Vacunas最新文献 - Book学术

Acceptance of malaria vaccine among mothers of under-five children in Nigeria: Results from the M-VAN survey 尼日利亚五岁以下儿童的母亲对疟疾疫苗的接受程度：M-VAN 调查的结果

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.06.007

{"title":"Acceptance of malaria vaccine among mothers of under-five children in Nigeria: Results from the M-VAN survey","authors":"","doi":"10.1016/j.vacun.2024.06.007","DOIUrl":"10.1016/j.vacun.2024.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Malaria is one of the most common causes of death among children under 5 years of age in sub-Saharan Africa. Nigeria accounts for 1 in every 4 global malaria incidences and deaths. We evaluated the prevalence and correlates of malaria vaccine acceptance among mothers of children under 5 years in Nigeria.</div></div><div><h3>Methods</h3><div><span><span>A convenient sample of mothers of children under the age of 5 was recruited via a cross-sectional online survey conducted between 20 and 25 October 2021. Participants who replied ‘yes’ to a questionnaire assessing their willingness to accept the malaria vaccine were considered “acceptant”. We fit a multivariate </span>logistic regression model to report the adjusted odds ratio (aOR) and 95% confidence interval (CI) for the factors associated with </span>vaccine acceptance.</div></div><div><h3>Results</h3><div><span>Among the 595 participants (mean age 35 years [SD; 9.84]), 463 (77.82%) were willing to accept a malaria vaccine for their children. The results of our multivariable analysis showed that belonging to the Hausa tribe is associated with significantly higher odds of acceptance, compared to Igbo (aOR: 2.78, 95% CI:1.09–7.14) and other tribes (aOR:2.27, 95% CI: 1.11–4.55). The most common reasons for malaria vaccine acceptance include preventing the development of complicated malaria, reducing the frequency of malaria episodes in children, improving a child's </span>quality of life, and reducing the number of school hours lost to malaria.</div></div><div><h3>Conclusion</h3><div>Further efforts are needed to understand the cultural barriers to malaria vaccine acceptance in order to maximize malaria vaccine uptake when the actual vaccine roll-out commences.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could molecular farming be a game changing paradigm in the production of immune checkpoint inhibitors for cancer immunotherapy? 在生产用于癌症免疫疗法的免疫检查点抑制剂的过程中，分子农业能否成为改变游戏规则的范例？

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.07.005

引用次数: 0

Revisión de los formatos de presentación de vacunas y sus principales características 审查疫苗提交格式及其主要特点

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.06.004

{"title":"Revisión de los formatos de presentación de vacunas y sus principales características","authors":"","doi":"10.1016/j.vacun.2024.06.004","DOIUrl":"10.1016/j.vacun.2024.06.004","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore the implications for use of the different vaccine packaging options, in terms of sustainability, safety and nurses' preferences; as well as to elaborate a proposal for main concepts of vaccine packaging that could serve as a user guide for nurses.</div></div><div><h3>Methods</h3><div>A literature review has been carried out about logistic, ergonomic, and practical aspects of the different vaccine packaging options. The search was performed in several databases. The review included 19 articles.</div></div><div><h3>Review/Results</h3><div>The findings have been grouped in four categories: description of vaccine packaging options, implications in sustainability, safety, and nurses' preferences in clinical practice.</div></div><div><h3>Conclusions and Implications for practice</h3><div>Nationwide, there are just a few studies addressing logistic, ergonomic, and practical aspects of the different vaccine packaging options. Regarding the review process of packaging formats, a descriptive section within the document has been developed by experts, including a summary chart. There exists knowledge about liquid formulations, in particular, the prefilled-syringe and multi-dose and single-dose formats. In relation to sustainability, in terms of packaging, cold storage and transport, among others; we consider that these are main aspects that should be addressed by its contribution to the reduction of environmental impact; given its scarce presence in the current literature.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Psychological characteristics and their impact on the efficacy and safety of COVID-19 vaccines 心理特征及其对 COVID-19 疫苗有效性和安全性的影响

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.07.003

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Ecological distribution and phylogenetic diversity of measles virus genotypes in West Africa, 2001 to 2020 2001 至 2020 年西非麻疹病毒基因型的生态分布和系统发育多样性

