Human Antibodies最新文献_第6页

Impact of anti-thyroid peroxidase and anti-thyroglobulin antibodies on the gestational outcome of euthyroid pregnancies: A retrospective study. 抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体对甲状腺功能正常妊娠结局的影响:一项回顾性研究。

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-220010

Kemal Beksac, Hanife Guler Donmez, Murat Cagan, Mehmet Sinan Beksac

{"title":"Impact of anti-thyroid peroxidase and anti-thyroglobulin antibodies on the gestational outcome of euthyroid pregnancies: A retrospective study.","authors":"Kemal Beksac, Hanife Guler Donmez, Murat Cagan, Mehmet Sinan Beksac","doi":"10.3233/HAB-220010","DOIUrl":"https://doi.org/10.3233/HAB-220010","url":null,"abstract":"Background: Thyroglobulin (anti-TG) and/or thyroid peroxidase (anti-TPO) autoantibodies are associated with higher rates of poor gestational outcomes.Objective: To demonstrate the impact of anti-TPO and anti-TG autoantibodies on the gestational outcomes of euthyroid pregnant women with a history of poor gestational outcome and thyroid gland disorders.Methods: This retrospective study included totally 75 euthyroid pregnant, 30 of women with high thyroid autoantibodies (Anti-TPO/Thyroglobulin-positive group) and 45 of them without autoantibodies (control group).Results: We could not demonstrate significant differences between two groups in terms of risk factors/co-morbidities, obstetric complications, gestational outcomes, and birth data (p> 0.05). However, enhanced miscarriage rates were observed among the Anti-TPO/Thyroglobulin-positive and control groups without significance (36.7% and 17.8% respectively, p= 0.116). High neonatal intensive care unit (NICU) admission rates were found for control and Anti-TPO/Thyroglobulin-positive groups (16.2% and 21.1%, respectively) (p= 0.720). Clinically, we compared the two groups in terms of the existence and the types of goiter (diffuse and nodular), and demonstrated that nodular goiter was statistically more frequent in the control group (40.0% vs. 8.7%, p= 0.015). Alongside, relatively high hereditary thrombophilia and type-2 diabetes mellitus rates were found in the Anti-TPO/Thyroglobulin-positive group (20.0% and 20.0%).Conclusion: Thyroid autoantibody positivity is likely a risk factor for early pregnancy loss and NICU admission.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-review: The market growth of diagnostic and therapeutic monoclonal antibodies - SARS CoV-2 as an example. 小回顾:诊断和治疗单克隆抗体的市场增长——以SARS CoV-2为例。

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-211513

Yasmine El Abd, Ashraf Tabll, Robert Smolic, Martina Smolic

{"title":"Mini-review: The market growth of diagnostic and therapeutic monoclonal antibodies - SARS CoV-2 as an example.","authors":"Yasmine El Abd, Ashraf Tabll, Robert Smolic, Martina Smolic","doi":"10.3233/HAB-211513","DOIUrl":"https://doi.org/10.3233/HAB-211513","url":null,"abstract":"Background: The emergence of novel viruses poses severe challenges to global public health highlighting the crucial necessity for new antivirals.Main body: Monoclonal antibodies (mAbs) are immunoglobulins that bind to a single epitope. Mouse mAbs are generated by classic hybridoma technology and are mainly used for immunodiagnostics. For immunotherapy, it is critical to use monoclonal antibodies in their human form to minimize adverse reactions. They have been successfully used to treat numerous illnesses, accordingly, an increasing number of mAbs, with high potency against emerging viruses is the target of every biopharmaceutical company. The diagnostic and therapeutic mAbs market grows rapidly into a multi-billion-dollar business. Biopharmaceuticals are innovative resolutions which revolutionized the treatment of significant chronic diseases and malignancies. Currently, a variety of therapeutic options that include antiviral medications, monoclonal antibodies, and immunomodulatory agents are available for the management of COVID-19.Short conclusion: The invasion of mAbs in new medical sectors will increase the market magnitude as it is expected to generate revenue of about 300 billion $ by 2025. In the current mini-review, the applications of monoclonal antibodies in immune-diagnosis and immunotherapy will be demonstrated, particularly for COVID-19 infection and will focus mainly on monoclonal antibodies in the market.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39878194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparison of some hematological parameters between male and female patients infected with COVID-19. 新型冠状病毒肺炎(COVID-19)男女患者血液学指标比较

