The seroprevalence of celiac disease in patients with symptoms of irritable bowel syndrome: A cross-sectional study in north of Iran.

Q3 Medicine

Human Antibodies Pub Date : 2022-03-16 DOI:10.3233/hab-211516

F. Joukar, S. Yeganeh, A. Shafaghi, Alireza Mahjoob, Soheil Hassanipour, L. Santacroce, Sara Mavaddati, F. Mansour-Ghanaei

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引用次数: 1

Abstract

BACKGROUND Celiac disease (CD) is a common cause of malabsorption that is definitively diagnosed by abnormal bowel biopsy, symptoms and histologic changes to gluten free diet. The symptoms of irritable bowel syndrome (IBS) are common in our community as the majority of people in Guilan, north of Iran, consume rice daily. Also, a number of celiac patients are unknown, and IBS are mistakenly diagnosed. OBJECTIVE This study aimed to evaluate the prevalence of CD among IBS patients. METHODS A total of 475 consecutive patients with IBS, confirmed by Rome IV, underwent celiac serological tests antitissue transglutaminase antibodies (IgA-tTG, IgG-tTG) after obtaining a written consent form. In case of positive serological tests, biopsy was performed from small intestine after endoscopyRESULTS: Thirty-one (6.53%, 95% CI: 4.55-9.22) patients were positive for celiac serology. Based on Marsh-Oberhuber criteria, out of 9 patients with positive pathology 77.78% (95% CI: 40.19-96.05) had marsh IIIc. In IBS patients cramp (0.009) and stomach fullness (0.021) were two statistically significant IBS symptoms. CONCLUSIONS We suggest physicians to consider celiac examinations for all patients with IBS symptoms, even for patients with no obvious celiac symptoms.

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肠易激综合征患者乳糜泻的血清患病率:伊朗北部的一项横断面研究

背景:乳糜泻(CD)是一种常见的吸收不良的原因，通过异常的肠活检、症状和无麸质饮食的组织学改变来确诊。肠易激综合征(IBS)的症状在我们的社区很常见，因为在伊朗北部的吉兰，大多数人每天都吃米饭。此外，许多乳糜泻患者是未知的，肠易激综合征被误诊。目的本研究旨在评估肠易激综合征患者中CD的患病率。方法连续475例经Rome IV确认的IBS患者，在获得书面同意后接受了抗组织转谷氨酰胺酶抗体(IgA-tTG, IgG-tTG)的乳糜泻血清学检测。结果:31例(6.53%，95% CI: 4.55-9.22)患者乳糜泻血清学阳性。根据marsh - oberhuber标准，9例病理阳性患者中77.78% (95% CI: 40.19-96.05)为marsh IIIc。在肠易激综合征患者中，痉挛(0.009)和胃饱(0.021)是两种具有统计学意义的肠易激综合征症状。结论我们建议医生对所有有肠易激综合征症状的患者进行腹腔检查，即使对没有明显腹腔症状的患者也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.