Journal of Affective Disorders Reports最新文献

{"title":"Prolonged grief and posttraumatic stress in parents who lost a child in a road traffic accident: A latent class analysis","authors":"I. van Dijk ,&nbsp;P.A. Boelen ,&nbsp;J. de Keijser ,&nbsp;L. Reitsma ,&nbsp;L.I.M. Lenferink","doi":"10.1016/j.jadr.2025.100879","DOIUrl":"10.1016/j.jadr.2025.100879","url":null,"abstract":"<div><h3>Background</h3><div>The traumatic loss of a child in a road traffic accident (RTA) can lead to mental health issues in parents, such as symptoms of prolonged grief (PG) and posttraumatic stress (PTS). Latent class analysis (LCA) provides insights into different responses to such losses.</div></div><div><h3>Methods</h3><div>Using LCA, 148 parents that were bereaved at least twelve months earlier, were categorized into latent classes based on similar response patterns. Associations between class membership and sociodemographic and loss-related variables and self-directed anger were examined.</div></div><div><h3>Results</h3><div>Two symptom patterns emerged: a 'High PG/Moderate PTS' pattern (73.2 %) and a 'Moderate-High PG/Low PTS' pattern (26.8 %). Mothers and those with more self-directed anger were more likely to present with the first symptom pattern.</div></div><div><h3>Limitations</h3><div>Inclusion of parents undergoing therapy for clinically relevant symptoms, small sample size, no differentiation between parents of minor and adult children, and including only four PTS symptoms are limitations that may have influenced the identified symptom patterns.</div></div><div><h3>Conclusions</h3><div>Parents who lost a child in a RTA seem at risk for developing psychological symptoms, with PG being more predominant than PTS. The study highlights the possible value of addressing modifiable factors such as self-directed anger in therapeutic interventions for PG and PTS after traumatic loss of a child.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100879"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143260141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers","authors":"Yuki Ishikawa ,&nbsp;Tatsuki Sugio ,&nbsp;Kiko Shiga ,&nbsp;Keisuke Izumi ,&nbsp;Kazumichi Minato ,&nbsp;Momoko Kitazawa ,&nbsp;Sayaka Hanashiro ,&nbsp;Ryo Takemura ,&nbsp;Hiroyuki Uchida ,&nbsp;Taishiro Kishimoto","doi":"10.1016/j.jadr.2025.100877","DOIUrl":"10.1016/j.jadr.2025.100877","url":null,"abstract":"<div><h3>Background</h3><div>Mental health problems, particularly depression, significantly impact the working-age population and incur substantial socioeconomic costs. Electrodermal activity (EDA) and skin temperature, measurable through wearable devices, have emerged as potential biomarkers of depression. However, there is a lack of long-term observational studies in real-world settings.</div></div><div><h3>Methods</h3><div>This 4-week observational study analyzed data from 147 office workers across 11 Japanese companies. Participants wore wearable devices during working hours for four weeks to collect EDA and skin temperature data. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and stress was assessed using the 10-item version of the Perceived Stress Scale (PSS-10). The associations between electrodermal activity, skin temperature, and depressive/stress states were analyzed using the Mann–Whitney U test and logistic regression analysis.</div></div><div><h3>Results</h3><div>Participants with PHQ-9 scores ≥5 showed higher median skin conductance and median tonic signal, although these differences lost statistical significance after Bonferroni correction. Logistic regression analysis revealed a negative correlation between age and both PHQ-9 and PSS-10 scores (OR=0.525, 0.646). The mean and standard deviation of skin temperature showed a positive association with depressive symptoms (OR=1.687, 1.733), while normalized EDASymp showed a negative association (OR=0.564).</div></div><div><h3>Conclusions</h3><div>This study suggests that EDA and skin temperature, measured by wearable devices, may be associated with depressive symptoms among office workers. These physiological indicators could be utilized for mental health monitoring and early intervention in the workplace. Further validation with larger samples, and long-term follow-up studies, are warranted.