Human Antibodies最新文献_第10页

Unconventional immunotherapy with an unconventional target. 具有非常规靶点的非常规免疫疗法。

Human Antibodies Pub Date : 2020-09-04 DOI: 10.3233/HAB-200427

M. Glassy

引用次数: 1

Association between tumor necrosis factor-alpha gene rs1800629 (-308G/A) and rs361525 (-238G > A) polymorphisms and prostate cancer risk in an Iranian cohort. 伊朗人群中肿瘤坏死因子- α基因rs1800629 (-308G/A)和rs361525 (-238G /A)多态性与前列腺癌风险的关系

Human Antibodies Pub Date : 2020-02-13 DOI: 10.3233/hab-190397

Saeideh Alidoost, Mohsen Habibi, Z. Noormohammadi, J. Hosseini, E. Azargashb, F. Pouresmaeili

{"title":"Association between tumor necrosis factor-alpha gene rs1800629 (-308G/A) and rs361525 (-238G > A) polymorphisms and prostate cancer risk in an Iranian cohort.","authors":"Saeideh Alidoost, Mohsen Habibi, Z. Noormohammadi, J. Hosseini, E. Azargashb, F. Pouresmaeili","doi":"10.3233/hab-190397","DOIUrl":"https://doi.org/10.3233/hab-190397","url":null,"abstract":"BACKGROUND Prostate cancer (PCa) as the first men's common cancer in the world and the third cancer in Iranian men is a heterogeneous disorder which sometimes several biopsies are needed for its diagnosis. OBJECTIVES The aim of current study is finding new biomarkers in order to diagnose of PCa at the earliest possible stage. Hence, the relationship between rs1800629 and rs361525 polymorphisms of TNF-α gene with PCa was investigated. MATERIALS AND METHODS Blood DNA samples were collected from 100 patients with PCa, 110 with BPH, and 110 controls. Collected samples were examined using PCR-RFLP and Tetra-ARMS-PCR techniques to detect the desired polymorphisms. RESULTS The frequency of rs1800629 genotypes in smokers was significantly different from non-smokers with PCa (p= 0.001). Logistic regression analysis results showed that GA heterozygotes in comparison to GG homozygotes had higher risk of developing Benign Prostatic Hyperplasia (BPH) or prostate cancer. However, no significant correlation was considered between the risk of PCa and the TNF-α gene polymorphisms (rs1800629 and rs361525). CONCLUSIONS Although, the achieved results of this investigation demonstrated that the two examined genetic variants do not seem to be suitable markers for early diagnosis of prostate cancer in this pilot study; however increased risk for the disease is shown in GA heterozygotes and smokers which is indicative of some epigenetic factors influence on prostate cancer etiology.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/hab-190397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69903835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The relationship between health literacy and quality of life among hemodialysis patients: An integrative review. 血液透析患者健康素养与生活质量的关系:一项综合综述

