Journal of Affective Disorders Reports最新文献

{"title":"Structural examination of the relationships between insecure attachment styles and intolerance of uncertainty: the mediating role of rumination in predicting obsessive–compulsive symptoms in high school students","authors":"Mohammadreza Noroozi Homayoon,&nbsp;Esmaeil Sadri Damirchi,&nbsp;Amirhossein Abdoli","doi":"10.1016/j.jadr.2026.101137","DOIUrl":"10.1016/j.jadr.2026.101137","url":null,"abstract":"<div><div>The present study aimed to develop and test a conceptual model examining whether rumination mediates the relationship between insecure attachment style and intolerance of uncertainty with obsessive–compulsive symptoms among high school students. A descriptive–correlational design with structural equation modeling was employed, involving 378 high school students from Ardabil. Participants completed measures of adult attachment style, intolerance of uncertainty, rumination, and obsessive–compulsive symptoms. Results indicated that insecure attachment and intolerance of uncertainty were positively and significantly associated with rumination and obsessive–compulsive symptoms. Furthermore, rumination significantly mediated the relationships between both insecure attachment and intolerance of uncertainty in students with obsessive–compulsive symptoms. These findings highlight the cognitive and emotional mechanisms underlying the development and maintenance of obsessive–compulsive symptoms during adolescence. Practically, the results suggest that interventions aimed at reducing obsessive–compulsive symptoms should focus on enhancing emotional security, increasing tolerance of uncertainty, and addressing maladaptive rumination. However, due to the cross‑sectional nature of the data, these findings should be interpreted with caution, and causal inferences regarding the mediating role of anxiety sensitivity are not warranted.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101137"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID stress, anxiety and depressive symptoms, and multimorbidity: a longitudinal examination","authors":"Amanda Lima Barros Feitosa,&nbsp;Michelle M. Paluszek,&nbsp;Dalainey H. Drakes,&nbsp;Donald Sharpe,&nbsp;Steven Taylor,&nbsp;Gordon J.G. Asmundson","doi":"10.1016/j.jadr.2026.101119","DOIUrl":"10.1016/j.jadr.2026.101119","url":null,"abstract":"<div><h3>Background</h3><div>People with chronic medical conditions experienced additional stressors and a decline in their mental health during the COVID-19 pandemic compared to the general public. We examined the role of multimorbidity on anxiety, depression, and COVID stress over time in the general population.</div></div><div><h3>Methods</h3><div>Adults from Canada and the U.S. completed an online survey at three time points between March and August 2020. Multilevel models were used to compare anxiety and depressive symptoms and COVID stress between individuals who reported no chronic medical conditions (<em>n</em> = 2200), one chronic medical condition (<em>n</em> = 795), and multimorbidity (<em>n</em> = 731) across time while accounting for the presence of a mental health diagnosis.</div></div><div><h3>Results</h3><div>People with a pre-existing mental health diagnosis and females reported more severe anxiety, depression, and COVID stress symptoms, except for xenophobia. Anxiety and depressive symptoms and COVID stress decreased over time regardless of the number of chronic medical conditions. People living with multimorbidity reported lower compulsive checking and reassurance seeking behaviours than people with no medical conditions, but also had a less pronounced decline in checking behaviours several months into the pandemic. The discrepancy in checking behaviours between people with multimorbidity and those with no medical conditions was sustained over time.</div></div><div><h3>Limitations</h3><div>Data were based on self-report survey methods.</div></div><div><h3>Conclusions</h3><div>Results extend existing literature by describing patterns of COVID stress, anxiety, and depression over time across groups. Differences on some aspects of mental health among individuals living with multimorbidity, which slowly dissipated over time, may have implications for tailored pandemic stress interventions.