Vacunas最新文献

{"title":"Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population","authors":"Seyed Ali Hashemi ,&nbsp;Forouzan Rostami ,&nbsp;Babak Shaghaghi ,&nbsp;Mahla Niknam ,&nbsp;Elham Abani ,&nbsp;Abdol Sattar Pagheh ,&nbsp;Arezou Khosrojerdi ,&nbsp;Fatemeh Rezaei","doi":"10.1016/j.vacun.2024.06.008","DOIUrl":"10.1016/j.vacun.2024.06.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The wide spectrum of COVID-19 symptoms, ranging from mild manifestations to severe pulmonary damage and mortality, prompted this study to investigate the relationship between clinical symptoms and complement system (CS) activation in COVID-19 patients.</div></div><div><h3>Materials and method</h3><div>This retrospective study focused on 100 PCR-positive COVID-19 individuals admitted to Imam Khomeini and Bu Ali hospitals in Sari City from April to June 2021. The levels of C3 and C4 proteins in their blood were measured using nephelometry, and CH50 tests were done with single radial immunodiffusion to determine the activity of CS.</div></div><div><h3>Results</h3><div>The study found that high blood pressure, smoking, and diabetes were the most common underlying conditions among the patients, with prevalence rates of 29%, 24%, and 23%, respectively. Positive correlations were found between C4 and CH50 levels and the presence of cough<span> and rhinorrhea in the subjects. Stratifying patients into 2 groups based on cough or rhinorrhea revealed a significant difference in CH50.</span></div></div><div><h3>Conclusion</h3><div>The findings suggest that COVID-19 patients with hypertension or diabetes mellitus may benefit from targeting CS for disease management.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 448-453"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importancia de la optimización de los calendarios de vacunación en el trasplante cardíaco infantil","authors":"Sofía Bassy Navarro ,&nbsp;Nuria Gil Villanueva ,&nbsp;Manuela Camino-López ,&nbsp;Roberto Alonso Fernández ,&nbsp;Beatriz Lázaro-Martín ,&nbsp;Alicia Hernanz-Lobo ,&nbsp;Marisa Navarro Gómez","doi":"10.1016/j.vacun.2024.07.002","DOIUrl":"10.1016/j.vacun.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>Vaccination is the most effective preventive measure to reduce the risk of infection in patients receiving immunosuppressive treatment, such as heart transplant (HT) patients. The objectives of this study are to describe and evaluate the vaccination status of a group of pediatric HT recipients.</div></div><div><h3>Material and methods</h3><div>Retrospective descriptive study of 75 pediatric patients who underwent HT at a tertiary hospital between January 2000 and September 2020. Demographic, clinical (immunization before and after HT, and attendance to vaccination counseling consultation) and analytical (hepatitis A and B serology before and after HT) variables were collected.</div></div><div><h3>Results</h3><div>Patients &gt;<!--> <!-->12 months reached the HT with better vaccination coverage than those &lt;<!--> <!-->12 months: 78.9% versus 60.7% had a complete vaccination schedule (<em>p</em> = 0.15). Post- HT vaccination update rate is low; only 13.3% of patients had a complete schedule according to their age. A total of 13.3% of patients attended post-HT vaccination counseling consultation, being better immunized than those who did not (<em>p</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>The evaluation and optimization of vaccination schedules of patients with HT remains suboptimal. A follow-up of these patients and their relatives in vaccination specialized consultations can improve the immunization status of pediatric HT recipients.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 454-461"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing an immuno-epitope candidate vaccine from (Opa, ProA, ProB, RmpM and BamD) proteins against Neisseria gonorrhoeae and Neisseria meningitides","authors":"Ali Adel Dawood","doi":"10.1016/j.vacun.2024.07.004","DOIUrl":"10.1016/j.vacun.2024.07.004","url":null,"abstract":"<div><div>The development of a conventional vaccine against gonococci has been difficult since there are no precise correlates of immune protection and the mechanisms of protective immunity are not yet understood. However, the drop in gonorrhea infections might be attributed to the development of vaccines based on <em>Neisseria meningitidis</em>' outer membrane. The goal of this research was to develop a multi-epitope vaccination utilizing proteins from <em>N. meningitidis</em> and <em>Neisseria gonorrhoeae</em>. A <em>Neisseria</em> Multi-Epitope Vaccine (NMEV), containing Opa, ProA, ProB, RmpM, and BamD, was developed using immunophysicochemical informatics techniques. The vaccine consists of 297 amino acids. Antigenicity and sensitivity to NMEV were evaluated. NMEV generates a substantial amount of immune cells and cytokines. The total quality factor of the NMEV 2D structure is around 91%. The vaccine's safety, effectiveness, and other properties make it an attractive option for in vitro and in vivo testing. The suggested NMEV subunit vaccine has the potential to elicit a strong immune response, necessitating additional in vitro and in vivo studies to eliminate Neisseria infections.