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-220006

Hayder H Abed, Ahmed Ghdhban Al-Ziaydi, Ihab Abbas Taher, Ahmed K Al Dulaimi

{"title":"Comparison of some hematological parameters between male and female patients infected with COVID-19.","authors":"Hayder H Abed, Ahmed Ghdhban Al-Ziaydi, Ihab Abbas Taher, Ahmed K Al Dulaimi","doi":"10.3233/HAB-220006","DOIUrl":"https://doi.org/10.3233/HAB-220006","url":null,"abstract":"Background: COVID-19 is a highly contagious virus that is rapidly spreading across the world. As the number of COVID-19 patients is quickly rising, and certain nations and areas, such as the third world countries, lack the medical resources, it is critical to track and monitor a patient's status using blood parameters on regular testing. The aim of this study is to compare the serum D-dimer levels, Ferritin, CRP, WBCs, Lymphocytes, and Neutrophils in male and female patients infected with COVID-19.Objective and methods: The study procedure includes evaluating the D-dimer level, Ferritin, CRP, WBCs, lymphocytes, and neutrophils in 116 patients infected with COVID-19 (48 Females and 68 Males).Result: The result of this study shows a significant increase in the D-dimer level in males 1618 ± 247.7 ng/ml compared to females 684.5 ± 53.69 ng/ml and a significant increase in Ferritin level in males 525.6 ± 69.55 μg/L compared to females 254.1 ± 33.73 μg/L. However, no other significant change is seen in the other parameters (CRP, LDH, and WBCs, L, and N) although all of these parameters are abnormal, compared to the normal reference values.Conclusion: This study concludes that there is a significant increase in the D-dimer and Ferritin concentrations in male patients compared to female patients, who were infected with COVID-19. Also there are no significant differences in other parameters (CRP, LDH, WBCs, L, and N) between male and female patients.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"151-155"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40470317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-229000

引用次数: 0

Evaluation of molecular apoptosis signaling pathways and its correlation with EBV viral load in SLE patients using systems biology approach. 应用系统生物学方法评估SLE患者分子凋亡信号通路及其与EBV病毒载量的相关性

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-211505

Soad Ghabeshi, Ali Najafi, Batol Zamani, Mozhdeh Soltani, Amanuel Godana Arero, Shim Izadi, Ahmad Piroozmand

{"title":"Evaluation of molecular apoptosis signaling pathways and its correlation with EBV viral load in SLE patients using systems biology approach.","authors":"Soad Ghabeshi, Ali Najafi, Batol Zamani, Mozhdeh Soltani, Amanuel Godana Arero, Shim Izadi, Ahmad Piroozmand","doi":"10.3233/HAB-211505","DOIUrl":"https://doi.org/10.3233/HAB-211505","url":null,"abstract":"Background: Considerable evidence supports that SLE could be related to apoptotic cells and EBV infection.Objective: The aim of this study was to identify the transcriptional signature of EBV infection in SLE patients for survey of the molecular apoptosis signaling pathways.Methods: The PBMCs gene expression profiles of healthy control and SLE patients were obtained from GEO. Functional annotation and signaling pathway enrichment were carried out using DAVID, KEGG. To validate bioinformatics analysis the changes in genes expression of some of obtained genes, Real time PCR was performed on PBMCs from 28 SLE patients and 18 controls.Results: We found that mean viral load was 6013 ± 390.1 copy/μg DNA from PBMCs in all patients. QRT-PCR results showed that the expression of the DUSP1 and LAMP3 genes which had most changes in the logFC among 4 candidate genes, increased significantly in comparison with control. The consistent expression of LMP2 as viral latency gene involve in apoptosis signaling pathways was detected in SLE patients with EBV viral load and some controls.Conclusions: The study indicated that some cellular genes may have an important role in pathogenesis of SLE through apoptosis signaling pathways. Beside, EBV infection as an environmental risk factor for SLE may affect the dysfunction of apoptosis.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer. 程序性死亡-1和程序性死亡配体-1蛋白在乳腺癌中的预后意义。