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101119"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Hurricane Harvey on adult and young adult mental health and health behaviors","authors":"James C. Hodges,&nbsp;Summer Sherburne Hawkins,&nbsp;Alexa Riobueno-Naylor,&nbsp;Christopher F. Baum,&nbsp;Betty S. Lai","doi":"10.1016/j.jadr.2026.101120","DOIUrl":"10.1016/j.jadr.2026.101120","url":null,"abstract":"<div><div>Disasters such as hurricanes have considerable implications for mental health and health behaviors, and it is likely that these implications are influenced by social vulnerability. Young adults are uniquely vulnerable to the negative effects of disasters, and population-level, quasi-experimental approaches can help overcome some limitations of disaster mental health epidemiology, including retrospective data. We used a difference-in-differences modeling strategy with the 2012-2019 waves of the Behavioral Risk Factor Surveillance System to estimate the behavioral health impacts of Hurricane Harvey in Texas in August 2017. Individuals that were fully or partially exposed to the hurricane had a statistically significant increase in poor mental health at the population level (1.62 percentage points, 95% confidence interval: 0.20, 3.04). However, this change was not significantly different from the change in unexposed individuals. Results also did not find any statistically significant changes in self-reported health or health behaviors between individuals exposed to the hurricane as compared to unexposed individuals. Young adults did not significantly differ from other adults, nor did individuals with high school or less significantly differ from individuals with some college or more. White adults exposed to Hurricane Harvey had larger increases in poor mental health compared to those in unexposed areas (2.89, 95% CI: 0.20, 5.58). Findings did not support that young adults experience worse effects from the hurricane. The results highlight the importance of considering the mental health ramifications of disasters and the need for targeted mental health interventions in fully and partially exposed areas.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101120"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in neuroticism and values after naturalistic use of psychedelics and MDMA: A prospective survey study","authors":"Abigail E. Calder,&nbsp;Vincent J. Diehl,&nbsp;Bernd Hinney,&nbsp;Gregor Hasler","doi":"10.1016/j.jadr.2026.101127","DOIUrl":"10.1016/j.jadr.2026.101127","url":null,"abstract":"<div><h3>Background</h3><div>Serotonergic psychedelics and MDMA may improve mental health through reductions in neuroticism and changes in personal values. While decreases in neuroticism following serotonergic psychedelics are sometimes observed, it is unclear which facets of neuroticism respond the most, and MDMA remains understudied. People also report value shifts after psychedelic experiences, but prospective data are limited. This study examined changes in neuroticism and twelve personal values after planned, naturalistic use of psychedelics and MDMA.</div></div><div><h3>Methods</h3><div>Participants planning to use psychedelics or MDMA (N = 74) completed surveys at baseline, one day post-experience, one week, and four weeks follow-up. Neuroticism was assessed with the NEO-FFI and personal values with a modified Valued Living Questionnaire. Linear mixed effects models examined changes over time.</div></div><div><h3>Results</h3><div>Neuroticism significantly decreased at four weeks (β=-2.64, <em>p</em>&lt;.001), though not at one week (β=0.01, <em>p</em> = 0.99), for users of both serotonergic psychedelics and MDMA. Reductions were most pronounced for items assessing shame and feelings of tension. Participants rated the values of citizenship (β = 0.68, t = 2.63, p = 0.01), family (β = 0.80, t = 3.64, p &lt; .001), intimate relationships (β = 0.57, t = 2.88, p = 0.01), and spirituality (β = 1.04, t = 4.08, p &lt; .001) as more important one week after their psychedelic experience; only family remained elevated at four weeks (β = 0.57, t = 2.41, p = 0.02). Serotonergic psychedelics were associated with greater spirituality increases than MDMA (β = 2.19, t = 4.19, p = .005).</div></div><div><h3>Discussion</h3><div>Planned consumption of psychedelics and MDMA in naturalistic settings was associated with decreased neuroticism and transiently increased importance of relational and spiritual values. The increased importance of family persisted longest, lasting up to four weeks. These findings expand the literature on self-reported changes in neuroticism and identify potential mechanisms underlying changes in well-being after psychedelic experiences.