Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population

Q3 Medicine

Vacunas Pub Date : 2024-10-01 DOI:10.1016/j.vacun.2024.06.008

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引用次数: 0

Abstract

Introduction

The wide spectrum of COVID-19 symptoms, ranging from mild manifestations to severe pulmonary damage and mortality, prompted this study to investigate the relationship between clinical symptoms and complement system (CS) activation in COVID-19 patients.

Materials and method

This retrospective study focused on 100 PCR-positive COVID-19 individuals admitted to Imam Khomeini and Bu Ali hospitals in Sari City from April to June 2021. The levels of C3 and C4 proteins in their blood were measured using nephelometry, and CH50 tests were done with single radial immunodiffusion to determine the activity of CS.

Results

The study found that high blood pressure, smoking, and diabetes were the most common underlying conditions among the patients, with prevalence rates of 29%, 24%, and 23%, respectively. Positive correlations were found between C4 and CH50 levels and the presence of cough and rhinorrhea in the subjects. Stratifying patients into 2 groups based on cough or rhinorrhea revealed a significant difference in CH50.

Conclusion

The findings suggest that COVID-19 patients with hypertension or diabetes mellitus may benefit from targeting CS for disease management.

查看原文本刊更多论文

COVID-19患者的C4和CH50水平与咳嗽和鼻出血的关系：伊朗人群的回顾性分析

导言：COVID-19 的症状范围很广，从轻微表现到严重的肺损伤和死亡，这促使本研究调查 COVID-19 患者的临床症状与补体系统（CS）激活之间的关系。材料和方法本回顾性研究的重点是 2021 年 4 月至 6 月在萨里市伊玛目霍梅尼医院和布阿里医院住院的 100 例 PCR 阳性 COVID-19 患者。研究发现，高血压、吸烟和糖尿病是患者最常见的基础疾病，患病率分别为 29%、24% 和 23%。研究发现，C4和CH50水平与受试者是否咳嗽和流鼻涕呈正相关。结论研究结果表明，COVID-19 患者中的高血压或糖尿病患者可能会从针对 CS 的疾病管理中获益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vacunas Medicine-Infectious Diseases

CiteScore

3.90

自引率

0.00%

发文量

138

审稿时长

62 days

期刊介绍： Sin duda una de las mejores publicaciones para conocer los avances en el campo de las vacunaciones preventivas, tanto en el ámbito de la investigación básica como aplicada y en la evaluación de programas de vacunaciones. Su alta calidad y utilidad la ha llevado a estar indexada en los prestigiosos índices IME y SCOPUS.