International Journal of Women''s Dermatology最新文献

{"title":"Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis.","authors":"Anissa Zaouak, Wafa Jouini, Ghaith Abdessalem, Sonia Abdelhak, Houda Hammami, Cherine Charfeddine, Samy Fenniche","doi":"10.1097/JW9.0000000000000175","DOIUrl":"10.1097/JW9.0000000000000175","url":null,"abstract":"<p><strong>Background: </strong>Autosomal recessive congenital ichthyosis (ARCI) is a rare genodermatosis categorized among nonsyndromic ichthyoses. While ARCI patients often manifest hair abnormalities, their impact on the quality of life remains underreported in the literature.</p><p><strong>Objective: </strong>This study aims to comprehensively characterize the clinical and trichoscopic findings of alopecia in ARCI patients.</p><p><strong>Methods: </strong>A prospective study spanning from January 2019 to December 2021 (3 years) was conducted at the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. Clinical and trichoscopic examinations were performed on the hair of the participants, with molecular studies conducted on 15 patients.</p><p><strong>Results: </strong>The study included 30 patients, predominantly female (male/female = 0.58), with a mean age of 20 years. Twenty-eight patients were born from consanguineous marriages. Lamellar ichthyosis was observed in 22 cases, while congenital ichthyosiform erythroderma and bathing suit ichthyosis were each present in 4 cases. The ARCI severity score, assessed using the Visual Index For Ichthyosis Severity scale, had a mean value of 15 (4-28). Alopecia emerged as a prominent finding in 11 patients, presenting as hairline recession (13%), multiple patchy alopecia (27%), and alopecia of the eyebrows (13%). Trichoscopic findings included interfollicular and perifollicular scaling, perifollicular lamellar hyperkeratosis, peripilar casts, interfollicular erythema, loss of hair openings, predominance of single hair follicles, broken hair, vellus hair, anisotrichosis, pili torti, dystrophic hair, and comma hair. Several trichoscopic findings showed statistically significant associations with the severity of ARCI.</p><p><strong>Limitations: </strong>In our study, we only included 30 patients due to the rarity of this genodermatosis.</p><p><strong>Conclusion: </strong>Contrary to previous perceptions, alopecia is a notable finding in ARCI, particularly in patients with a severe form. This study provides a detailed characterization of alopecia in ARCI, shedding light on its prevalence and associated trichoscopic features, thereby enhancing our understanding of this dermatological condition.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e175"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular adverse event reporting in psoriasis and psoriatic arthritis biological therapy clinical trials.","authors":"Sreejan Saha, Molly Ottensoser, Brittany N Weber, Jeffrey S Berger, Michael S Garshick","doi":"10.1097/JW9.0000000000000172","DOIUrl":"10.1097/JW9.0000000000000172","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e172"},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic contact dermatitis of the scalp: a review of an underdiagnosed entity.","authors":"Jonathan C Hwang, Colleen J Beatty, Kuzma Khobzei, Viktoryia Kazlouskaya","doi":"10.1097/JW9.0000000000000167","DOIUrl":"10.1097/JW9.0000000000000167","url":null,"abstract":"<p><strong>Background: </strong>It is hypothesized that scalp allergic contact dermatitis (ACD) in women is commonly mistaken for other disorders due to overlapping symptoms and unique clinical presentations.</p><p><strong>Objective: </strong>This study reviews the potential underdiagnosis and misdiagnosis of scalp ACD and explores ways to improve diagnostic accuracy.</p><p><strong>Methods: </strong>This study conducted an extensive literature review to identify diagnostic challenges, common misdiagnoses, and diagnostic approaches for scalp ACD, focusing on standard versus targeted patch testing techniques.</p><p><strong>Results: </strong>Scalp ACD, often misdiagnosed as seborrheic dermatitis due to similar symptoms, has atypical presentations such as hair thinning, hair loss, and erythematous lesions affecting neighboring regions. Trichoscopy can help distinguish scalp ACD, identifying its patchy distribution of thin white scales, in contrast to the yellow scaling of seborrheic dermatitis. Standardized patch testing further contributes to diagnostic errors, with a study reporting 83% of patients who tested negative with standardized patch tests were positive when using their personal products. Individualized patch testing is more effective in identifying causative allergens and accurately diagnosing scalp ACD.</p><p><strong>Limitations: </strong>It is a retrospective review.</p><p><strong>Conclusion: </strong>Several factors contribute to scalp ACD's misdiagnosis for conditions such as seborrheic dermatitis. The significant discrepancy in ACD detection rates between personalized and standardized patch tests in women emphasizes the importance of using patient-specific products in diagnostic testing. Incorporating scalp ACD more readily into one's differential, employing individualized patch testing with trichoscopy, and accounting for neighboring symptomatic areas are all crucial elements in improving diagnostic accuracy for scalp ACD in women.