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101127"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific emotion regulation strategies are transdiagnostically associated with hippocampal connectivity markers of vulnerability to emotion dysregulation","authors":"Luigi F Saccaro,&nbsp;Farnaz Delavari,&nbsp;Nader Perroud,&nbsp;Dimitri Van De Ville,&nbsp;Camille Piguet","doi":"10.1016/j.jadr.2026.101125","DOIUrl":"10.1016/j.jadr.2026.101125","url":null,"abstract":"<div><div>Emotion dysregulation (ED) is a core transdiagnostic feature of multiple psychiatric conditions and a key marker of vulnerability in high-risk populations, such as the offspring of patients with emotion dysregulation disorders (EDD; e.g., bipolar disorder, borderline personality disorder, attention-deficit/hyperactivity disorder). The hippocampus, central to integrating affective, cognitive, and sensorimotor processes, shows altered dynamic functional connectivity (dFC) in both EDD patients and their unaffected offspring. Building on our previous characterization of hippocampal dFC patterns using micro-coactivation patterns (μCAPs) in this cohort, the present study explored the relationship between these hippocampal connectivity patterns andin the specific cognitive emotion regulation strategies. We applied Partial Least Squares Correlation (PLS-C) to identify multivariate associations between hippocampal dFC and Cognitive Emotion Regulation Questionnaire (CERQ) scores in 201 participants (74 EDD patients, 57 offspring of EDD patients, and 70 healthy controls). One significant transdiagnostic latent component emerged (<em>p_adj</em> = 0.03), linking higher use of non-adaptive strategies (e.g., self-blame, rumination) to increased hippocampal dFC with the limbic and default mode networks, and greater reliance on adaptive strategies (e.g., positive reappraisal, putting into perspective) to hippocampal dFC with the sensorimotor network, a connectivity profile previously associated with resilience to ED. These associations did not differ significantly between diagnostic groups, underscoring their transdiagnostic relevance. By integrating hippocampal connectivity markers with detailed behavioral profiling, this study highlights specific cognitive strategies as potential modifiable targets for prevention and early intervention in individuals at risk for EDD, including the unaffected offspring of EDD patients.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101125"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced temporal neural coherence in major depressive disorder: A multimodal EEG study of active information storage across resting state and reward anticipation task–","authors":"Damian Jan","doi":"10.1016/j.jadr.2026.101117","DOIUrl":"10.1016/j.jadr.2026.101117","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) involves reward processing deficits and anticipatory anhedonia, but reliable electrophysiological biomarkers are lacking. Active Information Storage (AIS), a measure of neural self-predictability, may index the brain’s capacity for anticipatory states. We tested whether frontocentral AIS is reduced in MDD across task and rest.</div></div><div><h3>Methods</h3><div>Three primary EEG datasets (total N = 412 unique participants across all five datasets) were analyzed: (1) a probabilistic selection task (109 participants: 86 healthy controls [HC], 23 MDD); (2) resting-state EEG from the same cohort (N = 113); and (3) a clinical resting-state dataset (N = 168). AIS was estimated using bin-based Shannon mutual information.</div></div><div><h3>Results</h3><div>HC showed significantly higher AIS than MDD during reward anticipation (d = 0.81, p &lt; .001) and resting state (d = 0.70, p = .003; d = 0.53, p=.006). A fourth resting-state dataset (N = 53) showed the same directional pattern (d = 0.32) but was underpowered. The task effect was specific to reward-contingent contexts. Exploratory analysis found AIS was lower in partially remitted than currently depressed MDD (d = 0.96, p = .034), independent of residual symptom severity (ANCOVA, p = .033, partial η²=0.21).</div></div><div><h3>Conclusions</h3><div>AIS at FCz is a robust, replicable candidate marker of reduced temporal neural coherence in MDD. The exploratory “scar” finding requires prospective replication in larger samples with documented episode histories.