Revista Romana de Boli Infectioase最新文献

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COVID-19-ASSOCIATED IMMUNE THROMBOCYTOPENIA 新冠肺炎相关免疫性血小板增多症
Revista Romana de Boli Infectioase Pub Date : 2021-06-30 DOI: 10.37897/rjid.2021.2.1
Mara-Andrada Plesu, G. Bejan, I. Grăjdeanu, A. Simionescu, A. Stănescu
{"title":"COVID-19-ASSOCIATED IMMUNE THROMBOCYTOPENIA","authors":"Mara-Andrada Plesu, G. Bejan, I. Grăjdeanu, A. Simionescu, A. Stănescu","doi":"10.37897/rjid.2021.2.1","DOIUrl":"https://doi.org/10.37897/rjid.2021.2.1","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) is a contagious respiratory tract infection caused by the betacoronavirus SARS-CoV-2. The World Health Organization declared the COVID-19 outbreak a pandemic on March 11, 2020. Since the COVID-19 pandemic started, more than 166 million patients have been tested positive worldwide with more than 3.4 million related death recorded. COVID-19 has a wide range of signs and symptoms. Hematological changes such as lymphopenia, thrombocytopenia, and coagulation disturbances are not unusual in patients with COVID-19. However, the mechanisms causing these changes are partially comprehended. Immune thrombocytopenia was identified to be among the hematologic autoimmune diseases seen in patients infected with SARS-CoV-2. This review summarizes the evidence on COVID-19-associated immune thrombocytopenia and the underlying mechanisms involved in its development.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41859694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COVID-19 IN A PATIENT WITH HIV AND KAPOSI SARCOMA 艾滋病毒和卡波西肉瘤患者的COVID-19
Revista Romana de Boli Infectioase Pub Date : 2021-06-30 DOI: 10.37897/rjid.2021.2.10
Maria-Andrada Corodeanu, Sorina Vasile, A. Oprea, Casa Doru” Hiv, B. Pharmacy
{"title":"COVID-19 IN A PATIENT WITH HIV AND KAPOSI SARCOMA","authors":"Maria-Andrada Corodeanu, Sorina Vasile, A. Oprea, Casa Doru” Hiv, B. Pharmacy","doi":"10.37897/rjid.2021.2.10","DOIUrl":"https://doi.org/10.37897/rjid.2021.2.10","url":null,"abstract":"A 53 year old male diagnosed with HIV, SARS-CoV-2 and Kaposi sarcoma developed a purple-brown maculopapular rash on the left calf approximately 6 months before hospitalization and was diagnosed with venous ulcer. The lesions grew in size, spread on the whole body and also appeared on the palate. During this time the patient did not ask for a second opinion and was not monitored by a medical specialist. In December 2020, he developed a severe form of COVID-19 with acute respiratory failure and was admitted to the hospital. He was simultaneously diagnosed with HIV and severe immunosuppression. The skin biopsy confirmed Kaposi sarcoma in the nodular stage. Antiretroviral therapy (ART) was initiated and the patient later received liposomal doxorubicin chemotherapy. The patient slowly recovered whilst showing improvement of his clinical condition and immunological status.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44530790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A PARTICULAR CASE OF SARS-COV-2 INFECTION IN TWINS 双胞胎中sars-cov-2感染的特殊病例
Revista Romana de Boli Infectioase Pub Date : 2021-06-30 DOI: 10.37897/rjid.2021.2.9
A. Stoenescu, G. Vancea, D. Ispas, Nicoleta Voicu-Pârvu, Nicoleta Tudor, Gabriela Scurtu, R. Popescu, C. Chirilă, E. Sandu, E. Ceaușu, S. Florescu
{"title":"A PARTICULAR CASE OF SARS-COV-2 INFECTION IN TWINS","authors":"A. Stoenescu, G. Vancea, D. Ispas, Nicoleta Voicu-Pârvu, Nicoleta Tudor, Gabriela Scurtu, R. Popescu, C. Chirilă, E. Sandu, E. Ceaușu, S. Florescu","doi":"10.37897/rjid.2021.2.9","DOIUrl":"https://doi.org/10.37897/rjid.2021.2.9","url":null,"abstract":"Introduction. Although SARS-CoV-2 infection is more common in adults, many cases have been reported in the pediatric population. Case presentation. An 8-month-old infant from twin pregnancy, confirmed with COVID-19, is hospitalized with nasal obstruction, serous rhinorrhea, rare cough and watery stools. The epidemiological link is