Journal of Biosafety and Biosecurity最新文献

{"title":"Numerical simulations of a two-strain dengue model to investigate the efficacy of the deployment of Wolbachia-carrying mosquitoes and vaccination for reducing the incidence of dengue infections","authors":"Meksianis Z. Ndii ,&nbsp;Nursanti Anggriani ,&nbsp;Bertha S. Djahi ,&nbsp;Sanubari Tansah Tresna ,&nbsp;Fatuh Inayaturohmat","doi":"10.1016/j.jobb.2024.08.003","DOIUrl":"10.1016/j.jobb.2024.08.003","url":null,"abstract":"<div><p>This study investigated the usefulness of a two-serotype dengue mathematical model to gain insights into the effects of antibody-dependent enhancement and temperature on dengue transmission dynamics in the presence of vaccination and <em>Wolbachia</em>-carrying mosquitoes. In particular, the effects of temperature on the mosquito death and maturation rates in secondary infections were examined. A deterministic mathematical model was formulated and analysed to address this problem. The results suggest that controlling the population of aquatic mosquitoes is appropriate for reducing the incidence of secondary infections. Furthermore, the <em>wAu Wolbachia</em> strain was more effective in reducing secondary infections.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Pages 244-251"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000487/pdfft?md5=c755ea23a43690b6930ae1a984285d28&pid=1-s2.0-S2588933824000487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effectiveness of chemical inactivation of infectious liquid biological waste: A randomized sample study of research laboratories in Switzerland” [J. Biosaf. Biosecur. 6(1) (2024) 16–26]","authors":"Alina C. Teuscher ,&nbsp;Charlotte Ruhnau ,&nbsp;Nicole Stöcklin ,&nbsp;Fabienne Wichmann ,&nbsp;Evelyn Ilg Hampe ,&nbsp;Claudia Bagutti","doi":"10.1016/j.jobb.2024.09.001","DOIUrl":"10.1016/j.jobb.2024.09.001","url":null,"abstract":"","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Page 271"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stochastic epidemic model with time delays and unreported cases based on Markovian switching","authors":"H.J. Alsakaji ,&nbsp;Y.A. El-Khatib ,&nbsp;F.A. Rihan (PhD; DSc) ,&nbsp;A. Hashish","doi":"10.1016/j.jobb.2024.08.002","DOIUrl":"10.1016/j.jobb.2024.08.002","url":null,"abstract":"<div><p>Disease dynamics are influenced by changes in the environment. In this study, unreported cases (U), environmental perturbations, and exogenous events are included in the epidemic Susceptible–Exposed–Infectious–Unreported–Removed model with time delays. We examine the process of switching from one regime to another at random. Ergodicity and stationary distribution criteria are discussed. A Lyapunov function is used to determine several conditions for disease extinction. The spread of a disease is affected when transitioning from one random regime to another via sudden external events, such as hurricanes. The model and theoretical results are validated using numerical simulations.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Pages 234-243"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000475/pdfft?md5=f82949cbd4a1b36883019913a7b759e8&pid=1-s2.0-S2588933824000475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity, virulence profiles, and antimicrobial resistance of Salmonella enterica serovar Typhi isolated from typhoid fever patients in Baghdad, Iraq","authors":"Muna Sabah Dawood,&nbsp;Nadheema Hammood Hussein,&nbsp;Khetam Habeeb Rasool","doi":"10.1016/j.jobb.2024.08.001","DOIUrl":"10.1016/j.jobb.2024.08.001","url":null,"abstract":"<div><p>Typhoid fever is an important health issue in developing countries, and the pathogenicity of <em>Salmonella enterica</em> serovar Typhi (<em>S.</em> ser. Typhi) depends on the presence of different virulence factors. Therefore, this study aimed to investigate the spread of virulence genes among <em>S.</em> Typhi isolates from patients with typhoid fever in Baghdad, Iraq. Sixty <em>S.</em> Typhi isolates were collected from several hospitals in Baghdad and identified using VITEK-II and confirmed by polymerase chain reaction <strong>(</strong>PCR) to detect the <em>16S rRNA</em> gene. After testing their susceptibility to different antimicrobials (via the disk diffusion method), we found the highest resistance rates (100 %) were to ampicillin, piperacillin, cefotaxime, and ceftriaxone. The highest sensitivity rates (100 %) were to ertapenem, imipenem, meropenem, and sulfamethoxazole/trimethoprim. The presence of genes encoding for virulence in <em>S.