Journal of Affective Disorders Reports最新文献

{"title":"Antidepressant effects of exercise: Does mindset matter?","authors":"Kendall Kohnle,&nbsp;Rick Ingram","doi":"10.1016/j.jadr.2025.100901","DOIUrl":"10.1016/j.jadr.2025.100901","url":null,"abstract":"<div><h3>Background</h3><div>Following research by reported by Crum and Langer (2007), perhaps changing a person's mindset (i.e., beliefs and expectations) about exercise could be a key to facilitating the antidepressant effects of exercise without changing the behavior itself.</div></div><div><h3>Methods</h3><div>The experimental group participants were told that their daily activities were considered exercise which would alleviate their depressive symptoms. Control participants read a script that discussed various effective strategies to alleviate depressive symptoms.</div></div><div><h3>Results</h3><div>No preexisting differences in depression between groups approached significance, nor were there differences on any measure administered pre-experiment. A multilevel model analysis indicated a significant difference between the groups’ depression scores over time, with the mindset group's depressive symptoms decreasing more rapidly than those of the control groups. Although not of prime interest, result showed that anxiety scores also decreased more rapidly in the mindset condition.</div></div><div><h3>Conclusion</h3><div>Altering mindset about exercise appears to, accelerates decreases in depressive symptoms. mindfulness-based therapies may quite naturally integrate elements that facilitate a patient's positive mindset and expectations. Broadly speaking, clinicians who are attuned to finding ways to incorporate therapeutic placebos like a positive mindset may find this beneficial to patients. As such, influencing mindset may be an effective aid in the treatment of depression.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100901"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired family functioning is associated with depressive symptoms in a community-dwelling Japanese population: The Hisayama Study","authors":"Fumi Nagasawa ,&nbsp;Mao Shibata ,&nbsp;Naoki Hirabayashi ,&nbsp;Sanmei Chen ,&nbsp;Daigo Yoshida ,&nbsp;Jun Hata ,&nbsp;Nobuyuki Sudo ,&nbsp;Toshiharu Ninomiya","doi":"10.1016/j.jadr.2025.100900","DOIUrl":"10.1016/j.jadr.2025.100900","url":null,"abstract":"<div><h3>Background</h3><div>Several clinical studies have reported an association between impaired family functioning and depressive symptoms. However, epidemiological evidence is limited. The aim of this study was to investigate the association between family functioning and the presence of depressive symptoms in a community-dwelling Japanese population.</div></div><div><h3>Methods</h3><div>A total of 2,595 participants aged ≥40 years were included. Impaired family functioning levels were assessed by using a short version of the general functioning subscale of the McMaster Family Assessment Device (GF6+). Impaired family functioning levels were categorized as healthy (GF6+ score: ≤1.80), borderline (1.81–2.00), or unhealthy (&gt;2.00). The presence of depressive symptoms was defined as a score of ≥10 on Patient Health Questionaire-9. A logistic regression model was used to compute the odds ratios (ORs) for the presence of depressive symptom.</div></div><div><h3>Results</h3><div>The age-adjusted prevalence of depressive symptoms was 5.4 % for men and 7.0 % for women. In both sexes, the age-adjusted prevalence of depressive symptoms increased significantly with increasing impaired family functioning levels (both P for trend &lt;0.001). The ORs (95 % confidence intervals) for having depressive symptoms among the borderline and unhealthy groups were 3.32 (1.51–7.29) and 4.09 (1.76–9.54) for men, and 1.04 (0.56–1.95) and 3.02 (1.76–5.18) for women, respectively, compared with the healthy group after adjustment for potential confounders.</div></div><div><h3>Limitation</h3><div>Reverse causality is possible due to the cross-sectional design.</div></div><div><h3>Conclusions</h3><div>Impaired family functioning was associated with an increased risk of the presence of depressive symptoms. It may be important considering the family functioning in managing depressive symptoms.