Vacunas最新文献

{"title":"Perceptions, attitude, and knowledge of Saudi parents towards the human papilloma virus vaccine","authors":"Muazzam Sheriff Maqbul ,&nbsp;Fatemah Saad Allihaydan ,&nbsp;Rania Hisham Elfaham ,&nbsp;Lina Abdulaziz Ahmed Baragaa ,&nbsp;Shireen Hisham Elfaham ,&nbsp;Nahlaa Saad Allihaydan ,&nbsp;Abdulrahman Khalid Alswat ,&nbsp;Salam Omar Alhilal ,&nbsp;Reem Saleh Alzaki ,&nbsp;Walaa Ebrahim Jaafar Jasim ,&nbsp;Yousef Ahmed Alduhailan ,&nbsp;Abdullah Dhafer Alshehri ,&nbsp;Saeed Ayidh Alshahrani ,&nbsp;Abdulrahman Musaed Al Sumaih","doi":"10.1016/j.vacun.2023.08.007","DOIUrl":"10.1016/j.vacun.2023.08.007","url":null,"abstract":"<div><h3>Objectives</h3><p>HPV infection<span> is a widely acknowledged cause of infection-related cancers globally. However, HPV<span><span> vaccine is a reliable and risk-free method to avert HPV infection and is advised for children aged from 9 to 14, irrespective of their gender. Therefore, when considering the vaccination for human papilloma virus (HPV), viewpoints held by parents hugely impact their decision to vaccinate their daughters. This study aims to evaluate Saudi parents' comprehension and perception of HPV (human papilloma virus) and the </span>HPV vaccine and its acceptability.</span></span></p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted to investigate parents of adolescent daughters. An online questionnaire was conducted using Google form to gather information about socio-demographic data, awareness, and knowledge of HPV, and the willingness to accept the HPV vaccine.</p></div><div><h3>Results</h3><p>Out of 424 participants, three-quarters of the participants were mothers 319 (75.2%) and 105 (24.8%) were fathers. Over half of the respondents (53.8%) were acknowledged that HPV is a cause of cervical cancer where the relationship was found to be significant in relation to gender. Almost half of the participants (47.0%) were acknowledged that HPV vaccine is used to prevent cervical cancer which was statistically significant in relation to gender (<em>P</em> <!-->=<!--> <span><span>.034) but (47.9%) did not know. Encouragingly, levels of vaccine acceptance were high (54.7%) although (41.0%) had a negative attitude towards the effectiveness of HPV vaccine with strong belief that the vaccine can cause serious side effects (67.0%). Parents with </span>family history of cervical cancer and were aware that the vaccine can prevent cervical cancer were positively associated.</span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New potent vaccine against brucellosis based on multi-epitope prediction method of inf C protein. In silico study","authors":"Laref Nora ,&nbsp;Belkheir Khadidja","doi":"10.1016/j.vacun.2023.10.004","DOIUrl":"10.1016/j.vacun.2023.10.004","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Brucellosis infection could be eradicated by using an effective vaccine. </span><em>Inf</em> C gene expression generates one of the main <span><span>Brucella</span></span> pathogenesis proteins. The purpose of this study was to design a new vaccine against <em>Brucella</em> disease by <span><em>in silico</em></span> determination of epitopes of <em>inf</em><span> C protein.</span></p></div><div><h3>Methods</h3><p>In the first, <em>Inf</em><span> C amino acid sequences were extracted from the UniProt database and subjected to </span><em>in silico</em><span><span><span><span> analysis, including multiple sequence alignment, conserved region determination, </span>allergenicity, </span>antigenicity<span>, and toxicity of the selected epitopes for TCL, HTL<span>, and BCl. Vaccine-target (MHC alleles and TLRs) interactions, binding affinities, and dynamical stabilities were inspected through </span></span></span>molecular docking<span> and molecular dynamic simulation (MD) using Cluspro 2 server and GROMACS packages respectively. Further, the codon adaptation of the designed vaccine was determined by the JCat server and the obtained sequence was cloned in pET19b(+)vector by pDRAW32 software. Finally, the ability of the newer vaccine to stimulate the immune response was assessed using a computational immune simulation.</span></span></p></div><div><h3>Results</h3><p><span>Results allowed us to select a peptide vaccine<span> on basis of its good binding affinities with TLR-8 allele. The multi-peptide vaccine showed also to be highly antigenic, non-allergenic, non-toxic, and potential expression in </span></span><em>E coli</em><span>. Results showed also good stability of the vaccine–TLR8 complex and strong cellular and humoral immune response after three </span><em>in silico</em> injections of the vaccine construct.</p></div><div><h3>Conclusion</h3><p>All these theoretical results reveal that the conserved region of <em>inf</em> C protein could be used for designing of a new potent vaccine against <em>Brucella</em>.