known, both the parents and the maternal grandparents of the infant being confirmed with COVID-19. Biologically, he presented with thrombocytosis and discrete inflammatory syndrome, and the lung radiograph did not show any lesions. At the same time, the twin sister was hospitalized, who presented a similar symptomatology, with a negative SARS-CoV-2 PCR test, but the lung radiograph showed specific lesions of COVID-19. During hospitalization, 2 more SARS-CoV-2 PCR tests were performed, but with negative results. The evolution of the twins was favorable under symptomatic treatment, respectively antibiotic and symptomatic treatment. Conclusion. SARS-CoV-2 infection may be asymptomatic, especially in infants and newborns, and has a lower prevalence.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41787276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profilul de rezistenţă la antimicrobiene al tulpinilor de Klebsiella pneumoniae într-o clinică de boli infecţioase 一家传染病诊所肺炎克雷伯菌菌株的耐药性分析
Revista Romana de Boli Infectioase Pub Date : 2021-03-31 DOI: 10.37897/rjid.2021.1.5
Lucian Giubelan, Livia Dragonu, Andreea-Cristina Stoian, Florentina Dumitrescu
{"title":"Profilul de rezistenţă la antimicrobiene al tulpinilor de Klebsiella pneumoniae într-o clinică de boli infecţioase","authors":"Lucian Giubelan, Livia Dragonu, Andreea-Cristina Stoian, Florentina Dumitrescu","doi":"10.37897/rjid.2021.1.5","DOIUrl":"https://doi.org/10.37897/rjid.2021.1.5","url":null,"abstract":"Obiective. Stabilirea profilului de rezistenţă al tulpinilor de Klebsiella pneumoniae (KP) izolate în Clinica de Boli Infecţioase Craiova. Material şi metodă. Studiu retrospectiv (ianuarie 2017-decembrie 2018); KP au fost identificate cu ajutorul sistemului automat Vitek 2, care a stabilit ulterior sensibilitatea acestora la antimicrobiene (testare uzuală la 17 antibiotice, testare extinsă la alte 9); pentru fiecare tulpină a fost calculat indicele de rezistenţă MAR (limite: 0-1); informaţiile au fost introduse într-o baza de date Excel. Au fost testate 45 de tulpini în 2017 şi 290 în 2018. Procentul de tulpini MDR a fost calculat pe baza definiţiilor internaţional acceptate. Rezultate. Au fost identificate 335 de tulpini, marea majoritatea izolate prin cultura sputei (192 tulpini – 57,31%). Date demografice: 330 tulpini (99%) au fost izolate la subiecţi adulţi, 190 (57%) la pacienţi de sex masculin, 185 (55%) la bolnavi ce trăiesc în mediul urban. Valoarea globală a MAR a fost de 0,37 (faţă de 0,32 pentru ansamblul tulpinilor germenilor Gram negativi izolaţi). Peste 80% din tulpinile de KP a fost sensibile la Amikacină şi Polimixina E; sensibilităţi între 60 şi 79% au fost observate pentru Meropenem, Gentamicină, Tobramicină, Ciprofloxacină, Ertapenem, Trimetoprim-Sulfametoxazol, Levofloxacina, Cefepima, iar între 40 şi 59% pentru Ceftriaxonă, Cefoxitină, Ceftazidimă, Minociclină şi Imipenem. Sub 39% dintre tulpini sunt sensibile la Ampicilină (±Sulbactam), Piperacilină (±Tazobactam), Ticarcilină (±Acid clavulanic), Aztreonam, Pefloxacină, Cefazolin, Nitrofurantoin. Rezistenţa la principalele clase de antibiotice arată valori mai mici faţă de datele naţionale şi europene pentru cefalosporine de generaţia a 3-a, fluorochinolone şi aminoglicozide, dar un procent mult mai mare de rezistenţă la carbapeneme. Peste 68% dintre izolate sunt multidrog-rezistente (MDR); peste 60% dintre tulpini provin din surse în care există un contact important cu substanţele antimicrobiene. Concluzii. Peste 80% dintre tulpinile izolate sunt sensibile la Amikacină sau Polimixina E.; peste 29% dintre tulpini demonstrează rezistenţă la clasa carbapenemelor în 2018; peste 68% dintre izolate sunt multidrogrezistente; peste 60% dintre tulpini provin din surse în care există un contact important cu substanţele antimicrobiene.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46668992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efectele SARS-CoV-2 în sarcină și la nou-născuți – un nou agent TORCH?