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.09.002

{"title":"Ecological distribution and phylogenetic diversity of measles virus genotypes in West Africa, 2001 to 2020","authors":"","doi":"10.1016/j.vacun.2024.09.002","DOIUrl":"10.1016/j.vacun.2024.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Measles remains a significant threat to public health in developing countries, particularly among children under the age of 5. A pivotal aspect of the measles eradication initiative involves the genetic characterization of wild-type viruses to better understand transmission patterns and inform vaccination strategies.</div></div><div><h3>Objective</h3><div>This study aims to investigate the ecology and genotype diversity of the measles virus in West Africa from 2001 to 2020, utilizing available sequence data from the GenBank.</div></div><div><h3>Methodology</h3><div>We conducted a comprehensive analysis using maximum-likelihood phylogenetics, focusing on the N450 fragment from measles virus isolates found in West Africa between 2001 and 2020. Additionally, pairwise sequence comparison analysis was carried out to determine the evolutionary divergence of various genotypes in West Africa and their genetic distance from vaccine strains.</div></div><div><h3>Results</h3><div>Our findings indicate that over the past 2 decades, B3, D3, and D8 isolates have been circulating in various West African countries. Notably, B3 isolates have been identified as the primary contributors to endemic transmission, as evidenced by the concurrent presence of the same isolate in different countries within the subregion. Furthermore, our analysis reveals a significant shift in the circulation of D3 and D8 isolates, which were originally reported exclusively in New Guinea over 15 years ago but are now dominated by the B3 genotype.</div></div><div><h3>Conclusion</h3><div>Over the past 2 decades, B3, D3, and D8 measles virus genotypes have circulated in 10 West African countries. Particularly, B3.1 isolates currently dominate, especially in Nigeria, indicating endemic transmission. However, despite the informative value of N450, complete genome sequencing data is highly needed to accurately understand the evolutionary dynamics of the measles virus in West Africa.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on “Prevalence of HCV among patients with HIV in Iran: A systematic review and meta-analysis” 关于 "伊朗艾滋病毒感染者中的丙型肝炎病毒流行率：系统回顾和荟萃分析"

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.09.001

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Plant system as a versatile and robust platform for the development of vaccines against arboviral infections 将植物系统作为开发预防虫媒病毒感染疫苗的多功能稳健平台

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.06.005

{"title":"Plant system as a versatile and robust platform for the development of vaccines against arboviral infections","authors":"","doi":"10.1016/j.vacun.2024.06.005","DOIUrl":"10.1016/j.vacun.2024.06.005","url":null,"abstract":"<div><div><span>Arboviral infections are predominantly transmitted by arthropods causing significant mortality, morbidity, and represent a major global health concern. These infections pose significant economic burdens especially in endemic regions. Dengue<span>, chikungunya, yellow fever, and zika are the most common arboviral diseases spread by </span></span><em>Aedes</em><span><span> mosquitoes. Extensive research has been conducted on vector surveillance and vector control strategies to limit the arboviral transmission. However, vaccines remain the most powerful tool in the fight against infectious diseases. Over the years, significant progress has been made in developing vaccines against several infectious diseases. The global disease burden has been drastically reduced due to effective </span>vaccination<span><span>. The continual threat of arboviral outbreaks necessitates the need for effective vaccine and therapeutic development. For most arboviral diseases, vaccines are not available. Recently, plant-based vaccine development represents a promising platform for the rapid supply of antigens and antibodies for developing diagnostic kits or vaccines against pathogens. The concept of producing pharmaceutically significant and commercially viable therapeutic proteins in plants is defined as molecular farming. Substantial efforts have been made in this field, with improved expression strategies, refinement of downstream processing, and sufficient evidence showing the </span>immunogenicity<span><span> and efficacy of plant-produced recombinant proteins. Currently, few plant-produced vaccine antigens have reached the </span>clinical trials. Notably, the plant-produced COVID-19 vaccine, Covifenz has been approved by Canada, and plant-produced influenza candidates showed safety and efficacy in clinical trials. In this review, we briefly summarize the potential of plant-derived vaccines in the fight against arboviral infections.</span></span></span></div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population COVID-19患者的C4和CH50水平与咳嗽和鼻出血的关系：伊朗人群的回顾性分析

