Journal of Biosafety and Biosecurity最新文献

{"title":"Strengthening the cross-cutting issue of the biological weapons convention in Pakistan","authors":"Maria Khan ,&nbsp;Saba Khan","doi":"10.1016/j.jobb.2023.08.002","DOIUrl":"10.1016/j.jobb.2023.08.002","url":null,"abstract":"<div><p>Development and sharing of model approaches to national science policies can enable States Parties to effectively raise awareness about the security dimensions of life science research and to promote research integrity and the responsible use of science, as well as enhancing accountability practices among practitioners and fostering access to emerging capabilities in science and technology. It is also important to incorporate convergent domains of scientific endeavors in biological and particularly computer and information sciences, upon which the life sciences increasingly depend. Indeed, the rapid development of science and technology may be outpacing necessary ethical and regulatory practices. Thus, governments and civil society often struggle to anticipate emerging capabilities and to identify and implement appropriate oversight mechanisms, particularly for activities that occur outside the direct oversight of government programs. However, these efforts are critical for public health and serve as an extremely powerful action to counter the use of biological weapons.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 3","pages":"Pages 116-117"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45806424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the binding energies of approved mpox drugs and phytochemicals through molecular docking, molecular dynamics simulation, and ADMET studies: An in silico approach","authors":"Ranjan K. Mohapatra ,&nbsp;Ahmed Mahal ,&nbsp;Azaj Ansari ,&nbsp;Manjeet Kumar ,&nbsp;Jyoti Prakash Guru ,&nbsp;Ashish K. Sarangi ,&nbsp;Aly Abdou ,&nbsp;Snehasish Mishra ,&nbsp;Mohammed Aljeldah ,&nbsp;Bashayer M. AlShehail ,&nbsp;Mohammed Alissa ,&nbsp;Mohammed Garout ,&nbsp;Ahmed Alsayyah ,&nbsp;Ahmad A. Alshehri ,&nbsp;Ahmed Saif ,&nbsp;Abdulaziz Alqahtani ,&nbsp;Fahd A. Alshehri ,&nbsp;Aref A. Alamri ,&nbsp;Ali A. Rabaan","doi":"10.1016/j.jobb.2023.09.001","DOIUrl":"https://doi.org/10.1016/j.jobb.2023.09.001","url":null,"abstract":"<div><p>The mpox (previously monkeypox) outbreak in more than 100 non-endemic countries in 2022 posed a serious global health concern. Mpox is emerging as a global public health threat from a seemingly neglected disease. A42R profilin-like protein from mpox virus (PDB ID: 4QWO) could be a preferred target lead. The binding affinity of commonly used drugs/mAbs (tecovirimat, brincidofovir, cidofovir) for A42R profilin-like protein was examined <em>in silico</em> through molecular docking. Further, the results were compared with those of the phytochemicals curcumin, rutin, and theaflavin. Tecovirimat (−7.31 kcal/mol, IC₅₀ = 4.39 µM) and theaflavin (−6.99 kcal/mol, IC₅₀ = 7.54 µM) had the highest affinities. Molecular dynamics simulation of the theaflavin–4QWO complex was performed to ascertain the stability of ligand–protein interactions in natural charge, molecular electrostatic potential, and frontier molecular orbital analyses. The predicted QSAR and pharmacokinetic properties of all compounds were evaluated to find a suitable candidate for designing and developing new drugs. The evaluated log P values for brincidofovir and tecovirimat were higher than those of the other drugs in the QSAR study. Theaflavin had an impressive log P of 4.77, which hints at its high biological activity. The findings recommend further <em>in vitro</em> experimental validation to develop potential low-cost mpox therapies.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 3","pages":"Pages 118-132"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49870553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physico-chemical quality of ashes post-incineration and waste from laboratory automaton biochemistry, hematology and serology in Togo","authors":"Sadikou Agbere ,&nbsp;Mabozou Kpemissi ,&nbsp;Mamatchi Melila ,&nbsp;Kamilou Ouro-Sama ,&nbsp;Ameyo Dorkenoo ,&nbsp;Gnon Tanouayi ,&nbsp;Hodabalo Dheoulaba Solitoke ,&nbsp;Koudjo Adje ,&nbsp;Kissao Gnandi","doi":"10.1016/j.jobb.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.jobb.2023.07.002","url":null,"abstract":"<div><p>Biochemistry, hematology and serology laboratories produce very heterogeneous discharges capable of polluting water, soil and the environment. The aim of this study is to evaluate the physico-chemical quality of the ashes, effluents and the range of equipment that produce the much effluent and pollutions.