Human Antibodies最新文献

{"title":"Evaluation of molecular apoptosis signaling pathways and its correlation with EBV viral load in SLE patients using systems biology approach.","authors":"Soad Ghabeshi,&nbsp;Ali Najafi,&nbsp;Batol Zamani,&nbsp;Mozhdeh Soltani,&nbsp;Amanuel Godana Arero,&nbsp;Shim Izadi,&nbsp;Ahmad Piroozmand","doi":"10.3233/HAB-211505","DOIUrl":"https://doi.org/10.3233/HAB-211505","url":null,"abstract":"<p><strong>Background: </strong>Considerable evidence supports that SLE could be related to apoptotic cells and EBV infection.</p><p><strong>Objective: </strong>The aim of this study was to identify the transcriptional signature of EBV infection in SLE patients for survey of the molecular apoptosis signaling pathways.</p><p><strong>Methods: </strong>The PBMCs gene expression profiles of healthy control and SLE patients were obtained from GEO. Functional annotation and signaling pathway enrichment were carried out using DAVID, KEGG. To validate bioinformatics analysis the changes in genes expression of some of obtained genes, Real time PCR was performed on PBMCs from 28 SLE patients and 18 controls.</p><p><strong>Results: </strong>We found that mean viral load was 6013 ± 390.1 copy/μg DNA from PBMCs in all patients. QRT-PCR results showed that the expression of the DUSP1 and LAMP3 genes which had most changes in the logFC among 4 candidate genes, increased significantly in comparison with control. The consistent expression of LMP2 as viral latency gene involve in apoptosis signaling pathways was detected in SLE patients with EBV viral load and some controls.</p><p><strong>Conclusions: </strong>The study indicated that some cellular genes may have an important role in pathogenesis of SLE through apoptosis signaling pathways. Beside, EBV infection as an environmental risk factor for SLE may affect the dysfunction of apoptosis.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer.","authors":"Imtiaz Mahmood Tahir,&nbsp;Abdur Rauf,&nbsp;Huma Mehboob,&nbsp;Samia Sadaf,&nbsp;Muhammad Shaiful Alam,&nbsp;Fadia Kalsoom,&nbsp;Abdelhakim Bouyahya,&nbsp;Aicha El Allam,&nbsp;Nasreddine El Omari,&nbsp;Saad Bakrim,&nbsp;Muhammad Akram,&nbsp;Syed Kashif Raza,&nbsp;Talha Bin Emran,&nbsp;Yahia N Mabkhot,&nbsp;Gokhan Zengin,&nbsp;Marina Derkho,&nbsp;Suray Natalya,&nbsp;Mohammad Ali Shariati","doi":"10.3233/HAB-220001","DOIUrl":"https://doi.org/10.3233/HAB-220001","url":null,"abstract":"<p><p>In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer. Our inclusion criteria included studies showing the synergy between the expression of PD-L1 and PD-1 in primary breast cancers as prognostic markers and this research was limited to humans only. We included review articles, original research, letters to the editor, case reports, and short communications in our study, published in English. We focused our work on PD-L1 mRNA expression in breast cancer cell lines. PD-L1 expression has been decisively demonstrated to be a high-risk factor for breast cancer with a bad prognosis.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"131-150"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and methylenetetrahydrofolate reductase polymorphisms.","authors":"Murat Cagan,&nbsp;Ummuhan Okuducu,&nbsp;Hanife Guler Donmez,&nbsp;Mehmet Sinan Beksac","doi":"10.3233/HAB-211517","DOIUrl":"https://doi.org/10.3233/HAB-211517","url":null,"abstract":"<p><strong>Background: </strong>The rates of pregnancy losses (PLs) are increased by maternal risk factors such as autoimmune disorders (AD) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.</p><p><strong>Objective: </strong>To evaluate singleton PLs before gestational week (gw) 22 among patients with AD and MTHFR polymorphisms.</p><p><strong>Methods: </strong>Totally, 1108 singleton pregnancies in 243 women were categorized as: 1) 148 pregnancies in 33 patients with AD, 2) 316 pregnancies in 66 patients with MTHFR polymorphisms, 3) 644 pregnancies in 144 patients with AD +MTHFR polymorphisms. PLs were classified into subgroups: a) Chemical Pregnancy(CP), b) Blighted Ovum(BO), c) gw ⩽ 10, d) gw11-14 e) gw15-22, f) Ectopic Pregnancy(EP), g) Trophoblastic Disease(TD). Obstetric histories were compared using Beksac Obstetrics Index (BOI): [number of living child + (π/10)]/gravida.</p><p><strong>Results: </strong>PL rates before gw22 were 39.2% (58/148), 33.2% (105/316), and 36.3% (234/644) in AD, MTHFR, and AD +MTHFR groups, respectively (p= 0.421). The rate of Pre-Prenatal Screening Period fetal losses (CP + BO + gw ⩽ 10 fetal losses + EP + TD) were 84.8%, 75.9%, and 77.8% in AD, MTHFR, and AD +MTHFR, respectively (p= 0.264). Gravidity ⩽ 4 versus those with gravidity ⩾ 5 had statistically significant differences in BOI (p< 0.001).