Revista Romana de Boli Infectioase Pub Date : 2021-03-31 DOI: 10.37897/rjid.2021.1.2
Andreia Florina Niță, București România Universitatea de Medicină și Farmacie „Carol Davil, Sabina Cornelia Manolescu, M. Popa, Loredana Gabriela Popa, București România Institutul Național de Cercetare-Dezvoltare Medico, București România Spitalul Clinic Colentina
{"title":"Efectele SARS-CoV-2 în sarcină și la nou-născuți – un nou agent TORCH?","authors":"Andreia Florina Niță, București România Universitatea de Medicină și Farmacie „Carol Davil, Sabina Cornelia Manolescu, M. Popa, Loredana Gabriela Popa, București România Institutul Național de Cercetare-Dezvoltare Medico, București România Spitalul Clinic Colentina","doi":"10.37897/rjid.2021.1.2","DOIUrl":"https://doi.org/10.37897/rjid.2021.1.2","url":null,"abstract":"Obiective. Acest studiu și-a propus să efectueze o revizuire sistematică a literaturii existente pentru a evalua efectele COVID-19 la femeile însărcinate și la nou-născuții acestora, estimând, în același timp, posibilitatea transmiterii verticale. Materiale şi metode. Am efectuat o cercetare sistematică a literaturii folosind Pubmed și Google Scholar, acoperind perioada decembrie 2019-noiembrie 2020. Revizuirea a fost efectuată în conformitate cu ghidurile PRISMA. Rezultate. Am inclus 16 studii – recenzii sistematice și metaanalize publicate între mai 2020 și noiembrie 2020 – care s-au concentrat pe rezultatele perinatale ale femeilor însărcinate cu COVID-19 și 7 prezentări de cazuri ale nou-născuților cu transmitere verticală a COVID-19. În general, rata cazurilor de COVID-19 la nou-născuții din mame COVID-19 pozitive a fost de 3% cu CI 95% [1,86, 4,24]). Rata nașterii premature a fost de 16,4%, cu CI 95% [10,5, 22,3], iar rata mortalității și a deceselor fetale a fost de 1,4% (11 studii, 0 până la 4,8%). Dintre cei 7 nou-născuți cu transmitere verticală dovedită, majoritatea s-au născut prematuri, cu greutate bună la naștere și scor APGAR, iar manifestările clinice au fost heterogene; 4 au dezvoltat simptome severe. Evoluțiile atât pentru mamă, cât și pentru nou-născuţi au fost bune în 85% dintre cazuri. Concluzii. În ceea ce privește rata prematurității și rata mortalității la femeile cu COVID-19, rezultatul este similar cu populația generală. Transmiterea verticală este posibilă și pare să aibă loc în aproximativ 3% dintre cazuri. Prognosticul matern și perinatal este favorabil, iar prezentarea clinică a transmiterii în uter a SARS-CoV-2 la nou-născuți este heterogenă.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42414340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of SARS-CoV-2 infection in pregnancy 妊娠期SARS-CoV-2感染的管理
Revista Romana de Boli Infectioase Pub Date : 2021-01-01 DOI: 10.37897/rjid.2021.1.3
C. Stănică, R. Sima, Raluca Gabriela Ioan, C. Nanu, A. Neacșu
{"title":"Management of SARS-CoV-2 infection in pregnancy","authors":"C. Stănică, R. Sima, Raluca Gabriela Ioan, C. Nanu, A. Neacșu","doi":"10.37897/rjid.2021.1.3","DOIUrl":"https://doi.org/10.37897/rjid.2021.1.3","url":null,"abstract":"The SARS-CoV-2 infection, which originated from a market in Wuhan, China, spread rapidly, so on March 11, 2020, the WHO decreed that the outbreak became a pandemic. Over 90% of people infected with SARS-CoV-2 are either asymptomatic or have mild symptoms. However, there are cases that develop severe forms of the disease, from acute respiratory distress syndrome to septic