Journal of Affective Disorders Reports最新文献

{"title":"Temporal fluctuations of adolescent suicides in OECD countries from 1990–2019","authors":"Ruri Okubo,&nbsp;Ryusuke Matsumoto,&nbsp;Eishi Motomura,&nbsp;Motohiro Okada","doi":"10.1016/j.jadr.2024.100857","DOIUrl":"10.1016/j.jadr.2024.100857","url":null,"abstract":"<div><h3>Background</h3><div>In this century, globally suicides have decreased, but decreasing trend was attenuated since the late 2010s, with these tendencies being more pronounced in adolescents. This study identified actual trends and risks of adolescent suicide in OECD countries during 1990–2019.</div></div><div><h3>Methods</h3><div>Fluctuation of adolescent (10–25 years) age-standardized death rate (ASDR), crude-mortality rate (CMR) and percentage of suicide per total-deaths (PTD) in 37 OECD countries obtained from “WHO Mortality Database” was analyzed by joinpoint regression. Fixed effects of gross domestic product per capita (GDPC) obtained from “OECD Data Explore” were determined using hierarchical linear model.</div></div><div><h3>Results</h3><div>Adolescent ASDR-suicide increased. Adolescent ASDR-suicide increased among males and females in Asia, Central/South America, and females in North America, unchanged in males and females in Oceania and males in North America, but decreased in males and females in Europe. PTD-suicide among adolescents in all regions consistently increased in 1990–2019 (with female predominance). Surprisingly, PTD-suicide in adolescents in Asia was approximately 50 % in the late 2010s. Fixed effects of males ASDR caused by traffic accidents and of females ASDR caused by violence positively related to ASDR-suicide of adolescent males and females, respectively.</div></div><div><h3>Conclusions</h3><div>Fluctuation adolescent males and females ASDR-suicide was not uniform across five regions among OECD. Contrary, adolescent PTD-suicide in five regions indicated increasing in all five regions; however, those in Asia and Oceania markedly larger compared to other regions. These results suggest that suicide prevention among adolescent health activities is lagging compared to other causes of death, especially in Asia and Oceania.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100857"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of suicidal behaviors in childhood, adolescent and young adults cancer survivors: A systematic review and meta-analysis","authors":"Naohiro Yonemoto ,&nbsp;Yoshitaka Kawashima","doi":"10.1016/j.jadr.2024.100858","DOIUrl":"10.1016/j.jadr.2024.100858","url":null,"abstract":"<div><h3>Background</h3><div>Many studies have shown that Childhood, adolescent and young adult cancer (CAYAC) survivors have an increased risk of late physical and mental health effects. However, comprehensive data on the risks of suicidal behaviors in CAYAC survivors are still lacking. We investigated the evidence of suicidal behaviors in CAYAC survivors.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis. The literature search was conducted using MEDLINE, Embase, CINAHL, PsycINFO, the Cochrane Database, and reference lists from previous relevant reviews. We summarized the characteristics of eligible studies on suicidal behavior. We performed meta-analysis with random-effect model for available data of them and calculated pooled prevalences with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>We identified 1108 articles from the search and 22 articles from previous review. We identified 38 eligible studies. 26 cohort studies and 12 cross-sectional studies were compromised. The meta-analysis showed pooled prevalence of suicide was 0.152 % (95 % CI: 0.103–0.209), suicide attempt was 2.2 % (95 %CI; 1.9–2.6) and suicidal ideation was 9.2 % (95 %CI: 7.8–10.6). Some studies identified specific CAYAC survivors at risk of suicide as age, type of cancer and treatments.</div></div><div><h3>Limitations</h3><div>Outcome measures could not be identified in some studies in the meta-analysis.</div></div><div><h3>Conclusions</h3><div>The findings revealed prevalence of suicidal behaviors in CAYAC survivors. Greater awareness and monitoring are needed of these risks, and of issues that affect support to prevent suicidal behaviors in CAYAC survivors.