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139303705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estado actual del herpes zóster y las nuevas perspectivas para su prevención","authors":"José María Molero ,&nbsp;Jesús Ortega ,&nbsp;Irene Montoro ,&nbsp;Natalia McCormick","doi":"10.1016/j.vacun.2023.12.005","DOIUrl":"10.1016/j.vacun.2023.12.005","url":null,"abstract":"<div><p>Herpes zoster (HZ) is a relatively common disease whose incidence increases with age and in immunocompromising situations. Mortality caused by HZ is low, but its complications impact on physical, psychological, functional, and social aspects of patients, significantly reducing health-related quality of life. Postherpetic neuralgia is the most common complication, and is characterized by symptoms of neuropathic pain including allodynia and hyperalgesia with electrical, burning, and/or stabbing sensations that persist more than 90 days. Its management is complex and has limitations, which increases the demand for health resources and also increases direct and indirect costs. This article reviews the epidemiological and clinical features of HZ, the available treatments and vaccines against HZ, as well as national and international vaccination recommendations. In addition, the role of Primary Care is emphasized as a catalyst for the implementation of adult vaccination.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1576988724000025/pdfft?md5=9fb6cb25aab129901ed285333246863f&pid=1-s2.0-S1576988724000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The co-infection of SARS-CoV-2 with atypical bacterial respiratory infections: A mini review","authors":"Fateme Taheri ,&nbsp;Soheil Vesal ,&nbsp;Parnian Goudarzi ,&nbsp;Zahra Sahafnejad ,&nbsp;Amin Khoshbayan","doi":"10.1016/j.vacun.2023.08.004","DOIUrl":"10.1016/j.vacun.2023.08.004","url":null,"abstract":"<div><p><span>In 2019, the Coronavirus disease (COVID-19) rapidly spread worldwide and posed a global threat. The co-infection among COVID-19 patients was reported variable in different studies. However, it could reach 50% of non-survivor patients. </span><span><span>Chlamydia pneumoniae</span></span>, <span><em>Mycoplasma pneumoniae</em></span>, and <span><span>Legionella pneumophila</span></span><span> are responsible for respiratory infections and also can act as co-pathogens with COVID-19, making their detection challenging. These bacteria exhibit similar clinical signs to COVID-19, leading to potential oversight. Furthermore, treating these bacteria requires a different antibiotic regimen compared to typical respiratory bacterial agents. Thus, recognizing the clinical characteristics, laboratory findings, and outcomes of co-infections is crucial for improving understanding and treatment strategies.</span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134976966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacunación COVID-19 y búsquedas web sobre salud mental: un estudio infodemiológico mundial","authors":"Juan Antonio Becerra-García ,&nbsp;Sara Barbeito ,&nbsp;Teresa Sánchez-Gutiérrez","doi":"10.1016/j.vacun.2024.02.004","DOIUrl":"10.1016/j.vacun.2024.02.004","url":null,"abstract":"<div><h3>Background</h3><p>The association between worldwide COVID-19 vaccination and mental health has been largely unexplored by means of infodemiological studies.</p></div><div><h3>Objective</h3><p>To explore how global public interest in different mental health topics changed between the pre-vaccination pandemic stage and the different periods of the COVID-19 vaccination campaign.</p></div><div><h3>Methods</h3><p>In this study were examined the relative search volume (RSV) in Google Trends for “anxiety”, “depression”, “stress”, and “suicide” between March 1st, 2020 to January 1st, 2023. The RSV for each term was compared with respect to 4 periods: the pre-vaccination pandemic stage; the period from initiation of vaccination until 50% of the population was fully vaccinated (FV); the period from 50% FV to 60% FV; and the period after 60% FV.</p></div><div><h3>Results</h3><p>A significant lower mean RSV on anxiety, depression and suicide was found once 60% of the world population had been FV compared to different previous vaccination periods and with the pre-vaccination pandemic stage.</p></div><div><h3>Conclusions</h3><p>There seems to be less need for information worldwide on anxiety, depression and suicide topics once 60% of the population is FV against COVID-19. Overcoming this vaccination milestone may have had a positive impact on public interest in specific mental health issues.