International Journal of Women''s Dermatology最新文献

{"title":"Data wobbles in hidradenitis suppurativa clinical trials and potential contributing factors: a retrospective review.","authors":"Corey L Snyder, Ruby S Gibson, Stella X Chen, Martina L Porter, Alexa B Kimball","doi":"10.1097/JW9.0000000000000152","DOIUrl":"10.1097/JW9.0000000000000152","url":null,"abstract":"<p><strong>Background: </strong>In some hidradenitis suppurativa (HS) clinical trial study arms, there is an unexpected decline in efficacy between the penultimate visit and the prespecified primary endpoint week, which we have termed a \"wobble.\"</p><p><strong>Objective: </strong>We aimed to establish how often study arms in HS programs wobble.</p><p><strong>Methods: </strong>In a retrospective review, we identified HS clinical trials listed on ClinicalTrials.gov testing systemic, nonantibiotic medications that utilized Hidradenitis Suppurativa Clinical Response (HiSCR) as an outcome measure. We identified study arms demonstrating greater improvement in a visit prior to the primary endpoint week. Baseline subject characteristics were compared between studies with HiSCR wobble and no HiSCR wobble.</p><p><strong>Results: </strong>A total of 21 studies (randomized control trial [RCT], <i>n</i> = 14; open-label, <i>n</i> = 7) with 35 study drug arms (RCT, <i>n</i> = 27; open-label, <i>n</i> = 8) and 14 placebo arms were identified. HiSCR wobble occurred significantly more often in RCT compared to open-label study drug arms (11/27 [40.7%] vs 0/8 [0%]). In RCT study arms with HiSCR wobble, baseline draining fistula counts were significantly lower (2.3 vs 3.2), and numerically fewer Hurley stage 3 patients (33.2% vs 42.5%), lower weighted total abscess and nodule counts (12.1 vs 12.6), lower weighted dermatology life quality index scores (12.5 vs 14.5), and a higher proportion of female patients (63.9% vs 58.3%) were observed.</p><p><strong>Limitations: </strong>Include low number of HS clinical trials and insufficient data reported in many studies to assess for wobble, degree of wobble, and to compare all baseline characteristics.</p><p><strong>Conclusion: </strong>Nonlinear improvement in study arm response occurs in some HS RCTs. Potential contributing factors include a higher proportion of less severe patients at baseline and more female patients.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e152"},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The three c's: vulvar exam terminology considerations for dermatologists.","authors":"Ellee P Vikram, Marianne R Rara, Christina N Kraus","doi":"10.1097/JW9.0000000000000147","DOIUrl":"10.1097/JW9.0000000000000147","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 2","pages":"e147"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spironolactone in hidradenitis suppurativa: a single-center.","authors":"Rahul Masson, Sarah E Park, Terri Shih, Marcia Hogeling, Vivian Y Shi, Jennifer L Hsiao","doi":"10.1097/JW9.0000000000000135","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000135","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 1","pages":"e135"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating patients with hidradenitis suppurativa for disordered eating.","authors":"Amina Ziad, Yiwen Helen Li, Kristin N Javaras, Karla Santiago-Soltero, Alexandra Charrow","doi":"10.1097/JW9.0000000000000138","DOIUrl":"10.1097/JW9.0000000000000138","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"10 1","pages":"e138"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global facial rejuvenation with one treatment of incobotulinumtoxinA, hyaluronic acid, and calcium hydroxyapatite results in long-term patient-reported satisfaction.","authors":"Jasmine Thai Lu, Kachiu C Lee","doi":"10.1097/JW9.0000000000000124","DOIUrl":"10.1097/JW9.0000000000000124","url":null,"abstract":"<p><strong>Background: </strong>Global facial rejuvenation using injectables (neuromodulators and fillers) has reported patient satisfaction after 2 treatments: an initial and touch-up treatment at 2-4 weeks afterward. In practice, patients typically receive only 1 treatment and do not return for a touch-up treatment within a month.</p><p><strong>Objective: </strong>The purpose of this study was to assess patient-reported satisfaction after only 1 treatment, thus mimicking real-world scenarios.</p><p><strong>Methods: </strong>Patients with facial photoaging (Glogau facial aging scale ≥2) were treated with calcium hydroxyapatite, hyaluronic acid 22.5 mg/mL, and incobotulinumtoxinA injections for full facial rejuvenation, with no touch-up treatments. Patients completed the FACE-Q Satisfaction with Facial Appearance survey at baseline and 1- and 3-month post-treatment. The treating physician completed the Global Aesthetic Improvement Scale at 1- and 3-month post-treatment.</p><p><strong>Results: </strong>Twenty-two patients were enrolled in the study, with 1 patient lost to follow-up. There was a significant improvement in mean FACE-Q scores at 1-month (80.1, <i>P</i> = .01) and 3-month (77.9, <i>P</i> = .02) compared to baseline (71.4). Mean Global Aesthetic Improvement Scale scores at 1-month (2.1) and 3-month (2.2) were not statistically significant, indicating sustained improvement at 3 months. The product amount used per patient varied and was not correlated with either score. Limitations included a lack of a control group and follow-up ending at 3 months. Strengths included assessment of patient satisfaction after only 1 treatment, compared to other studies allowing 2 treatments.</p><p><strong>Limitations: </strong>Limitations include a small sample size and lack of a control group.</p><p><strong>Conclusion: </strong>Global full facial rejuvenation using 1 treatment of calcium hydroxyapatite, hyaluronic acid 22.5 mg/mL, and incobotulinumtoxinA provides sustained patient-reported satisfaction at 3 months.