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100877"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic correlates of mental health in Moldova: A nationally representative door-to-door survey","authors":"J.M. van Baar ,&nbsp;C. Ciofu ,&nbsp;F. Thompson ,&nbsp;A.I. Luik ,&nbsp;O. Mereanu ,&nbsp;J. Kramer ,&nbsp;F. Schouten ,&nbsp;V. Condrat ,&nbsp;L. Voorham ,&nbsp;J. Chihai ,&nbsp;L. Shields-Zeeman","doi":"10.1016/j.jadr.2025.100876","DOIUrl":"10.1016/j.jadr.2025.100876","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>The mental health system in Moldova is transitioning toward a community-based model, which requires data on population mental health. This is the first mental health survey among a representative sample of the adult population.</div></div><div><h3>Methods</h3><div>A stratified multistage sample (n = 1826) was collected using in-person door-to-door interviewing during July and August of 2022. The main outcome measures were depression symptoms (PHQ-2), anxiety symptoms (GAD-2), loneliness (UCLA-3), and mental well-being (WHO-5). Multivariable regression models were used to compare outcomes across age, gender, ethnicity, education, employment, and household income groups.</div></div><div><h3>Results</h3><div>Prevalence was 19.8% for depression, 25.5% for anxiety, and 16.1% for loneliness. Average well-being was 69.6 out of 100. Women reported higher prevalence of depression and anxiety symptoms, more loneliness, and lower well-being than men. Older individuals reported higher prevalence of anxiety, more loneliness, and lower well-being than younger individuals. Individuals with low household income reported higher prevalence of depression and anxiety symptoms, more loneliness, and lower well-being than those with higher income, even when adjusting for education and employment.</div></div><div><h3>Conclusions</h3><div>The study provides new data-supported insights into the target populations most at need of mental health support in Moldova (women, older adults, and those with low income) and provides baseline data for population mental health that can inform and guide future policy and research.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100876"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide risk estimation in bipolar disorder using N200 and P300 event-related potentials and machine learning: A pilot study","authors":"Chaewon Lee ,&nbsp;Kathleen M. Gates ,&nbsp;Jinsoo Chun ,&nbsp;Raed Al Kontar ,&nbsp;Masoud Kamali ,&nbsp;Melvin G. McInnis ,&nbsp;Patricia Deldin","doi":"10.1016/j.jadr.2025.100875","DOIUrl":"10.1016/j.jadr.2025.100875","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with bipolar disorder (BD) face an elevated suicide risk. While machine learning (ML) has been used to estimate suicide risk in BD, early predictors like demographics, past attempts, and self-reports are limited by their inability to provide individualized risk estimation, overemphasis on past attempters, and susceptibility to personal biases, underscoring the need for effective, objective markers. Event-related potentials (ERPs), widely studied in suicide research, remain unexplored in ML applications for BD. This pilot study applies ML to N200 and P300 ERP components from a response inhibition paradigm to estimate suicide risk in BD.</div></div><div><h3>Methods</h3><div>We collected N200 and P300 peak amplitude and latency data from 57 Type I BD individuals (22 attempters and 35 non-attempters). Our two-stage ML approach employed adaptive Lasso logistic regression for feature selection, followed by deep neural network (DNN) modeling for classification. For post-hoc analysis, we used explainable AI to interpret ERP feature importance in top-performing DNN predictions.</div></div><div><h3>Results</h3><div>Key features were exclusively identified from latency data. Notably, N200 latency DNN models effectively distinguished attempters from non-attempters, achieving AUCs of 78.2–89.3 %. Explainable AI pinpointed a right visual hemifield Go stimuli-induced ERP from the left-parietal site as the most predictive.</div></div><div><h3>Conclusion</h3><div>Our ERP-ML approach showed promising preliminary results, with N200 latency identified as a potential suicide marker in BD. Larger samples are required to validate these results. While findings are sample-specific, the methodological approach may have broader applicability and could inform future research to refine clinical strategies for detecting high-risk BD individuals.