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100858"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep and eating disorders in Canada before and during the first wave of the COVID-19 pandemic","authors":"Samantha Kenny ,&nbsp;Rébecca Robillard ,&nbsp;Mysa Saad ,&nbsp;Tetyana Kendzerska ,&nbsp;Lena Quilty ,&nbsp;Elizaveta Solomonova ,&nbsp;Elliott Lee ,&nbsp;Alexander R. Daros ,&nbsp;Roger Godbout ,&nbsp;Marie-Hélène Pennestri","doi":"10.1016/j.jadr.2024.100860","DOIUrl":"10.1016/j.jadr.2024.100860","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are prevalent among individuals with eating disorders (EDs), yet limited research has explored the interplay between EDs and sleep during the COVID-19 pandemic. This study aimed to compare 1) self-reported sleep quality before the pandemic (retrospectively) among individuals with current EDs, remitted EDs, and controls (no psychiatric history); and 2) sleep quality differences among these groups from before to during the pandemic.</div></div><div><h3>Methods</h3><div>Participants (<em>N</em> = 1033) completed the Pittsburgh Sleep Quality Index and reported anxiety and depression symptoms for the month before the pandemic onset (retrospectively) and during the pandemic. One-way ANCOVAs compared sleep quality among groups before the pandemic, adjusting for anxiety and depression symptoms and demographics. Repeated measures ANCOVAs assessed sleep quality differences between before and during the pandemic, controlling for the same covariates.</div></div><div><h3>Results</h3><div>Pre-pandemic, individuals with current EDs reported the highest sleep disturbance levels, followed by those with remitted EDs and controls (<em>F</em> (2, 955) = 11.01, <em>p</em> &lt; 0.001). During the pandemic, sleep disturbance worsened across all groups, with individuals in current and remitted ED groups experiencing a more significant deterioration than controls, even when accounting for anxiety and depression symptoms (<em>p</em> &lt; 0.05).</div></div><div><h3>Limitations</h3><div>The cross-sectional design and retrospective self-reports of sleep quality.</div></div><div><h3>Conclusions</h3><div>Individuals with current and remitted EDs seemed to be vulnerable to sleep disruptions during the pandemic. Sleep disruptions may persist during ED remission. Awareness of these dynamics can enhance mental health practitioners’ attention to sleep disruptions in adults with current or remitted EDs.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100860"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antepartum depression among women attending antenatal care in the third trimester in Conakry, Guinea: Findings from the MISPOD study","authors":"Anteneh Asefa ,&nbsp;Tamba Mina Millimouno ,&nbsp;Nigus Bililign Yimer ,&nbsp;Gracia Fellmeth ,&nbsp;Grace Marie V. Ku ,&nbsp;Makany Sangare ,&nbsp;Abdoulaye Sow ,&nbsp;Alexandre Delamou ,&nbsp;Lenka Beňová","doi":"10.1016/j.jadr.2024.100867","DOIUrl":"10.1016/j.jadr.2024.100867","url":null,"abstract":"<div><div>Depression in pregnancy (antepartum depression) is a common mental health condition associated with multiple adverse outcomes. Despite high prevalence in sub-Saharan African countries, there is a critical evidence gap on its prevalence in Guinea. We aimed to estimate the prevalence of symptoms suggestive of antepartum depression among women seeking antenatal care (ANC) in urban Guinea and to identify factors associated with it. As baseline of a longitudinal mixed methods study, we surveyed 417 pregnant women at ≥28 weeks gestation seeking ANC at 22 selected health facilities in Conakry and screened them using the Edinburgh Postnatal Depression Scale, with a score of 11 or higher indicating symptoms suggestive of depression. We used bivariate and multivariable logistic regression to identify factors associated with symptoms suggestive of antepartum depression. The prevalence of symptoms suggestive of antepartum depression was 34.5 % (95 % CI: 30.1–39.2). Women who worried 'sometimes' (aOR 3.10; 95 % CI: 1.83, 5.29) and 'very often' (aOR 5.69; 95 % CI: 2.72, 11.91) about feeding their family in the last weeks before the survey were more likely to have symptoms suggestive of antepartum depression than those who ‘never’ worried. Women who attended ANC at private health facilities were less likely to have symptoms suggestive of antepartum depression compared with those who attended ANC at public facilities (aOR 0.34; 95 % CI: 0.16, 0.69). The high prevalence of antepartum depressive symptoms in Conakry highlights the need to integrate mental health services into routine maternal healthcare and address socioeconomic determinants of perinatal mental health.