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100900"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network approach to shame: The central roles of self-criticism, self-compassion and self-forgiveness in an aged-diverse sample","authors":"Bahar ShamsAlam ,&nbsp;Hojjatollah Farahani ,&nbsp;Peter Watson ,&nbsp;Sajjad Bagheri","doi":"10.1016/j.jadr.2025.100890","DOIUrl":"10.1016/j.jadr.2025.100890","url":null,"abstract":"<div><h3>Background</h3><div>Shame, as a complex and global self-conscious emotion, plays a significant role in mental health. Self-criticism is a crucial factor in generating negative emotions, including shame, while self-compassion and self-forgiveness can mitigate the effects of self-criticism and shame. The present study examines the coexistence of these psychological constructs using a network analysis model.</div></div><div><h3>Methods</h3><div>A diverse sample of 474 Iranian residents, comprising men and women aged 13 to 73, participated in this study through convenience sampling. Variables were assessed using the External and Internal Shame Scale (EISS), the Self-Compassion Scale Short Form, the Levels of Self-Criticism Scale, and the Heartland Forgiveness Scale (HFS).</div></div><div><h3>Results</h3><div>We utilized a Graphical Gaussian Model (GGM) with polychoric correlations visualized using the qgraph, bootnet R packages and employed bridge centrality metrics along with permutation-based stability tests and bootstrap resampling to analyse the network's structure and stability. The network analysis revealed that nodes representing internalized self-criticism (IC), comparative self-criticism (CC), and self-forgiveness (SF) exhibited the highest bridge strength, indicating their critical roles in maintaining network connectivity. The network's stability was confirmed with a robust CS coefficient of 0.517, ensuring the reliability of these findings.</div></div><div><h3>Conclusion</h3><div>This network analysis provides a precise understanding of the relationships between shame, self-criticism, self-compassion, and self-forgiveness. In this study, comparative self-criticism and internal self-criticism emerged as critical factors in the regulation and generation of shame. Comparative self-criticism appears to play a more decisive role in the manifestation of shame.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100890"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience as a protective factor to academic Burnout in adolescents during COVID-19","authors":"Ángel Alberto Puig-Lagunes ,&nbsp;León Jesús German-Ponciano ,&nbsp;Guerson Yael Varela-Castillo ,&nbsp;Fabiola Ortiz-Cruz ,&nbsp;Gilberto Uriel Rosas-Sánchez ,&nbsp;Rodrigo Ramírez-Rodríguez","doi":"10.1016/j.jadr.2025.100899","DOIUrl":"10.1016/j.jadr.2025.100899","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 pandemic increased academic concerns and risk for development of academic burnout syndrome (ABS) among adolescents. In Mexico, little research has been conducted on the impact of resilience in adolescents as a potential coping strategy against ABS. Therefore, this study aimed to examine the link between resilience and ABS symptoms in Mexican high school adolescents during the COVID- 19 pandemic.</div></div><div><h3>Method</h3><div>An analytical and observational cross-sectional study was conducted with 2,194 adolescents from nine public high schools in Veracruz. Resilience and ABS were assessed between May-June 2021 by Google form, using the Mexican Resilience Scale and the Maslach Burnout Inventory - Student Survey. Using resilience domains, we conducted a binomial logistic regression model to predict the protective or risk factors for burnout syndrome.</div></div><div><h3>Results</h3><div>A total of 9.73 % of adolescents exhibited symptoms of ABS. Female gender was found to be significantly associated with ABS. Furthermore, lack of value in domains such as strength and self-confidence (OR = 2.14, 95 % CI: 0.59–1.57), family support (OR = 1.89, 95 % CI: 1.47–2.44), and structure (OR = 1.62, 95 % CI: 1.22–2.16) were identified as risk factors for the development of burnout syndrome. In contrast, increase of value in social support (OR = 0.59, 95 % CI: 1.22–2.16) emerged as a protective factor.</div></div><div><h3>Conclusions</h3><div>Resilience served as a crucial protective factor against ABS in high school adolescents highlighting the need for interventions aimed at promoting their emotional well-being, particularly among females.