</p><p>This is a descriptive and cross-sectional study of 82 laboratories followed by the sampling of effluents from automatons. The physico-chemical parameters and trace elements are determined according to French Standardization Association (AFNOR) standards and used atomic absorption spectrometers and molecular absorption spectrometers. The Mindray hematology automaton is used for 64.7% and 81.5% of the cans are used to collect waste. Semehow 77.8% of discharges are released into sinks without adequate treatment in 42.6% of cases. Chemical analyses show that trace elements (TE) levels in effluents range from 5.89 ± 0.21 to 105.80 ± 0.96 μg/L for Arsenic; from 5.62 ± 0.34 to 6.53 ± 0.49 μg/L for Cadmium; 0.70 ± 0.01 to 10.63 ± 1.17 μg/L for Mercure and 35.72 ± 1.88 to 61.98 ± 5.15 μg/L for Plomb. pH ranges from 7.17 ± 0.65 to 8.3 ± 1.35 with total dissolved salts (TDS) range from 3260.20 ± 401.68 to 17117.41 ± 265.37 mg/L. All averages of contamination indices (CI) and polymetallic contamination indices (PCI) for post-incineration ashes are greater than 1.5 with the exception of Hg (0.22). For effluents, in addition to polymetallic contamination indices (PCI), CI in hematology effluents (1.09), all CI are less than 1. Hematology effluents have a lower pH and are much more mineralized and concentrated in trace elements while those from biochemistry and serology appear to be similar. However, the effluents of Biochemistry and Serology are more basic and concentrated in Suspended Solids with higher values obtained in Biochemistry. Although the physico-chemical parameters comply with WHO standards, discharges from automatons deserve appropriate treatment before their disposal.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 3","pages":"Pages 107-115"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49870554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID’s future: Viral multi-lineage evolution and the dynamics of small epidemic waves without seasonality in COVID-19","authors":"Yamin Sun ,&nbsp;Min Wang ,&nbsp;Fengying Wei ,&nbsp;Senzhong Huang ,&nbsp;Jianguo Xu","doi":"10.1016/j.jobb.2023.07.003","DOIUrl":"10.1016/j.jobb.2023.07.003","url":null,"abstract":"<div><p>Since its emergence, SARS-CoV-2 virus, the causative agent of COVID-19, has undergone over three years of evolutionary changes. Throughout this evolutionary process, multiple variants, such as Alpha, Beta, Gamma, Delta, and Omicron, have emerged, leading to widespread outbreaks and pandemics. A comprehensive analysis of the evolution of SARS-CoV-2 over the past three years reveals its progression through three distinct stages.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 3","pages":"Pages 96-99"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41653654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 4th Global Biosafety and Biosecurity Symposium held in Beijing, China","authors":"","doi":"10.1016/j.jobb.2023.09.002","DOIUrl":"https://doi.org/10.1016/j.jobb.2023.09.002","url":null,"abstract":"","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 3","pages":"Page 133"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical analysis of post-incineration ash and effluent from laboratory biochemistry, hematology, and serology robots in Togo","authors":"Sadikou Agbere, Mabozou Kpemissi, M. Mélila, Kamilou Ouro-Sama, A. Dorkenoo, Gnon Tanouayi, Hodabalo Dheoulaba Solitoke, K. Adje, K. Gnandi","doi":"10.1016/j.jobb.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.jobb.2023.07.002","url":null,"abstract":"","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42965513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile biosafety level (BSL) 2 laboratories deployment: Strengthening the diagnostic facilities in Pakistan with emerging public health challenges and the way forward","authors":"Shamsul Arfin Qasmi ,&nbsp;Aamer Ikram ,&nbsp;Muhammad Tariq ,&nbsp;Muhammad Tahir Khadim ,&nbsp;Nabeel Ahmed Maqbool","doi":"10.1016/j.jobb.2023.05.002","DOIUrl":"10.1016/j.jobb.2023.05.002","url":null,"abstract":"<div><p>Availability of mobile laboratories can facilitate rapid on-spot detection of pathogens, monitor its presence in certain populations and inform health authorities to take immediate remedial measures. Currently available biosafety and biosecurity guidelines and policies may not completely articulate the increased demand to manage mobile units in infectious disease outbreaks in remote parts of the country for rapid diagnosis, and also allows research and epidemiological study take place appropriately.</p><p>The main objective of this study is to evaluate the current limitations and develop and implement biosafety and biosecurity guidelines as well as the protocols for operations, security, and response plan of mobile biosafety level 2 laboratories and their deployment.</p><p>Keeping in view the sensitivity of it, a comprehensive plan was developed to address it in view of Global Health Security framework. Biosafety and biosecurity protocols were developed including Risk Assessment Tool (RAT) fitting the needs and strengthen the diagnostic and epidemiological capacity in the field covering remote parts of country to fill the gaps observed during the COVID-19 pandemic.