Journal of Affective Disorders Reports最新文献

{"title":"Understanding risk and protective factors for suicidal behaviour in a military context: A concept mapping approach","authors":"Kairi Kõlves ,&nbsp;Luke Bayliss ,&nbsp;Alex Donaldson ,&nbsp;Geoff Dickson ,&nbsp;Zoe Jenkins ,&nbsp;Nikki Jamieson ,&nbsp;Martine Cosgrove ,&nbsp;Ed Heffernan ,&nbsp;Jennifer Wild ,&nbsp;Jacinta Hawgood","doi":"10.1016/j.jadr.2025.100977","DOIUrl":"10.1016/j.jadr.2025.100977","url":null,"abstract":"<div><h3>Background</h3><div>There are increasing efforts to better understand suicidal behaviour among current and former military personnel in Australia. More research using innovative methodologies is needed to identify risk and protective factors that could be addressed within the military.</div></div><div><h3>Objective</h3><div>To better understand perceived risk and protective factors associated with suicidal behaviour within the military context.</div></div><div><h3>Methods</h3><div>Three groups of stakeholders were recruited: people with lived experience of suicide in a military context, military mental health clinicians, and researchers with expertise in suicide in a military context. Using concept mapping, participants individually generated risk and/or protective factors for suicidal behaviour in a military context, before organising and rating all statements. Data were collected, analysed, and visually represented using the GroupWisdom platform.</div></div><div><h3>Results</h3><div>In total, 57 stakeholders participated in at least one stage of the study (i.e., brainstorming, sorting and/or rating). Brainstorming generated 97 perceived risk-factors and 63 perceived protective factors, which were thematically grouped by participants. A multidimensional scaling and hierarchical cluster analysis generated a 7-cluster solution for risk factors and a 5-cluster solution for protective factors. Most of the risk and protective factors rated highly both in terms of importance and feasibility for the military to address were from workplace-related clusters.</div></div><div><h3>Conclusions</h3><div>The risk and protective factors for suicidal behaviours within a military context were identified on three social-ecological levels: workplace (community), relational, and individual. The results of this study may inform future suicide research and prevention activities targeted to military personnel.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100977"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between childhood maltreatment, self-harm, and pain sensitivity in care-experienced adolescents living in the UK: a cross-sectional study","authors":"Tatum M. Cummins ,&nbsp;Oliver Maltby ,&nbsp;Martin Bellander ,&nbsp;Moa Pontén ,&nbsp;Johan Bjureberg ,&nbsp;Daniel Stahl ,&nbsp;Rory C. O’Connor ,&nbsp;Stephen B. McMahon ,&nbsp;Susanne Millar ,&nbsp;Isabel Mathews ,&nbsp;Helen Minnis ,&nbsp;Dennis Ougrin","doi":"10.1016/j.jadr.2025.100975","DOIUrl":"10.1016/j.jadr.2025.100975","url":null,"abstract":"<div><h3>Background</h3><div>Childhood maltreatment is a major public health issue and associated with self-harm in adolescents. Self-harm is the strongest recognised predictor of suicide. Associations between reduced pain sensitivity and childhood maltreatment have been reported. We have previously shown that pain hyposensitivity is a robust feature of adolescents living in residential care with self-harm. Here, we explore the relationship between adverse childhood experiences (ACE), self-harm, and pain sensitivity in this sample.</div></div><div><h3>Methods</h3><div>Forty-eight adolescents (13-17 years) completed the ACE 10-item scale and were tested using a standardised quantitative sensory testing (QST) protocol. Participants were categorised according to the subtypes of abuse experienced (e.g., physical versus sexual) and frequency of self-harm within the past year. Associations between subtypes of childhood maltreatment, self-harm, and pain sensitivity were examined using ordinal regression, linear regression and independent samples t-test.</div></div><div><h3>Results</h3><div>In our sample, history of sexual abuse was the strongest predictor of self-harm (p = .01). Those with experience of sexual abuse (n = 13) also showed significantly higher pain thresholds (p = .01). Those with experience of sexual abuse and the most frequent self-harm (n = 11) showed significantly higher pain thresholds compared to those without experience of sexual abuse (n = 10, p = .009).