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100867"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating the German version of the entrapment scale among suicidal psychiatric inpatients","authors":"Emmy Wichelhaus ,&nbsp;Dajana Schreiber ,&nbsp;Laura Paashaus ,&nbsp;Antje Schönfelder ,&nbsp;Georg Juckel ,&nbsp;Heide Glaesmer ,&nbsp;Tobias Teismann ,&nbsp;Thomas Forkmann","doi":"10.1016/j.jadr.2024.100862","DOIUrl":"10.1016/j.jadr.2024.100862","url":null,"abstract":"<div><h3>Introduction</h3><div>Entrapment, the feeling of being trapped by external (EE) or internal (IE) circumstances, is an important transdiagnostic construct that is associated with both the development of depressiveness and suicide ideation. Entrapment can be validly assessed by the original English version of the Entrapment Scale (ES). So far, the German version of the Entrapment Scale has been psychometrically examined only once and exclusively in a non-clinical sample. In the present study we therefore examined whether the German version of the Entrapment Scale (ES-d) is a valid and reliable instrument for measuring entrapment in a clinical sample.</div></div><div><h3>Methods</h3><div>The study represents a secondary analysis of a large multicentre project that investigated risk factors for suicide ideation and suicidal behaviour in a longitudinal design. The analyses are based on data from 287 patients who were admitted to hospital for a recent suicide attempt or an acute suicidal crisis. The factorial validity of the ES-d is tested by means of a confirmatory factor analysis (CFA). The internal consistency of the scale as well as its retest reliability are reported. Convergent validity (DESC, BSS, BHS), discriminant validity (PMH), and predictive validity with regard to suicide ideation and depression were examined at 6-month follow-up.</div></div><div><h3>Results</h3><div>The results confirm the two-factorial structure of ES-d, after three items were removed from the scale with a good internal consistency for external entrapment (EE: α = 0.84) as well as internal entrapment (IE: α = 0.85). The ES-d also showed good convergent (EE-DESC: r = 0.537. EE-BSS: r = 0.438, EE-BHS: r = 0.447; IE-DESC: r = 0.618, IE-BSS: r = 0.472, IE-BHS: r = 0.528) and discriminant (EE: r = -0.459, IE: r= -0.531) validity. Both the retest reliability (ES-d: r = 0.26, EE: r = 0.26, IE: r = 0.27) and the predictive validity prove to be low.</div></div><div><h3>Discussion</h3><div>The two-factorial structure of the Entrapment Scale was confirmed, however challenging the results of the previous validation of the German version, which had previously reported a single-factor structure of the scale based on a non-clinical sample. The German version of the Entrapment Scale is a valid and reliable instrument for measuring entrapment in a high-risk population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100862"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between birth-related expectation violations and postpartum somatic symptoms and stress in mothers","authors":"Pia Eitenmüller ,&nbsp;Ana Maria Fiesel ,&nbsp;Siegmund Köhler ,&nbsp;Pia von Blanckenburg ,&nbsp;Hanna Christiansen","doi":"10.1016/j.jadr.2024.100861","DOIUrl":"10.1016/j.jadr.2024.100861","url":null,"abstract":"<div><h3>Background</h3><div>The impact of unmet expectations on birth satisfaction and thus postpartum mental health has been described. Despite the high prevalence of postpartum mental distress, the direct influence of birth-related expectation violations has hardly been investigated. In this study, we explored the impact of birth-related expectation violations on postpartum maternal somatic symptoms and stress.</div></div><div><h3>Methods</h3><div>Our sample consisted of 125 women who filled out two surveys on childbirth expectations, on somatic symptom severity and psychosocial stress (German Patient Health Questionnaire; PHQ-D); during pregnancy (T1) and after birth (T2; up to six months postpartum<em>).</em> We identified expectation violations concerning pain, mode of birth, interaction with clinical staff and midwives, birth complications and support from partner/companion through evaluative qualitative content analysis and calculated their predictive power for postpartum somatic symptoms and stress via two regression analyses.</div></div><div><h3>Results</h3><div>Regression analyses yielded significant results, explaining 40.7 % of higher postpartum somatic symptoms with more negative expectation violation in mode of birth and the primiparous status. Overall, 38.7 % of higher postpartum stress was explained by more negative expectation violations with birth mode as the only predictor.