</p><p><strong>Conclusions: </strong>PL rate before gw22 among singleton pregnancies with AD and/or MTHFR polymorphisms was 35.8%. The clinical findings seem to be more complicated in patients with gravidity ⩾ 5.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 2","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39799966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of biologics used in the treatment of moderate to severe psoriasis.","authors":"Visha Patel,&nbsp;Alex Efimov,&nbsp;David Baker,&nbsp;Angray S Kang","doi":"10.3233/HAB-210447","DOIUrl":"https://doi.org/10.3233/HAB-210447","url":null,"abstract":"<p><p>The number of biologic drugs available for the treatment of psoriasis continue to expand. However, being biological proteins and thus potentially immunogenic, there is evidence that anti-drug-antibodies develop against the various therapeutic proteins currently being utilised. Although chimeric antibodies that contain elements of the parental rodent monoclonal antibodies are immunogenic, anti-drug antibodies occur even if the biologic is a fully human protein and these can impact on clinical efficacy and safety. However, there is a wide variation in the reported level of anti-drug-antibodies for the same and different treatments that is highlighting issues with various assays used in anti-drug antibody detection. Here we review the available data on the occurrence of anti-drug antibodies in people with psoriasis treated with biologic agents.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39251785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling.","authors":"Mehmet Sinan Beksac,&nbsp;Hanife Guler Donmez","doi":"10.3233/HAB-210452","DOIUrl":"https://doi.org/10.3233/HAB-210452","url":null,"abstract":"This study aimed to investigate the association of increased C-Reactive Protein (CRP) and hypocomplementemia with risk factors for thrombosis such as Factor V Leiden (FVLP) and Prothrombin G20210A polymorphisms (PP), increased Activated Protein C Resistance (APCR) and decreased anti-thrombin III (ATIII) activity in women who have metabolic (MTHFR polymorphisms) and immunological risk factors (autoimmune antibody positivity, autoimmune disorders, and chronic inflammatory diseases). All patients (n= 197) were evaluated in terms of risk factors for thrombosis including FVLP, PP, increased APCR, and decreased ATIII activity as well as CRP and complement (C) 3 and C4 levels within a framework of preconceptional care program. Patients with high CRP levels together with hypocomplementemia were included to the study group (n= 13), while women with normal levels of CRP, C3, and C4 were accepted as controls (n= 184). Decreased ATIII activity was found to be statistically more frequent in the study group compared to controls (p= 0.036). There were no significant differences between the study and control groups in terms of the presence of FVLP, PP and increased APCR (p= 0.386, p= 0.462, p= 0.625, respectively). Decreased ATIII activity should be the concern of preconceptional and antenatal care programs in risky patients with increased CRP levels and hypocomplementemia in order to prevent placental inflammation related gestational complications.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 4","pages":"249-254"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot.","authors":"Zahra Soleimani,&nbsp;Fatemeh Amighi,&nbsp;Zarichehr Vakili,&nbsp;Mansooreh Momen-Heravi,&nbsp;Seyyed Alireza Moravveji","doi":"10.3233/HAB-210439","DOIUrl":"https://doi.org/10.3233/HAB-210439","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of osteomyelitis is a key step of diabetic foot management. Procalcitonin (PCT) is a novel infection marker. This study aimed to investigate the diagnostic value of procalcitonin and other conventional infection markers and clinical findings in diagnosis of osteomyelitis in diabetic foot patients.</p><p><strong>Methods and materials: </strong>This diagnostic value study was carried out on ninety patients with diabetic infected foot ulcers admitted in Kashan Beheshti Hospital, 2016. After obtaining consent, 10 cc blood sample was taken for measuring serum PCT, CBC, ESR, CRP and FBS. Clinical characteristics of the wounds were noted. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis. All statistical analyses were done with the use of SPSS-16.