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101117"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying machine learning to investigate future life-oriented predictors of adolescents’ near-term suicidal ideation","authors":"Da-eun Lee,&nbsp;Olivia Lawrence,&nbsp;Ki Eun Shin,&nbsp;Shirley B. Wang,&nbsp;Christine B. Cha","doi":"10.1016/j.jadr.2026.101105","DOIUrl":"10.1016/j.jadr.2026.101105","url":null,"abstract":"<div><h3>Background</h3><div>Adolescents contemplating suicide consider <em>both</em> the discontinuation and continuation of their lives. Yet prior research has mainly focused on what suicidal youth want to escape from (i.e., distress-oriented predictors) rather than what may keep them living into the future. This study applies machine learning (ML) to examine how adolescents’ momentary Future Life-Oriented (FLO) processes predict their near-term changes in suicidal ideation (SI).</div></div><div><h3>Methods</h3><div>Adolescents (N = 121; 15–17 years) completed a 14-day, 5x/day smartphone-based ecological momentary assessment protocol, reporting on a range of FLO predictors (e.g., vividness, importance, emotional valence of future life events), distress-oriented predictors (e.g., prior SI, stressors, affect), and SI. ML algorithms were trained on time-series data to predict future SI based on FLO and distress-oriented predictors. To identify optimal temporal prediction windows, we implemented a sliding-window approach and compared models across multiple temporal frames.</div></div><div><h3>Results</h3><div>Models including FLO variables significantly improved prediction of subsequent SI (AUC = 0.880) relative to models using prior SI (AUC = 0.783) alone or prior SI with stress/affect (AUC = 0.781). The best-performing model (Random Forest; AUC = 0.956) achieved optimal prediction using seven prior observations to forecast SI two timepoints ahead (avg. 11h). SHAP analyses identified prior SI and two FLO variables (desire to live, future thought uncontrollability) as the most influential predictors of SI.</div></div><div><h3>Conclusions</h3><div>Adolescents’ momentary FLO processes meaningfully enhance near-term prediction of SI, highlighting a potentially promising collection of modifiable targets for suicide prevention.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101105"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generic group metacognitive therapy for mixed common mental disorders: An open trial with six-month follow-up in specialized mental health care","authors":"Erlend Pukstad,&nbsp;Eivind R. Strand,&nbsp;Odin Hjemdal,&nbsp;Lise Tidemann Veium,&nbsp;Henrik Nordahl","doi":"10.1016/j.jadr.2026.101116","DOIUrl":"10.1016/j.jadr.2026.101116","url":null,"abstract":"<div><div>Common mental disorders (CMDs) are highly prevalent and associated with substantial overlap and comorbidity. Metacognitive Therapy (MCT) was developed to target shared processes across CMDs such as repetitive negative thinking using a similar set of treatment interventions, with the implication that MCT is well-suited to be delivered in groups. The goal of the current study was therefore to evaluate the transdiagnostic nature of MCT delivered in groups consisting of mixed CMDs. Thirtyfour patients with a primary depressive or anxiety disorder and high levels of comorbidity received ten sessions of generic group MCT in a specialist mental health care setting. Changes over time were analyzed using linear mixed-effects models for the total sample and three diagnostic subgroups. Reliable change was calculated based on disorder-specific outcome measures. Significant improvements were observed across all outcomes in the total sample, with large effect sizes from pre- to post-treatment and follow-up. Subgroup analyses indicated large effects on disorder-specific outcomes corresponding to primary diagnoses, alongside additional improvements in broader and secondary outcomes including metacognitive change. Approximately 80% of patients were classified as recovered from their primary diagnosis at post-treatment. These outcomes were achieved using an average of seven therapist hours per patient and were accompanied by improvements in health-related quality of life (QALY). In conclusion, targeting common cognitive-attentional processes and metacognitive beliefs in groups with mixed CMDs was associated with broad improvements across diagnostic subgroups, supporting the feasibility and potential resource efficiency of delivering generic group MCT in routine specialist care.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101116"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wish list from people with lived experience of bipolar disorder - for clinicians and researchers","authors":"Cecilie Busch,&nbsp;Torill Ueland,&nbsp;Margrethe C. Høegh,&nbsp;Carmen Simonsen,&nbsp;Sofie R. Aminoff,&nbsp;Elizabeth A. Barrett,&nbsp;Thomas Bjella,&nbsp;Akiah A. Ottesen,&nbsp;Ingrid Melle,&nbsp;Isabel V. Kreis,&nbsp;Trine Vik Lagerberg","doi":"10.1016/j.jadr.2026.101114","DOIUrl":"10.1016/j.jadr.2026.101114","url":null,"abstract":"<div><h3>Background</h3><div>The insights and experiential knowledge of individuals with lived experience of bipolar disorder represent a valuable yet underutilized resource for informing clinical practice and guiding research. We conducted an online survey asking people with bipolar disorder what they want from clinicians and which research topics they find important.