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-220001

Imtiaz Mahmood Tahir, Abdur Rauf, Huma Mehboob, Samia Sadaf, Muhammad Shaiful Alam, Fadia Kalsoom, Abdelhakim Bouyahya, Aicha El Allam, Nasreddine El Omari, Saad Bakrim, Muhammad Akram, Syed Kashif Raza, Talha Bin Emran, Yahia N Mabkhot, Gokhan Zengin, Marina Derkho, Suray Natalya, Mohammad Ali Shariati

{"title":"Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer.","authors":"Imtiaz Mahmood Tahir, Abdur Rauf, Huma Mehboob, Samia Sadaf, Muhammad Shaiful Alam, Fadia Kalsoom, Abdelhakim Bouyahya, Aicha El Allam, Nasreddine El Omari, Saad Bakrim, Muhammad Akram, Syed Kashif Raza, Talha Bin Emran, Yahia N Mabkhot, Gokhan Zengin, Marina Derkho, Suray Natalya, Mohammad Ali Shariati","doi":"10.3233/HAB-220001","DOIUrl":"https://doi.org/10.3233/HAB-220001","url":null,"abstract":"In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer. Our inclusion criteria included studies showing the synergy between the expression of PD-L1 and PD-1 in primary breast cancers as prognostic markers and this research was limited to humans only. We included review articles, original research, letters to the editor, case reports, and short communications in our study, published in English. We focused our work on PD-L1 mRNA expression in breast cancer cell lines. PD-L1 expression has been decisively demonstrated to be a high-risk factor for breast cancer with a bad prognosis.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"131-150"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and methylenetetrahydrofolate reductase polymorphisms. 自身免疫性疾病和亚甲基四氢叶酸还原酶多态性患者在妊娠22周前的单胎妊娠丢失

Human Antibodies Pub Date : 2022-01-01 DOI: 10.3233/HAB-211517

Murat Cagan, Ummuhan Okuducu, Hanife Guler Donmez, Mehmet Sinan Beksac

{"title":"Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and methylenetetrahydrofolate reductase polymorphisms.","authors":"Murat Cagan, Ummuhan Okuducu, Hanife Guler Donmez, Mehmet Sinan Beksac","doi":"10.3233/HAB-211517","DOIUrl":"https://doi.org/10.3233/HAB-211517","url":null,"abstract":"Background: The rates of pregnancy losses (PLs) are increased by maternal risk factors such as autoimmune disorders (AD) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.Objective: To evaluate singleton PLs before gestational week (gw) 22 among patients with AD and MTHFR polymorphisms.Methods: Totally, 1108 singleton pregnancies in 243 women were categorized as: 1) 148 pregnancies in 33 patients with AD, 2) 316 pregnancies in 66 patients with MTHFR polymorphisms, 3) 644 pregnancies in 144 patients with AD +MTHFR polymorphisms. PLs were classified into subgroups: a) Chemical Pregnancy(CP), b) Blighted Ovum(BO), c) gw ⩽ 10, d) gw11-14 e) gw15-22, f) Ectopic Pregnancy(EP), g) Trophoblastic Disease(TD). Obstetric histories were compared using Beksac Obstetrics Index (BOI): [number of living child + (π/10)]/gravida.Results: PL rates before gw22 were 39.2% (58/148), 33.2% (105/316), and 36.3% (234/644) in AD, MTHFR, and AD +MTHFR groups, respectively (p= 0.421). The rate of Pre-Prenatal Screening Period fetal losses (CP + BO + gw ⩽ 10 fetal losses + EP + TD) were 84.8%, 75.9%, and 77.8% in AD, MTHFR, and AD +MTHFR, respectively (p= 0.264). Gravidity ⩽ 4 versus those with gravidity ⩾ 5 had statistically significant differences in BOI (p< 0.001).Conclusions: PL rate before gw22 among singleton pregnancies with AD and/or MTHFR polymorphisms was 35.8%. The clinical findings seem to be more complicated in patients with gravidity ⩾ 5.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 2","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39799966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunogenicity of biologics used in the treatment of moderate to severe psoriasis. 用于治疗中重度牛皮癣的生物制剂的免疫原性。