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e167"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the inclusion of women of color in lichen sclerosus treatment studies: a scoping review.","authors":"Jessica C Evans, Ekene A Ezenwa, Olushola L Akinshemoyin Vaughn","doi":"10.1097/JW9.0000000000000170","DOIUrl":"10.1097/JW9.0000000000000170","url":null,"abstract":"<p><strong>Background: </strong>Vulvar lichen sclerosus (VLS) is an underrecognized chronic inflammatory skin condition with significant clinical features and potential for malignant transformation. To date, there are no studies comparing the course of this disease in women of color to other racial groups.</p><p><strong>Objective: </strong>The objective of this study was to provide a scoping review examining racial demographic data in VLS treatment studies and specifically assessing for the inclusion of women of color.</p><p><strong>Methods: </strong>Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a primary literature search was conducted using 4 databases: Ovid Medline(R), Scopus, Cochrane, and Web of Science from all years to December 2022. We included published studies with adult women diagnosed with VLS and containing a treatment arm using topical corticosteroids. Single case reports, literature reviews, systemic reviews, meta-analyses, and reports not available in English were excluded.</p><p><strong>Results: </strong>Overall, 1340 nonduplicate studies were assessed for eligibility criteria. In total, 65 publications were included. Only 6 included racial demographic data. Black women made up at most 3.8% of the sample population and Latinx women made up at most 5.7%.</p><p><strong>Limitations: </strong>Our review focused on a specific intervention (ie, the use of topical corticosteroids for the treatment of VLS), which may restrict the generalizability of our findings to other interventions. No risk of bias assessment was done due to the scoping nature of the review.</p><p><strong>Conclusion: </strong>Women of color are underrepresented in studies of topical corticosteroid use in adult women with VLS. Intentional diversity in recruitment will enable the collection of data that is both more accurate and reflective of a broader spectrum of perspectives and life experiences.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e170"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-induced anogenital melanosis is a very frequent finding in patients with vulvar lichen sclerosus.","authors":"Thilo Gambichler, Gülgün Erdogan, Sera S Weyer-Fahlbusch, Laura Susok","doi":"10.1097/JW9.0000000000000169","DOIUrl":"10.1097/JW9.0000000000000169","url":null,"abstract":"<p><strong>Background: </strong>Pigmented lesions such as melanosis have rarely been reported in patients with vulvar lichen sclerosus (VLS) that is typically characterized by hypopigmented lesions.</p><p><strong>Objective: </strong>We aimed to analyze systematically anogenital melanosis in a large cohort of VLS patients.</p><p><strong>Methods: </strong>We analyzed the clinical data of 198 female patients with VLS. The anogenital lesions of all patients were professionally photographed in a standardized position and illumination. Severity classification of architectural findings followed an easy-to-use clinical score. A modified Melasma Area and Severity Index and an image analysis software were used to evaluate the area and intensity of pigmentation.</p><p><strong>Results: </strong>According to the clinical score, 79 (198/39.9%) patients showed grade 1 disease, 78 (198/39.4%) grade 2, 37 (198/18.7%) grade 3, and 4 (198/2%) grade 4 disease. About 111 (56.1%) of the 198 patients had anogenital melanosis with a median modified Melasma Area and Severity Index of 3.6 (0.4-14). Univariate analysis revealed that anogenital melanosis was positively correlated with the use of topical estrogens (<i>P</i> = .0018) and negatively correlated with the use of pulsed high-dose corticosteroids plus low-dose methotrexate (PHDC-LDM, <i>P</i> = .021). On multivariable analysis, the use of topical hormone therapy turned out to be a strong independent predictor for the presence of anogenital melanosis (odds ratio: 4.57, 95% confidence interval: 1.66-12.57, <i>P</i> = .0033), whereas PHDC-LDM use was an independent predictor for the absence of anogenital melanosis (odds ratio: 0.35, 95% confidence interval: 0.15-0.84, <i>P</i> = .018).</p><p><strong>Limitations: </strong>The study includes the retrospective monocentric design.</p><p><strong>Conclusion: </strong>Anogenital melanosis is a very frequent and so far, under-reported clinical finding in VLS patients. It is likely caused by the use of topical estrogens employed for VLS treatment. In contrast, patients with more severe disease and PHDC-LDM treatment appear to develop less likely anogenital melanosis.