shock with multiorgan failure and exitus. However, reports of pregnant women diagnosed with Covid-19 are low. Changes in the maternal organism in pregnancy, including immunity, respiratory system and hypercoagulability, but also various comorbidities, could be a risk factor for pregnant women to develop complications associated with COVID-19, with increased morbidity and mortality compared to the general population. The effects of SARS-CoV-2 infection on pregnancy are not sufficiently understood, nor are the effects of pregnancy on disease progression. Although the existence of the virus has been shown in biological samples such as the placenta, umbilical cord, or amniotic fluid, the maternal and fetal effects of the virus are not well known. Recent studies confirm the possibility of intrauterine maternal-fetal transmission of the virus, but also of specific antibodies. The possibility of infection by breastfeeding is not yet sufficiently investigated. We looked for data on the treatment and prophylaxis of SARS-CoV-2 infection during pregnancy, as well as on the choice of the optimal birth pathway in these women. The aim of this paper was to conduct a systematic review of the literature on pregnancy and birth management in patients infected with SARS-CoV-2 that could lead to an improvement in the quality of their medical care.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70136729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome of SARS-CoV-2 in pregnancy and newborns – is there a new kid in the TORCH block? SARS-CoV-2在妊娠和新生儿中的结局——TORCH区块中是否有新成员?
Revista Romana de Boli Infectioase Pub Date : 2021-01-01 DOI: 10.37897/rjid.2021.1.1
A. Niţă, Sabina Cornelia Manolescu, M. Popa, L. Popa
{"title":"Outcome of SARS-CoV-2 in pregnancy and newborns – is there a new kid in the TORCH block?","authors":"A. Niţă, Sabina Cornelia Manolescu, M. Popa, L. Popa","doi":"10.37897/rjid.2021.1.1","DOIUrl":"https://doi.org/10.37897/rjid.2021.1.1","url":null,"abstract":"Objective. This study aimed to perform a systematic review of existing literature to assess the outcomes of pregnancy in women with COVID-19 infection and their newborns while estimating the possibility of vertical transmission. Materials and methods. We conducted a systematic literature research using Pubmed and Google Scholar covering the period from December 2019 to 20th of November 2020. The review was conducted in accordance with PRISMA guidelines. Outcomes. We included 16 studies – systematic reviews and meta-analyses published between May 2020 and November 2020 – which focused on perinatal outcomes of pregnant women with COVID-19 and 7 case reports of neonates with congenital transmission of COVID-19. Overall, the rate of COVID-19 cases in neonates of COVID-19 positive mothers was 3% with 95% CI [1.86, 4.24]). The preterm birth rate was 16.4% with 95% CI [10.5, 22.3] and the rate of stillbirths and foetal deaths was 1.4% (11 studies, 0 to 4.8%). From the 7 newborns with proved vertical transmission, majority were born preterm, with good birth weight and APGAR score and heterogenous symptoms; 4 developed severe symptoms. Overall progress and evolution for both mother and newborn was good. Conclusions. COVID-19 impact on pregnancy outcome is similar to general population in regard to preterm rate and stillbirth rate. Vertical transmission is possible and it seems to occur in about 3% of cases. Overall maternal and perinatal outcome is favourable and clinical presentation of in utero transmission of SARSCoV-2 in newborns is heterogenous.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70136634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asocierea dintre colita ulcerativă şi infecţia cu Clostridium difficile la vârsta pediatrică – prezentare de caz 溃疡性结肠炎合并艰难梭菌感染的儿童年龄病例