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100875"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of alexithymia in worsening symptoms and quality of life of Systemic Lupus Erythematosus patients (SLE)","authors":"Fabio Rapisarda ,&nbsp;Concetta Mezzatesta ,&nbsp;Antonina Butticè ,&nbsp;Alessandro Raffa ,&nbsp;Stefano Boca","doi":"10.1016/j.jadr.2025.100874","DOIUrl":"10.1016/j.jadr.2025.100874","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and Objectives&lt;/h3&gt;&lt;div&gt;Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease affecting connective tissues, with the potential to impact various organs and systems, thereby limiting the quality of life for affected individuals given that it influences their psychological well-being. Indeed, various stress-inducing factors can lead to alterations in emotional regulation, often presenting, as difficulties in identifying and describing emotions, such as those associated with alexithymia. The aim of the present study is to investigate a potential correlation between the incidence of alexithymia and the worsening of symptoms, subsequently influencing the quality of life in individuals with SLE.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and Methods&lt;/h3&gt;&lt;div&gt;For the realisation of the study a sample of 53 Systemic Lupus Erythematosus (SLE) patients, 47 females and 6 males, aged 16–59 years, was examined and compared with a control group (55 healthy subjects, aged 20–65). The group of patients was recruited within the Connetiviti outpatients’ clinic of the UOC (Complex Oparational Unit) of Rheumatology of the Paolo Giaccone University Polyclinic in Palermo, consisting of healthy subjects and/or with known diagnoses identified within non-clinical contexts, chosen randomly (statistical sense) in order to better represent the general population of the territorial context.&lt;/div&gt;&lt;div&gt;Specific psycho-diagnostic measures were administered: &lt;em&gt;Toronto Alexithymia Scale&lt;/em&gt; (TAS-20), &lt;em&gt;Response Evaluation Measure&lt;/em&gt; (REM-71),&lt;em&gt;Attachment Style Questionnaire&lt;/em&gt; (ASQ), &lt;em&gt;Eysenck Personality Inventory&lt;/em&gt; (EPI),&lt;em&gt;Symptom Check list&lt;/em&gt; (SCL-90), &lt;em&gt;Short Form&lt;/em&gt; (SF-36). The selection of these instruments allowed us to assess attachment styles, the presence of maladaptive personality traits, defence mechanisms employed, in order to define any symptoms indicative of a psychiatric diagnosis, and evaluate the quality of life in relation to the severity of the pathology.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Comparisons between the two groups revealed significant differences in the Systemic Lupus Erythematosus (SLE) patients, compared to the control group, about the difficulty in identifying feelings and distinguishing them from the bodily sensations accompanying emotional activation, the use of conversion as a defence mechanism and the production of positive symptoms.&lt;/div&gt;&lt;div&gt;Moreover, in the same group, the difficulty in identifying emotions was correlated with quality of life, since those who have difficulty identifying emotions have a poorer quality of life.&lt;/div&gt;&lt;div&gt;Further analysis regarding the construct of alexithymia, within the patient group alone, revealed a tendency towards somatisation and the use of immature defence mechanisms, including conversion, acting out, projection, dissociation and displacement, highlighting a tendency to act out and project emotional suffering.&lt;/div&gt;&lt;div&gt;Furthermore, there app","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100874"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the lean-to-fat mass ratio and depressive symptoms in adult Peruvian population: A cross-sectional analysis","authors":"Jamee Guerra Valencia ,&nbsp;Akram Hernández-Vásquez ,&nbsp;Rodrigo Vargas-Fernández","doi":"10.1016/j.jadr.2024.100868","DOIUrl":"10.1016/j.jadr.2024.100868","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies on the relationship between body composition and depressive symptoms have focused on fat or lean mass separately. We aimed to examine the association between the lean-to-fat mass ratio (LFMR) and depressive symptoms in the adult Peruvian population.</div></div><div><h3>Methods</h3><div>This cross-sectional study used the Peruvian Demographic and Health Survey 2023. Adults aged 18–59 years were included, while pregnant women and individuals with implausible anthropometric measurements were excluded. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), while the exposure variable, the LFMR, was calculated using validated regression equations derived from the National Health and Nutrition Examination Survey (NHANES) database, which included the Latino population. Nested regression models assessed the relationship between the LFMR and depressive symptoms, including linear and quadratic terms. Models were adjusted for sociodemographic, health, and behavioral factors. Marginal effects of LFMR were plotted.