Ning Huang , Evelyn Law , Helen Chen , Birit Broekman , Jonathan Huang , Shirong Cai , Ai Peng Tan , Jerry Chan , Chong Yap Seng , Bobby Cheon , Anne Rifkin-Graboi
{"title":"How does maternal “belief in a dangerous world” affect maternal and child depressive symptoms during times of crisis?","authors":"Ning Huang , Evelyn Law , Helen Chen , Birit Broekman , Jonathan Huang , Shirong Cai , Ai Peng Tan , Jerry Chan , Chong Yap Seng , Bobby Cheon , Anne Rifkin-Graboi","doi":"10.1016/j.jadr.2025.100968","DOIUrl":"10.1016/j.jadr.2025.100968","url":null,"abstract":"<div><h3>Background</h3><div>Crises like a pandemic can exacerbate maternal and child depressive symptoms. The relationship between a pre-existing maternal dangerous world belief (BDW<sub>Pre</sub>) with subsequent maternal (DEP<sub>Post_Mat)</sub> and child depressive symptoms (DEP<sub>Post_Child</sub>) during the actual crisis, and related mechanisms, remain unclear. This study 1) examines associations between BDW<sub>Pre</sub>, DEP<sub>Post_Mat</sub> and DEP<sub>Post_Child</sub>, and 2) explores moderating and mediating roles of COVID-19 stress and pre-pandemic maternal depressive symptoms (DEP<sub>Pre_Mat</sub>), along with the mediating effect of household conflict (HC<sub>post</sub>).</div></div><div><h3>Methods</h3><div>This cohort data were from the Singapore PREconception Study of Long-Term Maternal and Child Outcomes, including 90 complete cases and 373 imputed cases. Multiple linear regression detected longitudinal associations between BDW<sub>Pre</sub>, DEP<sub>Post_Mat</sub>, and DEP<sub>Post_Child</sub>, with COVID-19 stress and DEP<sub>Pre_Mat</sub> as moderators. Structural equation modeling tested mediating roles of COVID-19 stress, DEP<sub>Pre_Mat</sub>, and HC<sub>post</sub>; insensitive maternal behavior was examined as an additional mediator.</div></div><div><h3>Results</h3><div>There were total associations of BDW<sub>Pre</sub> with DEP<sub>Post_Mat</sub> (β = 0.172, 90 % CI [0.039, 0.306]) and DEP<sub>Post_Child</sub> (β = 0.161, 90 % CI [0.031,0.291]). DEP<sub>Pre_Mat</sub> directly associated with an increase in DEP<sub>Post_Mat</sub> (β = 0.361, 90 % CI [0.248, 0.475]) and DEP<sub>Post_Child</sub> (β = 0.262, 90 % CI [0.121, 0.401]). COVID-19 stress and HC<sub>Post</sub> sequentially mediated the association between DEP<sub>Pre_Mat</sub> and DEP<sub>Post_Mat</sub>, and this relationship could be independently mediated by the HC<sub>Post</sub>.</div></div><div><h3>Conclusions</h3><div>Early interventions for pre-existing maternal depressive symptoms and BDW are critical to protect maternal and preschooler mental health during crises. Interventions prioritizing household conflict, alongside crises-related stress, livelihood impacts, and media exposure, may be beneficial for susceptible preschoolers and their mothers during crises.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100968"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Sarlon , Timur Liwinski , Annette Beatrix Bruehl , Deanne Thomi , Undine Emmi Lang
{"title":"Intranasal racemic ketamine in treatment-resistant depression: Efficacy and tolerability in outpatient treatment","authors":"Jan Sarlon , Timur Liwinski , Annette Beatrix Bruehl , Deanne Thomi , Undine Emmi Lang","doi":"10.1016/j.jadr.2025.100954","DOIUrl":"10.1016/j.jadr.2025.100954","url":null,"abstract":"<div><h3>Background and aim</h3><div>Intranasal racemic ketamine is an off-label alternative for treatment-resistant depression (TRD), offering a non-invasive and compared to esketamine less expensive option. However, its efficacy and safety in outpatient settings remain underexplored. This study aimed to assess the safety, tolerability, and efficacy of intranasal racemic ketamine in patients with TRD.</div></div><div><h3>Methods</h3><div>This retrospective analysis included 45 patients (mean age 50.7 years, 21 women) who completed an induction phase of eight treatments with intranasal racemic ketamine over four weeks. Symptom severity was measured using the Montgomery-Åsberg Depression Rating Scale (MADRS). A complete response was defined as <em>a</em> ≥ 50 % reduction in MADRS scores from baseline, and a partial response as a 25–50 % reduction.</div></div><div><h3>Results</h3><div>The mean racemic ketamine dose was 114.0 mg, the mean MADRS score reduction after four weeks was 34.5 %. The mean increase in blood pressure was 7.4 mmHg systolic and 6.9 mmHg diastolic. A paired <em>t</em>-test comparing baseline and week 8 MADRS scores revealed a statistically significant reduction in scores, with a mean difference of 10.04. Cohen’s d for MADRS reduction was 1.30, indicating a large effect. A total of 31.1 % of patients achieved a complete response, and 33.3 % had a partial response. Euphoria was a significant predictor of treatment response (<em>p</em> < 0.001). Adverse events requiring medical intervention occurred in four patients, and the drop-out rate due to adverse effects was 4.2 %.</div></div><div><h3>Conclusions</h3><div>Intranasal racemic ketamine is an effective, well-tolerated treatment for TRD, with favorable safety outcomes and substantial antidepressant effects.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100954"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley W. Kranjac , Dinko Kranjac , Valentine Chung
