retinal dysfunction associated with alpha-methylacyl-CoA (alpha-methylacyl-CoA racemase) racemase deficiency.Methods: This was a retrospective analysis of the medical notes of a single patient. Detailed slit-lamp examination was completed by Optos color fundus photography and enhanced depth imaging optical coherence tomography. Genetic testing was conducted to establish the diagnosis, and the patient was also referred to the Department of Neurology for further assessment.Results: Dilated fundoscopy and ophthalmic imaging revealed bilateral retinal pigment epithelium abnormalities that could be associated with a genetic retinal disorder. Indeed, genetic testing showed that this lady was homozygous for alpha-methylacyl-CoA racemase (OMIM 604489; Gene ID 23600) variant NM 014324.6: c.154T>C; p.(Ser52Pro). She had no detectable neurological deficit.Conclusion: Alpha-methylacyl-CoA racemase deficiency is a rare genetic condition that can potentially contribute to retinal dystrophy through various mechanisms. In addition, it may lead to a wide spectrum of systemic signs and symptoms. Interestingly, in contrast to other reported studies, the patient was completely asymptomatic, with no evidence of systemic disorders.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"286-288"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHOROIDAL OSTEOMA IN AN INFANT. 婴儿脉络膜骨瘤

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001526

Adrianna E Eder, Karina Bostwick, Jill R Wells, G Baker Hubbard

{"title":"CHOROIDAL OSTEOMA IN AN INFANT.","authors":"Adrianna E Eder, Karina Bostwick, Jill R Wells, G Baker Hubbard","doi":"10.1097/ICB.0000000000001526","DOIUrl":"10.1097/ICB.0000000000001526","url":null,"abstract":"Purpose: The aim of this study was to describe a case of choroidal osteoma with macular involvement in an infant who was treated with transpupillary thermotherapy.Methods: This was a case report.Results: An 11-month-old infant presented for retinopathy of prematurity follow-up examination and was found to have a three disk-diameter round, orange, subretinal, slightly elevated lesion with well-defined margins in the superior macula of the left eye. B-scan ultrasonography showed a slightly elevated, highly reflective choroidal mass with acoustic shadowing. A diagnosis of choroidal osteoma was made. Six months later, repeat examination under anesthesia showed the lesion to be increasing in size and encroaching on the fovea. Given demonstrated growth and the risk of central vision loss, the patient was treated with transpupillary thermotherapy. Subsequent EUAs, over a period of 4 months, have shown complete decalcification with no subsequent growth.Conclusion: Choroidal osteomas are benign lesions that can be sight-threatening if located in the macula. Transpupillary thermotherapy in this case resulted in complete regression of a sight-threatening extrafoveal choroidal osteoma at 4-month follow-up.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"202-204"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DISTINCTIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND INDOCYANINE GREEN ANGIOGRAPHY IMAGING PATTERNS IN TOPIRAMATE-INDUCED CHOROIDAL EFFUSION. 托吡酯诱发脉络膜渗出的独特光学相干断层血管造影和吲哚菁绿血管造影成像模式。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001538

Jacques Bijon, Erin Flynn, K Bailey Freund

{"title":"DISTINCTIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND INDOCYANINE GREEN ANGIOGRAPHY IMAGING PATTERNS IN TOPIRAMATE-INDUCED CHOROIDAL EFFUSION.","authors":"Jacques Bijon, Erin Flynn, K Bailey Freund","doi":"10.1097/ICB.0000000000001538","DOIUrl":"10.1097/ICB.0000000000001538","url":null,"abstract":"Purpose: The aim of this study was to describe novel findings seen on optical coherence tomography angiography (OCTA) and indocyanine green angiography in a young male patient presenting with bilateral topiramate-induced choroidal effusion.Methods: This is a retrospective case report. A comprehensive ophthalmic examination was conducted and multimodal imaging techniques, including B-scan ultrasound, OCT, OCTA, and indocyanine green angiography were analyzed.Results: A male patient in his 30s presented with a myopic shift due to bilateral choroidal effusion induced by a medication containing topiramate prescribed for weight loss. Indocyanine green angiography showed multiple hypofluorescent spots within the choroid corresponding to areas of reduced OCTA flow signal in both the inner and deeper en face choroidal slabs. Symptoms and abnormal imaging findings resolved within 5 days of discontinuing the medication.Conclusion: Findings observed with OCTA and indocyanine green angiography together suggest multifocal reversible areas of reduced choroidal vascular flow occurring in a topiramate-induced choroidal effusion. The authors propose that this transient hypoperfusion is due to compression from deeper choroidal vessels with a congested choroid.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"163-168"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CASE OF HYPERTENSIVE UVEITIS WITH INTRAVITREAL FARICIMAB. 一例使用玻璃体内法尼单抗的高血压葡萄膜炎病例。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001527