</div></div><div><h3>Results</h3><div>24,674 subjects were included. A non-linear association between LFMR and depressive symptoms, with a J-shaped curve was found. An initial decrease in depressive symptoms score with increasing LFMR was observed in the adjusted model (β: −1.89; 95 %CI: −2.24, −1.54), followed by an increase in PHQ-9 score at higher LFMR values (β: 0.23; 95 %CI: 0.18, 0.28).</div></div><div><h3>Limitations</h3><div>Lean and fat mass were estimated via equations rather than direct measurements.</div></div><div><h3>Conclusions</h3><div>These results underscore a non-linear association between the LFMR and depressive symptoms among Peruvian adults. An optimal balance between lean and fat mass, rather than focusing solely on one component, may be crucial in reducing depressive symptoms.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100868"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of optimized treatment on the postpartum recurrence in women with bipolar I disorder: A case series","authors":"Verinder Sharma ,&nbsp;Katelyn N. Wood","doi":"10.1016/j.jadr.2025.100873","DOIUrl":"10.1016/j.jadr.2025.100873","url":null,"abstract":"<div><h3>Background</h3><div>Women with bipolar I disorder are at a high risk of recurrence postpartum. This case series describes the postpartum course of bipolar I disorder among women receiving optimized treatment aimed specifically at the prevention of mania.</div></div><div><h3>Methods</h3><div>Clinical records of 12 pregnant females with bipolar I disorder who were seen consecutively at a perinatal clinic between 2020 and 2023 were reviewed to assess the effect of treatment including psychoeducation, good sleep hygiene, avoidance of antidepressants, and use of sedating atypical antipsychotics on postpartum recurrence.</div></div><div><h3>Results</h3><div>All except one patient had been hospitalized for bipolar disorder. The mean follow-up period was 56 ± 73 weeks postpartum. Only two patients (16.7 %) had a relapse (both depression) during the postpartum period. No one required psychiatric hospitalization.</div></div><div><h3>Limitations</h3><div>Small sample size, retrospective design, and lack of comparison group.</div></div><div><h3>Conclusion</h3><div>Combining psychoeducation, social rhythm therapy, and targeted pharmacotherapy may be effective in the prevention of postpartum recurrence in women with bipolar I disorder.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100873"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total and subregional thalamic volumes before and after cognitive behavioral therapy in obsessive-compulsive disorder","authors":"Vilde Brecke ,&nbsp;Anders Lillevik Thorsen ,&nbsp;Chaim Huyser ,&nbsp;Niels de Joode ,&nbsp;Bjarne Hansen ,&nbsp;Kristen Hagen ,&nbsp;Gerd Kvale ,&nbsp;Chris Vriend ,&nbsp;Odile A. van den Heuvel ,&nbsp;Olga Therese Ousdal","doi":"10.1016/j.jadr.2025.100872","DOIUrl":"10.1016/j.jadr.2025.100872","url":null,"abstract":"<div><h3>Background</h3><div>Thalamic volumetric alterations are frequently reported in children and adults with obsessive-compulsive disorder (OCD). However, whether successful cognitive behavioral therapy (CBT) is accompanied by thalamic macrostructural plasticity is unclear.</div></div><div><h3>Methods</h3><div>Twenty-five pediatric (8–19 years) and 53 adult (16–55 years) OCD patients underwent magnetic resonance imaging before and after CBT with exposure and response prevention (CBT with ERP). The data also included 27 pediatric and 37 adult healthy controls that were scanned at similar time intervals. Thalamic nuclei volumes were estimated from T1-weighted images using the longitudinal stream of FreeSurfer's ThalamicNuclei pipeline and aggregated into five subregions (anterior, lateral, medial, pulvinar and ventral). Repeated measures ANCOVAs and linear models were used to investigate pre-post changes in total or subregional thalamic volumes and their associations with clinical response.</div></div><div><h3>Results</h3><div>There were no significant changes in total or subregional thalamic volumes following CBT with ERP in the pediatric or the adult OCD patients. Moreover, the individual clinical response was not associated with changes in thalamic volume, and baseline thalamic volumes did not predict clinical outcome<strong>.</strong></div></div><div><h3>Limitations</h3><div>Low variance in the clinical outcome and power to detect only moderate-to-large effect sizes.