Human Antibodies Pub Date : 2020-02-13 DOI: 10.3233/hab-190394

Yisak Hagos Alemayehu, K. Seylani, F. Bahramnezhad

{"title":"The relationship between health literacy and quality of life among hemodialysis patients: An integrative review.","authors":"Yisak Hagos Alemayehu, K. Seylani, F. Bahramnezhad","doi":"10.3233/hab-190394","DOIUrl":"https://doi.org/10.3233/hab-190394","url":null,"abstract":"BACKGROUND Various studies have highlighted the correlates to health literacy and quality of life among patients receiving hemodialysis therapy. However, evidence of how these two outcomes could influence each other is not clear. OBJECTIVE This study aimed to assess the correlation between health literacy and quality of life among patients receiving hemodialysis. METHODS This is an integrative review of correlational studies. This study conforms to the preferred reporting items for integrative reviews described by Whitemore and Knafl. We search for studies reporting on the correlation of health literacy and quality of life among patients receiving hemodialysis in six databases, that is PubMed, Web of Science/Knowledge, Scopus and Embase, Google Scholar and Ovid MEDLINE. RESULTS In this review five studies were included after screening them against the inclusion criteria. Two studies were identified from Iran, and one study was identified each from Australia, Turkey, and the USA. Most studies were descriptive comparative in nature, while two studies were experimental. Shayan's study had the highest number of participants. This study reports on 1,063 patients receiving dialysis. Most studies were conducted at different centers. Findings from three studies showed that there was a significant relationship between health literacy and quality of life among patients receiving hemodialysis. CONCLUSION There is a relationship between health literacy and quality of life among patients receiving hemodialysis. Conclusively, addressing health literacy may improve the quality of life among patients receiving hemodialysis.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/hab-190394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69903697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Nanobodies: The "magic bullets" in therapeutics, drug delivery and diagnostics. 纳米体:治疗、药物输送和诊断领域的“灵丹妙药”。

Human Antibodies Pub Date : 2020-02-13 DOI: 10.3233/HAB-190390

M. A. Mir, Umar Mehraj, Bashir A. Sheikh, Syed S. Hamdani

{"title":"Nanobodies: The \"magic bullets\" in therapeutics, drug delivery and diagnostics.","authors":"M. A. Mir, Umar Mehraj, Bashir A. Sheikh, Syed S. Hamdani","doi":"10.3233/HAB-190390","DOIUrl":"https://doi.org/10.3233/HAB-190390","url":null,"abstract":"Antibodies represent a well-established class of clinical diagnostics for medical applications as well as essential research and biotechnological tools. Although both polyclonal and monoclonal antibodies are indispensable reagents in basic research and diagnostics but both of them have their limitations. Hence, there is urgent need to develop strategies aimed at production of alternative scaffolds and recombinant antibodies of smaller dimensions that could be easily produced, selected and manipulated. Unlike conventional antibodies, members of Camelidae and sharks produce antibodies composed only of heavy chains with small size, high solubility, thermal stability, refolding capacity and good tissue penetration in vivo. The discovery of these naturally occurring antibodies having only heavy-chain in Camelidae family and their further development into small recombinant nanobodies represents an attractive alternative in drug delivery, diagnostics and imaging. Nanobody derivatives are soluble, stable, versatile, have unique refolding capacities, reduced aggregation tendencies and high-target binding capabilities. They can be genetically customized to target enzymes, transmembrane proteins or molecular interactions. Their ability to recognize recessed antigenic sites has been attributed to their smaller size and the ability of the extended CDR3 loop to quickly penetrate into such epitopes. With the advent of molecular engineering and phage display technology, they can be of potential use in molecular imaging, drug delivery and therapeutics for several major diseases. In this review we present the recent advances in nanobodies for modulating immune functions, for targeting cancers, viruses, toxins and microbes as well as their utility as diagnostic and biosensor tools.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-190390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69903595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Assessment of anti-cancer effects of koenimbine on colon cancer cells. 柯尼滨对结肠癌细胞的抗癌作用评价。

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-200405

Maliheh Astaneh, Soudeh Ghafouri-Fard, Zahra Fazeli, Zahra Taherian-Esfahani, Sepideh Dashti, Elahe Motevaseli