</em> Typhi isolates was tested by conventional PCR. The results showed that out of 60 isolates, 59 (98.3 %), 59 (98.3 %), 58 (96.7 %), and 60 (100 %) were positive for <em>viaB, staA, cdtB,</em> and <em>orfL</em> genes, respectively. The sequencing of PCR products (<em>viaB, staA, cdtB,</em> and <em>orfL</em> genes) was carried out at the Macrogen Company (Seoul, Korea). The sequences were compared with nucleotide sequences in the BLAST GenBank database, and data obtained from the sequencing of these virulence genes were submitted to GenBank under different accession numbers. A phylogenetic analysis of the <em>16S rRNA</em> gene sequence found a high similarity between local sequences and the closely related sequences of genes in GenBank. The presence of the <em>viaB, staA, cdtB,</em> and <em>orfL</em> virulence genes in nearly all of the isolates under examination suggests that they play an important role in the pathogenicity of local isolates.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Pages 225-233"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000396/pdfft?md5=29e047c9e195776b3f4303349920534c&pid=1-s2.0-S2588933824000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons for biosecurity education from the International Nuclear Security Education Network","authors":"Iris Magne ,&nbsp;Olivia Ibbotson ,&nbsp;Lijun Shang ,&nbsp;Malcolm Dando","doi":"10.1016/j.jobb.2024.09.002","DOIUrl":"10.1016/j.jobb.2024.09.002","url":null,"abstract":"<div><div>With the rapid advances in technology and life science, biological security is now at a defining moment. The mandate of the 2022 Biological and Toxin Weapons Convention 9th Review Conference emphasised the urgent need for new tools to strengthen the Convention. In this paper, we review the development and efforts of the International Nuclear Security Education Network (INSEN) to provide examples of best practice for implementation of the newly founded International Biological Security Education Network (IBSEN). Learning from the lessons of the INSEN, the sustainability of the network through continuous engagement of its members is essential for the further development of global biosecurity education.</div></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Pages 252-257"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation methods of reproduction numbers for epidemics of varying strains of COVID-19","authors":"Siying Xiong ,&nbsp;Shaojian Cai ,&nbsp;Fengying Wei ,&nbsp;Guangmin Chen ,&nbsp;Kuicheng Zheng ,&nbsp;Jianfeng Xie","doi":"10.1016/j.jobb.2024.10.003","DOIUrl":"10.1016/j.jobb.2024.10.003","url":null,"abstract":"<div><div>The estimation methods of reproduction numbers and serial intervals are important in the early stages of infectious diseases. During the COVID pandemic, China implemented a dynamic zero-COVID policy on the Chinese mainland until the end of 2022. This study compares three estimation methods of basic reproduction numbers on small-scale, short-duration COVID-19 epidemics in Fujian Province. Basic reproduction numbers were investigated using a varying-strain model via a next-generation matrix method. Serial intervals were derived using the infector–infectee pairs of two epidemics from the Fujian Provincial Center for Disease Control and Prevention. Basic reproduction numbers were estimated using the maximum likelihood estimation method and the exponential growth method. The curves of the effective reproduction numbers of the three epidemics were plotted by utilizing daily cases and the EpiEstim R package. The spatial heterogeneity of infection cases was described using the Gini coefficient. This study provides significant insights on the estimation methods of reproduction numbers for policymakers in the local government. The results reveal that social contacts between infectors and susceptible individuals should be reduced to avoid an increase in deaths and to fight against the spread of infectious diseases.