</div></div><div><h3>Limitations</h3><div>The cross-sectional study design does not allow us to establish causal relationships. Due to the limited sample size, findings should be interpreted as exploratory.</div></div><div><h3>Conclusions</h3><div>Based on a limited sample of 48, our findings suggest that a history of sexual abuse may have a unique relationship to self-harm and pain hyposensitivity. Longitudinal research is needed to estimate the predictive value of pain sensitivity as a potential biomarker to identify those at risk for self-harm and suicide.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100975"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of the unified protocol for emotional disorders in children and adolescents: A systematic review and meta-analysis","authors":"Malte Schäpermeier ,&nbsp;Anna-Lena Jesussek ,&nbsp;Jasmin Kirchherr ,&nbsp;Maximilian Monninger ,&nbsp;Anja C. Feneberg ,&nbsp;Tanja Hechler","doi":"10.1016/j.jadr.2025.100970","DOIUrl":"10.1016/j.jadr.2025.100970","url":null,"abstract":"<div><div>Transdiagnostic treatments such as the Unified Protocol for Emotional Disorders in Children and Adolescents (UP-C/A; Ehrenreich-May, J., Kennedy, S.M., Sherman, J.A., Bilek, E.L., Buzzella, B.A., Bennett, S.M., Barlow, D.H., 2017a) aim to target shared mechanisms across mental disorders and to achieve positive treatment outcomes. Several studies investigated the UP-C/A with promising results regarding the improvement of internalizing symptoms. However, there is currently no meta-analysis investigating the efficacy across the existing studies. In this preregistered systematic review and meta-analysis (PROSPERO CRD 42023474832), we analyzed whether the UP-C/A is effective in reducing internalizing symptoms (primary outcome) and secondary outcomes such as emotion regulation in comparison to control treatments where applicable, and from pre- to post-treatment and follow-up. We also examined whether moderators (i.e., sample and treatment characteristics) predicted the effects of the UP-C/A. We included 21 studies (9 RCTs, 11 uncontrolled studies, 1 single-case experimental study) with a total of <em>N</em> = 994 participants. For internalizing symptoms, we found moderate to large controlled effects post-treatment (<em>g</em> = 0.58, <em>p</em> = .014) and at follow-up (<em>g</em> = 0.79, <em>p</em> = .003). Uncontrolled effects were large in both cases. We also found moderate to large effects for secondary outcomes (i.e., emotion regulation, global severity of psychopathology, global functioning). Treatment format did not impact the efficacy. Overall, our findings suggest that the UP-C/A is effective in treating internalizing symptoms in children and adolescents that can be offered in different formats. However, more research is needed to draw robust conclusions regarding specific treatment mechanisms underlying these effects.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100970"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of repetitive transcranial magnetic stimulation on anxiety and cognitive function in generalized anxiety disorder: a comprehensive review","authors":"Xuan Zhang ,&nbsp;Xiaodong Chen ,&nbsp;Leijun Li,&nbsp;Xiuhua Wu,&nbsp;Jiaxin Huang,&nbsp;Xin Qin,&nbsp;Qinsheng Chen,&nbsp;Hongyun Zhou,&nbsp;Jiong Tao,&nbsp;Jihui Wang","doi":"10.1016/j.jadr.2025.100945","DOIUrl":"10.1016/j.jadr.2025.100945","url":null,"abstract":"<div><div>Anxiety disorder is one of the major health burdens in the world, and most of the patients have significantly impaired social function, which seriously affects their quality of life. Currently, conventional treatment methods include medication and psychotherapy. However, due to the limitations of these treatments and the lack of response in some patients, finding effective alternative treatment options has become urgent. Repetitive transcranial magnetic stimulation (rTMS), a relatively non-invasive and safe physical therapy, has been increasingly recommended for anxiety disorders in recent years. Nevertheless, the therapeutic effects, optimal stimulation sites, and stimulation parameters remain unclear. This article aims to provide a systematic review of the current state of rTMS treatment for generalized anxiety disorder(GAD), offering new perspectives for identifying more effective and personalised adjunctive options.