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 481-491"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of hepatitis B knowledge among Moroccans","authors":"Salma Madihi ,&nbsp;Samia Boukaira ,&nbsp;Hind Bouafi ,&nbsp;Abdelouaheb Benani","doi":"10.1016/j.vacun.2024.07.006","DOIUrl":"10.1016/j.vacun.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><div>Little is known about the knowledge of hepatitis B infection in Morocco. This article describes the general population and students' knowledge of hepatitis B infection.</div></div><div><h3>Material and methods</h3><div>A questionnaire was designed between November and December 2022 to capture demographic data (gender, age, occupation, and city) and 12 HBV-related questions. The study population comprised 402 Moroccan individuals, of whom 100 were students. Students' knowledge was compared between public and private middle and high schools.</div></div><div><h3>Results</h3><div>Overall, 64.43% indicated prior awareness of hepatitis B, 33.58% were aware of the nature and the global prevalence of the disease, and 13.68% were knowledgeable about chronicity rate in Morocco. The contagious potential of hepatitis B virus (HBV) was appreciated by 35.1% of respondents while 51.5% were aware of its various transmission routes. The risk of vertical transmission and the availability of a hepatitis B vaccine were recognized by 57.7% and 56.1%, respectively. Vaccination status against hepatitis B was confirmed by 23% of respondents and 16.3% were aware of their HBV serostatus. While only 28% knew someone affected by hepatitis B, 69.4% acknowledged awareness of other types of hepatitis. Age and education type were factors associated with a good knowledge of the different aspects of HBV infection. The only gender-related difference reported concerned the existence of a hepatitis B vaccine knowledge.</div></div><div><h3>Conclusion</h3><div>We highlight contrasting levels of HBV knowledge in the Moroccan general population and students. Results demonstrate the need to implement prevention programs in order to overcome the gap between public and private school outcomes.</div></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 462-469"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erradicación del sarampión: todavía un largo y difícil camino","authors":"Fernando Moraga-Llop ,&nbsp;Magda Campins-Martí","doi":"10.1016/j.vacun.2024.07.001","DOIUrl":"10.1016/j.vacun.2024.07.001","url":null,"abstract":"","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 431-435"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuna polio oral de nueva generación ¿solución para la erradicación?","authors":"Nuria Torner","doi":"10.1016/j.vacun.2024.09.003","DOIUrl":"10.1016/j.vacun.2024.09.003","url":null,"abstract":"","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 4","pages":"Pages 436-438"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efecto de la vacunación contra el SARS-CoV-2 sobre la coagulación en pacientes mayores de 60 años tratados con acenocumarol","authors":"","doi":"10.1016/j.vacun.2024.04.004","DOIUrl":"10.1016/j.vacun.2024.04.004","url":null,"abstract":"<div><h3>Background and objective</h3><p>After the SARS-CoV-2 vaccination campaign, we observed alterations in post-vaccination International Normalized Ratio (INR) in patients treated with acenocoumarol. The aim of the study was to investigate whether there is an association between the observed blood coagulation alterations and SARS-CoV2 vaccination.</p></div><div><h3>Materials and methods</h3><p>A retrospective, longitudinal, observational study of patients over 60 years of age vaccinated against SARS-CoV-2 and treated with acenocoumarol was conducted. The main variable measured was the INR before and after vaccination, and secondary variables were date of vaccination, age, sex, type of vaccine and dose of acenocoumarol. Paired means were compared using nonparametric Friedman and Wilcoxon tests with Benjamini-Hochberg correction, and a linear regression analysis between age and differences between pre and post vaccination INR measurements. The analysis was performed on the total sample and by subgroups. Statistical significance was set at p-value<!--> <!-->&lt;<!--> <!-->0.05.</p></div><div><h3>Results</h3><p>Overall statistically significant differences (Friedman, p-value<!--> <!-->&lt;<!--> <!-->0.05) were found between INR measurements in the total sample, women, Comirnaty® vaccine and Sintrom® 1g dose, although the differences found are weak (W-Kendall<!--> <!-->&lt;<!--> <!-->0.01). No statistically significant differences were found between specific pairs in INR measurements (Wilcoxon, p-value<!--> <!-->&gt;<!--> <!-->0.05). The goodness-of-fit of all linear regressions was R2<!--> <!-->&lt;<!--> <!-->0.1.</p></div><div><h3>Conclusions</h3><p>The alteration of coagulation due to vaccination against SARS-CoV-2 is not a population or generalized effect, but a possible side effect, and reinforces the safety of SARS-CoV-2 vaccination in this type of patients.