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100899"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of suicidal ideation and attempts among colleges students in India: A multi-state cross-sectional survey","authors":"Gregory Armstrong ,&nbsp;Anish V. Cherian ,&nbsp;Tilahun Haregu ,&nbsp;Delfina Bilello ,&nbsp;H. Sobhana ,&nbsp;Sonia P. Deuri ,&nbsp;Shrinivasa U. Bhat ,&nbsp;Agnieta Aiman ,&nbsp;Soyuz John ,&nbsp;Yamini Kannappan ,&nbsp;Sonali S. Tesia ,&nbsp;Sujit Gosh ,&nbsp;Manisha Kiran","doi":"10.1016/j.jadr.2025.100898","DOIUrl":"10.1016/j.jadr.2025.100898","url":null,"abstract":"<div><h3>Background</h3><div>Youth suicide represents a significant public health problem in India. This paper reports on the results of a large survey examining the correlates of suicidal ideation and attempts among college students in India, adopting an ideation-to-action framework.</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 8,542) were recruited from 30 universities spanning nine states of India, and they completed a self-administered questionnaire assessing the 12-month prevalence of suicidal thoughts and attempts, symptoms of depression and anxiety, non-suicidal self-injury, exposure to suicidality in others, as well as a suite of other health and social indicators. Generalised linear models were used to examine the correlates of suicidal ideation, and the correlates of suicide attempts among ideators.</div></div><div><h3>Results</h3><div>Just over one-in-ten (12.3 %) reported suicidal ideation in the preceding 12 months, 5.2 % reported a suicide attempt and 12.2 % reported non-suicidal self-injury. Just over one-third (34.8 %) of ideators reported a suicide attempt in the past 12 months. Higher odds of a suicide attempt among ideators were observed among those who: had bad/very bad quality family relationships, were consuming greater amounts of alcohol, had used cannabis, had been exposed to suicidal ideation in others, had been exposed to the suicide death of people they had personally known, and those who had been engaging in non-suicidal self-injury.</div></div><div><h3>Conclusions</h3><div>Our study revealed a suite of important factors that correlate with suicidality among college students in India, and our analytical approach highlights those factors that are associated with the progression from suicidal ideation to suicide attempts.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100898"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between social demographic factors and anxiety in college students","authors":"Joyce Olushola Ogunrinde ,&nbsp;Patrick Dang ,&nbsp;Luiza Martins ,&nbsp;Nimra Niazi-Galindo ,&nbsp;Omolola Adepoju ,&nbsp;LaDessa Y. Mitchell","doi":"10.1016/j.jadr.2025.100896","DOIUrl":"10.1016/j.jadr.2025.100896","url":null,"abstract":"<div><h3>Introduction</h3><div>Untreated anxiety increases risk for depression and disruption in college matriculation. Thirty seven percent of college students experience anxiety, but the role of intersectional social identities in providing patient center support is unclear. We conducted a quantitative study of college students to identify the social identities salient to their anxiety risk to optimize mental health support post pandemic.</div></div><div><h3>Methods</h3><div>The GAD- 7 was administered online to 584 US college students from Fall 2020 to Fall 2021. A binary outcome indicated whether students experienced significant anxiety (GAD-7 score ≥15). Independent variables include race/ethnicity, biological sex, age, sports involvement, college level, relationship status, and social class. Descriptive statistics were computed using frequencies and proportions. Bivariate between each independent variable and the outcome of interest were examined using chi-square tests. Multivariate logistic regression was used to assess the strength of the relationships while controlling for all independent variables.</div></div><div><h3>Results</h3><div>The key finding is that lower socioeconomic class was associated with higher risk of anxiety.</div></div><div><h3>Conclusion</h3><div>While no significant interaction effect was seen with the other demographic variables, the high number of women in the study suggests that further investigation is needed into the intersectional effects of gender and class. Moreover, 76 % of participants reported not engaging in sport which suggests sport is an underutilized coping mechanism for reducing anxiety and can serve a possible intervention tool.