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e169"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anogenital pruritus is associated with anxiety, depression, and other psychiatric disorders.","authors":"Alex Balfour, Christina Kraus","doi":"10.1097/JW9.0000000000000168","DOIUrl":"10.1097/JW9.0000000000000168","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e168"},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation in patients with vulvar lichen sclerosus.","authors":"Hannah R Chang, Madeline Ngo, Shivani Jain, Melissa M Mauskar","doi":"10.1097/JW9.0000000000000164","DOIUrl":"10.1097/JW9.0000000000000164","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e164"},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichenoid tissue eruption of the vulva associated with immune checkpoint inhibitor.","authors":"Maya I Davis, David J DiCaudo, Leah A Swanson","doi":"10.1097/JW9.0000000000000161","DOIUrl":"10.1097/JW9.0000000000000161","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e161"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of spironolactone in treating hidradenitis suppurativa in women of childbearing age: a single-center retrospective analysis.","authors":"Suma V Gangidi, Rachel K Greene, Eric Olsen, Shanelle Jackson, Mio Nakamura","doi":"10.1097/JW9.0000000000000159","DOIUrl":"10.1097/JW9.0000000000000159","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent nodules that affect areas with a high density of apocrine sweat glands, such as the axillae and groin. Androgens are implicated in the pathophysiology of HS. Therefore, spironolactone, an antiandrogen therapy, is recommended. However, data on its use in women of childbearing age are limited, especially since its antiandrogenic effects may affect menstruation, fertility, and pubertal development.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of spironolactone in the treatment of hidradenitis suppurativa in women of childbearing age and to identify factors associated with treatment response.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on female patients aged 12 to 50 with HS treated with spironolactone at Michigan Medicine dermatology clinics from 2000 to 2021. The patients' demographic data, HS characteristics, and spironolactone responses were examined. Statistical assessments were performed to determine the efficacy indicators.</p><p><strong>Results: </strong>Of the 157 patients reviewed, 31 showed an improvement in treatment. Variables such as axillary involvement, previous treatment failures, and use of intralesional steroids were linked to a lack of improvement in spironolactone. Through adjusted multiple logistic regression analysis, a significant association was observed between improvement status and Hurley stage 3 (odds ratio = 0.15 [95% CI: 0.02-0.79], <i>P</i> = .036), suggesting that patients with Hurley stage 3 were 85% less likely to exhibit improvement in spironolactone therapy.</p><p><strong>Limitations: </strong>The study's retrospective nature and reliance on single-center data can limit generalizability. The sample size is limited and therefore affects the study's statistical power.</p><p><strong>Conclusion: </strong>Thus, spironolactone may offer therapeutic benefits for HS in women of childbearing age. However, patients with severe disease (Hurley stage 3) had reduced response rates. Further prospective studies are recommended to validate these findings and determine the most suitable patient profile for spironolactone therapy for HS.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 3","pages":"e159"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in high-quality dermatology research over the past 15 years.","authors":"Barak Zlakishvili, Amir Horev","doi":"10.1097/JW9.0000000000000160","DOIUrl":"10.1097/JW9.0000000000000160","url":null,"abstract":"<p><strong>Background: </strong>In the last 15 years, an increase in U.S. female dermatologists from 41 to 52.2% and a surge in female authorship (FAP) have been noted. Authorship is a pivotal objective measurement of academic productivity and, contribution as first or senior author, plays a major role in the promotion process of active physicians and faculty members.</p><p><strong>Objective: </strong>To validate, analyze, and clarify trends in FAP in high-quality dermatology research in the last 15 years.</p><p><strong>Methods: </strong>The Thomson Reuters Web of Science Journal Citation Reports 2021 was used to retrieve the 100 most-cited original articles from the top 5 dermatology journals (determined by 2021 impact factors) in 5 consecutive 3-year intervals between 2009 and 2023. Gender application programming interface, a gender algorithm, was used to identify FAP according to country of origin and first name. Monotonic trend test significance level was set at 5%.</p><p><strong>Results: </strong>In total, 14,187 articles were retrieved and subdivided into the 100 most-cited in 3-year intervals. A total of 418 first and 447 senior authors' gender were identified. FAP was found in 43%, 31%, and 37% of the first, last, and total authors. Trend analysis revealed a decrease in the last 15 years (<i>S</i> = -4610, <i>P</i> = .068) in senior FAP. Similarly, the trend persists in the United States (<i>S</i> = -1606, <i>P</i> = .052).</p><p><strong>Limitations: </strong>Due to the usage of a binary gender identification algorithm, Nonbinary gender could not be identified in this analysis.</p><p><strong>Conclusion: </strong>The last 15 years show an inverse relationship, with an increase in female dermatologists and a decrease in senior FAP in high-quality journals in the general dermatology community.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e160"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}