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 323-330"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccination and concerns regarding the maternal and neonatal safety outcomes","authors":"","doi":"10.1016/j.vacun.2024.03.003","DOIUrl":"10.1016/j.vacun.2024.03.003","url":null,"abstract":"","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 428-429"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencia de nuevas herramientas para aumentar la tasa de vacunación contra la gripe en pacientes considerados de riesgo durante las campañas de los años 2019, 2020 y 2021","authors":"Beatriz Santos López ,&nbsp;Mónica López Campos ,&nbsp;Carmen Viñas Viamonte ,&nbsp;Paula Aragón Puig ,&nbsp;Elena Buades Pérez ,&nbsp;Inés Loreto Gallán Farina","doi":"10.1016/j.vacun.2024.05.002","DOIUrl":"10.1016/j.vacun.2024.05.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Influenza infection was a significant public health issue that causes substantial morbidity and mortality in the population every year. Vaccination is the most effective measure for its prevention. The aim of this study is to analyze the influence of automated letters as a patient recruitment method after their discontinuation in a population where they were previously used, comparing it with the population of another healthcare center with similar characteristics that has never employed this method.</p></div><div><h3>Materials and methods</h3><p>An observational and retrospective study was conducted, analyzing the influenza vaccination coverage among the at-risk population in two healthcare centers with very similar population characteristics during three vaccination campaigns (2019, 2020 and 2021). Both descriptive and analytical studies were carried out.</p></div><div><h3>Results</h3><p>Vaccination rates in the center that actively recruited patients while the letter sending was still in effect were 46.4% in 2019 and 61% in 2020, decreasing to 25.8% in 2021 after its withdrawal (<em>p</em> <!-->&lt;<!--> <!-->0.001). Influenza vaccination was significantly higher during the 3 campaigns at the health center that used the letter. The groups in which vaccination rates decreased most significantly were those aged 65 and older and those with heart disease.</p></div><div><h3>Conclusions</h3><p>The implementation of automated letters has proven to be particularly effective among patients considered at risk.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 340-346"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141954350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversy on fair and exclusive vaccine decisions for controlling infectious diseases among medical professionals in LMICs. Embracing the Trans-Theoretical Model for Moving Forward","authors":"","doi":"10.1016/j.vacun.2024.02.007","DOIUrl":"10.1016/j.vacun.2024.02.007","url":null,"abstract":"<div><p>The equitable distribution of vaccines for infectious diseases in low- and middle-income countries (LMICs) has become a hotly debated topic among public professionals and Government The decisions made in this regard can have far-reaching consequences for the health and well-being of millions of people including general population and healthcare professionals. There is need toconsider a fair and just distribution system to ensure that vaccines are provided to those who need them the most. For instance, Hepatitis B virus (HBV), influenza, and COVID-19 are crucial for healthcare professionals as they play in the fight against infectious disease outbreaks. However, in LMICs, poor vaccine confidence and uptake rates represent substantial hurdles for healthcare practitioners in obtaining and administering vaccines. Further, equitable vaccine uptake is a debatable policy matter in LMICs. These challenges stem from doubts regarding vaccine efficacy and safety, inaccurate information, and a lack of trust in government and medical institutions. Addressing misconceptions and building confidence, robust monitoring and evaluation mechanisms requires to ensure the safety of vaccines. . This review highlighted the importance of enhancing vaccine uptake motivation among health workers. Moreover, enhance the the need to respect individual choice when refuse. Ultimately, building confidence in the healthcare system is critical for addressing healthcare providers' reluctance about vaccines. The transtheoretical model is extremely useful for for understanding the behaviours and factors increasing vaccine uptake notably for infection prevention against hepatitis B, COVID-19, and influenza. The immplication of framework provided a holistic approach by customizing solutions to each stage of behavior change, from awareness to continuing support. Emphasizing education, incentives, and a supportive environment promotes a resilient healthcare system, allowing health workers community to actively contribute to public health through effective infection control.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":"25 3","pages":"Pages 367-373"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}