International Journal of Women''s Dermatology最新文献

{"title":"Genetic factors associated with hidradenitis suppurativa, a literature review.","authors":"Shannon M Eble, Oliver J Wisco, Luigi Boccuto, Brian Laffin, Veronica G Parker, Nicole J Davis, Heide S Temples","doi":"10.1097/JW9.0000000000000158","DOIUrl":"10.1097/JW9.0000000000000158","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by deep-seated, painful lesions most frequently occurring in intertriginous areas of the skin. HS leads to poor quality of life in affected individuals and is difficult to diagnose and treat.</p><p><strong>Objective: </strong>Understanding the genetics associated with familial inheritance may lead to a better understanding of the pathogenesis of this debilitating disease.</p><p><strong>Methods: </strong>Articles published until March 9, 2023, were identified in PubMed using the following search terms: hidradenitis suppurativa and gene* or acne inversa and gene*.</p><p><strong>Results: </strong>The rate of monogenic mutations associated with HS is less than 7%, with the most common genetic mutations reported in sporadic and familial HS cases being in <i>NCSTN</i> and less frequently in <i>PSENEN.</i> Individuals with mutations in the gamma-secretase complex tended to have more severe HS and an early age of onset.</p><p><strong>Limitations: </strong>This study was limited to the case studies available in PubMed, the majority of which used targeted gene panels to detect genetic mutations.</p><p><strong>Conclusion: </strong>Approximately 30% of individuals diagnosed with HS report having a positive family history; however, very few studies demonstrate monogenic familial transmission of HS. The case studies of syndromic HS reported a variety of genetic mutations associated with HS, some of which were familial, while others were sporadic, suggesting that other pathways may be involved in the pathogenesis of HS and other potential mutations that have yet to be evaluated. More research is needed to understand the genetic mutations in HS.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e158"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the efficacy of popular eye cream ingredients.","authors":"Hanin Hamie, Reem Yassine, Rajaa Shoukfeh, Dilara Turk, Farhan Huq, Meena Moossavi","doi":"10.1097/JW9.0000000000000156","DOIUrl":"10.1097/JW9.0000000000000156","url":null,"abstract":"<p><strong>Background: </strong>Due to the periorbital region's high susceptibility to damage from external factors, along with its tendency to demonstrate early signs of aging, periorbital skin is a common target for antiaging therapy.</p><p><strong>Objective: </strong>This review aims to evaluate the efficacy of active ingredients commonly found in eye creams, particularly focusing on their impact on periorbital skin concerns.</p><p><strong>Methods: </strong>A comprehensive review of the literature on active ingredients in eye creams, including retinoids, vitamins C and E, peptides, ceramides, hyaluronic acid, caffeine, and niacinamide, was conducted. Clinical studies assessing the efficacy of these ingredients in addressing periorbital concerns were examined.</p><p><strong>Results: </strong>Studies demonstrate the potential of these ingredients to improve various aspects of periorbital skin, including hydration, elasticity, collagen synthesis, and reduction of inflammatory mediators. Ingredients such as retinoids, vitamin C, and caffeine show promise in addressing wrinkles and hyperpigmentation, while peptides and hyaluronic acid aid in collagen production and hydration. Niacinamide and ceramides offer benefits in reducing wrinkles and enhancing the skin barrier function.</p><p><strong>Limitations: </strong>The lack of clinical trials specifically targeting eye cream formulations and periorbital skin is a notable limitation. Furthermore, the variability in study designs, sample sizes, and concentrations of active ingredients across studies complicates direct comparisons.</p><p><strong>Conclusion: </strong>The reviewed studies highlight the potential of active ingredients in eye creams to address various periorbital concerns. Further research, particularly large-scale clinical trials focusing on eye cream formulations and their efficacy on periorbital skin, is warranted to establish their significance and comparability with other dermatologic products.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e156"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11175953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatology resident comfort level treating hair conditions related to patients with skin of color.","authors":"Starling Tolliver, Camilla Cascardo, Nikita Wong, Yasmine Abushukur, Geoffrey Potts","doi":"10.1097/JW9.0000000000000137","DOIUrl":"10.1097/JW9.0000000000000137","url":null,"abstract":"<p><strong>Background: </strong>Although recent studies demonstrated resident satisfaction in the treatment of skin of color (SOC) related disease, comfort levels treating hair specific to populations within the SOC spectrum is unclear.</p><p><strong>Objective: </strong>The purpose of this study is to assess dermatology residents comfort level in recognizing and treating various common hair conditions with a focus on those specific to SOC.</p><p><strong>Methods: </strong>An Institutional Review Board-approved survey was distributed to United States residents of Accreditation Council for Graduate Medical Education-accredited dermatology programs. Data pertaining to hair care knowledge and treatment comfort levels were collected. Analysis was completed using equal variance 2-sample <i>t</i> tests and analysis of variance <i>F</i> tests, <i>P</i> < .05.</p><p><strong>Results: </strong>Dermatology residents were relatively comfortable with common conditions such as androgenetic alopecia and alopecia areata, but uncomfortable with creating healthy hair regimens, discussing natural hair care products, and treating trichorrhexis nodosa. Resident self-identification as underrepresented in medicine significantly impacted resident knowledge of hair care and treatment in patients with SOC.</p><p><strong>Limitations: </strong>This study was limited due to small sample size and potential recall bias.