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140085315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of gene expression between children with type 1 diabetes and Coxsackie viruses B","authors":"Zeyad Thonnoon Al-Rrassam","doi":"10.1016/j.vacun.2023.09.001","DOIUrl":"10.1016/j.vacun.2023.09.001","url":null,"abstract":"<div><p><span>Type 1 diabetes<span> is classified as an autoimmune disorder. Researchers observed the presence of viral Coxsackie virus B proteins within the β-cells in islets shortly after inoculating mice. This observation led them to establish a link between children who have T1D and an infection with the CVB. The objective of this research was to measure the degree of gene expression of highly expressed genes in individuals who were both infected with Coxsackie viruses B and previously had T1D. Additionally, levels of CVB IgG and </span></span>HbA1c<span><span> were assessed in the blood serum of patients with T1D.This correlation was assessed by analyzing the expression of genes with significantly extreme expression levels using logarithmic analysis with specialized mathematical software. This study revealed that there is an association between CVB IgG and HbA1c levels in T1D patients. Additionally, T1D patients with a family history of diabetes showed associations with </span>genetic factors<span> and gene expression. Interestingly, no significant differences in HbA1c levels were observed between patients based on their gender. Furthermore, the genes IGFBP5, GPNMB, and GJA1 exhibited a strong association with CVB. We propose a new strategy that may open up new therapy options for T1D caused by CVB through monitoring the physiological pathways of these genes.</span></span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135762961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the level of protective serum antibody after third dose of different COVID-19 vaccines","authors":"Atena Mansouri ,&nbsp;Mitra Rafiee ,&nbsp;Seyed-Alireza Esmaeili ,&nbsp;Saboura Nikpour ,&nbsp;Alireza Fereidouni ,&nbsp;Mohammad Fereidouni","doi":"10.1016/j.vacun.2024.02.006","DOIUrl":"10.1016/j.vacun.2024.02.006","url":null,"abstract":"<div><p>A new coronavirus (SARS-CoV-2), causing COVID-19 (coronavirus disease 2019), is a member of the Coronaviridae family. The benefits of the primary COVID-19 vaccination far outweigh the risks. Nevertheless, the risks associated with too early and too frequent boosters should be considered, especially when vaccines have immune-mediated effects like myocarditis, which is more commonly associated with the second dose of some mRNA vaccines. Booster vaccinations against SARS-CoV-2 are needed because of either reduced immunity to the original vaccine or evolved viruses producing immunity to the initial vaccine antigens. So, the aim of this study was to detect the difference in neutralizing anti-RBD antibodies between the third and second doses of COVID-19 vaccines. A study was performed among 29 eligible participants in Birjand (Iran). Blood samples were taken from all participants 2–4 weeks after the third dose. In the next step, humoral responses were assessed with a kit detecting neutralization of SARS-CoV-2. SPSS software version 22.0 (SPSS Inc., Chicago, IL) was used to analyze the data. The mean age of cases was 35.62<!--> <!-->±<!--> <!-->8.72 years, with a range of 21–53 years. The obtained results showed that all vaccines significantly had a higher efficacy in the third dose than the second. Participants who received Vaxzevria in the second dose and PastoCovac Plus in the third dose had more immunogenicity. According to the results of this study, a third dose of the vaccine should be given to persons aged ≥<!--> <!-->20 years to provide an increased level of protection against COVID-19. Especially, participants who received Sputnik-V and Vaxzevria in the second dose and PastoCovac Plus in the third dose showed a more effective immune response against the virus.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the vaccine (Covaxin®) on different age groups of people: A pilot study","authors":"Vivek Chauhan ,&nbsp;Adrija Rakshit ,&nbsp;Vivek Kumar Dhiman ,&nbsp;Gaytri Mahajan ,&nbsp;Akash Pnadey ,&nbsp;Shamsher Singh Kanwar ,&nbsp;Devendra Singh","doi":"10.1016/j.vacun.2023.07.005","DOIUrl":"10.1016/j.vacun.2023.07.005","url":null,"abstract":"<div><h3>Background</h3><p><span>Covaxin® is a COVID-19 vaccine created and produced by Bharat Biotech in India. The vaccine is based on the strain of SARS-CoV-2 that was first identified in India and has undergone Phase III </span>clinical trials. Covaxin® has been authorized for emergency use in India and has been distributed as part of India's vaccination campaign. The vaccine has been shown to be effective in preventing COVID-19 infection and hospitalization, but additional studies are needed to determine its efficacy as well as safety in the long term.</p></div><div><h3>Methods</h3><p><span><span>The antibody titer against Covaxin® was detected through indirect </span>ELISA </span>immunoassay. Optimization was performed on 500 samples to get an idea and work further on a larger number of samples.</p></div><div><h3>Results</h3><p><span>The vaccine had the best immune response in individuals between the ages of 21 and 30 and the least response in those between 61 and 70. This was attributed to the phenomenon of immunosenescence, which explains the weakening of the </span>immune system<span> with age. Additionally, the study found that the equine anti-CoV-19 serum had a higher binding affinity<span> with Covaxin®, highlighting the effectiveness of horse Ig against COVID-19 antigens.