</div></div><div><h3>Conclusion</h3><div>The results suggest that total and subregional thalamic volumes remain stable following successful CBT with ERP in OCD patients. Hence, thalamus or its subregions may not serve as feasible biomarkers of CBT outcome in OCD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100872"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of asthma and allergy history with premenstrual symptom severity in young adult women","authors":"Isabella Caruso ,&nbsp;Donghao Lu ,&nbsp;Sofija Zagarins ,&nbsp;Elizabeth Bertone-Johnson","doi":"10.1016/j.jadr.2025.100871","DOIUrl":"10.1016/j.jadr.2025.100871","url":null,"abstract":"<div><h3>Background</h3><div>Premenstrual disorders (PMDs) impact quality of life, increase morbidity, and impair school and work performance, affecting approximately 15–20 % of women of reproductive age. Chronic inflammation has been hypothesized to contribute to the development of PMDs and premenstrual symptoms. However, to our knowledge, few studies have studied the potential associations between premenstrual symptoms and inflammation-related conditions, specifically asthma and eczema.</div></div><div><h3>Methods</h3><div>We investigated the relationship of asthma and eczema with premenstrual symptom severity and PMS risk among 414 women aged 18–31. We used a modified version of the Calendar of Premenstrual Experiences to assess menstrual symptom score. Participants self-reported history of asthma and eczema, as well as their behavioral, dietary, and medical history. A sample of participants (<em>n</em> = 287) provided blood samples to evaluate inflammatory factor levels.</div></div><div><h3>Results</h3><div>We observed significant positive associations between history of asthma (<em>n</em> = 98) and mean total symptom and physical symptom scores. In adjusted analyses, mean total symptom scores were 2.68 (SE = 1.3) points higher among women with asthma than without (<em>P</em> = 0.04). Mean total symptom scores were 4.8 points higher for women reporting both asthma and eczema (<em>n</em> = 36) than those reporting neither condition (<em>n</em> = 256; <em>P</em> = 0.04).</div></div><div><h3>Limitations</h3><div>The cross-sectional study design does not allow us to establish how the timing of asthma onset is related to the timing of premenstrual symptoms.</div></div><div><h3>Conclusions</h3><div>Our results provide support for a relationship between asthma and premenstrual symptoms. More research is needed to understand whether allergic and other inflammatory conditions share common etiology with PMDs.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100871"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in bipolar disorder type I and type II exposed to childhood trauma: A retrospective cohort study","authors":"Hernán F Guillen-Burgos ,&nbsp;Juan F Gálvez-Flórez ,&nbsp;Sergio Moreno-Lopez ,&nbsp;Angela T.H. Kwan ,&nbsp;Oscar Gomez ,&nbsp;Gerardo González-Haddad ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.jadr.2024.100869","DOIUrl":"10.1016/j.jadr.2024.100869","url":null,"abstract":"<div><h3>Background</h3><div>Childhood trauma (CT) exposure is associated with a more pernicious course in bipolar disorder (BD). However, few studies have reported differences between BD I and BD II regarding CT exposure. We explore the differences in the CT trajectories in bipolar disorders.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of individuals with BD (BD I = 73 vs BD II = 73) was carried out. Early age at onset (EAO) and suicide ideation/behavior were used as severity outcomes. Timespan between EAO and treatment was documented and the associations between CT and comorbid alcohol used disorder (AUD), anxiety disorders (AD), and post-traumatic stress disorder (PTSD) were also described. Univariate, bivariate analyses, and a Poisson regression model with bootstrap resampling were used.</div></div><div><h3>Results</h3><div>Higher scores of CT, physical abuse (PA), and sexual abuse (SA) were statistically significant for BD II than BD I (<em>p &lt;</em> 0.001, <em>p =</em> 0.048, <em>p &lt;</em> 0.001, respectively). Early age at onset, suicide ideation/behavior and treatment delay were associated with CT in both BD I and BD II. However, AUD and PTSD showed association with CT only for BD I.</div></div><div><h3>Limitations</h3><div>Sample size, non-comparison control group, and recall bias.</div></div><div><h3>Conclusions</h3><div>There are differences in CT subtype exposure between BD I and BD II with regards to early age onset, suicide ideation/behavior, delayed time to treatment, and comorbid mental disorders. These results claim for early access to strategies such as CT exposure screening in individuals with BD to detect possible pernicious course and improve the quality of life and clinical outcomes.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100869"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}