</p><p>Currently the biosafety and biosecurity best practices guidelines and biosecurity policy and regulations are directed mostly towards static laboratories. A biosafety and biosecurity manual developed to adopt and meet the requirements for MBSL 2. For acute health infectious threats including the COVID-19 outbreak and other epidemics, rapid diagnosis can curb and mitigate the problem before it gets out of its boundaries creating significant health risks for the public and economy. The deployment of mobile laboratories will certainly help in curbing these catastrophes.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 2","pages":"Pages 79-83"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41788842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of surface inactivation disinfectants for bacteria studied in an aquaculture microbiology laboratory","authors":"Manfred Weidmann","doi":"10.1016/j.jobb.2023.06.001","DOIUrl":"10.1016/j.jobb.2023.06.001","url":null,"abstract":"<div><p>Routine microbial inactivation procedures used in microbiology laboratories must be verified. In this study, the efficacy of surface disinfection using 70% Isopropanol, 0.45% Presept, and 1% Virkon was tested against 24 bacterial strains commonly handled in aquaculture microbiology laboratories. Isopropanol was ineffective against <em>Nocardia asteroides NCIMB 1290,</em> while Virkon was not effective against <em>Aeromonas eucrenophila NCIMB 74</em> or <em>Pediococcus acidilacti R52037</em>.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 2","pages":"Pages 84-86"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45272785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of an emerging zoonotic Nipah virus: An emerging concern","authors":"Diptanu Paul ,&nbsp;Aroop Mohanty ,&nbsp;Abhishek Shah ,&nbsp;Bijaya Kumar Padhi ,&nbsp;Ranjit Sah","doi":"10.1016/j.jobb.2023.04.002","DOIUrl":"10.1016/j.jobb.2023.04.002","url":null,"abstract":"<div><p>The Nipah virus (NiV) infection is one of the newly emerging deadly zoonotic diseases which carries a significant weightage of mortality among its victims. Due to the relatively recent history of its emergence and only a few known outbreaks, we cannot predict but foresee its potential to create havoc, which can be far more dreadful than the current ongoing COVID-19 pandemic. Here we have tried to depict the fatal potential of the virus and the increased propensity with which it can spread to rest of the world.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 2","pages":"Pages 57-59"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9403761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and comparative genomic analyses of Multidrug-Resistant Acinetobacter baumannii collected between 2020 and 2022 in Liaocheng City, Shandong Province, China","authors":"Fangyuan Cui ,&nbsp;Li Liu ,&nbsp;Xuefeng Miao ,&nbsp;Haiying Qian ,&nbsp;Shaocai Lu ,&nbsp;Jinjing Tian ,&nbsp;Guanhua Qiao ,&nbsp;Baobin Shao ,&nbsp;Qian Li ,&nbsp;Ran Zhang ,&nbsp;Shengnan Liang","doi":"10.1016/j.jobb.2023.04.001","DOIUrl":"10.1016/j.jobb.2023.04.001","url":null,"abstract":"<div><p>The emergence and prevalence of multidrug-resistant <em>Acinetobacter baumannii</em> (MRAB) poses a huge challenge to clinical treatment. To investigate the genetic and epidemiologic characteristics of MRAB in Liaocheng, China, and to explore potential resistance mechanisms, 56 MRAB strains were collected from the clinical departments of seven hospitals in Liaocheng between 2020 and 2022. Molecular typing, antimicrobial resistance patterns, and epidemiological characteristics were determined by genome sequencing and comparative genome analysis. Sequence type (ST) 540 was the most prevalent ST of the 56 MRAB in Liaocheng, and most strains (92.86%) were grouped into CC92. Core genome multilocus sequence typing subdivided the strains according to the number of allelic differences and could distinguish different outbreaks caused by ST540 isolates in the hospitals. All the isolates harbored <em>bla_OXA-23</em> and <em>bla_ADC-25</em>, and at least 92.86% of the isolates were resistant to 10 antibiotics. The major MRAB epidemic clone detected in Liaocheng was ST540, which was different from the results reported in other regions in China. Furthermore, several inter-hospital transmissions of ST540 isolates were observed. The findings highlight the urgent need for effective nosocomial infection control measures and the continuous surveillance of ST540 MRAB in Liaocheng.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"5 2","pages":"Pages 60-66"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46738221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}