</p><p><strong>Conclusion: </strong>This study highlights knowledge gaps in understanding hair-related care for patients with SOC, affirming the continued importance of diversifying dermatology programs as well as hair-specific training for residents.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e137"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Fitzpatrick skin type distribution of vitiligo on Instagram.","authors":"Britney T Nguyen, Jessica Shiu","doi":"10.1097/JW9.0000000000000157","DOIUrl":"10.1097/JW9.0000000000000157","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e157"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis in women: special considerations in the childbearing years.","authors":"Rodolfo Valentini, Mona Shahriari","doi":"10.1097/JW9.0000000000000151","DOIUrl":"10.1097/JW9.0000000000000151","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is one of the most common inflammatory dermatoses in adults. Women are disproportionately impacted by AD and report significant impacts on quality of life compared to men.</p><p><strong>Objective: </strong>Given the absence of formal guidelines for the treatment of AD in women of childbearing age, we will review special considerations for treating women of childbearing age with AD to ensure consistent care and optimal outcomes for these patients.</p><p><strong>Methods: </strong>PubMed and Google Scholar databases were searched for relevant articles from database inception through May of 2023.</p><p><strong>Results: </strong>There are several treatments including topical therapies, systemic therapies, and phototherapy that are considered safe during preconception, pregnancy and breastfeeding. Given the negative consequences of uncontrolled AD for both the mother and the unborn baby, the risks and benefits of potential therapies should be reviewed with all women of childbearing age suffering from AD.</p><p><strong>Limitations: </strong>The gold standard in recommending therapies is randomized controlled trials; however, pregnant and lactating women are often excluded from these trials.</p><p><strong>Conclusion: </strong>Through shared decision-making between the dermatologist, obstetrician, and patient, the risks and benefits of any therapy should be thoroughly discussed and considered with all women of childbearing age, to optimize care and outcomes for this unique population.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e151"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Janus kinase inhibitor access for alopecia areata: a retrospective analysis.","authors":"Elizabeth J Klein, Dolly Taiwò, Efe Kakpovbia, Melissa Laughter, Ambika Nohria, Kristen I Lo Sicco","doi":"10.1097/JW9.0000000000000155","DOIUrl":"10.1097/JW9.0000000000000155","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e155"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data wobbles in hidradenitis suppurativa clinical trials and potential contributing factors: a retrospective review.","authors":"Corey L Snyder, Ruby S Gibson, Stella X Chen, Martina L Porter, Alexa B Kimball","doi":"10.1097/JW9.0000000000000152","DOIUrl":"10.1097/JW9.0000000000000152","url":null,"abstract":"<p><strong>Background: </strong>In some hidradenitis suppurativa (HS) clinical trial study arms, there is an unexpected decline in efficacy between the penultimate visit and the prespecified primary endpoint week, which we have termed a \"wobble.\"</p><p><strong>Objective: </strong>We aimed to establish how often study arms in HS programs wobble.</p><p><strong>Methods: </strong>In a retrospective review, we identified HS clinical trials listed on ClinicalTrials.gov testing systemic, nonantibiotic medications that utilized Hidradenitis Suppurativa Clinical Response (HiSCR) as an outcome measure. We identified study arms demonstrating greater improvement in a visit prior to the primary endpoint week. Baseline subject characteristics were compared between studies with HiSCR wobble and no HiSCR wobble.</p><p><strong>Results: </strong>A total of 21 studies (randomized control trial [RCT], <i>n</i> = 14; open-label, <i>n</i> = 7) with 35 study drug arms (RCT, <i>n</i> = 27; open-label, <i>n</i> = 8) and 14 placebo arms were identified. HiSCR wobble occurred significantly more often in RCT compared to open-label study drug arms (11/27 [40.7%] vs 0/8 [0%]). In RCT study arms with HiSCR wobble, baseline draining fistula counts were significantly lower (2.3 vs 3.2), and numerically fewer Hurley stage 3 patients (33.2% vs 42.5%), lower weighted total abscess and nodule counts (12.1 vs 12.6), lower weighted dermatology life quality index scores (12.5 vs 14.5), and a higher proportion of female patients (63.9% vs 58.3%) were observed.</p><p><strong>Limitations: </strong>Include low number of HS clinical trials and insufficient data reported in many studies to assess for wobble, degree of wobble, and to compare all baseline characteristics.</p><p><strong>Conclusion: </strong>Nonlinear improvement in study arm response occurs in some HS RCTs. Potential contributing factors include a higher proportion of less severe patients at baseline and more female patients.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e152"},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The three c's: vulvar exam terminology considerations for dermatologists.","authors":"Ellee P Vikram, Marianne R Rara, Christina N Kraus","doi":"10.1097/JW9.0000000000000147","DOIUrl":"10.1097/JW9.0000000000000147","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e147"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spironolactone in hidradenitis suppurativa: a single-center.","authors":"Rahul Masson, Sarah E Park, Terri Shih, Marcia Hogeling, Vivian Y Shi, Jennifer L Hsiao","doi":"10.1097/JW9.0000000000000135","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000135","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 1","pages":"e135"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating patients with hidradenitis suppurativa for disordered eating.","authors":"Amina Ziad, Yiwen Helen Li, Kristin N Javaras, Karla Santiago-Soltero, Alexandra Charrow","doi":"10.1097/JW9.0000000000000138","DOIUrl":"10.1097/JW9.0000000000000138","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 1","pages":"e138"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}