{"title":"Assessment of anti-cancer effects of koenimbine on colon cancer cells.","authors":"Maliheh Astaneh, Soudeh Ghafouri-Fard, Zahra Fazeli, Zahra Taherian-Esfahani, Sepideh Dashti, Elahe Motevaseli","doi":"10.3233/HAB-200405","DOIUrl":"https://doi.org/10.3233/HAB-200405","url":null,"abstract":"Background: Recent studies have highlighted the role of natural elements in reduction of cancer cell growth and apoptosis. Koenimbine, a natural product isolated from Murraya koenigii (L) Spreng is a substance with cytotoxic effects on cancer cells.Aim: The effects of koenimbine on HT-29 and SW48 colon cancer cells were evaluated by MTT and Annexin V assays. Expression levels of Wnt/β-catenin pathway genes were quantified by real time PCR.Results: The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the results of MTT assay. This value was 75 μg/ml in IEC-18 cells which were used as normal control. Annexin V assays revealed induction of cell apoptosis and necrosis in HT-29 and SW48 cells but not IEG18 cells by koenimbine. Koenimbin treatment resulted in significant down-regulation of CYCLD1 expression in SW48 cell line, but up-regulation of this gene in HT29 cell line. Expression of TBLR1, DKK1, GSK3B and β-catenin was significantly decreased after koenimbin treatment in HT-19 cell line. Moreover, expression of DKK1 and GSK3B was significantly decreased after koenimbin treatment in SW-40 cell line. TCF4 expression was not detected in any of cell lines either before or after treatment with koenimbin.Conclusion: The current in vitro study showed the cytotoxic effects of koenimbin on two colon cancer cell lines and the effects of this substance on expression of selected genes from Wnt-β catenin pathway. Future in vivo studies are needed before suggestion of this substance as an anti-cancer drug.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 3","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-200405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37692138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The association between diet quality and obesity-related metabolic risks. 饮食质量与肥胖相关代谢风险之间的关系。

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-190387

Ahmed Abdulahi Abdurahman, Mohammed Bule, Leyla Azadbakhat, Masoume Fallahyekta, Ali Parouhan, Mostefa Qorbani, Ahmad Reza Dorosty

{"title":"The association between diet quality and obesity-related metabolic risks.","authors":"Ahmed Abdulahi Abdurahman, Mohammed Bule, Leyla Azadbakhat, Masoume Fallahyekta, Ali Parouhan, Mostefa Qorbani, Ahmad Reza Dorosty","doi":"10.3233/HAB-190387","DOIUrl":"https://doi.org/10.3233/HAB-190387","url":null,"abstract":"Background: The aim of this study was to examine the association between dietary quality measured by inflammatory potential of a diet and Alternative Healthy Eating Index-2010 (AHEI-2010), and obesity-related metabolic risks in a representative sample of Iranian obese adults.Method: This cross-sectional study was conducted on 300 obese adults. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Diet quality was measured using AHEI-2010 and Empirical Dietary Inflammatory Pattern (EDIP) scores.Results: Those in the upper quartile of AHEI-2010 were associated with lower serum level of triglycerides (TG), and higher body mass index (BMI), compared to participants in the lower quartile. Those in the higher quartile of EDIP score were associated with higher serum level of TG. Greater adherence to AHEI-2010 had 70% lower odds of high fasting blood glucose (FBG), compared with those in the first quartile [Q4 vs Q1: OR, 0.3 (95% CI: 0.1-0.8), p trend = 0.02] Those in the highest quartile of EDIP score had a 60% higher odds of high diastolic blood pressure, compared with those in the lowest quartile [Q4 vs Q1: OR, 2.4 (95% CI: 1.1-5.5), p trend = 0.05] after controlling for potential covariates.Conclusions: High diet quality incorporating more anti-inflammatory diet may have a potential benefit in reducing obesity-related metabolic risks.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-190387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37403442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Production and purification of polyclonal antibody against attenuated and wild type Leishmania infantum in dogs. 犬幼利什曼原虫减毒和野生型多克隆抗体的制备和纯化。

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-200406

Somaiyeh Malekghasemi, Jafar Majidi, Hamid Daneshvar, Jalal Abdolalizadeh, Leili Aghebati-Maleki