</p><p><strong>Results: </strong>PCT levels were 0.13 ± 0.02 ng/mili patients with osteomyelitis (n= 45) and 0.04 ± 0.02 ng/ml in patients without osteomyelitis (n= 45). PCT, Erythrocyte sedimentation rate and C-reactive protein was found significantly higher in patients with osteomyelitis (p< 0.001). The ROC curve was calculated for PCT. The area under the ROC curve for infection identification was 1 (p< 0.001). The best cut-off value for PCT was 0.085 ng/ml. Sensitivity, specificity, and positive and negative predictive values were 100%, 97.8%,97.8% and 100%, respectively.</p><p><strong>Conclusion: </strong>In this group of patients, PCT was useful to discriminate patients with bone infection. Also, Erythrocyte sedimentation rate and C-reactive protein can be used as a marker of osteomyelitis in diabetic patients.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 2","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25503009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of KRAS and BRAF mutations in metastatic colorectal cancer patients: A systematic review and meta-analysis based on tumor sidedness and KRAS subtypes.","authors":"Khadijeh Saravani,&nbsp;Morteza Salarzaei,&nbsp;Fateme Parooie","doi":"10.3233/HAB-210451","DOIUrl":"https://doi.org/10.3233/HAB-210451","url":null,"abstract":"<p><strong>Introduction: </strong>Metastatic or recurrent colorectal cancer (MRCRC) has a poor prognosis. The aim of the present meta-analysis was to assess the prevalence of different subtypes of KRAS mutation and BRAF mutation in metastatic CRC patients, and evaluate the relationship between the tumor sidedness and prevalence of KRAS and BRAF mutation.</p><p><strong>Methods: </strong>We searched MEDLINE/PubMed, the Cochrane Library, and ClinicalTrials.gov from January 2010 to July 2020. The data were extracted independently according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The statistical analysis was done using STATA and Meta-Disk 1.4 applications.</p><p><strong>Results: </strong>Overall, 6699 colorectal cancer patients were included. KRAS and BRAF mutation was reported in 28% and 6% of patients, respectively. The overall prevalence of right primary and left primary metastatic CRC patients with mutated KRAS was 40% and 60%. However, the prevalence BRAF mutated right primary and left primary metastatic CRC patients was 37% and 63%. The overall HR was 2.38 for patients with metastatic CRC who had a mutated type of KRAS. Our study showed a mean overall survival of 35.4 month for KRAS mutant and a 10.12 month survival for BRAF mutant patients with metastatic colorectal cancer patients.</p><p><strong>Conclusion: </strong>The prevalence of KRAS and BRAF mutations varied significantly according to the location of the tumor. BRAF mutations are more commonly found in metastatic colorectal cancers on the right side. Liver was the most common site of metastases in patients with mutant KRAS and the mortality of patients with mutant KRAS was 2.3 times higher than the patients with wild types. These results help to better describe the population of mCRC patients and can have implications for improving and organizing anti-EGFR therapies. Further research is needed to assess differences in survival through mutation status and primary tumor location.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 4","pages":"275-284"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39264240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between health literacy and quality of life among hemodialysis patients, Tehran, Iran, 2019.","authors":"Yisak Hagos Alemayehu,&nbsp;Khatereh Seylani,&nbsp;Farshad Sharifi,&nbsp;Parvaneh Asgari,&nbsp;Banafsheh Ghorbani,&nbsp;Fatemeh Bahramnezhad","doi":"10.3233/HAB-200423","DOIUrl":"https://doi.org/10.3233/HAB-200423","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease and dialysis are associated with various complications.</p><p><strong>Objective: </strong>This study aimed to determine the relationship between health literacy and quality of life among patients receiving hemodialysis in hospitals affiliated with Tehran University of Medical Sciences.</p><p><strong>Methods: </strong>In this study, a descriptive - correlational study design with 138 sample size was used. Convenience sampling was used to select the study participants. We collected the data on May-September 2019. Data collection was done using the HELIA and KDQOL SF™.</p><p><strong>Results: </strong>In this study, 133 respondents fully completed the questioners. The mean score of health literacy of the respondents was 49.03 (± 22.37) while the average score of quality of life of the respondents in this study was 53.01 (± 14.86).