{"title":"Temporal and generational changes in depression among young American adults","authors":"Ashley W. Kranjac , Dinko Kranjac , Valentine Chung","doi":"10.1016/j.jadr.2025.100949","DOIUrl":"10.1016/j.jadr.2025.100949","url":null,"abstract":"<div><div>The prevalence of depression among young American adults has risen significantly over the past two decades, but the mechanisms that underlie the population-level changes in depressive symptoms severity remain unclear. We used data from the 2005–2023 National Health and Nutrition Examination Survey (NHANES) and hierarchical age–period–cohort (HAPC) analysis to examine developmental (i.e., age), life stage (i.e., period), and generational (i.e., cohort) distribution of depressive symptoms among American adults aged 20–30 years old over an 18-year period. Our model results indicate that the probability of either mild, moderate, or severe depression increased among young adult females and males between 2005 and 2023 due to a positive age, period, and cohort effect. Specifically, when we consider the historical context (i.e., period-specific changes) and the generational shift (i.e., birth cohort membership), the youngest women and men have the highest probability of either mild or moderate depression, but the probability of severe depression increases among the individuals of both sexes with each consecutive year of age. Policy makers must develop population-level depression prevention strategies that focus on age and sex differences in illness symptoms severity.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100949"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pan Xu , Jinyu Li , Wuying Li , Huameng Huang , Weihua Deng , Xing Li
{"title":"Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality","authors":"Pan Xu , Jinyu Li , Wuying Li , Huameng Huang , Weihua Deng , Xing Li","doi":"10.1016/j.jadr.2025.100960","DOIUrl":"10.1016/j.jadr.2025.100960","url":null,"abstract":"<div><div>Acute ischemic stroke often results in a multitude of neuropsychiatric complications, including depression, dementia, delirium, and fatigue. Research has demonstrated a positive correlation between lower serum vitamin D levels and an elevated risk of these post-stroke symptoms, albeit the precise underlying mechanisms remain incompletely understood. Existing studies indicate that vitamin D deficiency can impair normal immune function, decrease neurotransmitter synthesis, exacerbate oxidative stress damage, and disrupt calcium ion homeostasis. This review consolidates findings from various studies, highlighting the strong association between vitamin D deficiency and abnormal post-stroke symptoms. Furthermore, it elucidates the pivotal role of vitamin D in modulating inflammatory responses, mitigating oxidative stress, and facilitating neurotransmitter synthesis. Based on these insights, we propose vitamin D as a promising therapeutic target for both preventing and alleviating abnormal post-stroke symptoms.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100960"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Venta , Ashley Bautista , Maria Cuervo , Alfonso Mercado , Luz Garcini , Cecilia Colunga-Rodríguez , Mario Ángel-González
{"title":"Migration and separation among Latinx asylum seekers: Experiences and relations with anxiety and depression","authors":"Amanda Venta , Ashley Bautista , Maria Cuervo , Alfonso Mercado , Luz Garcini , Cecilia Colunga-Rodríguez , Mario Ángel-González","doi":"10.1016/j.jadr.2025.100963","DOIUrl":"10.1016/j.jadr.2025.100963","url":null,"abstract":"<div><div>This study sought to describe the experiences of families seeking asylum at the U.S./Mexico border and explore how traveling with and without family was associated with mental health in a large group of Latinx adults. Additionally, we explored relations between experiences of family separation due to migration and anxiety and depression. <em>N</em> = 400 participants were recruited from two main locations: an encampment site along the Rio Grande River in Reynosa Tamaulipas, Mexico and a respite center serving families recently released by U.S. Customs and Border Protection in McAllen, Texas. The average age of participants was 31.35 years (<em>SD</em> = 9.30), and the gender distribution was as follows: 56.5 % identified as female, 41.8 % identified as male, and 1.8 % identified as transgender. All participants identified as Latinx and completed interview-based measures, including a demographic form, migration interview, and the Patient Health Questionnaire in Spanish. Results indicated that most participants (56 %) traveled with minor children and doing so was associated with increased anxiety and depressive symptoms, with neutralization of this effect when traveling with a spouse. All participants endorsed experiencing family separation due to migration and a relation between separation and symptoms of depression was noted, with particular vulnerability among a subset of participants who declined to discuss the separation. The findings of this study bring attention to a large and ongoing humanitarian crisis at the U.S.’s Southern border which renders Latinx asylum seeking families more vulnerable to affective disorders due to the traumatic and destabilizing effects of family separation.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100963"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dennis Rünger , James Campbell , Peter J. Huckfeldt , José J. Escarce