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100896"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual differences in anxious apprehension and anxious arousal alter resting-state network structure and connectivity","authors":"Stacie L. Warren ,&nbsp;Whitney N. Geller ,&nbsp;Brian Droncheff ,&nbsp;Kevin Liu","doi":"10.1016/j.jadr.2025.100895","DOIUrl":"10.1016/j.jadr.2025.100895","url":null,"abstract":"<div><h3>Background</h3><div>Pathological anxiety is commonly treated as a unitary construct, manifesting as various clinical subtypes. However, there is a growing consensus that anxiety has at least two unique dimensions, anxious arousal and anxious apprehension. Nevertheless, their distinguishable neurobiological mechanisms are unclear. Here, we take a transdiagnostic approach to disentangle network-level functional and structural disturbances at rest, a state when some anxiety symptoms may be most apparent.</div></div><div><h3>Methods</h3><div>53 adults experiencing a range of anxiety and/or depressive symptoms completed resting-state fMRI. Resting-state networks were identified by independent components analysis. Dual-regression tested anxious arousal and anxious apprehension derived within-network connectivity differences while controlling for depression. FSLNets tested differences in between-network functional connectivity.</div></div><div><h3>Results</h3><div>Anxious apprehension was associated with expansion of the default and somatomotor networks, while anxious arousal was associated with hyperconnectivity in the salience, limbic, frontoparietal, and default networks. Anxious apprehension was also associated with increased connectivity between the default and salience networks as well as decreased connectivity between the dorsal attention and limbic networks.</div></div><div><h3>Limitations</h3><div>Evaluating a larger sample size and longer resting-state scans can better ensure reproducibility of results. The cross-sectional design limits conclusions about the temporal dynamics of anxious apprehension and anxious arousal and functional connectivity alterations observed in the present study.</div></div><div><h3>Conclusions</h3><div>Results suggest that anxious apprehension and anxious arousal have distinguishable neurobiological mechanisms that contribute to maladaptive differences in threat evaluation, stress response, and self-referential thought. These findings enhance our understanding of anxiety's nosology and pathophysiology, informing potential mechanisms for intervention.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100895"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are amygdala and insula consistently hyperresponsive to aversive stimuli in PTSD? Comment on Bastos et al. 2022","authors":"Aline Rodrigues Cardoso ,&nbsp;Aline Furtado Bastos ,&nbsp;José Magalhães Oliveira ,&nbsp;João Ricardo Sato ,&nbsp;Liana Catarina Lima Portugal ,&nbsp;Mirtes Garcia Pereira ,&nbsp;Leticia de Oliveira ,&nbsp;Eliane Volchan ,&nbsp;Fátima Smith Erthal","doi":"10.1016/j.jadr.2025.100897","DOIUrl":"10.1016/j.jadr.2025.100897","url":null,"abstract":"<div><h3>Background</h3><div>A recurring theme in fMRI studies is the inconsistent findings in amygdala and insula hyperreactivity among patients with PTSD vs. trauma-exposed controls. This study reanalyzed data from Bastos et al. (2022) investigating group effects to aversive stimuli in those regions.</div></div><div><h3>Methods</h3><div>Patients with PTSD (<em>n</em> = 20) and trauma-exposed controls (<em>n</em> = 23) briefly viewed neutral and mutilation pictures. Amygdala and insula ROIs were analyzed for valence and group effects. Subsequently, regressor duration was extended to determine whether a longer regressor would capture a lasting valence effect beyond picture presentation.</div></div><div><h3>Results</h3><div>Significant main effects of valence were observed in the amygdala and insula ROIs, for both regressor durations. In both regions there were no significant main effects for group. Further no interactions between valence and group were found, indicating lack of consistent hyperresponsivity in patients with PTSD.</div></div><div><h3>Conclusions</h3><div>Our results help to challenge hyperreactivity as a proxy of PTSD. In fact, multiple traumatic experiences and/or childhood maltreatment were shown to be associated with hyporeactivity in PTSD. If this is not taken into consideration, the average pattern of reactivity recorded from a mixed sample with both hypo and hyper responders can be indistinguishable from controls.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100897"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting preventative effects of cognitive control training in remitted depressed individuals: A machine learning approach","authors":"Yannick Vander Zwalmen ,&nbsp;Ernst H.W. Koster ,&nbsp;David Demeester ,&nbsp;Chris Baeken ,&nbsp;Nick Verhaeghe ,&nbsp;Kristof Hoorelbeke","doi":"10.1016/j.jadr.2025.100894","DOIUrl":"10.1016/j.jadr.2025.100894","url":null,"abstract":"<div><h3>Background</h3><div>Residual cognitive complaints are frequently observed in remitted depressed individuals (RMD), which can impair full recovery and increase the likelihood of recurrent episodes of depression. Cognitive control training (CCT) has shown potential as a preventative intervention in RMD with small to moderate effect sizes, but substantial heterogeneity in effects between individuals exists.