</p><p><strong>Conclusion: </strong>Based on the findings, patients receiving haemodialysis had insufficient health literacy and a better quality of life. In order to address the health literacy needs of the patients, consideration of continuous health education and assessment in this patient subpopulation could gradually improve their health literacy and quality of life. Health care providers such as nurses could improve Health Literacy and substantially Quality of Life through interventions aimed at determining existing literacy needs in the long and short term treatment course for individual dialysis patients.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological study of celiac disease in children with dental caries.","authors":"Gholamreza Kalvandi,&nbsp;Iraj Shahramian,&nbsp;Abbas Farmany,&nbsp;Shirin Yadegari,&nbsp;Fateme Parooie","doi":"10.3233/HAB-210445","DOIUrl":"https://doi.org/10.3233/HAB-210445","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease is a common gastrointestinal autoimmune disorder. Studies have shown that the prevalence of tooth decay is high in patients with celiac disease. This study was performed to evaluate the serology of celiac disease in children with dental caries.</p><p><strong>Methods: </strong>Children aged 3 to 12 years who referred to the dental clinic with enamel caries were included in the study. Celiac disease was assessed by measuring serum IgA levels and anti-TTG (Anti TTG (IgA)) antibodies. Then, by analyzing the collected data, the prevalence of celiac disease in children with dental caries and its relationship with various variables were investigated.</p><p><strong>Results: </strong>120 children, 56 girls (46.7%) and 64 boys (53.3%) with dental caries were involved in this study. The positive celiac serology rate of studied population was 14 (11.6%). Based on the results of this study, a significant relationship was obtained between maternal education, sex and place of residence and celiac disease (p< 0.05). There were no significant relationships between celiac positive serology in children with dental caries, the number of decayed teeth, and breastfeeding (p> 0.05).</p><p><strong>Conclusion: </strong>The present study showed that dental caries, might be a red flag indicating possible celiac disease and prevent its complications. On the other hand, pediatricians and dentists should be aware of the oral symptoms of celiac disease. Further studies are needed to plan screening for children with celiac disease.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 4","pages":"237-241"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-210445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39065845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero tolerance for complacency by government of West African countries in the face of COVID-19.","authors":"O Erhabor,&nbsp;T Erhabor,&nbsp;T C Adias,&nbsp;G C Okara,&nbsp;M Retsky","doi":"10.3233/HAB-200413","DOIUrl":"https://doi.org/10.3233/HAB-200413","url":null,"abstract":"<p><p>A novel Coronavirus (SARS-CoV-2) causing a cluster of respiratory infections (Coronavirus Disease 2019, COVID-19) first discovered in Wuhan, China, is responsible for a new illness that has been found to affect the lungs and airways of patients with associated symptoms of fever, cough and shortness of breath. In the light of few cases recorded so far in West Africa there is tendency for complacency. The region needs to make strategic plans based on available evidence to enable them effectively deal with this rapidly evolving pandemic. At this very moment countries like China, Italy, France, Spain, Iran, UK and many others are witnessing sustained and intensive community transmission of this virus and increasing numbers of severe disease and death particularly among elderly patients with other comorbidities. The reality of the seriousness of this pandemic is alarming. Government of member states of ECOWAS need to prepare themselves by building capacity as well as implement evidenced-based steps to mitigate this rapidly evolving pandemic by testing persons presenting with symptoms (fever, cough and shortness of breath), isolating and treating those found positive, tracing and quarantining contacts, implementing social distancing as well as optimizing human and material endowment to allow healthcare workers offer safe quality clinical care for affected patients to prevent secondary infection among healthcare workers.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"29 1","pages":"27-40"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-200413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37943132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}