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100945"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout in the general population: Role of anxiety, depression and traumatic events","authors":"Lucia Romo ,&nbsp;Clément Duret ,&nbsp;Laurent Cruchet ,&nbsp;Stéphanie Nann ,&nbsp;Samantha Tessier ,&nbsp;Oulmann Zerhouni","doi":"10.1016/j.jadr.2025.100941","DOIUrl":"10.1016/j.jadr.2025.100941","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the predictors of work exhaustion in the general population, with a particular focus on the roles of burnout, anxiety, depression, and trauma-related symptoms.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted among a sample from the French general population. The survey included measures of burnout using the Copenhagen Burnout Inventory (CBI), anxiety (GAD-7), depression (PHQ-9), and trauma-related symptoms (International Trauma Questionnaire [ITQ]). Correlation and Regression analyses were performed to identify significant predictors of work exhaustion</div></div><div><h3>Results</h3><div>The analysis revealed that personal burnout (CBI) were significant positive predictors of work exhaustion. Older individuals and men reported higher levels of work exhaustion. However, anxiety, depression, and trauma-related symptoms did not emerge as significant predictors.</div></div><div><h3>Conclusion</h3><div>The findings underscore the critical role of specific dimensions of burnout, particularly personal burnout, in predicting work exhaustion. These results suggest that targeted interventions addressing these aspects of burnout may be crucial in reducing work-related stress and improving employee well-being. The study also highlights the need for further research on the indirect effects of trauma on work exhaustion in the general population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100941"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic predictors of depression among economically vulnerable mothers in urban Uruguay","authors":"Anahita Kumar ,&nbsp;Juanita Bloomfield ,&nbsp;Ana Balsa ,&nbsp;Hang Do (Heather) ,&nbsp;Alejandro Cid ,&nbsp;Guilherme Lichand ,&nbsp;Sharon Wolf","doi":"10.1016/j.jadr.2025.100978","DOIUrl":"10.1016/j.jadr.2025.100978","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a leading cause of disability worldwide, affecting women twice as much as men. In Latin America, rates are double the global average. Uruguay, despite investing in mental health, has the continent’s highest and still-rising suicide rate.</div></div><div><h3>Methods</h3><div>We examine predictors of depression among a sample of economically vulnerable mothers in Uruguay (<em>N</em> = 467). Depression was measured using the Center for Epidemiologic Studies Depression Scale (CES-D). Sociodemographic predictors were added in blocks using hierarchical regression with robust standard errors.</div></div><div><h3>Results</h3><div>On average, survey respondents were 29 years of age (SD = 6.65), with children aged 24 months (SD = 5.97). The average CES-D score was 6.9 (range 0–46), with 12 % of respondents at risk (CES-<em>D</em> ≥ 16). Mothers who had completed middle or secondary school had lower levels. In contrast, experiencing a negative economic shock in the past year and receiving government assistance were associated with higher depression. Mothers receiving government assistance were 8 percentage points more likely to be at risk of depression, suggesting a subgroup prevalence of ∼ 20 %- a figure that aligns closely with prior estimates in similar populations. Among subgroups, mothers (not receiving assistance) who worked part-time had higher CES-D scores than those working full-time.</div></div><div><h3>Limitations</h3><div>We rely on self-reported, cross-sectional data.</div></div><div><h3>Conclusions</h3><div>Indicators of economic strain predict increased depression levels among mothers in Uruguay. Higher education and full-time employment were protective factors. The elevated risk among mothers receiving government assistance highlights the need for integrated mental health and social support interventions.