Vacunas最新文献

{"title":"Volviendo a las vacunas trivalentes frente a la gripe humana","authors":"Jordi Reina, Julia Viana-Ramírez","doi":"10.1016/j.vacun.2024.06.006","DOIUrl":"10.1016/j.vacun.2024.06.006","url":null,"abstract":"","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 289-291"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoinformatics strategy for designing a multi-epitope chimeric vaccine to combat Neisseria gonorrhoeae","authors":"","doi":"10.1016/j.vacun.2024.04.003","DOIUrl":"10.1016/j.vacun.2024.04.003","url":null,"abstract":"<div><h3>Introduction</h3><p>The increasing prevalence of <em>Neisseria gonorrhoeae</em> has become a significant global concern. Consequently, it is of utmost importance to explore prophylactic approaches to combat the anti-microbial resistance in <em>N. gonorrhoeae</em>.</p></div><div><h3>Objective</h3><p>The present study aims to design a multi-epitopic vaccine construct using immunoinformatics and pan-genomic methodology.</p></div><div><h3>Methods</h3><p>The initial phase involves retrieving and re-annotating the 133 complete genome sets of <em>N. gonorrhoeae</em>. Subsequently, a pan-genome analysis was conducted to identify the core genes, followed by gene mapping. Non-homologous outer-membrane proteins were filtered out and analyzed using various epitope prediction algorithms targeting major histocompatibility complex (MHC-I, MHC-II), and B cells. The optimal epitopes were selected based on immunogenicity, antigenicity, toxicity, and solubility. Then, the vaccine constructs were designed using different combinations of linkers, Histidine (His) tags, adjuvants, and the finalized epitopes.</p></div><div><h3>Results</h3><p>The vaccine construct, V13 was screened as the most suitable candidate based on its physiochemical and antigenicity properties. Computational techniques assessed the efficacy of V13 against different immune receptors supported by immune simulation, indicating its safety for inducing immune responses against <em>N. gonorrhoeae.</em></p></div><div><h3>Conclusion</h3><p>The chimeric multi-epitopic vaccine V13 construct can potentially trigger a diverse array of protective immune responses and serve as a promising starting point for future experimental investigations.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 385-402"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine rumour and resistance in Indonesia: Analysing vaccine hesitancy and cultural myths circulated on online platforms","authors":"","doi":"10.1016/j.vacun.2024.03.002","DOIUrl":"10.1016/j.vacun.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Rumours and misinformation about the COVID-19 vaccine have been massively circulated on social media platforms, ranging from misleading information, hoaxes, and conspiracy theories to exaggerating stories mixed with the circulation of cultural myths regarding the vaccine.</p></div><div><h3>Methods</h3><p>This study examines the contents of social media platforms such as Twitter, YouTube, TikTok, and WhatsApp posts, also sourced from other Indonesian online portal news and mainstream media websites.</p></div><div><h3>Results</h3><p>This research identifies quantitatively several rumours, misleading information, conspiracy theories, and other misinformation, resistance, and rejection toward issues related to the COVID-19 vaccine from March to April 2021. We then combine it with an analysis of the narratives of vaccine resistance and cultural myths that have made people hesitate or apathetic in participating in national vaccine programs by the Indonesian government.</p></div><div><h3>Conclusion</h3><p>Sourced from the content analysis of this study, we categorised some themes such as vaccine development, availability, access, morbidity, mortality, harmful excesses, safety, and efficacy, both contained and presented in short narratives, visual graphics, memes, and cartoons. This study suggests that these rumours, misleading stories, and myths, may result in the Indonesian public's vaccine resistance and hesitancy, especially since May the Indonesian government stopped distributing the Astra Zeneca vaccines and the controversial issue regarding the availability of ‘Vaccine Nusantara’ (term as ‘Archipelago Vaccine’). This situation may influence the public's attitude to distrust the government and be distracted by misinformation about the vaccination program. Moreover, we see that cultural beliefs and religious stances have made complicated the hesitancy and resistance of the public against the COVID-19 vaccine.