</div></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 4","pages":"Pages 265-270"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-based discovery of F. religiosa phytochemicals as potential inhibitors against Monkeypox (mpox) viral protein","authors":"Ranjan K. Mohapatra ,&nbsp;Ahmed Mahal ,&nbsp;Pranab K. Mohapatra ,&nbsp;Ashish K. Sarangi ,&nbsp;Snehasish Mishra ,&nbsp;Meshari A. Alsuwat ,&nbsp;Nada N. Alshehri ,&nbsp;Sozan M. Abdelkhalig ,&nbsp;Mohammed Garout ,&nbsp;Mohammed Aljeldah ,&nbsp;Ahmad A. Alshehri ,&nbsp;Ahmed Saif ,&nbsp;Mohammed Abdulrahman Alshahrani ,&nbsp;Ali S. Alqahtani ,&nbsp;Yahya A. Almutawif ,&nbsp;Hamza M.A. Eid ,&nbsp;Faisal M Albaqami ,&nbsp;Mohnad Abdalla ,&nbsp;Ali A. Rabaan","doi":"10.1016/j.jobb.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.jobb.2024.05.004","url":null,"abstract":"<div><p>Outbreaks of Monkeypox (mpox) in over 100 non-endemic countries in 2022 represented a serious global health concern. Once a neglected disease, mpox has become a global public health issue. A42R profilin-like protein from mpox (PDB ID: 4QWO) represents a potential new lead for drug development and may interact with various synthetic and natural compounds. In this report, the interaction of A42R profilin-like protein with six phytochemicals found in the medicinal plant <em>Ficus religiosa</em> (abundant in India) was examined. Based on the predicted and compared protein–ligand binding energies, biological properties, IC₅₀ values and toxicity, two compounds, kaempferol (C-1) and piperine (C-4), were selected. ADMET characteristics and quantitative structure–activity relationship (QSAR) of these two compounds were determined, and molecular dynamics (MD) simulations were performed. <em>In silico</em> examination of the kaempferol (C-1) and piperine (C-4) interactions with A42R profilin-like protein gave best-pose ligand-binding energies of –6.98 and –5.57 kcal/mol, respectively. The predicted IC₅₀ of C-1 was 7.63 μM and 82 μM for C-4. Toxicity data indicated that kaempferol and piperine are non-mutagenic, and the QSAR data revealed that piperlongumine (5.92) and piperine (5.25) had higher log P values than the other compounds examined. MD simulations of A42R profilin-like protein in complex with C-1 and C-4 were performed to examine the stability of the ligand–protein interactions. As/C and C-4 showed the highest affinity and activities, they may be suitable lead candidates for developing mpox therapeutic drugs. This study should facilitate discovering and synthesizing innovative therapeutics to address other infectious diseases.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 3","pages":"Pages 157-169"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258893382400030X/pdfft?md5=ec15123379db8c297e57ae0d9b373a79&pid=1-s2.0-S258893382400030X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mathematical model for a disease outbreak considering waning-immunity class with nonlinear incidence and recovery rates","authors":"Nursanti Anggriani ,&nbsp;Lazarus Kalvein Beay ,&nbsp;Meksianis Z. Ndii ,&nbsp;Fatuh Inayaturohmat ,&nbsp;Sanubari Tansah Tresna","doi":"10.1016/j.jobb.2024.05.005","DOIUrl":"https://doi.org/10.1016/j.jobb.2024.05.005","url":null,"abstract":"<div><p>In the spread of infectious diseases, intervention levels play a crucial role in shaping interactions between healthy and infected individuals, leading to a nonlinear transmission process. Additionally, the availability of medical resources limits the recovery rate of infected patients, adding further nonlinear dynamics to the healing process. Our research introduces novelty by combining nonlinear incidence and recovery rates alongside waning immunity in an epidemic model. We present a modified SIRW-type model, examining the epidemic problem with these factors. Through analysis, we explore conditions for non-endemic and co-existing cases based on the basic reproduction ratio. The local stability of equilibria is verified using the Routh-Hurwitz criteria, while global stability is assessed using Lyapunov functions for each equilibrium. Furthermore, we investigate bifurcations around both non-endemic and co-existing equilibria. Numerically, we give some simulations to support our analytical findings.