{"title":"Production and purification of polyclonal antibody against attenuated and wild type Leishmania infantum in dogs.","authors":"Somaiyeh Malekghasemi, Jafar Majidi, Hamid Daneshvar, Jalal Abdolalizadeh, Leili Aghebati-Maleki","doi":"10.3233/HAB-200406","DOIUrl":"https://doi.org/10.3233/HAB-200406","url":null,"abstract":"Antibodies are still widely used in several programs including early research, imaging, Targeting drug delivery system, Affinity chromatography, flowcytometry technic, diagnosis and treatment. Purification of antibody is a standard approach for detection of infection agent in different species. The reservoir hosts for Leishmania infantum are Dogs and they have active role in the transmission of leishmania to humans by the bite of a sand fly belonging to genus Phlebotomus and Lutzomiya. Consequently, elimination of dogs in endemic areas and vaccination of dogs contributes to reduction of the human and canine VL cases. Serological antibody tests such as IFAT (Indirect Fluorescent Antbody Test), DFAT (Direct Fluorescent Antbody Test), ELISA (Enzyme-Linked Immunosorbent Assay), PCR (Polymerase chain Reaction Assay) have been extensively used to investigate canine infection with L. infantum. In this study we produced and purified polyclonal antibody against attenuated and wild type leishmania infantum in dogs. Anti-leishmania in dog serums precipitated with ammonium sulphate. The IgG recovered from ammonium sulphate precipitation was subject to ion exchange chromatography (IEC) and the purity of IgG was confirmed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under reduced condition. The purity of proteins were above 95% and then purified IgG was conjugated with FITC. We determined optimum titer of dog IgG by observation parasites under fluorescent microscope. The optimum dilution of prepared FITC conjugated dog IgG was 1: 400. This polyclonal antibody can be used for other applications in research, diagnosis and clinic.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 3","pages":"191-195"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-200406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37742080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LINK-A long non-coding RNA and VEGF RNA expression in epithelial ovarian cancer patients. 长链非编码RNA和VEGF RNA在上皮性卵巢癌患者中的表达。

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-200411

Parichehr Maleki, Sadaf Valeh Sheida, Seyed Javad Mowla, Vahid Soleimani, Mohammad Taheri, Jamshid Raheb

{"title":"LINK-A long non-coding RNA and VEGF RNA expression in epithelial ovarian cancer patients.","authors":"Parichehr Maleki, Sadaf Valeh Sheida, Seyed Javad Mowla, Vahid Soleimani, Mohammad Taheri, Jamshid Raheb","doi":"10.3233/HAB-200411","DOIUrl":"https://doi.org/10.3233/HAB-200411","url":null,"abstract":"LINK-A (long intergenic non-coding RNA for kinase activation) is a newly identified long non-coding RNA with oncogenic function, which leads to the hyperactivation of AKT and HIF1α. thereby, fosters cell proliferation, mobility and metastasis. VEGF (vascular endothelial growth factor), a well-known cytokine has an important role in angiogenesis. In this study, we quantified RNA expression of LINK-A and VEGF on 45 tumor specimens obtained from Iranian patients diagnosed with Epithelial Ovarian Cancer (EOC). Our goal was to evaluate expression of LINK-A lncRNA and VEGF mRNA in ovarian cancer tissues and find the probable correlation of LINK-A with VEGF as a major transcription target for HIF1α. LINK-A and VEGF were remarkably overexpressed in EOC tissues compared to normal tissues (P value: 0.004, 0.0001, respectively), but we did not find correlation between LINK-A and VEGF RNA expressions in this study. LINK-A was significantly overexpressed in higher stages of cancer and tumor grades. VEGF was only significantly elevated in higher stages. This study confirms importance of novel lncRNA of LINK-A in Iranian EOC patients.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 3","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-200411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37871098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The roles of miRNAs' clinical efficiencies in the colorectal cancer pathobiology: A review article. mirna在结直肠癌病理生物学中的临床作用综述