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100978"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between impulsivity and vocal emotion recognition following cerebellar stroke","authors":"Annie Sautebin ,&nbsp;Ioana Medeleine Constantin ,&nbsp;Philippe Voruz ,&nbsp;Marine Thomasson ,&nbsp;Didier Grandjean ,&nbsp;Frédéric Assal ,&nbsp;Julie Anne Péron","doi":"10.1016/j.jadr.2025.100969","DOIUrl":"10.1016/j.jadr.2025.100969","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has established a link between impulsivity and emotion recognition across various pathologies, highlighting the cerebellum's role in both impulsive behavior and vocal emotion processing. However, the relationship between these factors in patients with chronic cerebellar stroke remains unexplored.</div></div><div><h3>Aim</h3><div>This study aimed to investigate whether impulsivity predicts the auditory recognition of emotions previously identified as deficient—specifically anger, sadness, and neutral—in cerebellar stroke patients.</div></div><div><h3>Methods</h3><div>We conducted LASSO regressions using data extracted from the dataset of the CEREBEMO project, which assessed emotional prosody recognition through a validated task. The analysis included the French-validated Urgency-Premeditation-Perseverance-Sensation Seeking (UPPS) impulsivity scale, with a sample of 26 patients.</div></div><div><h3>Results</h3><div>Results revealed significant effects of sensation seeking, urgency and lack of premeditation scores on the emotional prosody recognition of anger and sadness stimuli. Significant effects of gender, age, lesion side and time since the stroke on emotional prosody performances were also found.</div></div><div><h3>Conclusions</h3><div>Impulsivity can predict the ability to identify vocal emotions among patients in the chronic phase following cerebellar stroke. These insights suggest that addressing impulsivity may enhance emotional recognition capabilities and, consequently, improve social functioning in this population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100969"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased PON1 activity as a biological marker for depressive disorders: a narrative review","authors":"Oleg A. Levada,&nbsp;Oleksandra S. Troian","doi":"10.1016/j.jadr.2025.100947","DOIUrl":"10.1016/j.jadr.2025.100947","url":null,"abstract":"<div><h3>Background</h3><div>This study conducts a narrative review to summarize evidence regarding changes in serum/plasma paraoxonase 1 (PON1) activity in patients with major depressive disorder (MDD) or other depressive disorders and assess their possible marker value.</div></div><div><h3>Methods</h3><div>We searched the PubMed database for articles published from inception to December 2024 on the relationship between depression and PON1 activities/concentrations.</div></div><div><h3>Results</h3><div>Seventeen articles from 2006 to 2022 were included in the final analysis. 70 % of the studies demonstrated a decline in PON1 (predominantly arylesterase activity) during MDD episodes and depressive disorders induced by methamphetamine and Parkinson`s disease. Lower PON1 paraoxonase activity was associated with the number of previous depressive episodes (DE), worse outcomes, and higher DE severity. Two studies showed an increase in PON1 activity after antidepressant treatment. The decline of PON1 has a genetic predisposition. QQ and QR genotypes of PON1 increased the odds of depression. MDD patients with QQ genotype (in contrast to QR and RR) showed lowered PON1 activity.</div></div><div><h3>Conclusion</h3><div>There is a decline in arylesterase/paraoxonase activity and PON1 concentrations in MDD and secondary depressive disorders. The decline is also associated with the severity and number of DE. Antidepressant treatment might increase PON1 activity. Genetic predisposition and epigenetic mechanisms that decrease PON1 activity might disrupt antioxidative mechanisms and lipid metabolism, which could be a part of complex pathogenesis and/or lead to comorbid somatic MDD pathology related to accelerated aging. PON1 activity and concentrations decline might be a marker for MDD and other DE, whereas PON1 increase – for treatment efficacy.