Samantha Kitson, Andrew McAllister

{"title":"A CASE OF HYPERTENSIVE UVEITIS WITH INTRAVITREAL FARICIMAB.","authors":"Samantha Kitson, Andrew McAllister","doi":"10.1097/ICB.0000000000001527","DOIUrl":"10.1097/ICB.0000000000001527","url":null,"abstract":"Purpose: The aim of this study was to report a novel case of hypertensive uveitis with intravitreal faricimab.Methods: This is a case report. A 69-year-old woman undergoing treatment of bilateral diabetic macular edema with intravitreal faricimab presented for routine review. Ophthalmic examination was performed including VA, intraocular pressure, gonioscopy, and slitlamp examination. Findings consistent with hypertensive uveitis prompted further infectious/inflammatory/infiltrative uveitis screen.Results: The patient developed hypertensive uveitis in the left eye (four weeks after the third injection) with an intraocular pressure of 42 mmHg. Slitlamp examination revealed fine keratic precipitates and mild anterior uveitis. Anterior chamber angle was open on gonioscopy, and there was no vitritis or vasculitis. At the review a week later, the patient had developed hypertensive uveitis in the right eye (six weeks after the fourth injection) with intraocular pressure of 35 mmHg. Slitlamp examination revealed fine keratic precipitates, open angles, and mild vitritis. There was no vasculitis. At both presentations, the patient had preserved VA with no significant visual symptoms. The hypertensive uveitis resolved in both eyes with a course of steroid and antihypertensive eye drops. The uveitis screen was negative apart from elevated urine protein (negative beta-2 microglobulin), which could be explained by known diabetes and hypertension.Conclusion: Hypertensive uveitis is a potential adverse reaction to intravitreal faricimab. This case highlights the importance of monitoring intraocular pressure in patients undergoing treatment with faricimab and emphasizes the need for reporting other cases in the community.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"187-188"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENCIRCLING CONTINUOUS SUTURE TECHNIQUE FOR THE MANAGEMENT OF EXTENSIVE TRAUMATIC CYCLODIALYSIS: A CASE REPORT. 环绕连续缝合技术用于治疗大面积外伤性环形透析：病例报告。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001546

Takashi Ueta, Tomoyuki Matsuura, Kiyohiyo Totsuka, Koichiro Sugimoto, Fumiyuki Araki, Taku Toyama, Tomoyasu Shiraya

{"title":"ENCIRCLING CONTINUOUS SUTURE TECHNIQUE FOR THE MANAGEMENT OF EXTENSIVE TRAUMATIC CYCLODIALYSIS: A CASE REPORT.","authors":"Takashi Ueta, Tomoyuki Matsuura, Kiyohiyo Totsuka, Koichiro Sugimoto, Fumiyuki Araki, Taku Toyama, Tomoyasu Shiraya","doi":"10.1097/ICB.0000000000001546","DOIUrl":"10.1097/ICB.0000000000001546","url":null,"abstract":"Purpose: None of the authors has any financial/conflicting interests to disclose.The aim of this study was to report a surgical technique of cyclopexy, wherein two laps of encircling continuous sutures are placed around the limbus to treat refractory extensive cyclodialysis.Methods: This study employed swept-source optical coherence tomography for anterior segment, color fundus photography, and spectral-domain optical coherence tomography for the macula.Results: Previous attempts, including indirect cyclopexy and direct external cyclopexy with gas injection, failed to successfully resolve the severe cyclodialysis and associated hypotonic maculopathy. In the third surgery, two laps of encircling continuous sutures were placed around the limbus at the distances of 2-3 mm and 3-4 mm, respectively, along with phacoemulsification, intraocular lens implantation, and capsular tension ring placement. After surgery, hypotony and hypotonic maculopathy were effectively resolved, resulting in a significant improvement in VA that has been maintained over a year.Conclusion: The described surgical technique of encircling continuous sutures may be a viable option for the treatment of severe cyclodialysis.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SHWACHMAN-DIAMOND SYNDROME ASSOCIATED WITH ROD-CONE DYSTROPHY. 舒瓦赫曼-钻石综合征（Shwachman-Diamond Syndrome）伴有杆-锥体营养不良症。

Retinal Cases and Brief Reports Pub Date : 2025-03-01 DOI: 10.1097/ICB.0000000000001568

Jingwen Zhang, Thales A C de Guimaraes, Dorothy Thompson, Michel Michaelides

{"title":"SHWACHMAN-DIAMOND SYNDROME ASSOCIATED WITH ROD-CONE DYSTROPHY.","authors":"Jingwen Zhang, Thales A C de Guimaraes, Dorothy Thompson, Michel Michaelides","doi":"10.1097/ICB.0000000000001568","DOIUrl":"10.1097/ICB.0000000000001568","url":null,"abstract":"Purpose: The aim of this study was to report a patient with Shwachman-Diamond syndrome and concomitant rod-cone dystrophy who underwent bone marrow transplantation.Methods: This was a retrospective single case report.Results: A female patient with Shwachman-Diamond syndrome was referred to a tertiary hospital to investigate possible pigmentary retinopathy at the age of 16 years. She described poor night vision and was found to have reduced VA (6/20 right eye, 6/38 left eye). Over the 10-year follow-up, her VA remained relatively stable with no new visual symptoms. Optical coherence tomography revealed progressive, diffuse outer retinal thinning with disruption of the ellipsoid zone, which initially was relatively preserved subfoveally. Fundus autofluorescence images revealed generalized areas of hypoautofluorescence beyond the vascular arcades and a perimacular ring of increased autofluorescence. The flash electroretinogram was in keeping with a severe rod-cone dystrophy. The pattern visual evoked potential was abnormal but detectable, indicating macular pathway dysfunction, suggesting encroachment into central macular regions but with some functional preservation.Conclusion: The authors report a patient with Shwachman-Diamond syndrome with severe early-onset rod-cone dystrophy noted at the age of 16 years. Slow anatomical progression has been observed over the subsequent 10 years, with relative functional macular preservation to support a VA of 6/36 in both eyes.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"152-156"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active External Drainage of Subretinal Fluid without Vitrectomy to Treat Advanced Coats Disease with Exudative Retinal Detachment - A Case Report and Literature Review. 主动外引流视网膜下液治疗晚期Coats病伴渗出性视网膜脱离1例并文献复习。

Retinal Cases and Brief Reports Pub Date : 2025-02-26 DOI: 10.1097/ICB.0000000000001745

Prabu Baskaran, Savithri Palanivel, Yeshwanth Kumar

引用次数: 0