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-200417

Nahal Eshghifar, Elham Badrlou, Farkhondeh Pouresmaeili

{"title":"The roles of miRNAs' clinical efficiencies in the colorectal cancer pathobiology: A review article.","authors":"Nahal Eshghifar, Elham Badrlou, Farkhondeh Pouresmaeili","doi":"10.3233/HAB-200417","DOIUrl":"https://doi.org/10.3233/HAB-200417","url":null,"abstract":"MiRNAs (microRNAs) are defined as micro directors and regulators of gene expression. Since altered miRNA expression is signified in the pathobiology of diverse cancers such as colorectal cancers (CRCs), these molecules are described as therapeutic targets, either. Manipulation of miRNAs could lead to further therapy for chemo and radio-resistant CRCs. The usage of microRNAs has indicated prominent promise in the prognosis and diagnosis of CRC, because of their unique expression pattern associated with cancer types and malignancies. Nowadays, many researchers are analyzing the correlation between miRNA polymorphisms and cancer risk. With continuous incompatibility in colorectal cancer (CRC) miRNAs expression data, it is critical to move toward the content of a \"pre-laboratory\" analysis to speed up efficient accuracy medicine and translational study. Pathway study for the highest expressed miRNAs- regulated target genes resulted in the identification of a considerable number of genes associated with CRC pathway including PI3K, TGFβ, and APC. In this review, we aimed to collect fruitful information about miRNAs and their potential roles in CRC, and provide a meta-analysis of the most frequently studied miRNAs in association with the disease.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 4","pages":"273-285"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-200417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38123958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

CXCL9 chemokine level is associated with spontaneous clearance and sustained virological response in Egyptian Chronic Hepatitis C patients receiving direct acting antivirals. CXCL9趋化因子水平与接受直接抗病毒药物治疗的埃及慢性丙型肝炎患者的自发清除和持续病毒学反应相关。

Human Antibodies Pub Date : 2020-01-01 DOI: 10.3233/HAB-190400

Ashraf A Tabll, Mamdouh S Afifi, Abd-Allah S El-Etrawy, Salah M El-Kousy, Martina Smolic, Yasmine S El Abd

{"title":"CXCL9 chemokine level is associated with spontaneous clearance and sustained virological response in Egyptian Chronic Hepatitis C patients receiving direct acting antivirals.","authors":"Ashraf A Tabll, Mamdouh S Afifi, Abd-Allah S El-Etrawy, Salah M El-Kousy, Martina Smolic, Yasmine S El Abd","doi":"10.3233/HAB-190400","DOIUrl":"https://doi.org/10.3233/HAB-190400","url":null,"abstract":"Background: Chronic Hepatitis C virus (HCV) infection is associated with progressive liver inflammation which in turn leads to cirrhosis and finally causes hepatocellular carcinoma (HCC). By different escape mechanisms, the virus succeeds to evade the innate and acquired immune responses to establish chronic infection.Aim: This study aimed to evaluate the level of chemokine CXCL9 and its correlation with some biochemical parameters in different subjects of HCV patients.Materials and methods: A total of 83 persons participated in this study including healthy subjects without both HCV antibodies and HCV RNA (22.9%), HCV treated responders accomplished SVR post treatment, with HCV antibodies and absence of HCV RNA (24.1%), spontaneous or natural clearance patients, with positive HCV antibodies and negative HCV RNA without treatment (26.5%) and chronic HCV-patients, with both positive HCV antibodies and HCV RNA with no treatment (26.5%). HCV RNA was quantitated by real time PCR and serum CXCL9 level was measured by ELISA commercial kit pre-coated with human MIG/CXCL9 antibody. Assessment of biochemical and hematological parameters was carried out.Results: Data showed that, the level of CXCL9 was significantly increased in chronic individuals (627.1 pg/ml) (P< 0.001) than spontaneous clearance (107.76 pg/ml) and responder subjects (117.28 pg/ml) (P⩽ 0.05). No correlation has been found between CXCL9 level and viral load. Furthermore, CXCL9 levels correlated variably with some biochemical and hematological parameters according to each subject.Conclusion: Serum Chemokine CXCL9 level is associated with spontaneous clearance of HCV and response to HCV treatment, which may be identified as a predictive marker among HCV patients.","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"28 2","pages":"141-148"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/HAB-190400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38163534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0