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e124"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venture capital funding of dermatology companies founded by women: a unique set of challenges.","authors":"Amar D Desai, Jacquelyn M Roth, Nilesh Kodali, Simona Alomary, Rahul Bhatia, Vinod E Nambudiri, Cindy Wassef, Shari R Lipner","doi":"10.1097/JW9.0000000000000120","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000120","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e120"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding perceptions of hair loss in hijab-wearing women: a pilot survey study.","authors":"Lina Alhanshali, Fatima Bawany, Michael G Buontempo, Jerry Shapiro, Kristen Lo Sicco","doi":"10.1097/JW9.0000000000000115","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000115","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e115"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young women in sororities more likely to have used tanning beds and report improved appearance and self-confidence with tan skin.","authors":"Jazmin Newton, Allen Wellman, Lauren Ochoa, Alyssa Reinschmidt, Samuel John Vassar, Minga Vargas, DenYelle B Kenyon, Marcus Frohm","doi":"10.1097/JW9.0000000000000116","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000116","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e116"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender perspective in psoriasis: a scoping review and proposal of strategies for improved clinical practice by European dermatologists.","authors":"Alvaro Gonzalez-Cantero, María Magdalena Constantin, Annunziata Dattola, Tom Hillary, Elise Kleyn, Nina Magnolo","doi":"10.1097/JW9.0000000000000112","DOIUrl":"10.1097/JW9.0000000000000112","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of psoriasis is similar between men and women; however, evidence exists of sex- and gender-related differences in disease expression, impact, coping, and needs of patients with psoriasis. These differences are essential and should be considered in clinical practice and research.</p><p><strong>Objective: </strong>To compile available evidence on sex- and gender-related differences in psoriasis, identify the most critical gaps in clinical practice and research, and use it to propose strategies for improved clinical practice.</p><p><strong>Methods: </strong>Six European dermatologists selected the topics to consider according to their relevance in the dermatology setting with the support of methodologists. Evidence on sex- and gender-related differences was obtained by a scoping review based on search strategies in Medline and Cochrane Library from inception to October 2021 using the following terms: arthritis, psoriatic, psoriasis, gender, and sex. The panel discussed the results and proposed strategies by consensus.</p><p><strong>Results: </strong>The scoping review identified broad themes: (1) clinical expression, (2) severity and patient-reported outcomes, (3) psychosocial impact, (4) access to treatments and propensity to treat, (5) comorbidities, and (6) treatment effect. The strategies are based on these broad themes.</p><p><strong>Limitations: </strong>No risk of bias assessment was done due to the scoping nature of the review.</p><p><strong>Conclusion: </strong>This review offers insights into gender differences in psoriasis, providing a foundation for improving clinical practice and patient outcomes.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e112"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and phototrichogrammatic evaluation of estradiol replacement therapy on hair growth in postmenopausal Japanese women with female pattern hair loss: a pilot study.","authors":"Yujiro Endo, Yuko Obayashi, Michiaki Murakoshi, Juichiro Saito, Rie Ueki","doi":"10.1097/JW9.0000000000000109","DOIUrl":"10.1097/JW9.0000000000000109","url":null,"abstract":"<p><strong>Background: </strong>Female pattern hair loss (FPHL) is known to present with characteristic pathological conditions, including reduced overall hair density. Female hormones affect hair condition; however, the detailed mechanism is unknown. Furthermore, research on the topic is complicated by the fact that senescent alopecia often occurs concurrently with FPHL. Therefore, we investigated the effect of estradiol, a female hormone, on hair growth by eliminating aging factors and objectively evaluating hair changes caused by female hormone replacement therapy (HRT).</p><p><strong>Objective: </strong>This study was conducted to elucidate the mechanism through which female hormones exert their effects on hair.</p><p><strong>Methods: </strong>The study included 11 female patients undergoing HRT who were evaluated before initiating HRT, 3 months after initiating HRT, and 6 months after initiating HRT. The thinning hair score, hair density, telogen hair rate, telogen plucking strength, hair growth rate, and hair thickness were measured and evaluated. Furthermore, hematological tests were performed to assess the general physical condition of the participants.</p><p><strong>Results: </strong>HRT increased the telogen hair rate (<i>P</i> = .010, paired <i>t</i> test) at 3 months, improved frontal hairline thinning score (<i>P</i> = .008, Wilcoxon test), and increased the plucking strength (<i>P</i> = .013, paired <i>t</i> test) at 6 months.</p><p><strong>Limitations: </strong>The limitation of this study included the relatively small sample size, inability to conduct further long-term tests because of participant burden, and lack of a control group.</p><p><strong>Conclusion: </strong>The results suggested that HRT improved the appearance of the frontal hairline. As few studies have analyzed the effects of female hormones on human hair, a novel finding of this study was the effects of estradiol on the plucking strength after excluding age as a factor. We believe that these findings will contribute to understanding FPHL and developing female hormone-related treatments.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 4","pages":"e109"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}