{"title":"Mental health and pre-existing physical illness during the COVID-19 pandemic: Evidence from the Medical Expenditure Panel Survey","authors":"Dennis Rünger , James Campbell , Peter J. Huckfeldt , José J. Escarce","doi":"10.1016/j.jadr.2025.100966","DOIUrl":"10.1016/j.jadr.2025.100966","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic poses substantial health risks, especially for individuals with pre-existing physical illness. While its physical toll is well-documented, its impact on mental health remains less well understood. This study examines mental health changes during the pandemic in U.S. adults with and without pre-existing physical conditions.</div></div><div><h3>Methods</h3><div>We analyzed data from the Medical Expenditure Panel Survey (MEPS), a nationally representative survey of the U.S. civilian population. Mental health outcomes, including psychological distress (Kessler-6 scale) and depressive symptoms (PHQ-2), were assessed pre-pandemic (typically between July and October 2019) and during the pandemic (between July and October 2020 in most cases). Linear regression models with individual fixed effects evaluated within-person changes in these outcomes.</div></div><div><h3>Results</h3><div>Overall, depressive symptoms (PHQ-2) increased slightly during the pandemic (<em>B</em> = 0.064, <em>p</em> = .002), with similar effects in individuals with (<em>B</em> = 0.066) and without (<em>B</em> = 0.062) pre-existing conditions. Psychological distress (K6) remained stable overall, but trajectories varied across population subgroups defined by sociodemographic characteristics (e.g., age, education, living arrangements) primarily among individuals with pre-existing illness.</div></div><div><h3>Limitations</h3><div>The magnitude of change in mental health may have been underestimated due to nonignorable sample attrition.</div></div><div><h3>Conclusions</h3><div>While depressive symptoms increased modestly across the population, the impact on psychological distress was more nuanced, with certain sociodemographic factors moderating change in psychological distress among individuals with chronic conditions. Findings highlight the need for targeted mental health strategies that consider both medical and sociodemographic factors to better support at-risk populations in future public health emergencies.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100966"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of changes in adolescent-adult relationships on help-seeking intention among Japanese schoolchildren","authors":"Nihaal Rahman , Kazue Ishitsuka , Aurélie Piedvache , Mayumi Hangai , Naho Morisaki","doi":"10.1016/j.jadr.2025.100959","DOIUrl":"10.1016/j.jadr.2025.100959","url":null,"abstract":"<div><h3>Background</h3><div>The purpose of this study is to investigate changes in child–adult relationships due to the COVID–19 pandemic and help–seeking intention. Moreover, this study investigated the role of loneliness in those relationships.</div></div><div><h3>Methods</h3><div>We recruited children in grades 5–9, aged 10–15, using a nationally representative 2–staged cluster sampling method. Help–seeking intention was determined using a single question answered upon reading a hypothetical scenario of a child with depressive symptoms. We used modified Poisson regression models to investigate the relationship between changes in child–adult relationships and help–seeking intention, and mediation analysis to assess the role of loneliness in those relationships, respectively.</div></div><div><h3>Results</h3><div>Among 2187 adolescents, 623 (28.5 %) of children reported that they would not seek help if experiencing depressive symptoms. When adjusting for covariates, the children who reported considerably less time to talk with family or considerably reduced ease of talking with teachers or adults reported lower help–seeking intention (RR = 0.49 [95 % CI: 0.34–0.68] and 0.47 [95 % CI: 0.25–0.79], respectively). Loneliness mediated 63 % (95 % CI: 56–70 %) of the relationship between time to talk with family and help–seeking intention and 62 % (95 % CI: 51–73 %) of the relationship between ease of talking with teachers or adults and help–seeking intention.</div></div><div><h3>Conclusion</h3><div>We observed that worsened child-adult relationships decreased help–seeking intention among children. Loneliness served as a partial mediator within both associations. Interventions targeted towards improving child–adult relationships and reducing loneliness may improve help–seeking intention.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100959"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bettina F. Piko , Orsolya Tóthpál-Halasi , David Mellor