Revista Romana de Boli Infectioase Pub Date : 2020-12-31 DOI: 10.37897/RJID.2020.4.6
Alina Negrea, Lorena Elena Meliț, Ana-Maria Șimon, V. Negrea, C. Mărginean
{"title":"Asocierea dintre colita ulcerativă şi infecţia cu Clostridium difficile la vârsta pediatrică – prezentare de caz","authors":"Alina Negrea, Lorena Elena Meliț, Ana-Maria Șimon, V. Negrea, C. Mărginean","doi":"10.37897/RJID.2020.4.6","DOIUrl":"https://doi.org/10.37897/RJID.2020.4.6","url":null,"abstract":"Dr. alina Negrea1, şef lucr. dr. lorena elena Meliţ1,2, dr. Ana-Maria şimon1, Dr. valentina Negrea3, prof. dr. cristina oana Mărginean1,2 1 Clinica Pediatrie I, Spitalul Clinic Judeţean de Urgenţă, Tg. Mureş, România 2 Universitatea de Medicină, Farmacie, Ştiinţe şi Tehnologie „G.E. Palade“, Tg. Mureş, România 3 Clinica Boli Infecţioase I, Spitalul Clinic Judeţean Mureş, Tg. Mureş, România PREZENTĂRI DE CAZ","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42474080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcom Kaposi cu evoluţie trenantă la un caz nou diagnosticat cu infecţie HI
Revista Romana de Boli Infectioase Pub Date : 2020-12-31 DOI: 10.37897/RJID.2020.4.8
E. Marcu, Craiova România Universitatea de Medicină și Farmacie, Amalia Romanescu, Florentina Dumitrescu
{"title":"Sarcom Kaposi cu evoluţie trenantă la un caz nou diagnosticat cu infecţie HI","authors":"E. Marcu, Craiova România Universitatea de Medicină și Farmacie, Amalia Romanescu, Florentina Dumitrescu","doi":"10.37897/RJID.2020.4.8","DOIUrl":"https://doi.org/10.37897/RJID.2020.4.8","url":null,"abstract":"REZUMAT Introducere. Sarcomul Kaposi (SK) este o neoplazie multicentrică vasculară, care apare, de obicei, în contextul imunodeficienţei. Deși introducerea terapiei antiretrovirale combinate (TARVc) a determinat o scădere remarcabilă a incidenţei SK asociat infecţiei cu HIV și o îmbunătăţire semnificativă a prognosticului, rămâne o cauză importantă de morbiditate și mortalitate în rândul pacienţilor HIV pozitivi. Prezentarea cazului. Pacient în vârstă de 34 de ani, se internează în Clinica de Dermatologie a Spitalului Clinic Judeţean de Urgenţă Craiova pentru apariţia unor placarde infiltrate, dureroase, localizate la nivelul mâinii stângi, inghinal și la nivelul piciorului stâng, ce au debutat în urmă cu aproximativ 3 ani. Se efectuează test ELISA-HIV 1,2, cu rezultat pozitiv și pacientul este internat la Compartimentul HIV/SIDA – Spitalul Clinic de Boli Infecţioase și Pneumoftiziologie „Victor Babeș“ din Craiova. Se instituie TARVc, tratament antibiotic, antimicotic, anticoagulant și simptomatic. Pe parcursul internării, pacientul prezintă extinderea leziunilor la nivelul cavităţii bucale, feţei plantare a piciorului drept și la nivelul lobului urechii stângi. Se efectuează biopsie de la nivelul leziunilor cutanate, iar examenul histopatologic confirmă diagnosticul de SK. După circa 2 luni, se iniţiază și tratament citostatic, evoluţia pacientului fiind favorabilă, cu remisiunea leziunilor cutaneo-mucoase în proporţie mai mare de 50%. Concluzii. Leziunile cutanate persistente la un pacient tânăr pot fi marker indicator de SIDA, întârzierea diagnosticului influenţând prognosticul infecţiei cu HIV.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44239193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An intermediate analysis of moderate and severe forms of COVID-19 treated in Craiova Infectious Disease Clinic 克拉约瓦传染病门诊治疗中、重度COVID-19的中间分析