</span></span></p></div><div><h3>Conclusions</h3><p>The study concluded that Covaxin® was effective in generating an immune response in individuals after 2 doses of vaccination; however, the generated immune response decreased with the time of vaccine administration and the age of the vaccinated. The study also showed that the ELISA technique used in this research is an efficient and sensitive method to evaluate vaccine efficiency and can be applied to a larger number of samples for further comparative analysis.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135606126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Health approach to Nipah virus prevention","authors":"Muhammad Safdar ,&nbsp;Shafeeq ur Rehman ,&nbsp;Muhammad Younus ,&nbsp;Muhammad Arif Rizwan ,&nbsp;Muhammad Kaleem ,&nbsp;Mehmet Ozaslan","doi":"10.1016/j.vacun.2024.02.002","DOIUrl":"10.1016/j.vacun.2024.02.002","url":null,"abstract":"<div><p>The Nipah virus (NiV) is a highly lethal disease, resulting in a mortality rate of 75%. Outbreaks have been observed in southeast Asian countries, including Singapore, Malaysia, Bangladesh, and India. As of September 24, 2023, 6 confirmed cases of the NiV had been reported, including 2 fatalities in the Kozhikode District in Northern Kerala, India. In January and February of 2023, this virus sparked an epidemic in Bangladesh. Bats are important hosts for zoonotic viruses such as the NiV, SARS-CoV-2, Ebola virus, and others; nevertheless, relatively little is known about the ecological determinants and dynamics of these viruses' propagation in their reservoir hosts. Therefore, this review assessed early detection, data integration, community awareness, and resource limitations. Moreover, it gives specific future directions, emphasizing the urgency of vaccine and antiviral development, genomic surveillance advancements, case studies, healthcare system reinforcement, and intensified global collaboration. By addressing these issues, the One Health approach emerges as a vital and proactive strategy for NiV prevention, ensuring comprehensive preparedness and response mechanisms against future outbreaks.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and adherence of the Cape Verdean population to the COVID-19 vaccine","authors":"Maria de Fátima Carvalho Alves,&nbsp;Janice de Jesus Soares,&nbsp;Maria da Luz Lima Mendonça","doi":"10.1016/j.vacun.2023.12.002","DOIUrl":"10.1016/j.vacun.2023.12.002","url":null,"abstract":"<div><h3>Background</h3><p>The spread of the COVID-19 pandemic at the end of 2019, with its well-known consequences in terms of morbidity and mortality, has triggered an intense mobilization of the scientific community in the search for knowledge about the SARS-Cov2 virus and the development of a vaccine.</p></div><div><h3>Objective</h3><p>This study aims to investigate the knowledge, perceptions, attitudes, and intentions of the resident Cape Verdean population regarding the COVID-19 vaccine.</p></div><div><h3>Methods</h3><p>This was a descriptive, cross-sectional, and analytical study involving 1704 resident Cape Verdeans, whose ages ranged from 16 to 60 years old and the majority of participants were male (52.6%). The data was collected using the Google form platform between March 9 and 15, 2021.</p></div><div><h3>Results</h3><p>The data indicated that the majority of participants (95.8%) knew of at least one approved vaccine against COVID-19, and this knowledge (74.9%) was obtained from television, radio, and newspapers. The Oxford-AstraZeneca vaccine was the best known (54.1%) among the study subjects and the majority of respondents (69.7%) had enough information to consciously decide whether or not to get vaccinated against COVID-19. The majority (68.0%) of participants were in favor of the COVID-19 vaccine being administered to all interested people. About 59% of participants considered the COVID-19 vaccine to be safe and 49.6% of participants intended to get vaccinated when the time came. The greatest vaccine hesitancy was related to fear of side effects (21.4%), followed by the fact that it was developed too quickly (12.8%). Health professionals were seen as the priority group (81.5%) to be vaccinated.</p></div><div><h3>Conclusions</h3><p>The results show that the Cape Verdean population had a good level of knowledge about the COVID-19 vaccine. Despite initial hesitation, the vast majority of participants were willing to get vaccinated. These data suggest that awareness-raising, education, and information campaigns about the COVID-19 vaccine should be strengthened to reduce hesitation and increase confidence and adherence to the COVID-19 vaccine among Cape Verdean residents.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}