Human Antibodies Pub Date : 2021-01-01 DOI: 10.3233/HAB-210447

Visha Patel, Alex Efimov, David Baker, Angray S Kang

引用次数: 1

Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling. c -反应蛋白升高和低补体血症与妊娠结局不良易感性妇女血栓形成危险因素的关系先入为主的咨询的重要性。

Human Antibodies Pub Date : 2021-01-01 DOI: 10.3233/HAB-210452

Mehmet Sinan Beksac, Hanife Guler Donmez

{"title":"Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling.","authors":"Mehmet Sinan Beksac, Hanife Guler Donmez","doi":"10.3233/HAB-210452","DOIUrl":"https://doi.org/10.3233/HAB-210452","url":null,"abstract":"This study aimed to investigate the association of increased C-Reactive Protein (CRP) and hypocomplementemia with risk factors for thrombosis such as Factor V Leiden (FVLP) and Prothrombin G20210A polymorphisms (PP), increased Activated Protein C Resistance (APCR) and decreased anti-thrombin III (ATIII) activity in women who have metabolic (MTHFR polymorphisms) and immunological risk factors (autoimmune antibody positivity, autoimmune disorders, and chronic inflammatory diseases). All patients (n= 197) were evaluated in terms of risk factors for thrombosis including FVLP, PP, increased APCR, and decreased ATIII activity as well as CRP and complement (C) 3 and C4 levels within a framework of preconceptional care program. Patients with high CRP levels together with hypocomplementemia were included to the study group (n= 13), while women with normal levels of CRP, C3, and C4 were accepted as controls (n= 184). Decreased ATIII activity was found to be statistically more frequent in the study group compared to controls (p= 0.036). There were no significant differences between the study and control groups in terms of the presence of FVLP, PP and increased APCR (p= 0.386, p= 0.462, p= 0.625, respectively). Decreased ATIII activity should be the concern of preconceptional and antenatal care programs in risky patients with increased CRP levels and hypocomplementemia in order to prevent placental inflammation related gestational complications.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 4","pages":"249-254"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot. 降钙素原、红细胞沉降率(ESR)、定量c反应蛋白(CRP)及临床表现与糖尿病足骨髓炎的诊断价值

Human Antibodies Pub Date : 2021-01-01 DOI: 10.3233/HAB-210439

Zahra Soleimani, Fatemeh Amighi, Zarichehr Vakili, Mansooreh Momen-Heravi, Seyyed Alireza Moravveji

{"title":"Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot.","authors":"Zahra Soleimani, Fatemeh Amighi, Zarichehr Vakili, Mansooreh Momen-Heravi, Seyyed Alireza Moravveji","doi":"10.3233/HAB-210439","DOIUrl":"https://doi.org/10.3233/HAB-210439","url":null,"abstract":"Background: The diagnosis of osteomyelitis is a key step of diabetic foot management. Procalcitonin (PCT) is a novel infection marker. This study aimed to investigate the diagnostic value of procalcitonin and other conventional infection markers and clinical findings in diagnosis of osteomyelitis in diabetic foot patients.Methods and materials: This diagnostic value study was carried out on ninety patients with diabetic infected foot ulcers admitted in Kashan Beheshti Hospital, 2016. After obtaining consent, 10 cc blood sample was taken for measuring serum PCT, CBC, ESR, CRP and FBS. Clinical characteristics of the wounds were noted. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis. All statistical analyses were done with the use of SPSS-16.Results: PCT levels were 0.13 ± 0.02 ng/mili patients with osteomyelitis (n= 45) and 0.04 ± 0.02 ng/ml in patients without osteomyelitis (n= 45). PCT, Erythrocyte sedimentation rate and C-reactive protein was found significantly higher in patients with osteomyelitis (p< 0.001). The ROC curve was calculated for PCT. The area under the ROC curve for infection identification was 1 (p< 0.001). The best cut-off value for PCT was 0.085 ng/ml. Sensitivity, specificity, and positive and negative predictive values were 100%, 97.8%,97.8% and 100%, respectively.Conclusion: In this group of patients, PCT was useful to discriminate patients with bone infection. Also, Erythrocyte sedimentation rate and C-reactive protein can be used as a marker of osteomyelitis in diabetic patients.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 2","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25503009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4