Revista Romana de Boli Infectioase Pub Date : 2020-12-31 DOI: 10.37897/RJID.2020.4.3
L. Giubelan, C. Pharmacy, L. Dragonu, A. Stoian, F. Dumitrescu
{"title":"An intermediate analysis of moderate and severe forms of COVID-19 treated in Craiova Infectious Disease Clinic","authors":"L. Giubelan, C. Pharmacy, L. Dragonu, A. Stoian, F. Dumitrescu","doi":"10.37897/RJID.2020.4.3","DOIUrl":"https://doi.org/10.37897/RJID.2020.4.3","url":null,"abstract":"Objective. Description and differentiation of moderate and severe forms of COVID-19 diagnosed and treated in Infectious Diseases Clinic, „Victor Babeş“ Infectious Diseases and Pneumology Hospital from Craiova. Material and method. Retrospective study (March 2020 – July 2020) of the first 300 hospitalized cases comparing the moderate and severe forms of COVID-19 from a clinical and biological point of view. Results. 56 moderate and 33 severe cases were recorded;between them there are a series of differences with statistical significance: age of patients (49.5 ± 16.13, p < 0.0001), number of obese patients (12 vs. 14, p = 0.06), with cardiovascular suffering, (8 vs. 18, p < 0.0001), diabetes (9 vs. 15, p = 0.005) or neoplasms (2 vs. 7, p = 0.02). Several severely ill patients have dyspnoea (14 vs. 24, p < 0.0001), pulmonary rales (8 vs. 13, p = 0.01), elevated systolic blood pressure (2 vs. 9, p = 0.01), coma (0 vs. 5, p = 0.01) or radio-logical image of bronchopneumonia (0 vs. 6, p = 0.004). Critically ill patients have a higher leukocyte count (6,176.07±2,512.05 vs. 8,666.67±4,565.88, p=0.01), higher ESR at 1 hour (43.05±18.09 vs. 71.18±30.8 mm, p < 0.0001), higher level of C-reactive protein (29.62±19.81 vs. 43.46±18.01 mg/l, p = 0.01), serum lactate (1.19±0.91 vs. 3.47±3.84 mEq/l, p = 0.006), blood glucose (112.5±25.01 vs. 304.45±273.58 mg/ dl, p < 0.0001), D dimers (518.7±455.32 vs. 1,314.22±1,347.54 µg/ml, p < 0.0001), troponin (1.8±4.02 vs. 90.81±202.08 mg/l, p < 0.0001);the neutrophil-to-lymphocyte ratio is higher in severe forms (3.66±1.2 vs. 6.21±4.21, p < 0.0001). Of the 33 patients with severe forms 16 (approximately 50% of them, respectively 5.33% of the 300 cases) died. Conclusions. Patients with severe forms of COVID-19 are much older and have more comorbidities (es-pecially obesity, cardiovascular disease, diabetes or malignancies). For the early detection of severe forms, physicians should detect dyspnea, low oxygen saturation or the presence of pulmonary rales, more com-monly encountered in severe forms. Tests for inflammation and procoagulant status are significantly better expressed in patients with severe forms. At the level of the studied group, the glycemic control was subop-timal for severe forms of the disease. Despite the intensive care support, about half of those admitted with severe forms (5.33% of all cases) died. © 2020, Amaltea Medical Publishing House. All rights reserved.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48159893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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