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 313-322"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, attitude, and knowledge of Saudi parents towards the human papilloma virus vaccine","authors":"Muazzam Sheriff Maqbul ,&nbsp;Fatemah Saad Allihaydan ,&nbsp;Rania Hisham Elfaham ,&nbsp;Lina Abdulaziz Ahmed Baragaa ,&nbsp;Shireen Hisham Elfaham ,&nbsp;Nahlaa Saad Allihaydan ,&nbsp;Abdulrahman Khalid Alswat ,&nbsp;Salam Omar Alhilal ,&nbsp;Reem Saleh Alzaki ,&nbsp;Walaa Ebrahim Jaafar Jasim ,&nbsp;Yousef Ahmed Alduhailan ,&nbsp;Abdullah Dhafer Alshehri ,&nbsp;Saeed Ayidh Alshahrani ,&nbsp;Abdulrahman Musaed Al Sumaih","doi":"10.1016/j.vacun.2023.08.007","DOIUrl":"10.1016/j.vacun.2023.08.007","url":null,"abstract":"<div><h3>Objectives</h3><p>HPV infection<span> is a widely acknowledged cause of infection-related cancers globally. However, HPV<span><span> vaccine is a reliable and risk-free method to avert HPV infection and is advised for children aged from 9 to 14, irrespective of their gender. Therefore, when considering the vaccination for human papilloma virus (HPV), viewpoints held by parents hugely impact their decision to vaccinate their daughters. This study aims to evaluate Saudi parents' comprehension and perception of HPV (human papilloma virus) and the </span>HPV vaccine and its acceptability.</span></span></p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted to investigate parents of adolescent daughters. An online questionnaire was conducted using Google form to gather information about socio-demographic data, awareness, and knowledge of HPV, and the willingness to accept the HPV vaccine.</p></div><div><h3>Results</h3><p>Out of 424 participants, three-quarters of the participants were mothers 319 (75.2%) and 105 (24.8%) were fathers. Over half of the respondents (53.8%) were acknowledged that HPV is a cause of cervical cancer where the relationship was found to be significant in relation to gender. Almost half of the participants (47.0%) were acknowledged that HPV vaccine is used to prevent cervical cancer which was statistically significant in relation to gender (<em>P</em> <!-->=<!--> <span><span>.034) but (47.9%) did not know. Encouragingly, levels of vaccine acceptance were high (54.7%) although (41.0%) had a negative attitude towards the effectiveness of HPV vaccine with strong belief that the vaccine can cause serious side effects (67.0%). Parents with </span>family history of cervical cancer and were aware that the vaccine can prevent cervical cancer were positively associated.</span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 181-192"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New potent vaccine against brucellosis based on multi-epitope prediction method of inf C protein. In silico study","authors":"Laref Nora ,&nbsp;Belkheir Khadidja","doi":"10.1016/j.vacun.2023.10.004","DOIUrl":"10.1016/j.vacun.2023.10.004","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Brucellosis infection could be eradicated by using an effective vaccine. </span><em>Inf</em> C gene expression generates one of the main <span><span>Brucella</span></span> pathogenesis proteins. The purpose of this study was to design a new vaccine against <em>Brucella</em> disease by <span><em>in silico</em></span> determination of epitopes of <em>inf</em><span> C protein.</span></p></div><div><h3>Methods</h3><p>In the first, <em>Inf</em><span> C amino acid sequences were extracted from the UniProt database and subjected to </span><em>in silico</em><span><span><span><span> analysis, including multiple sequence alignment, conserved region determination, </span>allergenicity, </span>antigenicity<span>, and toxicity of the selected epitopes for TCL, HTL<span>, and BCl. Vaccine-target (MHC alleles and TLRs) interactions, binding affinities, and dynamical stabilities were inspected through </span></span></span>molecular docking<span> and molecular dynamic simulation (MD) using Cluspro 2 server and GROMACS packages respectively. Further, the codon adaptation of the designed vaccine was determined by the JCat server and the obtained sequence was cloned in pET19b(+)vector by pDRAW32 software. Finally, the ability of the newer vaccine to stimulate the immune response was assessed using a computational immune simulation.</span></span></p></div><div><h3>Results</h3><p><span>Results allowed us to select a peptide vaccine<span> on basis of its good binding affinities with TLR-8 allele. The multi-peptide vaccine showed also to be highly antigenic, non-allergenic, non-toxic, and potential expression in </span></span><em>E coli</em><span>. Results showed also good stability of the vaccine–TLR8 complex and strong cellular and humoral immune response after three </span><em>in silico</em> injections of the vaccine construct.