</div></div><div><h3>Limitation</h3><div>A deductive approach to assess birth-related expectations might have contributed to biased responses, the retrospective assessment of birth experiences to biased recall. Further control variables such as pregnancy complications or the actual mode of birth should be investigated.</div></div><div><h3>Conclusion</h3><div>Our study revealed that unmet expectations about the birth mode significantly affect postpartum mental health. This suggests a potential opportunity for preventive measures to foster realistic childbirth expectations and thus enhance the overall birth experience.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100861"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression-specific P300 deficits compared to other forms of internalizing psychopathology","authors":"Brittney Thompson ,&nbsp;Nicholas Santopetro ,&nbsp;Brian Albanese ,&nbsp;Norman B. Schmidt","doi":"10.1016/j.jadr.2024.100865","DOIUrl":"10.1016/j.jadr.2024.100865","url":null,"abstract":"<div><h3>Background</h3><div>Depression involves dysfunctions in reward and cognitive processing, with event-related potentials (ERPs) demonstrating impaired reward positivity (RewP) and P300 components, reflecting deficits in processes such as reward consumption, decision making and motivation. However, depression is both a highly heterogenous disorder and highly comorbid with other internalizing disorders that are also characterized by similar deficits in RewP and P300, the specificity of these neural dysfunctions to depression and its symptom clusters, is less understood.</div></div><div><h3>Methods</h3><div>The current study employed a complex monetary gambling task, Gehring task, to examine depression-specific dysfunctions in decision making (choice-P300) and response to reward (RewP) within reward processing in a clinical sample of adults diagnosed with current depressive disorders (DEP; <em>n</em> = 107) compared to adults with other current internalizing disorders but no history of depression (non-DEP; <em>n</em> = 73).</div></div><div><h3>Results</h3><div>DEP participants exhibited significantly blunted P300 amplitude to mixed-choice (low and high reward) stimuli compared to non-DEP participants. No significant group differences emerged for P300 to other choice stimuli or for RewP. Moreover, reduced mixed-choice P300 was specifically associated with elevated anhedonic symptoms.</div></div><div><h3>Limitations</h3><div>Our work is cross-sectional in nature; therefore, we cannot establish a cause-effect relationship.</div></div><div><h3>Conclusions</h3><div>Findings suggest that within the internalizing disorders spectrum, depression is particularly characterized by deficits in decision making, indicated by reduced P300 amplitude, which is potentially reflecting elevations in anhedonia that does not characterize other internalizing disorders.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100865"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated intravenous infusions of esketamine in inpatients with bipolar depression: A retrospective real-world study","authors":"Naima Guhad Shire ,&nbsp;Michael Ioannou ,&nbsp;Örjan Falk ,&nbsp;Ane Bakken Wold ,&nbsp;Caroline Wass ,&nbsp;Zoltán Szabó ,&nbsp;Steinn Steingrimsson","doi":"10.1016/j.jadr.2024.100870","DOIUrl":"10.1016/j.jadr.2024.100870","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine shows promise for treating bipolar depression, particularly in severe cases. However, the optimal administration route and enantiomer (esketamine, arketamine, or racemic mixture) remain unclear. This case series presents data on intravenous (IV) esketamine in bipolar depression, addressing a gap in published literature.</div></div><div><h3>Methods</h3><div>This retrospective chart review included adult inpatients with bipolar depression treated with multiple IV esketamine infusions. Outcomes were measured using the self-rated Montgomery Åsberg Depression Scale (MADRS-S) and clinician-rated improved Global Clinical Impression Scale-Severity Index (rCGI-S). Tolerability data were also collected.</div></div><div><h3>Results</h3><div>Thirteen patients received 4–6 IV esketamine infusions over two weeks. Statistically significant improvements were observed in MADRS-S total scores (<em>p</em> = 0.002) and rCGI-S scores (<em>p</em> &lt; 0.001) but not in MADRS-S suicidal thoughts item (<em>p</em> = 0.125). Infusions were generally well-tolerated, with treatment-emergent hypomania in two patients (15.4 %).</div></div><div><h3>Limitations</h3><div>The retrospective design without a control group limited effectiveness evaluation.