{"title":"Depressive symptomatology and burnout among female teachers: An investigation of the contributions of work motivations, resilience and well-being","authors":"Bettina F. Piko , Orsolya Tóthpál-Halasi , David Mellor","doi":"10.1016/j.jadr.2025.100979","DOIUrl":"10.1016/j.jadr.2025.100979","url":null,"abstract":"<div><div><em>Background:</em> Burnout and depression are long-term consequences of occupational stress, especially among female educators who experience not only more stress from workload than their male counterparts but also greater levels of emotional exhaustion, and conflicts from social environment interference. The purpose of this study was to examine the relationships between mental health (burnout, depression, well-being) and job-related factors (work motivation, teacher well-being and resilience) in a sample of female teachers, and to identify the key predictors of teachers’ depression and burnout.</div><div><em>Methods</em>: Participants were Hungarian female teachers (<em>N</em> = 520) who completed an online survey that included measures of these variables. Data were analyzed using descriptive statistics, correlation and stepwise regression analyses.</div><div><em>Results:</em> The results revealed, in addition to a strong correlation between burnout and depressive symptomatology, both were negatively correlated with general and professional well-being, intrinsic and identified motivations, and dimensions of teacher resilience, while positively correlated with amotivation and extrinsic motivations. Stepwise regression revealed that five variables significantly predicted depressive symptoms in female teachers (R² = 0.328): general well-being, amotivation, extrinsic social motivation, family cohesion, and spiritual resilience. Burnout was significantly predicted by general well-being, amotivation, professional well-being, intrinsic motivation, and personal competence (R² = 0.603).</div><div><em>Conclusions</em>: These findings suggest that in contrast with the main predictors of depression, burnout was more predicted by work-related and personal factors, instead of social, familial and spiritual ones. Practical implications for interventions are discussed.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100979"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D.J. van der Mee , Z. Koyuncu , I.L.J. Lemmers-Jansen
{"title":"Are you stressed or just excited? What the Garmin Stress Score can say about your mood","authors":"D.J. van der Mee , Z. Koyuncu , I.L.J. Lemmers-Jansen","doi":"10.1016/j.jadr.2025.100974","DOIUrl":"10.1016/j.jadr.2025.100974","url":null,"abstract":"<div><div>Smartwatches are a practical tool to monitor the body's arousal state by measuring autonomic nervous system activity in daily life, commonly referred to as stress levels by the smartwatches. How these stress levels relate to mood, however, remains unclear. This study aimed to investigate the association between the Garmin Stress Score and mood. Over 28 days, Ecological Momentary Assessment (EMA) data were collected five times a day for mood, and Garmin Stress Score data were collected continuously, in a sample of 95 (80F) healthy young adult university students in the Netherlands. Binary and linear multilevel models were used to associate the Garmin Stress Score with the presence of mood, and a dose-response relationship, respectively. The Garmin Stress Score was associated with high- and moderate-intensity positive mood but not with negative or low-intensity mood. The mood \"calm\" and \"relaxed\" showed a negative dose-response relationship with average Garmin Stress Score, and a positive trend was found for \"enthusiastic.\" Since the Garmin Stress Score relies on parasympathetic activation, representing the rest-and-digest state, rather than fight-or-flight, it makes sense that it is associated with states of non-relaxation. However, it was not associated with states of high arousal negative mood. This makes the term \"Stress Score\" incorrect and misleading to consumers. Our findings warrant further research into mood, particularly those associated with high arousal negative mood. We recommend stronger collaborations between commercial companies like Garmin and researchers to enhance the accuracy of feedback provided by wearable devices and mitigate any harmful effects on consumers.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100974"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Illness perceptions as predictive factors for anxiety and depression symptoms among patients with coronary heart disease","authors":"Manal M. Al-Sutari , Omar Khraisat","doi":"10.1016/j.jadr.2025.100976","DOIUrl":"10.1016/j.jadr.2025.100976","url":null,"abstract":"<div><h3>Purposes</h3><div>This study aimed to describe illness perception (IP) in Jordanian patients with CHD and to examine the role of IP domains in predicting anxiety and depressive symptoms in Jordanian patients with Coronary Heart Disease (CHD).</div></div><div><h3>Methods</h3><div>In a cross-sectional study, a convenience sample of 193 patients with CHD, who visited the cardiac clinic for routine follow-up completed the Brief Illness Perception Questionnaire, and the Hospital Anxiety and Depression Scale.</div></div><div><h3>Results</h3><div>Participants perceived CHD as a chronic condition with moderate negative consequences, and they were highly concerned about their illness. Illness perceptions domains were significantly associated with anxiety and depressive symptoms. Personal control, treatment control, and disease identity were significant predictors of depressive symptoms, while personal control and emotional representation were significant predictors of anxiety symptoms. Conclusion: Findings indicate that negative illness perceptions are strongly associated with anxiety and depressive symptoms. Study findings suggest that interventions targeting personal control, treatment control, identity, and emotional representation could improve CHD patients’ mental well-being.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100976"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}