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.06.008

{"title":"Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population","authors":"","doi":"10.1016/j.vacun.2024.06.008","DOIUrl":"10.1016/j.vacun.2024.06.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The wide spectrum of COVID-19 symptoms, ranging from mild manifestations to severe pulmonary damage and mortality, prompted this study to investigate the relationship between clinical symptoms and complement system (CS) activation in COVID-19 patients.</div></div><div><h3>Materials and method</h3><div>This retrospective study focused on 100 PCR-positive COVID-19 individuals admitted to Imam Khomeini and Bu Ali hospitals in Sari City from April to June 2021. The levels of C3 and C4 proteins in their blood were measured using nephelometry, and CH50 tests were done with single radial immunodiffusion to determine the activity of CS.</div></div><div><h3>Results</h3><div>The study found that high blood pressure, smoking, and diabetes were the most common underlying conditions among the patients, with prevalence rates of 29%, 24%, and 23%, respectively. Positive correlations were found between C4 and CH50 levels and the presence of cough<span> and rhinorrhea in the subjects. Stratifying patients into 2 groups based on cough or rhinorrhea revealed a significant difference in CH50.</span></div></div><div><h3>Conclusion</h3><div>The findings suggest that COVID-19 patients with hypertension or diabetes mellitus may benefit from targeting CS for disease management.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing an immuno-epitope candidate vaccine from (Opa, ProA, ProB, RmpM and BamD) proteins against Neisseria gonorrhoeae and Neisseria meningitides 利用（Opa、ProA、ProB、RmpM 和 BamD）蛋白设计针对淋病奈瑟菌和脑膜炎奈瑟菌的免疫表位候选疫苗

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.07.004

{"title":"Designing an immuno-epitope candidate vaccine from (Opa, ProA, ProB, RmpM and BamD) proteins against Neisseria gonorrhoeae and Neisseria meningitides","authors":"","doi":"10.1016/j.vacun.2024.07.004","DOIUrl":"10.1016/j.vacun.2024.07.004","url":null,"abstract":"<div><div>The development of a conventional vaccine against gonococci has been difficult since there are no precise correlates of immune protection and the mechanisms of protective immunity are not yet understood. However, the drop in gonorrhea infections might be attributed to the development of vaccines based on <em>Neisseria meningitidis</em>' outer membrane. The goal of this research was to develop a multi-epitope vaccination utilizing proteins from <em>N. meningitidis</em> and <em>Neisseria gonorrhoeae</em>. A <em>Neisseria</em> Multi-Epitope Vaccine (NMEV), containing Opa, ProA, ProB, RmpM, and BamD, was developed using immunophysicochemical informatics techniques. The vaccine consists of 297 amino acids. Antigenicity and sensitivity to NMEV were evaluated. NMEV generates a substantial amount of immune cells and cytokines. The total quality factor of the NMEV 2D structure is around 91%. The vaccine's safety, effectiveness, and other properties make it an attractive option for in vitro and in vivo testing. The suggested NMEV subunit vaccine has the potential to elicit a strong immune response, necessitating additional in vitro and in vivo studies to eliminate Neisseria infections.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importancia de la optimización de los calendarios de vacunación en el trasplante cardíaco infantil 优化儿科心脏移植免疫计划的重要性

Vacunas Pub Date : 2024-10-01 DOI: 10.1016/j.vacun.2024.07.002

{"title":"Importancia de la optimización de los calendarios de vacunación en el trasplante cardíaco infantil","authors":"","doi":"10.1016/j.vacun.2024.07.002","DOIUrl":"10.1016/j.vacun.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>Vaccination is the most effective preventive measure to reduce the risk of infection in patients receiving immunosuppressive treatment, such as heart transplant (HT) patients. The objectives of this study are to describe and evaluate the vaccination status of a group of pediatric HT recipients.</div></div><div><h3>Material and methods</h3><div>Retrospective descriptive study of 75 pediatric patients who underwent HT at a tertiary hospital between January 2000 and September 2020. Demographic, clinical (immunization before and after HT, and attendance to vaccination counseling consultation) and analytical (hepatitis A and B serology before and after HT) variables were collected.</div></div><div><h3>Results</h3><div>Patients >12 months reached the HT with better vaccination coverage than those <12 months: 78.9% versus 60.7% had a complete vaccination schedule (<em>p</em> = 0.15). Post- HT vaccination update rate is low; only 13.3% of patients had a complete schedule according to their age. A total of 13.3% of patients attended post-HT vaccination counseling consultation, being better immunized than those who did not (<em>p</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>The evaluation and optimization of vaccination schedules of patients with HT remains suboptimal. A follow-up of these patients and their relatives in vaccination specialized consultations can improve the immunization status of pediatric HT recipients.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0