</p></div><div><h3>Conclusion</h3><p>All these theoretical results reveal that the conserved region of <em>inf</em> C protein could be used for designing of a new potent vaccine against <em>Brucella</em>.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 161-173"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139303705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estado actual del herpes zóster y las nuevas perspectivas para su prevención","authors":"José María Molero ,&nbsp;Jesús Ortega ,&nbsp;Irene Montoro ,&nbsp;Natalia McCormick","doi":"10.1016/j.vacun.2023.12.005","DOIUrl":"10.1016/j.vacun.2023.12.005","url":null,"abstract":"<div><p>Herpes zoster (HZ) is a relatively common disease whose incidence increases with age and in immunocompromising situations. Mortality caused by HZ is low, but its complications impact on physical, psychological, functional, and social aspects of patients, significantly reducing health-related quality of life. Postherpetic neuralgia is the most common complication, and is characterized by symptoms of neuropathic pain including allodynia and hyperalgesia with electrical, burning, and/or stabbing sensations that persist more than 90 days. Its management is complex and has limitations, which increases the demand for health resources and also increases direct and indirect costs. This article reviews the epidemiological and clinical features of HZ, the available treatments and vaccines against HZ, as well as national and international vaccination recommendations. In addition, the role of Primary Care is emphasized as a catalyst for the implementation of adult vaccination.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 254-263"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1576988724000025/pdfft?md5=9fb6cb25aab129901ed285333246863f&pid=1-s2.0-S1576988724000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The co-infection of SARS-CoV-2 with atypical bacterial respiratory infections: A mini review","authors":"Fateme Taheri ,&nbsp;Soheil Vesal ,&nbsp;Parnian Goudarzi ,&nbsp;Zahra Sahafnejad ,&nbsp;Amin Khoshbayan","doi":"10.1016/j.vacun.2023.08.004","DOIUrl":"10.1016/j.vacun.2023.08.004","url":null,"abstract":"<div><p><span>In 2019, the Coronavirus disease (COVID-19) rapidly spread worldwide and posed a global threat. The co-infection among COVID-19 patients was reported variable in different studies. However, it could reach 50% of non-survivor patients. </span><span><span>Chlamydia pneumoniae</span></span>, <span><em>Mycoplasma pneumoniae</em></span>, and <span><span>Legionella pneumophila</span></span><span> are responsible for respiratory infections and also can act as co-pathogens with COVID-19, making their detection challenging. These bacteria exhibit similar clinical signs to COVID-19, leading to potential oversight. Furthermore, treating these bacteria requires a different antibiotic regimen compared to typical respiratory bacterial agents. Thus, recognizing the clinical characteristics, laboratory findings, and outcomes of co-infections is crucial for improving understanding and treatment strategies.</span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 233-238"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134976966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacunación COVID-19 y búsquedas web sobre salud mental: un estudio infodemiológico mundial","authors":"Juan Antonio Becerra-García ,&nbsp;Sara Barbeito ,&nbsp;Teresa Sánchez-Gutiérrez","doi":"10.1016/j.vacun.2024.02.004","DOIUrl":"10.1016/j.vacun.2024.02.004","url":null,"abstract":"<div><h3>Background</h3><p>The association between worldwide COVID-19 vaccination and mental health has been largely unexplored by means of infodemiological studies.</p></div><div><h3>Objective</h3><p>To explore how global public interest in different mental health topics changed between the pre-vaccination pandemic stage and the different periods of the COVID-19 vaccination campaign.</p></div><div><h3>Methods</h3><p>In this study were examined the relative search volume (RSV) in Google Trends for “anxiety”, “depression”, “stress”, and “suicide” between March 1st, 2020 to January 1st, 2023. The RSV for each term was compared with respect to 4 periods: the pre-vaccination pandemic stage; the period from initiation of vaccination until 50% of the population was fully vaccinated (FV); the period from 50% FV to 60% FV; and the period after 60% FV.</p></div><div><h3>Results</h3><p>A significant lower mean RSV on anxiety, depression and suicide was found once 60% of the world population had been FV compared to different previous vaccination periods and with the pre-vaccination pandemic stage.