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100947"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of combined transcranial direct current stimulation and cognitive training on brain microstructure and network homogeneity in late-life depression: a pilot study","authors":"Junghee Ha ,&nbsp;Yu Fang ,&nbsp;Chandan Kittur ,&nbsp;Greg O. Cron ,&nbsp;Ok Kyu Song ,&nbsp;Jin Young Park ,&nbsp;Jin Hyung Lee","doi":"10.1016/j.jadr.2025.100973","DOIUrl":"10.1016/j.jadr.2025.100973","url":null,"abstract":"<div><h3>Background</h3><div>Depression and cognitive decline frequently coexist in older individuals. However, effective treatment options remain limited. Neuromodulation has shown potential beyond traditional cognitive training; however, its specific effects on brain connectivity and white matter structures remain unclear. The purpose of this study was to evaluate the effects of combining transcranial direct current stimulation (tDCS) with cognitive training on white matter microstructure integrity and default mode network (DMN) homogeneity in older adults with cognitive deficits and depressive symptoms.</div></div><div><h3>Methods</h3><div>This double-blind, randomized sham-controlled study compared cognitive training combined with either anodal or sham tDCS in older adults with late-life depression and cognitive decline. Multimodal magnetic resonance imaging was used to assess DMN homogeneity and white matter microstructure at baseline and after 5 weeks of treatment.</div></div><div><h3>Results</h3><div>Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity. However, tDCS did not provide additional benefit to white matter integrity. A higher baseline anterior-posterior DMN association correlated with better cognitive function, and treatment remission increased posterior DMN homogeneity. Enhancements in cingulum white matter integrity were associated with improvements in depressive symptoms, cognition, and brain-derived neurotrophic factor levels.</div></div><div><h3>Conclusions</h3><div>Cognitive training leads to improved white matter integrity in older adults experiencing cognitive deficit and depression. Changes in the structural integrity of the cingulum can predict clinical outcomes. No additional benefits of tDCS on white matter integrity or network homogeneity were observed.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100973"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining disordered eating and depressive symptomatology in adults with Sickle Cell Disease (SCD): Gender differences","authors":"Deja Buckner ,&nbsp;Bridgette Pittman Blackwell ,&nbsp;John J. Sollers III ,&nbsp;W. Jeff Bryson ,&nbsp;Alexandria McDougald ,&nbsp;Mary Wood ,&nbsp;Camela S. Barker ,&nbsp;Jessica Miller ,&nbsp;Elaine Whitworth ,&nbsp;Erika N. Cubilete ,&nbsp;Jenny Norris ,&nbsp;Danielle May ,&nbsp;Meredyth Galliher ,&nbsp;Beyonnshea N. Lucas ,&nbsp;Cara Green ,&nbsp;Erika Cubilete ,&nbsp;Ben Bayan ,&nbsp;Ashley Lopez ,&nbsp;John J. Sollers IV ,&nbsp;Malik Muhammad ,&nbsp;Christopher L. Edwards","doi":"10.1016/j.jadr.2025.100962","DOIUrl":"10.1016/j.jadr.2025.100962","url":null,"abstract":"<div><div>Sickle cell disease (SCD) is a genetic disorder characterized by distorted red blood cells that possess a decreased ability to carry oxygen and carbon dioxide throughout the body, primarily impacting individuals of African, Mediterranean, and South American backgrounds. The present study sought to examine the relationship between disordered eating patterns and depressive symptomatology by comparing self-identified gender differences in patients with SCD. Disordered eating was measured using the Eating Disorder Inventory (EDI-I), which encompasses four subscales including body dissatisfaction (BD), ineffectiveness (IE), interpersonal distress (ID), and interoceptive awareness (IA). Depressive symptoms were assessed using the Beck Depression Inventory-I (BDI-I) and the Center for Epidemiological Studies-Depression (CES-D). In a sample of 37 Black adults with SCD (30 female and 7 male), the results showed that women exhibited higher body dissatisfaction and depressive symptoms in comparison to men (<em>p</em> &lt; .05). Women with SCD simultaneously experiencing high incidences of body dissatisfaction and depressive symptoms could impact their prognosis, psychological functioning, and overall health. Further research is needed to examine this issue and its implications.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100962"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}