</div></div><div><h3>Objective</h3><div>This study aimed to identify individual characteristics associated with CCT treatment response in RMD participants using machine learning (ML) models.</div></div><div><h3>Methods</h3><div>227 RMD underwent a CCT regimen of at least 10 sessions. Three machine-learning models were evaluated: logistic regression, random forest, and XGBoost, alongside one random classifier benchmark. Performance metrics (accuracy, precision, recall, F1-score, and AUC-ROC) were computed. Feature importance was assessed using SHAP values.</div></div><div><h3>Result</h3><div>All models demonstrated low performance, regardless of ML methodology. The logistic regression model obtained the highest performance, although this was still considered low (accuracy: 0.54; AUC-ROC: 0.49). Exploratory feature importance analysis revealed that age, sense of well-being, and life satisfaction were important variables in the models, while current use of psychotherapy, number of prior depressive episodes, and history of inpatient treatment were not.</div></div><div><h3>Conclusion</h3><div>All models performed poorly, indicating that baseline characteristics did not confidently predict CCT treatment effects in this RMD sample. Exploratory feature analysis indicates that some clinical variables may increase the likelihood of benefiting from CCT, while most demographical variables did not seem to affect treatment effectiveness. However, due to low model performance, confidence in feature importance was low and additional research using larger samples is required.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100894"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of neurophysiological signatures of bipolar disorder by resting-state EEG microstate analysis","authors":"Keita Taniguchi ,&nbsp;Naotsugu Kaneko ,&nbsp;Masataka Wada ,&nbsp;Mayuko Takano ,&nbsp;Sotato Moriyama ,&nbsp;Yu Mimura ,&nbsp;Hiroyuki Uchida ,&nbsp;Shinichiro Nakajima ,&nbsp;Yoshihiro Noda","doi":"10.1016/j.jadr.2025.100891","DOIUrl":"10.1016/j.jadr.2025.100891","url":null,"abstract":"<div><h3>Background</h3><div>This investigation probed the neurophysiological disparities between patients with bipolar disorder (BD) and healthy controls (HC) utilizing resting-state electroencephalography (rs-EEG) microstate (MS) analysis. The study, conducted at Keio University Hospital from 2017 to 2023, sought to differentiate BD from HC for early detection.</div></div><div><h3>Methods</h3><div>The study included 36 BD (average age: 48.3 years) and 36 age- and sex-matched HC (average age: 47.8 years). Participants underwent a 5-min rs-EEG recording with eyes closed. MS analysis focused on the duration, occurrence, and coverage of MS (<em>A</em> − <em>E</em>) transitions. Comparisons were executed using Mann-Whitney U tests, and a logistic regression model distinguished the groups based on these MS indices.</div></div><div><h3>Results</h3><div>Patients with BD exhibited a shorter MS-D duration (<em>p</em> &lt; 0.001) and longer MS-C (<em>p</em> = 0.027) and MS-E (<em>p</em> = 0.020) durations compared to HC. The occurrence and coverage of MS-D were significantly lower in BD (<em>p</em> &lt; 0.001 for both). The logistic regression model accurately classified 84.7% of cases (χ2(3)=42.03, <em>p</em> &lt; 0.001).</div></div><div><h3>Limitations</h3><div>Limitations include the potential influence of medication on MS dynamics and the cross-sectional design, which prevents causal conclusions. Longitudinal studies are required to comprehend the relationship between MS alterations and BD symptoms.</div></div><div><h3>Conclusion</h3><div>Decreased MS-D indices, along with increased MS-C and MS-E indices in BD, imply dysfunction in the frontoparietal network and impairments in the default mode and salience networks. The altered temporal dynamics of rs-EEG MSs provide a unique neurophysiological profile of BD, suggesting that MS indices could potentially serve as neurophysiological markers for BD diagnosis.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100891"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}