</p></div><div><h3>Conclusions</h3><p>There seems to be less need for information worldwide on anxiety, depression and suicide topics once 60% of the population is FV against COVID-19. Overcoming this vaccination milestone may have had a positive impact on public interest in specific mental health issues.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 224-227"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140085315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of gene expression between children with type 1 diabetes and Coxsackie viruses B","authors":"Zeyad Thonnoon Al-Rrassam","doi":"10.1016/j.vacun.2023.09.001","DOIUrl":"10.1016/j.vacun.2023.09.001","url":null,"abstract":"<div><p><span>Type 1 diabetes<span> is classified as an autoimmune disorder. Researchers observed the presence of viral Coxsackie virus B proteins within the β-cells in islets shortly after inoculating mice. This observation led them to establish a link between children who have T1D and an infection with the CVB. The objective of this research was to measure the degree of gene expression of highly expressed genes in individuals who were both infected with Coxsackie viruses B and previously had T1D. Additionally, levels of CVB IgG and </span></span>HbA1c<span><span> were assessed in the blood serum of patients with T1D.This correlation was assessed by analyzing the expression of genes with significantly extreme expression levels using logarithmic analysis with specialized mathematical software. This study revealed that there is an association between CVB IgG and HbA1c levels in T1D patients. Additionally, T1D patients with a family history of diabetes showed associations with </span>genetic factors<span> and gene expression. Interestingly, no significant differences in HbA1c levels were observed between patients based on their gender. Furthermore, the genes IGFBP5, GPNMB, and GJA1 exhibited a strong association with CVB. We propose a new strategy that may open up new therapy options for T1D caused by CVB through monitoring the physiological pathways of these genes.</span></span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 193-202"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135762961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the level of protective serum antibody after third dose of different COVID-19 vaccines","authors":"Atena Mansouri ,&nbsp;Mitra Rafiee ,&nbsp;Seyed-Alireza Esmaeili ,&nbsp;Saboura Nikpour ,&nbsp;Alireza Fereidouni ,&nbsp;Mohammad Fereidouni","doi":"10.1016/j.vacun.2024.02.006","DOIUrl":"10.1016/j.vacun.2024.02.006","url":null,"abstract":"<div><p>A new coronavirus (SARS-CoV-2), causing COVID-19 (coronavirus disease 2019), is a member of the Coronaviridae family. The benefits of the primary COVID-19 vaccination far outweigh the risks. Nevertheless, the risks associated with too early and too frequent boosters should be considered, especially when vaccines have immune-mediated effects like myocarditis, which is more commonly associated with the second dose of some mRNA vaccines. Booster vaccinations against SARS-CoV-2 are needed because of either reduced immunity to the original vaccine or evolved viruses producing immunity to the initial vaccine antigens. So, the aim of this study was to detect the difference in neutralizing anti-RBD antibodies between the third and second doses of COVID-19 vaccines. A study was performed among 29 eligible participants in Birjand (Iran). Blood samples were taken from all participants 2–4 weeks after the third dose. In the next step, humoral responses were assessed with a kit detecting neutralization of SARS-CoV-2. SPSS software version 22.0 (SPSS Inc., Chicago, IL) was used to analyze the data. The mean age of cases was 35.62<!--> <!-->±<!--> <!-->8.72 years, with a range of 21–53 years. The obtained results showed that all vaccines significantly had a higher efficacy in the third dose than the second. Participants who received Vaxzevria in the second dose and PastoCovac Plus in the third dose had more immunogenicity. According to the results of this study, a third dose of the vaccine should be given to persons aged ≥<!--> <!-->20 years to provide an increased level of protection against COVID-19. Especially, participants who received Sputnik-V and Vaxzevria in the second dose and PastoCovac Plus in the third dose showed a more effective immune response against the virus.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 2","pages":"Pages 228-232"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}