</div></div><div><h3>Method</h3><div>The online survey “Wish list to clinicians and researchers in bipolar disorder” was distributed by the Norwegian Centre for Mental Disorders Research and the Norwegian Bipolar Association. Participants were asked to select 1–3 topics from a list of 16 predefined treatment targets and rate the importance of 20 research topics on a 5-point Likert scale.</div></div><div><h3>Results</h3><div>A total of 415 individuals with bipolar disorder responded. The three most frequent wishes to clinicians were 1) ”Stabilization of depression, mania and suicidal thoughts” 2) “Teach me to cope with and stabilize my emotions” and 3) “Help me to process trauma”. The three highest rated research topics were 1) “The association between bipolar disorder and cognitive functions” 2) “More effective medication with less side effects” and 3) “What has been helpful to those who have recovered”</div></div><div><h3>Conclusion</h3><div>Participants’ wishes for clinical help go beyond established guidelines by underscoring treatment of trauma and affect regulation in daily life. Their wishes for research highlight the importance of reducing medication side-effects, and broader dissemination of knowledge about cognitive impairments in addition to research findings that provide hope for recovery and a satisfying life.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101114"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depressive symptoms and sleep quality with menstrual health among female university students in the mymensingh division of Bangladesh: A cross-sectional study","authors":"Tahmina Akter Tithi,&nbsp;Anup Talukder","doi":"10.1016/j.jadr.2026.101115","DOIUrl":"10.1016/j.jadr.2026.101115","url":null,"abstract":"<div><h3>Background</h3><div>Menstruation is a fundamental biological phenomenon that influences both psychological and physical challenges, yet the link between menstrual health, depression, and sleep quality remains under-explored in Bangladesh. The study assessed the prevalence and associations between menstrual health, depression, and sleep quality among female university students in Bangladesh.</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted among 390 female students from four public universities in Bangladesh. PHQ-9 and PSQI scales were used to assess depression and sleep quality. Chi-square tests and independent sample <em>t</em>-tests were implemented to assess the associations and group differences, respectively. Moreover, variable selection was done using LASSO regression, followed by binary logistic regression to identify significant factors associated with depression and sleep quality after adjusting for potential confounders.</div></div><div><h3>Results</h3><div>Multivariable logistic regression models with LASSO-based variable selection showed a significant association between depression and sleep quality. Menstrual irregularity was significantly associated with higher odds of depression (aOR = 2.497, CI: 1.276–4.887, p &lt; 0.01), while short menstrual cycles were associated with a greater likelihood of sleep disorder (aOR = 4.538, CI: 1.192–17.280, p &lt; 0.05). Students experiencing all premenstrual symptoms were nearly three times more likely to be depressed (aOR = 2.757, CI: 1.194–6.367, p &lt; 0.05). Additionally, significant differences in depression (p &lt; 0.01) and sleep disorder (p &lt; 0.05) were found based on menstrual regularity.</div></div><div><h3>Conclusions</h3><div>Depression and sleep disturbances were significantly associated with menstrual disturbances, highlighting the need for integrated mental and reproductive health interventions. Enhancing awareness and accessible health care may improve students' academic and individual well-being. However, the findings should be interpreted with caution due to the cross-sectional design and convenience sampling approach, which may limit causal inference and generalizability. Longitudinal research is needed to establish causal relationships and guide preventive interventions.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101115"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}