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 3","pages":"Pages 170-180"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000311/pdfft?md5=9a3f3ac37c5d275226798d8df28d62fc&pid=1-s2.0-S2588933824000311-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Interplay Between Social Awareness and the Use of Bed Nets in a Malaria Control Program","authors":"Iffatricia Haura Febiriana ,&nbsp;Dipo Aldila ,&nbsp;Bevina Desjwiandra Handari ,&nbsp;Puji Budi Setia Asih ,&nbsp;Muhamad Hifzhudin Noor Aziz","doi":"10.1016/j.jobb.2024.06.005","DOIUrl":"10.1016/j.jobb.2024.06.005","url":null,"abstract":"<div><p>This research aims to understand the effect of human awareness and the use of bed nets on malaria control programs. A deterministic host-vector mathematical model was utilized and simplified using the Quasi-Steady State Approximation, assuming the mosquito population is at equilibrium due to its fast, dynamic behavior. The model reveals two equilibrium states: the malaria-free equilibrium and the endemic equilibrium. The malaria-free equilibrium is locally asymptotically stable when the basic reproduction number is less than one and unstable if it is larger than one. Conversely, the malaria-endemic equilibrium is unique and stable if the reproduction number exceeds one and does not exist otherwise. Based on incidence data from Papua, parameter estimation and sensitivity analyses indicate that human awareness and the use of bed nets significantly reduce the reproduction number. To address budget constraints for interventions, the model was reformulated as an optimal control problem, characterized using the Pontryagin Maximum Principle, and solved with the forward–backward sweep method. Numerical experiments were conducted to assess the impact of various scenarios on the malaria control program. Cost-effectiveness analyses employing ACER, ICER, and IAR metrics suggest that while the combined implementation of awareness campaigns and bed nets effectively reduces infections, it incurs high costs. In contrast, implementing human awareness campaigns alone emerges as the best strategy based on ACER, ICER, and IAR standards. This study demonstrates that enhancing human awareness and promoting the use of bed nets are effective strategies for controlling malaria. However, due to budget constraints, focusing solely on awareness campaigns proves to be the most cost-effective intervention. This approach not only reduces malaria transmission but also optimizes resource allocation, highlighting the importance of targeted educational programs in public health initiatives for malaria control.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 3","pages":"Pages 196-210"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000359/pdfft?md5=286803da5b7a0c85dfa5ff19326db67a&pid=1-s2.0-S2588933824000359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling and optimal control of COVID-19 with comorbidity and three-dose vaccination in Indonesia","authors":"Muhammad Abdurrahman Rois ,&nbsp;Fatmawati ,&nbsp;Cicik Alfiniyah ,&nbsp;Santi Martini ,&nbsp;Dipo Aldila ,&nbsp;Farai Nyabadza","doi":"10.1016/j.jobb.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.jobb.2024.06.004","url":null,"abstract":"<div><p>This paper presents and examines a COVID-19 model that takes comorbidities and up to three vaccine doses into account. We analyze the stability of the equilibria, examine herd immunity, and conduct a sensitivity analysis validated by data on COVID-19 in Indonesia. The disease-free equilibrium is locally and globally asymptotically stable whenever the basic reproduction number is less than one, while an endemic equilibrium exists and is globally asymptotically stable when the number is greater than one. Subsequently, the model incorporates two effective measures, namely public education and enhanced medical care, to determine the most advantageous approach for mitigating the transmission of the disease. The optimal control model is then determined using Pontryagin’s maximum principle. The integrated control strategy is the best method for reliably safeguarding the general population against COVID-19 infection. Cost evaluations and numerical simulations corroborate this conclusion.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 3","pages":"Pages 181-195"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000347/pdfft?md5=e3f237c1b54058dbee82e284d716e498&pid=1-s2.0-S2588933824000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}