</div></div><div><h3>Conclusions</h3><div>Preliminary results of IV esketamine for bipolar depression are promising, but its role in treatment algorithms requires clarification. Randomized controlled studies are needed to investigate its effectiveness further.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100870"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of a PTSD diagnosis following the Beirut port explosion: Comparing the direct and indirect effects of exposure to trauma","authors":"Rudy Abi-Habib,&nbsp;Wissam Kheir,&nbsp;Pia Tohme","doi":"10.1016/j.jadr.2024.100866","DOIUrl":"10.1016/j.jadr.2024.100866","url":null,"abstract":"<div><h3>Objective</h3><div>The Beirut Port explosion on August 4, 2020, led to widespread devastation and significant psychological impacts, including the development of psychological disorders like PTSD. This study investigates the predictors of PTSD following this event, focusing on the differences between direct and indirect exposure to trauma</div></div><div><h3>Methods</h3><div>The sample consisted of 743 Lebanese participants. The DSM-5 revised criteria for indirect exposure, including secondary traumatic stress, are considered. Measures included the PCL-5, DASS-21, RFQ-8, and CD-RISC-10.</div></div><div><h3>Results</h3><div>The study confirms that both direct and indirect exposures contribute to PTSD development, with direct exposure linked to more severe PTSD symptoms. It also highlights the importance of demographic factors like gender and age in PTSD prevalence, with women and younger individuals more susceptible to PTSD in indirect exposure scenarios.</div></div><div><h3>Conclusions</h3><div>Protective factors like mentalizing and resilience are discussed, revealing their complex relationship with trauma exposure. Our findings have significant implications for developing targeted prevention and intervention strategies for different trauma exposure types and subpopulations.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100866"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling the relationships of health-related quality of life, depressive symptoms, disability and social support after stroke: A network analysis","authors":"Simon Ladwig ,&nbsp;Matthias Volz ,&nbsp;Julia Haupt ,&nbsp;Anya Pedersen ,&nbsp;Katja Werheid","doi":"10.1016/j.jadr.2024.100855","DOIUrl":"10.1016/j.jadr.2024.100855","url":null,"abstract":"<div><h3>Background</h3><div>Health-related quality of life (HRQOL), depressive symptoms, disability, and social support show complex interdependences after stroke, which cannot be sufficiently depicted by commonly used uni- or bivariate analyses. Applying a network analysis, we aim to disentangle these multivariate relationships and deduce meaningful starting points for interventions.</div></div><div><h3>Methods</h3><div>Stroke survivors (<em>N</em> = 202) were recruited from two inpatient rehabilitation clinics. Participants self-reported mental and physical HRQOL, depressive symptoms, disability, and social support. We computed a partial correlation network and included these five variables as separate nodes. We estimated edge weights, node centrality (expected influence), node predictability, and clusters. Bootstrap methods were applied to assess network stability.</div></div><div><h3>Results</h3><div>Depressive symptoms and mental HRQOL were the most central and interconnected nodes in the network. Depressive symptoms built its own cluster. Social support showed a high association with depressive symptoms. Disability had no significant associations with other nodes in the network. Physical HRQOL was significantly connected only to its mental equivalent.</div></div><div><h3>Limitations</h3><div>The cross-sectional design limits the findings to the setting of inpatient rehabilitation few weeks after stroke and allows no longitudinal inferences. The relatively small sample size and varying metrics of applied measures are counterbalanced by a high stability of estimations.</div></div><div><h3>Conclusions</h3><div>Depression and social support show stronger associations with HRQOL than physical aspects during stroke inpatient rehabilitation. This underscores the significance of mental aspects shortly after stroke. Development and implementation of early interventions targeting depressive symptoms and social support may sustainably mitigate the burden on HRQOL after stroke.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100855"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}